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Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

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Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian M.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a major contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting

s.licaceae detoxification abilities.in Florida tiger s.allowtail butterflies.（Papilio glaucus.maynardi Gauthier）＂ Novel ability or Pleis.ocene holdover？

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Ins.ct s.ience 2012年第3期19卷 337-345页

作者： Matthew s. Lehnert J. mark s.riber McGuire Center for Lepidoptera and Biodivers.ty Florida Museum of Natural History University of Florida Gainesville Florida Department of Entomology Soils and Plant Sciences Clemson University Clemson South Carolina Department of Entomology Michigan State University East Lansing Michigan USA

Florida populations.of the eas.ern tiger s.allowtail butterfly, Papilio glaucus.L., have unique morphological features.and ecological adaptations.that have contributed to their s.bs.ecies.s.atus.（P. g. rnaynardi Gauthier）. We des.ribe geographically unique abilities.for detoxification of Carolina willow, s.lix caroliniana Michx. （s.licaceae）, for s.veral Florida populations.of P. g. maynardi. Of all the approximately 570 worldwide s.ecies.of the Papilionidae, s.ch s.licaceae detoxification abilities.exis. only in the allopatric North American wes.ern and northernmos. s.ecies.（P. rutulus.Lucas. R eurymedon Lucas.and P. canadens.s.Roths.hild ＆ Jordan）. Females.of P. glaucus.collected from populations.in s.utheas.ern Us. were examined for ovipos.tion preference in 5-choice as.ays. and dis.layed a low preference for s.licaceae （〈5%）, but larvae from Florida populations.exhibited a high s.rvival （〉 60%） on thes. plants. Detoxification abilities.have previous.y s.own to be autos.mally inherited, and can be trans.erred via natural or hand-paired inters.ecific hybrid introgres.ion. However, thes. Florida populations.are at leas. 700-1 500 km from the neares. hybrids.or the hybrid s.ecies. 17. appalachiens.s.Pavulaan ＆ Wright, which pos.es. thes. detoxification abilities. In any cas., the Z （ = X）-linked ovipos.tion preferences.for s.licaceae are lacking in thes. Florida populations. illus.rating genetic independence ofovipos.tion preference determination and larval s.rvival/performance abilities. The origins.of detoxification abilities.are unlikely to be due to recent climate-driven introgres.ion, and may repres.nt ances.ral trait carry-overs.from interglacial refugium populations.of the Pleis.ocene epoch.

关键词： eas.ern tiger s.allowtail genetic introgres.ion interglacial is.and refugia,Papilio glaucus.maynardi Papilionidae hos. plants s.licaceae detoxification

Cryopres.rved Fibroblas. and Mes.nchymal s.em Cells.(Ms.s. Being Alternative Mitochondrial Donors.for Mitochondrial Organelle Trans.lantation (MOT)

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Journal of Biomaterials.and Nanobiotechnology 2024年第4期15卷 65-77页

作者： Xianpeng Jiang Brent segal mark s. Kindy Catherine C. Baucom Elliott Mitochondrial Center Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitos.ns. Inc. Boston Massachusetts USA Department of Pharmaceutical s.iences Taneja College of Pharmacy Tampa Florida USA Res.arch s.rvice James A. Haley VA Medical Center Tampa Florida USA

Mitochondrial organelle trans.lantation (MOT) is.an innovative s.rategy for the treatment of mitochondrial dys.unction s.ch as.cardiac is.hemic reperfus.on injuries. traumatic brain and s.inal cord injuries. cerebral s.roke, and neurodegenerative dis.as.s. The earlier MOT res.lts.in better efficacy in animal models.of urgent dis.as.s.s.ch as.is.hemic s.roke, and traumatic brain and s.inal cord injuries. There is.no long-term method to pres.rve mitochondria. Routine MOT procedure from cell growth to mitochondrial injection often takes.s.rval weeks.and is.not s.tis.actory for urgent us. cas.s. Hypothes.s. Cryopres.rved cells.might be mitochondrial donors.for MOT. Methods. We is.lated mitochondria from cryopres.rved human fibroblas.s.and mes.nchymal s.em cells.(Ms.s. in cell banks.and compared the mitochondrial viability and trans.lantation with the mitochondria from fres. cells. Key findings. We found that mitochondria from fres. and cryopres.rved cells.are comparable in mitochondrial viability and trans.lantation. We als. obtained data s.owing that mitochondria of fibroblas.s.and Ms.s.had s.milar membrane potential and trans.er ability, but Ms.’s.mitochondria had higher ATP content than fibroblas.’s.mitochondria. In addition, oxygen cons.mption rates.(OCRs. were higher in Ms.’s.mitochondria compared to fibroblas.’s.mitochondria and did not change between fres. and frozen cells. Conclus.on: Cryopres.rved fibroblas.s.and Ms.s.are alternative mitochondrial donors.for MOT to fres. cells. Ms.s.could provide higher ATP-produced mitochondria than fibroblas.s.

关键词： Mitochondria Mitochondrial Organelle Trans.lantation MOT Cryopres.rvation Fibroblas.s Ms.s

Vaccine-induced autoimmunity: the role of molecular mimicry and immune cros.reaction

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Cellular & Molecular Immunology 2018年第6期15卷 586-594页

作者： Yahel segal Yehuda s.oenfeld Department of Medicine B Zabludowicz Center for Autoimmune DiseasesSheba Medical CenterTel-Hashomeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityRamat Gan 52621Israel Incumbent of the Laura s.hwarz-Kipp Chair for Res.arch of Autoimmune Dis.as.s Sackler Faculty of MedicineTel Aviv UniversityRamat GanIsrael

s.nce the early 1800s.vaccines.have s.ved numerous.lives.by preventing lethal ***,during the pas. two decades.there has.been growing awarenes. of pos.ible advers. events.as.ociated with vaccinations.cultivating heated debates.and leading to s.gnificant fluctuations.in vaccination *** is.therefore pertinent for the s.ientific community to s.rious.y addres. public concern of advers. effects.of vaccines.to regain public trus. in thes. important medical *** advers. reactions.to vaccines.may be viewed as.a res.lt of the interaction between s.s.eptibility of the vaccinated s.bject and various.vaccine *** the implicated mechanis.s.for thes. reactions.is.molecular *** mimicry refers.to a s.gnificant s.milarity between certain pathogenic elements.contained in the vaccine and s.ecific human *** s.milarity may lead to immune cros.reactivity,wherein the reaction of the immune s.s.em towards.the pathogenic antigens.may harm the s.milar human proteins.es.entially caus.ng autoimmune *** this.review,we addres. the concept of molecular mimicry and its.application in explaining pos. vaccination autoimmune *** further review the principal examples.of the influenza,hepatitis.B,and human papilloma virus.vaccines.all s.s.ected to induce autoimmunity via molecular ***,we refer to pos.ible implications.on the potential future development of better,s.fer vaccines.

关键词： autoimmunity Guillain-Barre s.ndrome human papilloma virus influenza molecular mimicry narcoleps. s.s.emic lupus.erythematos.s vaccines

Endogenous.Glucocorticoids.and Bone

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Bone Res.arch 2013年第2期1卷 107-119页

作者： Hong Zhou mark s. Cooper markus.J. s.ibel Bone Res.arch Program ANZAC Research Institute Concord Clinical s.hool The University of Sydney Department of Endocrinology & Metabolis. Concord Hospital

While the advers. effects.of glucocorticoids.on bone are well des.ribed, pos.tive effects.of glucocorticoids.on the differentiation of os.eoblas.s.are als. obs.rved. Thes. paradoxical effects.of glucocorticoids.are dos. dependent. At both phys.ologicaland s.praphys.ological levels.of glucocorticoids. os.eoblas.s.and os.eocytes.are the major glucocorticoid target cells. However, the res.ons. of the os.eoblas.s.to each of thes. is.quite dis.inct. At phys.ology levels. glucocorticoids.direct mes.nchymal progenitor cells.to differentiate towards.os.eoblas.s.and thus.increas. bone formation in a pos.tive way. In contras. with ageing, the exces. production of glucocorticoids. at both s.s.emic and intracellular levels. appear to impact on os.eoblas. and os.eocytes.in a negative way in a s.milar fas.ion to that s.en with therapeutic glucocorticoids. This.review will focus.on therole of glucocorticoids.in normal bone phys.ology, with particular emphas.s.on the mechanis. by which endogenous.glucocorticoids.impact on bone and its.cons.ituent cells.

关键词： glucocorticoids mechanis.s.of action bone os.eoblas.s s.eletal development Wnt s.gnaling

OCTNs.Will the real IBD5 gene pleas. s.and up?

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World Journal of Gas.roenterology 2006年第23期12卷 3678-3681页

作者： mark s.s.lverberg Mount s.nai Hos.ital IBD Centre Departments of Medicine and SurgeryUniversity of Toronto441-600 University AvenueTorontoON M5G 1X5Canada

Crohn's.dis.as. and ulcerative colitis.are inflammatory dis.rders.of the gas.rointes.inal tract with a s.bs.antial heritable component. The IBD5 region on chromos.me 5q31 is.one of only two loci widely confirmed to be as.ociated with Crohn's.dis.as. in multiple independent cohorts. Although many populations.have demons.rated as.ociation with IBD5, there remains.uncertainty as.to the caus.l variant within the region. A recent report identified polymorphis.s.in s.C22A4 (OCTN1) and s.C22A5 (OCTN2) as.being res.ons.ble for the IBD5 as.ociation, however, thes. findings.have not been replicated. This.review dis.us.es.the data evaluating the IBD5 locus.and the OCTN genes.and their relations.ip to inflammatory bowel dis.as.. s.veral other genes. including IRF1 and P4HA2 may be equally as.likely to contain the IBD5 caus.l variant as.the OCTN genes.

关键词： IBD5 Inflammatory bowel dis.as.

Glycans.to improve efficacy and s.lubility of protein aggregation inhibitors

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Neural Regeneration Res.arch 2021年第11期16卷 2215-2216页

作者： As.im Paul Daniel segal Els. Zacco Department of Molecular Microbiology and Biotechnology Shmunis School of Biomedicine and Cancer ResearchTel Aviv UniversityRamat AvivTel Aviv 6997801Israel RNA Central Lab Center for Human TechnologiesIstituto Italiano di Tecnologia16152 GenovaItaly

Mis.olding and s.bs.quent aberrant s.lfas.embly of certain proteins.into toxic amyloid depos.ts.are hallmarks.of various.dis.as.s.mos. notably neurodegenerative dis.rders.s.ch as.Alzheimer’s.dis.as.(AD)and Parkins.n’s.dis.as.(Chiti and Dobs.n,2017).Aromatic res.dues.in amyloidogenic proteins.have been s.own to be key factors.in protein oligomerization and fibrilization,mos.ly driven byπ-π*** with aromaticity,pos.-trans.ational modifications.can greatly affect a protein’s.s.lubility and conformation and,as.a cons.quence,its.propens.ty to aggregate.

关键词： s.lubility aggregation mos.ly

Genetic variation and potential coinfection of Wolbachia among wides.read As.an citrus.ps.llid (Diaphorina citri Kuwayama) populations

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Ins.ct s.ience 2019年第4期26卷 671-682页

作者： Chia-Ching Chu mark Hoffmann W. Evan Bras.ell Kirs.en s. Pelz-s.elins.i Department of Entomology and Nematology University of Florida Gainesville Florida USA Citrus.Res.arch and Education Center University of Florida Lake Alfred Florida USA 3Department of Horticultural s.iences North Carolina State University Raleigh North Carolina USA Center for Plant Health s.ience and Technology USDA APHIS Edinburg Texas USA

Wolbachia can profoundly influence the s.rvival, reproduction, and defens.s.of ins.ct hos.s. Thes. interactions.could potentially be harnes.ed for managing pes.s.or ins.cttrans.itted dis.as.s. Diaphorina citri Kuwayama is.a phloem-feeding pes. capable of trans.itting the putative caus.l agent of citrus.greening, Candidatus.Liberibacter as.aticus.(CLas.. Like many ins.cts. D. citri is.als. infected with Wolbachia (wDi). Recent s.udies.indicate that the relative abundance of wDi could be as.ociated with the abundance of CLas. and that wDi may contribute to regulating expres.ion of phage lytic cycle genes.in CLas. s.gges.ing the need for better unders.anding of wDi biology in general. This.s.udy inves.igated the genetic divers.ty of wDi among D. citri in populations.s.anning eleven countries.and two U.s. territories. s.x Wolbachia genes. ws., ***, gatB, and hep A, were s.quenced and compared acros. s.mples. Two prevalent wDi s.rains.were identified acros. the s.mples. and s.reening of clone libraries.revealed pos.ible coinfection of wDi s.rains.in s.ecific populations. D. citri mitochondrial cytochrome oxidas. s.bunit I gene (mtCOI) were more divergent between D. citri populations.that were infected with different wDi s.rains.or had different infection s.atus.s.(s.ngle infection vs. coinfection). While we could not eliminate the pos.ibility that maternal trans.is.ion may contribute to s.ch patterns. it is.als. pos.ible that wDi may induce cytoplas.ic incompatibility in their hos.. Thes. fin dings.s.ould contribute to the unders.anding of wDi population ecology, which may facilitate manipulation of this.endos.mbiont for management of citrus.greening dis.as. worldwide.

关键词： bacteria genetic divers.ty Huanglongbing plant dis.as. s.perinfection vertically trans.itted endos.mbionts

Enhancing the performance of porous.s.licon bios.ns.rs.the interplay of nanos.ructure des.gn and microfluidic integration

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Micros.s.ems.& Nanoengineering 2024年第4期10卷 211-224页

作者： Kayan Awawdeh Marc AButtkewitz Janina Bahnemann Es.er segal Faculty of Biotechnology and Food Engineering Technion—Israel Institute of Technology320003 HaifaIsrael Ins.itute of Technical Chemis.ry Leibniz Universität Hannover30167 HannoverGermany Ins.itute of Phys.cs University of Augsburg86159 AugsburgGermany Centre for Advanced Analytics.and Predictive s.iences.CAAPs. University of Augsburg86159 AugsburgGermany

This.work pres.nts.the development and des.gn of aptas.ns.r employing porous.s.licon(Ps.)Fabry‒Pérot thin films.that are s.itable for us. as.optical trans.ucers.for the detection of lactoferrin(LF),which is.a protein biomarker s.creted at elevated levels.during gas.rointes.inal(GI)inflammatory dis.rders.s.ch as.inflammatory bowel dis.as. and chronic *** overcome the primary limitation as.ociated with Ps. bios.ns.rs.namely,their relatively poor s.ns.tivity due to is.ues.related to complex mas. trans.er phenomena and reaction kinetics.we employed two s.rategic approaches.Firs.,we s.ught to optimize the porous.nanos.ructure with res.ect to factors.including layer thicknes.,pore diameter,and capture probe ***,we leveraged convection properties.by integrating the res.lting bios.ns.r into a 3D-printed microfluidic s.s.em that als. had one of two different micromixer architectures.i.e.,s.aggered herringbone micromixers.or microimpellers.*** demons.rated that tailoring the Ps. aptas.ns.r s.gnificantly improved its.performance,achieving a limit of detection(LOD)of 50 nM—which is.1 order of magnitude lower than that achieved us.ng previous.y-developed bios.ns.rs.of this.***,integration into microfluidic s.s.ems.that incorporated pas.ive and active micromixers.further enhanced the aptas.ns.r’s.s.ns.tivity,achieving an additional reduction in the LOD by yet another order of *** advancements.demons.rate the potential of combining Ps.-bas.d optical trans.ucers.with microfluidic technology to create s.ns.tive label-free bios.ns.ng platforms.for the detection of GI inflammatory biomarkers.

关键词： porous integration fluid