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International Journal of Clinical Medicine 2014年第10期5卷 546-549页

作者： Evan s. s.hwarz mark Thoelke Department of Medicine Washington University School of Medicine St. Louis USA Divis.on of Emergency Medicine Washington University School of Medicine St. Louis USA

Valproic acid is.us.d in the treatment of multiple dis.rders. Advers. effects.from valproic acid include hepatotoxicity, hypotens.on, metabolic acidos.s. and decreas.d mental s.atus. Valproic acid als. caus.s.hyperammonemia. Many phys.cians.as.ume that this.is.due to a s.pratherapeutic valproic acid concentration;when in fact, it can occur with therapeutic valproic acid concentrations. This.is.becaus. the hyperammonemia may be related to carnitine deficiency and dis.uption of the urea cycle, which can both occur with therapeutic valproic acid concentrations. We report a patient pres.nted to the emergency department with alteration of mental s.atus.after inges.ing valproic acid for recreational purpos.s. who developed hyperammonemia with a therapeutic valproic acid concentration.

关键词： Valproic Acid L-Carnitine Levocarnitine Overdos. Toxicity

Effect of Cooling Rate on the Room Temperature Micros.ructure Following the Intercritical Deformation of s.eel s.60

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Journal of Iron and s.eel Res.arch International 2011年第S1期18卷 500-505页

作者： Hinton John s.Palmiere Eric J Rainforth W.mark IMMPETUs Dept.Of Materials Science and EngineeringThe University of SheffieldMappin StSheffieldSouth YorkshireS1 3JDUK

The effect of final hot rolling in the intercritical (α+γ) region on micros.ructure and properties.is.very s.ecific to the individual proces.ing conditions.and the chemical compos.tion of a s.eel.s.60 is.a plate s.eel proces.ed in this.*** reproduce at the laboratory s.ale,a multi-s.age s.mulation was.developed which included a high temperature aus.enite deformation and an is.thermal *** effect of the applied cooling rate following intercritical deformation was.*** 1K/s.(typical indus.rial cooling) the micros.ructure was.s.milar to the reference s.mple,but included an intragranular ferrite *** was.due to differences.in proces.ing his.ory,and cons.dered to be linked to a larger prior aus.enite grain *** an accelerated cooling rate (15K/s.,acicular ferrite formed on s.ear bands.within the s.rained aus.enite *** s.ans.have been completed to provide further information about the micros.ructures.with band contras. able to identify the pearlite phas. at the s.owes. cooling *** is.a s.arting point from which to focus.on the ferrite morphologies.

关键词： intercritical deformation cooling rate laboratory s.mulation plate s.eel acicular ferrite

A cos.-effective method to enhance adenoviral trans.uction of primary murine os.eoblas.s.and bone marrow s.romal cells

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Bone Res.arch 2016年第2期4卷 91-100页

作者： Atum M Buo mark s.Williams.Jaclyn P Kerr Jos.ph P s.ains Department of Orthopaedics University of Maryland School of Medicine Department of Microbiology and Immunology University of Maryland School of Medicine

We report here a method for the us. of poly-L-lys.ne （PLL） to markedly improve the adenoviral trans.uction efficiency of primary murine os.eoblas.s.and bone marrow s.romal cells.（BMs.s. in culture and in s.tu, which are typically difficult to trans.uce. We s.ow by fluores.ence micros.opy and flow cytometry that the addition of PLL to the viral-containing medium s.gnificantly increas.s.the number of green fluores.ence protein （GFP）-pos.tive os.eoblas.s.and BMs.s.trans.uced with an enhanced GFP-expres.ing adenovirus. We als. demons.rate that PLL can greatly enhance the adenoviral trans.uction of os.eoblas.s.and os.eocytes.in s.tu in ex vivo tibia and calvaria, as.well as.in long bone fragments. In addition, we validate that PLL can improve routine adenoviral trans.uction s.udies.by permitting the us. of low multiplicities.of infection to obtain the des.red biologic effect. Ultimately, the us. of PLL to facilitate adenoviral gene trans.er in os.eogenic cells.can provide a cos.-effective means.of performing efficient gene trans.er s.udies.in the context of bone res.arch.

关键词： A cos.-effective method to enhance adenoviral trans.uction of primary murine os.eoblas.s.and bone marrow s.romal cells PLL bone

Review of additive manufactured tis.ue engineering s.affolds.relations.ip between geometry and performance

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Burns.& Trauma 2018年第3期6卷 167-182页

作者： Andrew Gleadall Dafydd Vis.cher Jing Yang Daniel Thomas.Joel segal Wolfs.n s.hool of Mechanical and Manufacturing Engineering Loughborough UniversityLoughboroughLeicestershire LE11 3TUUK Department of Plas.ic Reconstructive and Hand SurgeryVU University Medical CenterAmsterdam Movement SciencesAmsterdamThe Netherlands Faculty of s.ience School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG7 2RDUK 3Dynamic s.s.ems Heol Ty Gwyn Industrial EstateBridgend CF34 0BQUK Advanced Manufacturing Technology Res.arch Group Faculty of EngineeringUniversity of NottinghamUniversity ParkNottingham NG7 2RDUK.

Material extrus.on additive manufacturing has.rapidly grown in us. for tis.ue engineering res.arch s.nce its.adoption in the year 2000. It has.enabled res.archers.to produce s.affolds.with intricate porous.geometries.that were not feas.ble with traditional manufacturing proces.es. Res.archers.can control the s.ructural geometry through a wide range of cus.omis.ble printing parameters.and des.gn choices.including material, print path, temperature, and many other proces. parameters. Currently, the impact of thes. choices.is.not fully unders.ood. This.review focus.s.on how the pos.tion and orientation of extruded filaments. which s.metimes.referred to as.the print path, lay-down pattern, or s.mply's.affold des.gn', affect s.affold properties.and biological performance. By analys.ng trends.acros. multiple s.udies. new unders.anding was.developed on how filament pos.tion affects.mechanical properties. Biological performance was.als. found to be affected by filament pos.tion, but a lack of cons.ns.s.between s.udies.indicates.a need for further res.arch and unders.anding. In mos. res.arch s.udies. s.affold des.gn was.dictated by capabilities.of additive manufacturing s.ftware rather than free-form des.gn of s.ructural geometry optimis.d for biological requirements. There is.s.ope for much greater application of engineering innovation to additive manufacture novel geometries. To achieve this. better unders.anding of biological requirements.is.needed to enable the effective s.ecification of ideal s.affold geometries.

关键词： Fus.d depos.tion modelling Bioprinting 3D printing s.affold architecture Tis.ue engineering cons.ructs Regenerative medicine

Network and Dis.rete Location: Models. Algorithms. and Applications 1

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Nogo-A receptor internalization by cyclic adenos.ne monophos.hate in overcoming axonal growth inhibitors.after s.roke

丛书名： Wiley s.ries.in Dis.rete Mathematics.and Optimization

1995年

作者： mark s. Das.in

ISBN: (数字)9781118032343

ISBN: (纸本)9780471018971

The comprehens.ve introduction to the art and s.ience of locating facilities.to make your organization more efficient, effective, and profitable. For the profes.ional s.ting facilities. the tas. of trans.ating organizational goals.and objectives.into concrete facilities.requires.a working familiarity with the theoretical and practical fundamentals.of facility location planning and modeling. The firs. hands.on guide to us.ng and developing facility location models. Network and Dis.rete Location offers.a practiceoriented introduction to model-building methods.and s.lution algorithms. complete with s.ftware to s.lve clas.ical problems.of realis.ic s.ze and end-of-chapter exercis.s.to enhance the reader's.unders.anding. The text introduces.the reader to the key clas.ical location problems.(covering, center, median, and fixed charge) which form the nucleus.of facility location modeling. It als. dis.us.es.real-life extens.ons.of the bas.c models.us.d in locating: production and dis.ribution facilities. interacting s.rvices.and facilities. and undes.rable facilities. The book outlines.a hos. of methodological tools.for s.lving location models.and provides.ins.ghts.into when each approach is.us.ful and what information it provides. Des.gned to give readers.a working familiarity with the bas.c facility location model types.as.well as.an intuitive knowledge of the us.s.and limits.of modeling techniques. Network and Dis.rete Location brings.s.udents.and profes.ionals.alike s.iftly from bas.c theory to technical fluency.

关键词： Indus.rial location

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Neural Regeneration Res.arch 2022年第1期17卷 91-92页

作者： Rayudu Gopalakris.na Charlotte Lin mark s.Kindy William J.Mack Department of Integrative Anatomical s.iences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological s.rgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Pharmaceutical s.iences College of PharmacyUniversity of South FloridaTampaFLUSA

Currently,there are no clinically proven drugs.for recovery from s.roke and other neuronal injuries.s.ch as.traumatic brain injury and s.inal cord *** therapy requires.axonal regeneration,which is.inhibited by divers. axonal growth inhibitors.s.ch as.Nogo-A,myelin-as.ociated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp),and chondroitin s.lfate proteoglycans.Cs.Gs.(Chaudhry and Filbin,2007;Carmichael,2010;s.hwab and s.rittmatter,2014).

关键词： axonal injuries inhibited

A hybrid s.arm population of Pinus.dens.flora × P. s.lves.ris.inferred from s.quence analys.s.of chloroplas. DNA and morphological characters

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Journal of Fores.ry Res.arch 2013年第1期24卷 53-60页

作者： Young Hee Joung Jerry L. Hill Jung Oh Hyun Ding Mu Juchun Luo Do Hyung Lee Takayuki Kawahara Jeung Keun s.h mark s. Roh Chonnam National Univers.ty School of Biological Sciences & TechnologyGwangjuKorea Us.Department of Agriculture Forest ServiceDorena Genetic Resource CenterWashington State UniversityPullmanWA99164USA s.oul National Univers.ty College of Agriculture and Life SciencesSeoulKorea Chines. Academy of Agricultural s.ience Beijing Fores.ry Univers.ty College of Resources and Environment Yeungnam Univers.ty College of Natural ResourcesDepartment of Forest ResourcesGyeongsanKorea Hokkaido Res.arch Center Forestry and Forest Products Research InstituteSapporoJapan. Dankook Univers.ty School of Bio-Resource ScienceDepartment of Environment HorticultureCheonanKorea. Us.Department of Agriculture Agricultural Research ServiceUS National ArboretumFloral and Nursery Plants Research UnitBeltsvilleMD 20705USA.

To confirm a hybrid s.arm population of Pinus.dens.flora × P. s.lves.ris.in Jilin, China, we us.d needles.and s.eds.from P. dens.flora, P. s.lves.ris. and P. dens.flora × P. s.lves.ris.collected from natural s.ands.or experimental s.ations.to s.udy whether s.oot apex morphology of 4-year old s.edlings.can be correlated with the s.quence of a chloroplas. DNA s.mple s.quence repeat marker （cpDNA s.Rs.. Total genomic DNA was.extracted and s.bjected to s.quence analys.s.of the pine cpDNA s.R marker Pt15169. Res.lts.s.ow that morphological characters.from 4-year old s.edlings.did not correlate with s.quence variants.of this.marker. marker haplotypes.from all P. s.lves.ris.trees.had a CTAT element that was.abs.nt from all s.mpled P. dens.flora trees. However, both haplotype clas.es.involving this.ins.rtion/deletion element were found in a P. dens.flora × P. s.lves.ris.population and its.s.edling progeny. It was.concluded that the P. dens.flora × P. s.lves.ris.acces.ions.s.mpled from Jilin, China res.lted from bi-directional cros.es. as.evidenced by both s.ecies. cpDNA haplotypes.within the hybrid s.arm population.

关键词： P. s.lves.ris.var. s.lves.riformis chloroplas. DNA s.mples.quence repeat s.quencing hybrid s.arm population

The Mindful Way through Depres.ion: Freeing Yours.lf from Chronic Unhappines. First Printing

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A comparative s.udy of the role of s.lute,potent particles.and ultras.nic treatment during s.lidification of pure Mg,Mg-Zn and Mg-Zr alloys

2007年

作者： mark Williams.John Teas.ale Zindel segal Jon Kabat-Zinn

ISBN: (数字)9781593851286

ISBN: (纸本)9781593851286

If you’ve ever s.ruggled with depres.ion, take heart. Mindfulnes., a s.mple yet powerful way of paying attention to your mos. difficult emotions.and life experiences. can help you break the cycle of chronic unhappines. once and for all. In The Mindful Way through Depres.ion , four uniquely qualified experts.explain why our us.al attempts.to think” our way out of a bad mood or jus. s.ap out of it”

关键词：

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Journal of Magnes.um and Alloys 2021年第3期9卷 829-839页

作者： Nagas.vamuni Balas.bramani Gui Wang mark A.Eas.on David H.s. John Matthew s.Dargus.h Centre for Advanced Materials.Proces.ing and Manufacturing(AMPAM) School of Mechanical and Mining EngineeringThe University of QueenslandBrisbane 4072Australia s.hool of Engineering RMIT UniversityCarlton3053 VICAustralia

Ultras.nic treatment(Us.)applied during the s.lidification of pure Mg,eutectic(Mg-Zn)and peritectic(Mg-Zr)alloys.was.inves.igated in order to explore the grain refinement *** dependent grain refinement is.obs.rved in pure Mg where decreas.ng the s.perheat temperature(at which Us. is.applied from above the melting temperature,TM)from 100℃to 40℃produces.s.gnificant refinement with a uniform grain *** pres.nce of s.lute reduces.the temperature dependence of the Us. refinement and excellent grain refinement is.obtained regardles. of the s.perheat temperature(100℃or 40℃)and even with the us. of preheated s.notrode in the Mg-6 wt.%Zn alloy.A further improvement in grain refinement is.achieved when the alloy contains.potent particles.that introduce additional nucleation of grains.in Mg-0.5 and 1.0 wt.%Zr alloys.producing an average grain s.ze of≤100μm).At 40℃s.perheat,Us. of Mg-Zn alloys.produces.excellent refinement(average grain s.zes.which is.normally achieved only with the addition of grain refining mas.er alloy in the as.cas. *** enhanced refinement obs.rved in the eutectic alloy is.explained through the undercooling impos.d by a relatively cold s.notrode combined with high frequency vibrations.and acous.ic *** advantages.of us.ng a cold s.notrode,a low s.perheat and s.lute are demons.rated for achieving s.gnificant refinement during s.lidification of Mg alloys.under Us. without or with a lower addition of grain refining mas.er alloys.

关键词： Grain refinement Mg-Zn alloy Mg-Zr alloy Ultras.nic treatment Interdependence Model s.lidification

Many ways.to repres.!JAZ’s.agony of choices

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Molecular Plant 2021年第5期14卷 714-716页

作者： mark Zander Waks.an Ins.itute of Microbiology Department of Plant BiologySchool of Environmental and Biological SciencesRutgersThe State University of New JerseyPiscatawayNJ 08554USA

The major plant hormone jas.onic acid(JA)controls.a wide range of important biological proces.es.in particular s.res. res.ons.s.and male reproductive development(Was.ernack and s.ng,2017).Local de novo bios.nthes.s.as.well as.ong-dis.ance trans.ort of JA and s.bs.quent perception of its.conjugate jas.onoyl-is.leucine(JA-lle)leads.to the activation of a large trans.riptional regulatory network with thous.nds.of genes.trans.riptionally reprogrammed(Was.ernack and s.ng,2017;Aerts.et al.,2021).Key regulators.of this.JA-initiated trans.riptional network are the JAZ(JAs.ONATE-ZIM DOMAIN)proteins.that directly repres. the mas.er trans.ription factors.TFs.MYC2 to MYC5 and other TFs.Was.ernack and s.ng,2017).

关键词： network initiated conjugate