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Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman Lauren V.Terry Emma D.McLennan Carolina Chavez Emma L.Burrows John W.Scott Robyn M.Murphy Henriette van Praag Martin Whitham mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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新疆北部阿尔泰地区鸟类调查研究

林业科学研究 1995年第1期8卷 62-66页

作者：邓杰张孚允杨若莉郑荣光 mark R.fuller WILLIAM S.CLARK 中国北京林业科学院全国鸟类环志中心新疆维吾尔自治区阿尔泰地区林业局自然保护区办公室美国内政部渔类及野生动物管理局美国CAPE MAY猛禽保护区

１９９１年６～７月，对新疆北部阿尔泰地区的鸟类进行了广泛调查，共记录到１２０种鸟（包括猛禽２２种），其中４０种为当地首次记录，蜂鹰（ＰｅｒｎｉｓａｐｉｖｏｒｕｓＬｉｎｎａｅｕｓ）和黑翅燕（Ｇｌａｒｅｏ－ｌａｎｏｒｄｍ... 详细信息

１９９１年６～７月，对新疆北部阿尔泰地区的鸟类进行了广泛调查，共记录到１２０种鸟（包括猛禽２２种），其中４０种为当地首次记录，蜂鹰（ＰｅｒｎｉｓａｐｉｖｏｒｕｓＬｉｎｎａｅｕｓ）和黑翅燕（Ｇｌａｒｅｏ－ｌａｎｏｒｄｍａｎｎｉＮｏｒｄｍａｎｎ）两种为中国首次的正式记录。考察还收集到有关阿尔泰隼［Ｆａｌｃｏａｌｔａｉｃｕｓ（Ｍｅｎｚｂｉｅｒ）］栖息环境的有关资料，并在文中对其分类地位和中国两种新记录鸟种进行了讨论。

关键词：鸟类阿尔泰地区新疆北部

Numerical evaluation on sub-Nyquist spectrum reconstruction methods

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Frontiers of Computer Science 2023年第6期17卷 199-201页

作者： Zihang SONG Han ZHANG Sean fuller Andrew LAMBERT Zhinong YING Petri MAHONEN Yonina ELDAR Shuguang CUI mark DPLUMBLEY Clive PARINI Arumugam NALLANATHAN Yue GAO Department of Engineering King’s College LondonStrandLondon WC2R 2LSUK School of Computer Science and Electronic Engineering University of SurreyGuildfordSurrey GU27XHUK National Instruments Corporation(UK)Ltd. NewburyBerkshire RG142PZUK Electronic Media Services Ltd. BordonHampshire GU350FJUK Sony Research Center Sony CorporationLund 22188Sweden Institute for Networked Systems RWTH Aachen UniversityKackertstrasseAachen 52072Germany Faculty of Math&CS Weizmann Institute of ScienceRehovot 7610001Israel School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China School of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK School of Computer Science Fudan UniversityShanghai 200433China

1 Introduction As wireless technology continues to expand,there is a growing concern about the efficient use of spectrum *** though a significant portion of the spectrum is allocated to licensed primary users(PUs),studies indicate that their actual utilization is often limited to between 5%to 10%[1].The underutilization of spectrum has given rise to cognitive radio(CR)technology,which allows secondary users(SUs)to opportunistically access these underused resources[2].However,wideband spectrum sensing,the key of CR,is limited by the need for high-speed analog-to-digital converters(ADCs),which are costly and *** spectrum sensing(CSS)addresses this challenge by employing sub-Nyquist rate *** efficiency of active transmission detection heavily depends on the quality of spectrum reconstruction.

关键词： spectrum continue Nyquist

Systematic approaches to improving the performance of polyoxometalates in non-aqueous redox flow batteries

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Journal of Energy Chemistry 2020年第11期29卷 115-124页

作者： Yuan Cao Jee-Jay J.Chen mark A.Barteau Department of Chemical Engineering University of MichiganAnn ArborMI 48109United States Applied Materials 14J Fuller RoadAlbanyNY 12203United States Department of Chemical Engineering and Department of Chemistry Texas A&M UniversityCollege StationTX 77843United States

Polyoxometalates have been explored as multi-electron active species in both aqueous and non-aqueous redox flow batteries. Although non-aqueous systems in principle offer a wider voltage window for redox flow battery operation, realization of this potential requires a judicious choice of solvent as well as polyoxometalate properties. We demonstrate here the superior performance of N,N-dimethylformamide(DMF)compared to acetonitrile as a solvent for redox flow batteries based on Li3PMo12O40. This compound displays two 1-electron transfers in acetonitrile but can access an extra quasi-reversible 2-electron redox process in DMF. A cell containing 10 mM solution of Li3PMo12O40 in DMF produced a cell voltage of 0.7 V with 2-electron transfers(State of Charge = 60%) and showed a good cyclability. As a means to boost energy density, operation of the redox flow battery at a higher concentration of 0.1 M Li3PMo12O40 produced cells with cell voltage of 0.6 V in acetonitrile and a cell voltage of 1.0 V in DMF;both showed excellent coulombic efficiencies of more than 90% over the course of 30 cycles. Energy density was also increased by employing an asymmetric cell with different polyoxometalates on each side to extend cell ***6P2W18O62 exhibited 3 quasi-reversible 2-electron transfers in the potential range between-2.05 V and-0.5 V vs. Ag/Ag+. 10 mM Li6P2W18O62/Li3PMo12O40 in DMF produced a cell with cell voltage of 1.3 V involving 4-electron transfers(State of Charge = 50%) with coulombic efficiency of nearly 100% and energy efficiency of nearly 70% throughout the test with more than 20 cycles. These promising results demonstrate proof-of-concept approaches to improving the performance of polyoxometalates in non-aqueous redox flow batteries.

关键词： Polyoxometalate Energy density Redox flow battery Non-aqueous battery Cyclic voltammetry Bulk electrolysis

Sub-Nyquist spectrum sensing and learning challenge

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Frontiers of Computer Science 2021年第4期15卷 197-201页

作者： Yue GAO Zihang SONG Han ZHANG Sean fuller Andrew LAMBERT Zhinong YING Petri MAHONEN Yonina ELDAR Shuguang CUI mark D.PLUMBLEY Clive PARINI Arumugam NALLANATHAN School of Computer Science and Electronic Engineering University of SurreyGuildfordSurrey GU27XHUK National Instruments Corporation(UK)Ltd NewburyBerkshire RG142PZUK Electronic Media Services Ltd BordonHampshire GU350FJUK Sony Research Center Sony CorporationLund 22188Sweden Institute for Networked Systems RWTH Aachen UniversityKackertstrasse 9Aachen 52072Germany Faculty of Math&CS Weizmann institute of ScienceRehovot 7610001Israel School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China School of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

1 Introduction The fact that the spectrum resource is underutilised in certain bands has motivated the dynamic spectrum access(DSA)approach,which enables unlicensed secondary users(SUs)equipped with cognitive radio(CR)devices to access the spectrum without causing significant interference to primary users(PUs).Nowadays,the increasing bandwidth for wireless communication in millimetre-wave and Terahertz frequency bands puts higher requirements on the performance of spectrum sensing technique,the primary enabler of DSA.

关键词： spectrum enable bands

Body temperature,activity patterns and hunting in free-living cheetah:biologging reveals new insights

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Integrative Zoology 2019年第1期14卷 30-47页

作者： Robyn S.HETEM Duncan MITCHELL Brenda A.DE WITT Linda G.FICK Shane K.MALONEY Leith C.R.MEYER and Andrea fuller School of Animal Plant and Environmental SciencesFaculty of SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Brain Function Research Group School of PhysiologyFaculty of Health SciencesUniversity of the Witwatersrand Medical SchoolParktownJohannesburgSouth Africa School of Human Sciences University of Western AustraliaPerthAustralia Department of Paraclinical Science Faculty of Veterinary ScienceUniversity of PretoriaSouth Africa

As one of the few felids that is predominantly diurnal,cheetahs(Acinonyx jubatus)can be exposed to high heat loads in their natural *** is known about long-term patterns of body temperature and activity(including hunting)in cheetahs because long-term concurrent measurements of body temperature and activity have never been reported for cheetahs,or,indeed,for any free-living *** report here body temperature and locomo-tor activity measured with implanted data loggers over 7 months in 5 free-living cheetahs in *** tem-perature ranged from a maximum of 39°C in summer to−2°C in *** had higher(~0.4°C)max-imum 24-h body temperatures,later acrophase(~1 h),with larger fluctuations in the range of the 24-h body temperature rhythm(approximately 0.4°C)during a hot-dry period than during a cool-dry period,but main-tained homeothermy irrespective of the climatic *** ambient temperatures increased,the cheetahs shifted from a diurnal to a crepuscular activity pattern,with reduced activity between 900 and 1500 hours and increased nocturnal *** timing of hunts followed the general pattern of activity;the cheetahs hunted when they were on the *** hunted if an opportunity presented itself;on occasion they hunted in the midday heat or in total darkness(new moon).Biologging revealed insights into cheetah biology that are not ac-cessible by traditional observer-based techniques.

关键词： Acinonyx jubatus heat stress nocturnal intraguild predators moonlight

Treatment-Plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. Yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David fuller Gary Brandon Gunn Amol J. Ghia Jay P. Reddy Shaan M. Raza Franco De Monte mark S. Chambers Paul D. Brown Shirley Su Jack Phan Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Oncologic Dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMPT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMPT, and compared the quality of the three sets of plans. Methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMPT were generated with multi-field optimization. The optimized VMAT and IMPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated Proton Therapy Spot Scanning Proton Therapy

发育过程中的环境烟草烟雾暴露改变行为并扰乱线粒体能量代谢

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环境与职业医学 2013年第3期30卷 166-166页

作者： Brian F.fuller Diego F.Cortes Miranda K.Landis Hiyab Yohannes Hailey E.Griffin Jillian E.Stafflinger M.Scott Bowers mark H.Lewis Michael A.Fox Andrew K.Ottens

[背景]环境烟草烟雾(ETS)暴露与发育缺陷和疾病相关,已知包括影响小脑的功能。然而,直接的生物学效应及内在的神经化学机制仍不清楚。[目的]明确并评估在大鼠小脑发育的关键时期,ETS暴露所导致的潜在神经化学变化。[方法]将出生后第8天(... 详细信息

[背景]环境烟草烟雾(ETS)暴露与发育缺陷和疾病相关,已知包括影响小脑的功能。然而,直接的生物学效应及内在的神经化学机制仍不清楚。[目的]明确并评估在大鼠小脑发育的关键时期,ETS暴露所导致的潜在神经化学变化。[方法]将出生后第8天(PD8)到第PD23的大鼠,每天暴露于ETS(总悬浮颗粒浓度为300、100和0μg/m3),然后测定行为、神经蛋白质组和细胞水平的反应。[结果]产后ETS暴露诱导在新环境中的运动反应升高,等同于安非他明刺激诱发的效果。ETS暴露大鼠小脑的线粒体亚蛋白质组明显受到干扰。研究结果显示,呈剂量依赖性的需氧过程上调是通过修饰和增加HK1转运至线粒体,伴随ATP合成酶表达的相应提高。ETS暴露也诱导总Dnm1l线粒体分裂因素呈剂量依赖性增加;虽然发现更活跃的膜结合Dnm1l呈低剂量。Dnm1l激活与线粒体染色更强相关,特别是在分子层,它独立于应力诱导的Bcl-2家族的动态。此外,电子显微镜观察显示,Dnm1l介导的线粒体分裂与生物合成增加而非分裂相关。[结论]出生后小脑发育的关键时期对ETS暴露的影响易感,会导致行为改变。ETS的生物效应部分是因为在通常严格控制的情况下,Dnm1l介导的线粒体活跃应答。这些结果显示环境暴露影响神经系统发育和功能的一种新的机制。

关键词：环境烟草烟雾线粒体能量代谢烟雾暴露发育过程神经化学变化行为小脑发育生物学效应