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普通小麦多酚氧化酶活性的QTL分析

作物学报 2005年第1期31卷 7-10页

作者：张立平葛秀秀何中虎王德森闫俊夏先春 mark w sutherland 中国农业科学院作物栽培育种研究所国家小麦改良中心 CIMMYT中国办事处北京100081 澳大利亚南昆士兰大学

多酚氧化酶 (polyphenoloxidase ,PPO)是引起面团 (片 )颜色褐变的主要原因。利用 12 2对SSR引物、4对贮藏蛋白STS引物和 10对AFLP引物组合 ,分析了中优 95 0 7×CA96 32的 71个DH系的基因型 ,构建了由 173个位点组成的遗传连锁图 ,在小... 详细信息

多酚氧化酶 (polyphenoloxidase ,PPO)是引起面团 (片 )颜色褐变的主要原因。利用 12 2对SSR引物、4对贮藏蛋白STS引物和 10对AFLP引物组合 ,分析了中优 95 0 7×CA96 32的 71个DH系的基因型 ,构建了由 173个位点组成的遗传连锁图 ,在小麦 2 1个连锁群上覆盖 2 881cM。将该群体种植于 3个环境 ,采用复合区间作图法 (CIM)进行了PPO活性的QTL分析。结果表明 ,控制籽粒PPO活性的主效QTL有 2个 ,分别位于染色体 2AL和 2DL上 ,贡献率分别为 37 9%～5 0 0 %和 2 5 0 %～ 2 9 1%。所有QTL都来自高PPO活性亲本中优 95 0 7。讨论了通过遗传途径降低PPO活性及利用分子标记辅助育种的可能性。

关键词：普通小麦多酚氧化酶(PPO) 分子标记 QTL分析

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普通小麦多酚氧化酶活性的QTL分析

普通小麦多酚氧化酶活性的QTL分析

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

2003年全国作物遗传育种学术研讨会

作者：张立平葛秀秀何中虎 mark w sutherland 中国农业科学院作物栽培育种研究所澳大利亚南昆士兰大学

多酚氧化酶(Polyphenol Oxidase, PPO)是引起面团(片)颜色褐变的主要原因。利用122对SSR引物、4对贮藏蛋白的STS引物和10对AFLP引物组合,分析了中优9507CA9632的71个DH系的基因型,构建了由173个位点组成的遗传连锁图,在小麦21个连锁群... 详细信息

多酚氧化酶(Polyphenol Oxidase, PPO)是引起面团(片)颜色褐变的主要原因。利用122对SSR引物、4对贮藏蛋白的STS引物和10对AFLP引物组合,分析了中优9507CA9632的71个DH系的基因型,构建了由173个位点组成的遗传连锁图,在小麦21个连锁群上覆盖2881cM。将该群体种植在3个环境,采用复合区间作图法(CIM)进行了PPO活性的QTL分析。结果表明,控制籽粒PPO活性的主效QTL有两个,分别位于染色体2AL和2DL上, 贡献率分别为37.9-50.0%和25.0-29.1%。所有QTL都来自于高PPO活性亲本中优9507。讨论了通过遗传途径降低PPO活性及利用分子标记辅助育种的可能性。

关键词：普通小麦多酚氧化酶(PPO) 分子标记 QTL分析

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Survival in spatially variable thermal environments:Consequences of induced thermal defense

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Integrative Zoology 2018年第4期13卷 392-410页

作者： mark w.DENNY Hopkins Marine Station of Stanford University Pacific GroveCaliforniaUSA

As Earth’s climate warms,plants and animals are likely to encounter increased frequency and severity of extreme thermal events,and the ensuing destruction is likely to play an important role in structuring ecological ***,accurate prediction of the population-scale consequences of extreme thermal events requires detailed knowledge of the small-scale interaction between individual organisms and their thermal *** this study I propose a simple model that allows one to explore how individual-to-individual variation in body temperature and thermal physiology determines what fraction of a population will be killed by an extreme thermal *** model takes into account the possibility that each individual plant or animal can respond to an event by adjusting its thermal tolerance in proportion to the stress it *** thermal stress is relatively mild,the model shows that a graded physiological response of this sort leads to increased ***,the model predicts that in more severe events a proportional induced defense can actually reduce survivorship,a counterintuitive possibility that is not predicted by standard *** model can easily be tailored to different species and thermal environments to provide an estimate of when,where and how physiology can buffer the effects of climate warming.

关键词： induced defense plasticity small-scale variability thermal physiology thermal tolerance

Molecular mechanisms of insulin resistance in chronic hepatitis C

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world Journal of Gastroenterology 2009年第35期15卷 4356-4364页

作者： mark w Douglas Jacob George Storr Liver Unit Westmead Millennium InstituteUniversity of Sydney at Westmead Hospita

It is now widely recognized that chronic hepatitis C (CHC)is associated with insulin resistance(IR)and type 2 diabetes,so can be considered a metabolic *** is most strongly associated with hepatitis C virus(HCV)genotype 1,in contrast to hepatic steatosis, which is associated with genotype 3 *** from the well-described complications of diabetes,IR in CHC predicts faster progression to fibrosis and cirrhosis that may culminate in liver failure and hepatocellular *** recently,it has been recognized that IR in CHC predicts a poor response to antiviral therapy. The molecular mechanisms for the association between IR and HCV infection are not well *** review will elaborate on the clinical associations between CHC and IR and summarize current knowledge regarding the molecular mechanisms that potentially mediate HCV-associated IR.

关键词： Hepatitis C virus Insulin resistance Treatment response Interferon

Fuel and vegetation changes in southwestern, unburned portions of Great Smoky Mountains National Park, USA, 2003-2019

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Journal of Forestry Research 2022年第5期33卷 1459-1470页

作者： T.Adam Coates w.mark Ford Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA U.S.Geological Survey Virginia Cooperative Fish and Wildlife Research UnitDepartment of Fisheries and Wildlife ConservationVirginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

Overstory basal area,ericaceous shrub cover(Kalmia latifolia *** Rhododendron maximum L.),and fuels(i.e.,woody fuel loads and depths and O Horizon thickness) were assessed within Great Smoky Mountains National Park,USA,in *** to recent wildfire activity within the southern Appalachian Mountain region(including Great Smoky Mountains National Park),the potential spread and expansion of ericaceous shrubs,and the impacts of the hemlock woolly adelgid(Adelges tsugae Annand) on eastern hemlock(Tsuga canadensis(L.) Carrière),these same ecosystem components were again assessed in *** and moisture regime(xeric,intermediate,and mesic) were included in this assessment as potential influential *** evaluation of repeated measurements from 40 plots suggested that O Horizon thickness did not change significantly over the 16-year period,but increased as elevation increased,and moisture regime(xeric O Horizon thickness> mesic O Horizon thickness) was a significant,related *** sum of 1-,10-,and 100-h fuel loads(fuels less whereas woody fuel depth decreased over the16-year *** significant changes in 1000-h fuel lo ads(>7.6 cm diameter),total woody fuel loads,ericaceous shrub cover,total basal area,or live *** basal area were *** *** basal area decreased with increasing ***,standing *** basal area increased from 2003-2019,and that increase was most pronounced as elevation increased on xeric and intermediate ***,we found that:*** increases in total woody fuel loads and ericaceous shrub cover were not present;and *** and moisture regime were most related to observed changes in vegetation and fuel condition.

关键词： Eastern hemlock Hemlock woolly adelgid Mountain laurel Rhododendron

Repeated hydrogen peroxide dosing briefly reduces cyanobacterial blooms and microcystin while increasing fecal bacteria indicators in a eutrophic pond

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Journal of Environmental Sciences 2023年第2期124卷 522-543页

作者： mark w.Lusty Christopher J.Gobler School of Marine and Atmospheric Sciences Stony Brook UniversitySouthamptonNY 11968USA

This study explored the effects of H_(2)O_(2)on Cyanobacteria and non-target microbes using fluorometry,microscopy,flow cytometry,and high throughput DNA sequencing of the 16S rRNA gene during a series of mesocosm and whole-ecosystem experiments in a eutrophic pond in NY,*** addition of H_(2)O_(2)(8 mg/L)significantly reduced Cyanobacteria concentrations during a majority of experiments(66%;6 of 9)and significantly increased eukaryotic green and unicellular brown algae in 78%and 45%of experiments,*** heterotrophic bacteria declined significantly following H_(2)O_(2)addition in all experiments,bacteria indicative of potential fecal contamination(Escherichia coli,Enterococcus,fecal coliform bacteria)consistently and significantly increased in response to H_(2)O_(2),evidencing a form of‘pollution swapping’.H_(2)O_(2)more effectively reduced Cyanobacteria in enclosed mesocosms compared to whole-ecosystem *** whole-pond H_(2)O_(2)applications over a twoyear period temporarily reduced cyanobacterial levels but never reduced concentrations below bloom thresholds and populations always rebounded in two weeks or *** bacterial phyla of Cyanobacteria,Actinobacteria,and Planctomycetes were the most negatively impacted by H_(2)O_(2).Microcystis was always reduced by H_(2)O_(2),as was the toxin microcystin,but Microcystis remained dominant even after repeated H_(2)O_(2)*** H_(2)O_(2)favored the growth of eukaryotic algae over potentially harmful Cyanobacteria,the inability of H_(2)O_(2)to end cyanobacterial blooms in this eutrophic waterbody suggests it is a non-ideal mitigation approach in high biomass ecosystems and should be used judiciously due to potential negative impacts on non-target organisms and promotion of bacteria indicative of fecal contamination.

关键词： Indicator bacteria Toxic cyanobacteria Microcystin Microcystis Hydrogen peroxide Bacteria Enterococcus E.coli Pollution swapping

Cooperative visibility maintenance in SE（3） for multi-robot-networks with limited field-of-view sensors

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Control Theory and Technology 2017年第4期15卷 246-257页

作者： Hasan A. Poonawala mark w. Spong Institute for Computational Engineering & Sciences University of Texas Austin U.S.A. Erik Jonsson School of Engineering & Computer Science University of Texas at Dallas Richardson U.S.A.

Coordination of motion between multiple robots requires the robots to sense their relative poses. Common sensors depend on maintaining a line-of-sight between the sensor and the object being sensed. when the robots move relative to one another, they must coordinate their motions to ensure that these lines-of-sight are preserved. we propose a control method to preserve desired lines-of-sight in a multi-robot system where each robot has configuration space SE（3）. A key feature of the control method is its ability to reject persistent bounded disturbances, enabling its use alongside additional control tasks. we demonstrate the effectiveness of the edge-preserving control in simulations involving additional input velocities that tend to break the edges.

关键词： Multi-robot coordination decentralized control graph theoretic control

Noninvasive prognostic models,imaging,and elastography to predict clinical events in primary sclerosing cholangitis:A review

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world Journal of Hepatology 2023年第9期15卷 1013-1020页

作者： mark w Russo Division of Hepatology Atrium Health Wake ForestCharlotteNC 28204United States

Surrogate endpoints are needed to estimate clinical outcomes in primary sclerosing cholangitis(PSC).Serum alkaline phosphatase was among the first markers studied,but there is substantial variability in alkaline phosphatase levels during the natural history of PSC without *** Mayo risk score incorporates noninvasive variables and has served as a surrogate endpoint for survival for more than two *** models have better test performance than the Mayo risk score,including the primary sclerosing risk estimate tool(PREsTo)model and UK-PSC score that estimate hepatic decompensation and transplant free survival,*** c-statistics for transplant-free survival for the Mayo risk model and the long-term UK-PSC model are 0.68 and 0.85,*** c-statistics for hepatic decompensation for the Mayo risk model and PREsTo model are 0.85 and 0.90,*** Amsterdam-Oxford model included patients with large duct and small duct PSC and patients with PSCautoimmune hepatitis overlap and had a c-statistic of 0.68 for transplant-free *** noninvasive tests that warrant further validation include magnetic resonance imaging,elastography and the enhanced liver fibrosis *** models,noninvasive tests or a combination of these surrogate endpoints may not only serve to be useful in clinical trials of investigational agents,but also serve to inform our patients about their prognosis.

关键词： Cholestatic Survival Mortality Predict Cirrhosis Decompensation