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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 34-35,49,50页

作者： mark Morical 不详

2022年10月8日,儒·麦肯瑞走进俄勒冈州本德市的德瑞克公园时,他圆了用三年多时间追逐的梦想这里是他环美徒步路线最后一段行程的终点。这个环美步道长达14000英里,连接现有步道与非正式路线以环绕美国本土外围,是麦肯瑞的心血结晶。

关键词：俄勒冈州步道心血结晶独行者徒步麦肯

Does a large prostate size,small lesion volume,or long needle distance from the probe to the lesion reduce magnetic resonance imaging–targeted cancer detection?

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Current Urology 2024年第2期18卷 144-147页

作者： mark D.Bevill Justin N.Drobish Kevin J.Flynn Maheen Rajput Catherine Metz Chad R.Tracy Paul T.Gellhaus Department of Urology University of Iowa Carver College of MedicineIowa CityIAUSA Department of Radiology University of Iowa Carver College of MedicineIowa CityIAUSA

Background:We aimed to evaluate whether large prostate size,small lesion volume,or long lesion distance from the ultrasound probe tip would decrease cancer detection in transrectal magnetic resonance imaging(MRI)–targeted *** and methods:Patients who underwent MRI-targeted biopsy at our institution between May 2017 and August 2019 were enrolled in a prospective *** to 5 cores were obtained from≥2 prostate imaging reporting and data system v2 lesions.A multivariable model was created that included needle distance to the lesion,prostate specific antigen,prostate imaging reporting and data system,lesion volume,and prostate ***:A total of 377 patients with 533 lesions underwent a biopsy during the study period.A total of 233(44%)lesions were positive for prostate cancer,and 173(32%)lesions had clinically significant prostate *** mean needle distance to the lesion was 11.7mm(interquartile range,7.6–15.5mm).The likelihood of obtaining a positive core on biopsy decreased as the distance fromthe ultrasound probe increased for all prostate cancers and clinically significant prostate cancer(p=0.018 and p=0.004,respectively).Every 10mmfrom the rectum,there was an 8%–10%decrease in the rate of cancer ***,as the prostate volume increased,the odds of obtaining a positive core also decreased(p=0.039).There was no significant association between the lesion size and amount of cancer obtained on ***:Our data showed that transrectal MRI-targeted biopsy cancer detection modestly decreased the lesion from the ultrasound probe and with a large prostate volume but could not prove that lesion volume was a significant predictor of the amount of cancer detected.

关键词： Prostate cancer Biopsy Magnetic resonance imaging

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward Rob M.Ewing Donna E.Davies mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

Measuring Pedestrian Stress Response (MPSR) Using Wearable Technologies

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Journal of Transportation Technologies 2024年第2期14卷 224-235页

作者： Ishita Dash Rachael Anne Muscatello mark D. Abkowitz Ella R. Mostoller Mike Sewell Department of Civil and Environmental Engineering Vanderbilt University 2301 Vanderbilt Place Nashville USA Department of Psychiatry and Behavioral Sciences SENSE Lab Vanderbilt University Medical Center 1211 Medical Center Drive Nashville USA Gresham Smith 111 West Main Street Suite 201 Louisville USA

Walkability is an essential aspect of urban transportation systems. Properly designed walking paths can enhance transportation safety, encourage pedestrian activity, and improve community quality of life. This, in turn, can help achieve sustainable development goals in urban areas. This pilot study uses wearable technology data to present a new method for measuring pedestrian stress in urban environments and the results were presented as an interactive geographic information system map to support risk-informed decision-making. The approach involves analyzing data from wearable devices using heart rate variability (RMSSD and slope analysis) to identify high-stress locations. This data-driven approach can help urban planners and safety experts identify and address pedestrian stressors, ultimately creating safer, more walkable cities. The study addresses a significant challenge in pedestrian safety by providing insights into factors and locations that trigger stress in pedestrians. During the pilot study, high-stress pedestrian experiences were identified due to issues like pedestrian-scooter interaction on pedestrian paths, pedestrian behavior around high foot traffic areas, and poor visibility at pedestrian crossings due to inadequate lighting.

关键词： Wearable Technology Walkability Built Environment Pedestrian Safety

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan Susan Day Christopher Levi Stephen M Davis mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(5mL,regardless of anticoagulation *** Commencing anticoagulation<4days after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

Neonatal Direct Rigid Laryngoscopy and Bronchoscopy: A Near Miss

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Open Journal of Anesthesiology 2024年第4期14卷 126-130页

作者： Dennis E. Feierman mark Kronenfeld Jacob Sutton Gil Zoizner Evan P. Salant Department of Anesthesiology Maimonides Medical Center New York USA Rutgers Robert Wood Johnson University Hospital New Brunswick USA Meir Hospital Clalit Health Services Kefar Sava Israel

Airway management is a skill necessary for healthcare providers who manage patients. Intubation is a skill that both anesthesiologists and intensivists use daily. We present a case of a neonate that developed significant worsening stridor after a successful intubation for a hernia repair. After 4 intubation attempts, with easy visualization of the vocal cords and unsuccessful placement of the endotracheal tube, the patient was emergently brought to the operating room for evaluation.

关键词： Neonate Direct Laryngoscopy Intubation

Storylines of family medicine Ⅶ: family medicine across the lifespan

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Family Medicine and Community Health 2024年第S3期12卷 61-69页

作者： William B Ventres Leslie A Stone Katharine C Barnard Sara G Shields mark J Nelson Maria Verónica Svetaz Clara M Keegan Joel J Heidelbaugh Paige B Beck Lucille Marchand Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA John Peter Smith Hospital Family Medicine Residency Fort WorthTexasUSA Family and Community Medicine Hennepin HealthcareMinneapolisMinnesotaUSA Family Medicine University of Vermont Larner College of MedicineBurlingtonVermontUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅶ:family medicine across the lifespan’,authors address the following themes:‘Family medicine maternity care’,‘Seeing children as patients brings joy to work’,‘Family medicine and the care of adolescents’,‘Reproductive healthcare across the lifespan’,‘Men’s health’,‘Care of older adults’,and‘Being with dying’.May readers appreciate the range of family medicine in these essays.

关键词： life illustration family

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苹果探索可穿戴设备另类可能

商业周刊（中文版） 2024年第4期 54-55页

作者： mark Gurman 程玺(译) 不详

苹果正在考虑开发更多可穿戴设备,包括健身戒指、智能眼镜,甚至带摄像头的AirPods几年前,苹果公司工业设计团队向健康团队的高管提出了一个想法:打造一款智能戒指,将Apple Watch的健康追踪功能转移到手指上。最近,位于加州库比蒂诺的苹... 详细信息

苹果正在考虑开发更多可穿戴设备,包括健身戒指、智能眼镜,甚至带摄像头的AirPods几年前,苹果公司工业设计团队向健康团队的高管提出了一个想法:打造一款智能戒指,将Apple Watch的健康追踪功能转移到手指上。最近,位于加州库比蒂诺的苹果实验室的工程师们讨论了开发智能眼镜的可能性,它将类似于Meta Platforms Inc.和亚马逊公司(*** Inc.)的新产品。它有望提供音频功能(用户不必再佩戴AirPods),并可利用人工智能和摄像头识别周围事物。该设备还有助于推进苹果的一个长期梦想:真正可全天佩戴的增强现实眼镜。

关键词：可穿戴设备人工智能苹果公司周围事物苹果实验室智能眼镜摄像头工程师们

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纯真年代 NBA最好的十年

NBA特刊 2024年第7期 54-63页

作者：阿亮 mark49(设计) 不详

从迈克尔·乔丹(Michael Jordan)的公牛结束对总冠军的统治,到勒布朗·詹姆斯(LeBron James)出走迈阿密,NBA经历了最混乱、也最精彩的十年。毫不夸张地说,那是NBA在中国、甚至全世界蓬勃发展、稳固扎根的十年。

关键词：总冠军 NBA 纯真年代十年勒布朗迈阿密乔丹

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复仇之路不通俄克拉荷马城雷霆

NBA特刊 2024年第7期 72-77页

作者：二九 mark49(设计) 不详

2016年,杜兰特离开雷霆,加盟勇士。留给俄克拉荷马城的是无尽的失望和一套残阵。但他的老搭档威斯布鲁克并不打算放弃,他火力全开,连续三个赛季拿到三双数据。正因如此,雷霆队下决心以威斯布鲁克为核心进行补强,他们找来了保罗·乔治和... 详细信息

2016年,杜兰特离开雷霆,加盟勇士。留给俄克拉荷马城的是无尽的失望和一套残阵。但他的老搭档威斯布鲁克并不打算放弃,他火力全开,连续三个赛季拿到三双数据。正因如此,雷霆队下决心以威斯布鲁克为核心进行补强,他们找来了保罗·乔治和卡梅罗·安东尼,组成了华丽的巨头阵容。可惜,仇恨带不来总冠军,雷霆队的一系列操作最终也落了空。

关键词：总冠军俄克拉荷马杜兰特雷霆队安东尼