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Dysregulated bidirectional epithelial-mesenchymal crosstalk:A core determinant of lung fibrosis progression

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 27-33页

作者： Liudi Yao Zijian Xu Donna E.Davies mark G.jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK

Progressive lung fibrosis is characterized by dysregulated extracellular matrix(ECM)***-ing of disease pathogenesis remains limited and has prevented the development of effective *** an abnormal wound-healing response is strongly implicated in lung fibrosis initiation,factors that determine why fi-brosis progresses rather than regular tissue repair occur are not fully *** human lung fibrosis,there is evidence of altered epithelial and mesenchymal populations as well as cells undergoing epithelial-mesenchymal transition(EMT),a dynamic and reversible biological process by which epithelial cells lose their cell polarity and down-regulate cadherin-mediated cell-cell adhesion to gain migratory *** review will focus on the role of EMT and dysregulated epithelial-mesenchymal crosstalk in progressive lung fibrosis.

关键词： Lung fibrosis Epithelial-mesenchymal transition(EMT) Crosstalk

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward Rob M.Ewing Donna E.Davies mark G.jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

Social relationship satisfaction and accumulation of chronic conditions and multimorbidity:a national cohort of Australian women

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General Psychiatry 2023年第1期36卷 9-18页

作者： Xiaolin Xu Gita D Mishra Julianne Holt-Lunstad mark jones School of Public Health The University of QueenslandBrisbaneQueenslandAustralia Departments of Psychology and Neuroscience Brigham Young UniversityProvoUtahUSA

Background Social relationships are associated with mortality and chronic ***,little is known about the effects of social relationship satisfaction on multiple chronic conditions(multimorbidity).Aims To examine whether social relationship satisfaction is associated with the accumulation of *** Data from 7694 Australian women who were free from 11 chronic conditions at 45–50 years of age in 1996 were *** types of social relationship satisfaction(partner,family members,friends,work and social activities)were measured approximately every 3 years and scored from 0(very dissatisfied)to 3(very satisfied).Scores from each relationship type were summed to provide an overall satisfaction score(range:≤5–15).The outcome of interest was the accumulation of multimorbidity in 11 chronic *** Over a 20-year period,4484(58.3%)women reported ***,the level of social relationship satisfaction had a dose–response relationship with the accumulation of *** with women reporting the highest satisfaction(score 15),women with the lowest satisfaction(score≤5)had the highest odds of accumulating multimorbidity(odds ratio(OR)=2.35,95%confidence interval(CI):1.94 to 2.83)in the adjusted *** results were observed for each social relationship *** risk factors,such as socioeconomic,behavioural and menopausal status,together explained 22.72%of the *** Social relationship satisfaction is associated with the accumulation of multimorbidity,and the relationship is only partly explained by socioeconomic,behavioural and reproductive *** connections(eg,satisfaction with social relationships)should be considered a public health priority in chronic disease prevention and intervention.

关键词： morbidity prevention behaviour

Predicting the mode of flow in pneumatic conveying systems—A review

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Particuology 2008年第5期6卷 289-300页

作者： mark G.jones Kenneth C.Williams Centre for Bulk Solids and Particulate Technologies School of EngineeringUniversity of NewcastleNewcastle 2308Australia

An initial prediction of the particulate mode of flow in pneumatic conveying systems is beneficial as this knowledge can provide clearer direction to the pneumatic conveying design process. There are three general categories of modes of flow, two dense flows： fluidised dense phase and plug flow, and dilute phase oniy. Detailed in this paper is a review of the commonly used and available techniques for predicting mode of flow. Two types of predictive charts were defined： basic particle parameter based （e.g. particle size and density） and air-particle parameter based （e.g. permeability and de-aeration）. The basic particle techniques were found to have strong and weak areas of predictive ability, on the basis of a comparison with data from materials with known mode of flow capability. It was found that there was only slight improvement in predictive ability when the particle density was replaced by loose-poured bulk density in the basic parameter techniques. The air-particle-parameter-based techniques also showed well-defined regions for mode of flow prediction though the data set used was smaller than that for the basic techniques. Also, it was found to be difficult to utilise de-aeration values from different researchers and subsequently, an air-particle-based technique was developed which does not require any de-aeration parameter in its assessment.

关键词： Pneumatic conveying Mode of flow Dense phase Permeability De-aeration

Determination of slug permeability factor for pressure drop prediction of slug flow pneumatic conveying

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Particuology 2008年第5期6卷 307-315页

作者： Kenneth C.Williams mark G.jones Tobias Krull Centre for Bulk Solids and Particulate Technology The University of NewcastleCallaghanNSW 2308Australia

Current models for pressure drop prediction of slug flow pneumatic conveying in a horizontal pipeline system assume some type of steady state conditions for prediction, which limits their capability for increased predictive accuracy relative to experimental data. This is partly because of the nature of slug flow pneumatic conveying system, which, as a dynamic system, never becomes stable. By utilising conservation of mass （airflow）, a dynamic pressure analysis model is proposed on the basis of the derivative of the upstream pressure behaviour. The rate of air permeation through slug, one of the important factors in the conservation model, is expressed as a function of a slug permeability factor. Other factors such as slug velocity, slug length and the fraction of stationary layer were also considered. Several test materials were conveyed in single-slug tests to verify the proposed pressure drop model, showing good agreement between the model and experimental results.

关键词： Slug flow pneumatic conveying Pressure drop Air mass conversation Slug permeability factor

Characterization of the gas pulse frequency,amplitude and velocity in non-steady dense phase pneumatic conveying of powders

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Particuology 2008年第5期6卷 301-306页

作者： Kenneth C.Williams mark G.jones Ahmed A.Cenna Centre for Bulk Solids and Particulate Technologies School of EngineeringUniversity of Newcastle

Current modelling techniques for the prediction of conveying line pressure drop in low velocity dense phase pneumatic conveying are largely based on steady state analyses. Work in this area has been on-going for many years with only marginal improvements in the accuracy of prediction being achieved. Experimental and theoretical investigations undertaken by the authors suggest that the flow mechanisms involved in dense phase conveying are dominated by transient effects rather than those of steady state and are possibly the principal reasons for the limited improvement in accuracy. This paper reports on investigations on the pressure fluctuation behaviour in dense phase pneumatic conveying of powders. The pressure behaviour of the gas flow in the top section of the pipeline was found to exhibit pulsatile oscillations. In particular, the pulse velocity showed variation in magnitude while the frequency of the oscillations rarely exceeded 5 Hz. A wavelet analysis using the Daubechie 4 wavelet found that the amplitude of the oscillations increased along the pipeline. Furthermore, there was significant variation in gas pulse amplitude for different types of particulate material.

关键词： Pneumatic conveying Powders Dense phase Pulsatile flow Transient flow

A qualitative study on the pulsatile flow phenomenon in a dense fly ash pneumatic conveyor

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Particuology 2014年第6期12卷 81-91页

作者： Wei Chen Kenneth C.Williams Isabel Jabs mark G.jones Centre for Bulk Solids and Particulate Technologies Newcastle Institute for Energy and ResourcesThe University of Newcastle Faculty of Mechanical Engineering Leibniz University of Hanover

Understanding of the dynamic particulate flow structures within a dense gas-fly ash pneumatic conveyor must be improved in order to better aid its design *** complex pulsatile movement of the gas-fly ash mixture dominates the flow performance within the pipeline,and historically,non-invasive measurement devices such as the electrical capacitance tomography（ECT） were often used to sufficiently capture the flow ***,inadequate studies have been conducted on the pulsatile flow phenomenon,which directly relate to the gas-fly ash two-phase flow *** paper aims to investigate the pulsatile flows using an ECT ***,pulsatile flow patterns under various experimental conditions were obtained through *** within a flow were then characterised into pulse growth and decay segments,which represent the superficial fluidisation and deaeration processes during ***,structural and statistical analyses were performed on the pulse growth and decay *** suggested that the increasing air mass flow rate led to the decrease of the superficial fluidisation/deaeration magnitude,however,the increase of the superficial fluidisation/deaeration ***,the air mass flow rate was indicated as the dominant factor in determining the pulsing statistical *** research provides fundamental insights for further modelling the dense fly ash pneumatic flows.

关键词： Pneumatic conveying Electrical capacitance tomography Fly ash Pulsatile flows Flow pattern analysis

Effect of particle degradation on electrostatic sensor measurements and flow characteristics in dilute pneumatic conveying

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Particuology 2017年第4期15卷 73-79页

作者： Wei Chen Jianyong Zhang Timothy Donohua Kenneth Williams Ruixue Cheng mark jones Bin Zhou Centre for Bulk Solids and Particulate Technologies The University of Newcastle Callaghan 2308 Australia University of Teesside Middlesbrough Cleveland TS1 United Kingdom Southeast University Nanjing 210009 China

Vigorous particle collisions and mechanical processes occurring during high-velocity pneumatic con- veying often lead to particle degradation. The resulting particle size reduction and particle number increase will impact on the flow characteristics, and subsequently affect the electrostatic type of flow measurements. This study investigates this phenomenon using both experimental and numerical meth- ods. Particle degradation was induced experimentally by recursively conveying the fillite material within a pneumatic pipeline. The associated particle size reduction was monitored. Three electrostatic sensors were embedded along the pipeline to monitor the flow. The results indicated a decreasing trend in the electrostatic sensor outputs with decreasing particle size, which suggested the attenuation of the flow velocity fluctuation. This trend was more apparent at higher conveying velocities, which suggested that more severe particle degradation occurred under these conditions. Coupled computational fluid dynamics and discrete element methods （CFD-DEM） analysis was used to qualitatively validate these experimental results. The numerical results suggested that smaller particles exhibited lower flow velocity fluctua- tions, which was consistent with the observed experimental results. These findings provide important information for the accurate aoolication of electrostatic measurement devices in oneumatic conveyors.

关键词： Particle degradation Flow velocity fluctuation Electrostatic sensor CFD-DEM modelling Pneumatic conveying

Mobilization of Lead by Several Chelating Agents in Mice Injected with Lead

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中国医科大学学报 1989年第S2期18卷 36-42页

作者：徐兆发 mark M.jones Department of Public Health China Medical University Department of Chemistry and Center in Molecular Toxicology Vanderbilt University USA

The relative abilities of several chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the *** acute LD50 for lead acetate trihydrate was determined and found to be 135.3 mg Pb/kg for i. p. injection with a 95% confidence interval of 87.1 to 210.3 mg Pb/kg. The relative efficacy of chelating agents to reduce liver,kidney, spleen, bone and brain levels of lead was determined. The spleen levels were found to undergo little differences between the control and treated groups, but the liver, kidney, bone and brain levels showed significant differences in some cases. Of the compounds examind, meso-2, 3-dimercaptosuccinic acid （DMSA）and sodium 2,3-dimercaptopropane-1-sulfonate（DMPS） were as effective as disodium calcium ethylenediaminetetraacetate （Na2CaEDT A）. The resuits indicated that DMSA was a promising chelating agent and may be worthy of further investigation in the clinic.

关键词： chelating sulfonate acetate poisoning disodium spleen worthy confidence solubility allowed