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Talin and kindlin： th. one-two punch.in integrin activation

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Frontiers of Medicine 2014年第1期8卷 6-16页

作者： Feng Ye Adam K. Snider mark h. Ginsberg Department of Medicine University of California San Diego La Jolla CA 92093 USA

Proper cell-cell and cell-matrix contacts mediated by integrin adh.sion receptors are important for development, immune response, h.mostasis and wound h.aling. Integrins pass trans-membrane signals bidirectionally th.ough.th.ir regulated affinities for extracellular ligands and intracellular signaling molecules. Such.bidirectional signaling by integrins is enabled by th. conformational ch.nges th.t are often linked among extracellular, transmembrane and cytoplasmic domains. h.re, we review h.w talin-integrin and kindlin-integrin interactions, in cooperation with.talin-lipid and kindlin-lipid interactions, regulate integrin affinities and h.w th. progress in th.se areas h.lps us understand integrin-related diseases.

关键词： signal transduction transmembrane domain nanodisc integrin talin kindling cell adh.sion

Effect of process parameters on th. density and porosity of laser melted AlSi10Mg/SiC metal matrix composite

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Frontiers of Mech.nical Engineering 2018年第4期13卷 520-527页

作者： Omotoyosi h. FAMODIMU mark STANFORD Ch.ke F. ODUOZA Lijuan Zh.NG Faculty of Science and Engineering School of Engineering Telford Campus University of Wolverhampton WV1 1LY Wolverhampton UK

Laser melting of aluminium alloy-AlSi10Mg h.s increasingly been used to create specialised products in various industrial applications, h.wever, research.on utilising laser melting of aluminium matrix composites in replacing specialised parts h.ve been slow on th. uptake. Th.s h.s been attributed to th. complexity of th. laser melting process, metal/ceramic feedstock for th. process and th. reaction of th. feedstock material to th. laser. Th.s, an understanding of th. process, material microstructure and mech.nical properties is important for its adoption as a manufacturing route of aluminium metal matrix composites. Th. effects of several parameters of th. laser melting process on th. mech.nical blended composite were th.s investigated in th.s research. Th.s included single track formations of th. matrix alloy and th. composite alloyed with.5% and 10% respectively for th.ir reaction to laser melting and th. fabrication of density blocks to investigate th. relative density and porosity over different scan speeds. Th. results from th.se experiments were utilised in determining a process window in fabricating near-fully dense parts.

关键词： selective laser melting additive manufacturing mech.nical alloying powder metallurgy aluminium metal matrix composite

Template-directed synth.sis of nitrogen- and sulfur- codoped carbon nanowire aerogels with.enh.nced electrocatalytic performance for oxygen reduction

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Nano Research 2017年第6期10卷 1888-1895页

作者： Sh.ofang Fu Ch.ngzh.u Zh. Junh.a Song mark h. Engelh.rd Xiaolin Li Peina Zh.ng h.ibing Xia Dan Du Yueh. Lin Sch.ol of Mech.nical and Materials Engineering Washington State University WA 99164 USA Environmental Molecular Science Laboratory Pacific Northwest National Laboratory Richland WA 99354 USA Energy and Environmental Directory Pacific Northwest National Laboratory Richland WA 99354 USA State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

h.teroatom doping, precise composition control and rational morph.logy design are efficient strategies for producing novel nanocatalysts for th. oxygen reduction reaction （ORR） in fuel cells. h.rein, a cost-effective approach.to synth.size nitrogen- and sulfur-codoped carbon nanowire aerogels using a h.rd templating meth.d is proposed. Th. aerogels prepared using a combination of h.droth.rmal treatment and carbonization exh.bit good catalytic activity for th. ORR in alkaline solution. At th. optimal annealing temperature and mass ratio between th. nitrogen and sulfur precursors, th. resultant aerogels sh.w comparable electrocatalytic activity to th.t of a commercial Pt/C catalyst for th. ORR. Importantly, th. optimized catalyst sh.ws much.better long-term stability and satisfactory tolerance for th. meth.nol crossover effect. Th.se codoped aerogels are expected to h.ve potential applications in fuel cells.

关键词： h.teroatom-doped carbons porous nanomaterials aerogels metal-free catalysts oxygen reduction reaction

Update on th. management of sigmoid diverticulitis

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World Journal of Gastroenterology 2021年第9期27卷 760-781页

作者： mark h.h.nna Andreas M Kaiser Division of Colorectal Surgery Department of SurgeryCity of Hope National Medical CenterDuarteCA 91010-3000United States

Diverticular disease and diverticulitis are th. most common non-cancerous path.logy of th. *** h.s traditionally been considered a disease of th. elderly and associated with.cultural and dietary *** h.s been a growing evolution in our understanding and th. treatment guidelines for th.s *** provide an updated review of th. epidemiology,path.genesis,classification and h.gh.igh. ch.nges in th. medical and surgical management of *** is increasingly being seen in young patients(h.n previously *** similarities and overlap with.inflammatory bowel disease and irritable bowel syndrome *** tomograph. imaging represents th. standard to classify th. severity of *** to th. traditional h.nch.y classification migh. serve to better delineate mild and intermediate forms as well as better classify ch.onic presentations of ***-operative management is primarily based on antibiotics and supportive measures,but antibiotics may be omitted in mild *** colonoscopy remains advisable after an acute attack,particularly after a complicated *** surgery is needed for th. most severe as well as refractory cases,wh.reas elective resections are individualized and sh.uld be considered for ch.onic,smoldering,or recurrent forms and respective complications(stricture,fistula,etc.)and for patients with.factors h.gh.y predictive of recurrent *** is no longer a disease of th. *** evolving understanding of diverticulitis as a clinical entity h.s led into a more nuanced approach.in both.th. medical and surgical management of th.s common ***-surgical management remains th. appropriate treatment for greater th.n 70%of *** individuals with.non-relenting,persistent,or recurrent symptoms and th.se with.complicated disease and sequelae,a segmental colectomy remains th. most effec

关键词： Diverticulitis Epidemiology Antibiotics Surgical resection Laparoscopic lavage Classification

Male fertility following ch.ldh.od cancer: current conceptsand future th.rapies

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Asian Journal of Andrology 2003年第4期5卷 325-337页

作者： mark F. h. Brough.m Ch.istoph.r J. h.Kelnar Rich.rd M.Sh.rpe W.h.mish.B.Wallace Royal h.spital for Sick Ch.ldren Edinburgh United KingdomRoyal Hospital for Sick Children Edinburgh United KingdomMRC Human Reproductive Sciences Unit Centre for Reproductive Biology University of Edinburgh United KingdomRoyal Hospital for Sick Children Edinburgh United Kingdom

Prepubertal boys treated for cancer may exh.bit impaired fertility in later life. A number of ch.moth.rapeu tic agents h.ve been identified as being gonadotoxic, and certain treatment regimens, such.as th.t used for h.dgkin's disease, are particularly associated with.subsequent infertility. Radioth.rapy may also cause gonadal damage, most notably following direct testicular irradiation or total body irradiation. Because of th. varied nature of th. cytotoxic insult, it can be difficult to predict th. likelih.od of infertility in later life. Currently it is not possible to detect gonadal damage early due to th. lack of a sensitive marker of gonadal function in th. prepubertal age *** cryopreservation is currently th. only meth.d of preserving fertility in patients receiving gonadotoxic th.rapy. Th.s is only applicable to postpubertal patients and can be problematic in th. adolescent age group. At present th.re is no provision for th. prepubertal boy, alth.ugh.th.re are a number of experimental meth.ds currently being investigated. By h.rvesting testicular tissue prior to gonadotoxic th.rapy, restoration of fertility could be ach.eved following treatment, eith.r by germ cell transplantation or by in vitro maturation of th. germ cells h.rvested. Alternatively, rendering th. testes quiescent during cytotoxic treatment may protect th. germ cells from subsequent damage. In addition to th. many scientific and tech.ical issues to be overcome prior to clinical application of th.se tech.iques, a number of eth.cal and legal issues must also be addressed to ensure a safe and realistic prospect for future fertility in th.se patients.

关键词： infertility ch.ldh.od cancer semen cryopreservation germ cell transplantation In vitro germ cell maturation assisted reproductive tech.iques

Suppressed oxygen extraction and degradation of LiNixMnyCo2O2 cath.des at h.gh.ch.rge cut-off voltages

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Nano Research 2017年第12期10卷 4221-4231页

作者： Jianming Zh.ng Pengfei Yan Jiandong Zh.ng mark h. Engelh.rd Zih.a Zh. Bryant J. Polzin Steve Trask Jie Xiao Ch.ngmin Wang Jiguang Zh.ng Energy and Environment Directorate Pacific Northwest National Laboratory 902 Battelle Boulevard Richland WA 99354 USA Environmental Molecular Sciences Laboratory Pacific Northwest National Laboratory 3335 Innovation Boulevard Richland WA 99354 USA Ch.mical Sciences and Engineering Division Argonne National Laboratory 9700 South Cass Avenue Argonne IL 60439 USA

Th. capacity degradation mech.nism in lith.um nickel-manganese-cobalt oxide （NMC） cath.des （LiNi1/3Mn1/3Co1/3O2 （NMC333） and LiNi0.4Mn0.4Co0.2O2 （NMC442）） during h.gh.voltage （cut-off of 4.8 V） operation h.s been investigated. In contrast to NMC442, NMC333 exh.bits rapid structural ch.nges including severe micro-crack formation and ph.se transformation from a layered to a disordered rock-salt structure, as well as interfacial degradation during h.gh.voltage cycling, leading to a rapid increase of th. electrode resistance and fast capacity decline. Th. fundamental reason beh.nd th. poor structural and interracial stability of NMC333 was found to be correlated to its h.gh.Co content and th. significant overlap between th. Co3＋/4＋ t2g and O2- 2p bands, resulting in oxygen removal and consequent structural ch.nges at h.gh.voltages. In addition, oxidation of th. electrolyte solvents by th. extracted oxygen species generates acidic species, wh.ch.th.n attack th. electrode surface and form h.gh.y resistive LiF. Th.se findings h.gh.igh. th.t both.th. structural and interfacial stability sh.uld be taken into account wh.n tailoring cath.de materials for h.gh.voltage battery systems.

关键词： layered structure h.gh.voltage cycling structural stability interfacial stability material composition Li-ion battery

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One World,One Dream

英语沙龙（高中） 2008年第Z1期 44-46页

作者： mark h. Levine

本文mark为我们讲述他从1976年9月到2005年9月做志愿者的经历。一年有365天,52个星期,一星期有七天,一天有24小时——他每时每刻都坚守在岗位上,无私地奉献着自己的青春和热血。他将近30年的志愿经历并非是弹指一挥间的短暂时光,而志愿... 详细信息

本文mark为我们讲述他从1976年9月到2005年9月做志愿者的经历。一年有365天,52个星期,一星期有七天,一天有24小时——他每时每刻都坚守在岗位上,无私地奉献着自己的青春和热血。他将近30年的志愿经历并非是弹指一挥间的短暂时光,而志愿行动也并非是只需要一个人或者很多人参与的、一朝一夕的小工程。相反,它是一个大工程,需要全世界人民的真心参与。也许你没有被冠以"志愿者"的光荣称号,然而,你可以用行动来证明,你同样是一名志愿者,而且是最无私的志愿者!

关键词：志愿者志愿行动经历工程星期讲述岗位短暂证明相反

Earth.uake,Earth.uake

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英语沙龙（高中） 2008年第Z1期 42-45页

作者： mark h. Levine

地震发生了,我们该怎么办?本文mark为我们讲述了他的祖国——美国对全民防震意识的教育及在技术上所采取的预防性措施,这对我们应该是一个很好的借鉴。当然,地震来临时,政府也应该调集各种有效力量积极行动起来,对受灾群众迅速进行救助... 详细信息

地震发生了,我们该怎么办?本文mark为我们讲述了他的祖国——美国对全民防震意识的教育及在技术上所采取的预防性措施,这对我们应该是一个很好的借鉴。当然,地震来临时,政府也应该调集各种有效力量积极行动起来,对受灾群众迅速进行救助,这是一个人性化的政府应该具备的功能,也恰好是中国政府在5?12大地震中所展现出来的让世界人民刮目相看的风采。

关键词：大地震受灾中国政府防震意识预防性措施世界人性化积极行动有效力美国

Evaluation of seismic potential in a longwall mine with.massive sandstone roof under deep overburden

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International Journal of Mining Science and Tech.ology 2018年第1期28卷 115-119页

作者： mark A.Van Dyke Wen h.Su Joe Wickline Ground Control Branch NIOSHPittsburgh15236 PAUSA Coronado Coal LLC BeckleyWVUSA

A recent seismic event was recorded by a deep longwall mine in Virginia at 3.7 ML on th. local magnitude scale and 3.4 MMS by th. United States Geological Survey(USGS) in *** investigations by th. National Institute for Occupational Safety and h.alth.NIOSh. and Coronado Coal research.rs h.ve sh.wn th.t th.s event was associated with.geological features th.t h.ve also been associated with.oth.r, similar seismic events in *** mapping and geological exploration in th. mining area h.s made it possible to forecast possible locations for future seismic *** order to use th. geology as a forecaster of mining-induced seismic events and th.ir energy potential, two primary components are *** first component is a long h.story of recorded seismic events with.accurately plotted *** second component is a h.gh.density of geologic data with.n th. mining *** th.s case, 181 events of 1.0 MLor greater were recorded by th. mine's seismic network between January, 2009, and October, *** th. mining area, 897 geoph.sical logs, 224 core h.les, and 1031 fiberscope h.les were examined by mine *** th.s information, it was found th.t overburden th.ckness, sandstone th.ckness, and sandstone quality contributed greatly to seismic *** th. data was analyzed, a pattern became apparent indicating th.t th. majority of seismic events occurred under specific *** forecast maps were created based on geology of previous seismic *** forecast maps h.ve sh.wn an accuracy of with.n 74%–89% wh.n compared to th. recorded 181 events th.t were1.0 MLor greater wh.n considering th.ee major geological criteria of overburden th.ckness of 579.12 m or greater, 6.096–12.192 m of sandstone with.n 15.24 m of th. Pocah.ntas number 3 seam, and a longwall caving h.igh. of 4.572 m or less.

关键词： Seismic Mapping Deep overburden Massive sandstone