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Optimizing the oxide support composition in Pr-doped CeO_(2) towards highly active and selective Ni-based CO_(2) methanation catalysts

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journal of Energy Chemistry 2022年第8期31卷 547-561,I0015页

作者： Anastasios I.Tsiotsias Nikolaos D.Charisiou Ayesha AlKhoori Safa Gaber Vlad Stolojan Victor Sebastian Bart van der Linden Atul Bansode Steven j.Hinder mark A.Baker Kyriaki Polychronopoulou Maria A.Goula Laboratory of Alternative Fuels and Environmental Catalysis(LAFEC) Department of Chemical EngineeringUniversity of Western MacedoniaGR-50100Greece Department of Mechanical Engineering Khalifa University of Science and TechnologyAbu DhabiP.O.Box 127788United Arab Emirates Center for Catalysis and Separations Khalifa University of Science and TechnologyAbu DhabiP.O.Box 127788United Arab Emirates Advanced Technology Institute Department of Electrical and Electronic EngineeringUniversity of SurreyGuildford GU24DLUK Department of Chemical Engineering and Environmental Technology Universidad de ZaragozaCampus Río Ebro-Edificio I+D50018 ZaragozaSpain Instituto de Nanociencia y Materiales de Aragón(INMA) Universidad de Zaragoza-CSICc/María de Luna 350018 ZaragozaSpain Networking Research Center on Bioengineering Biomaterials and NanomedicineCIBERBBN28029 MadridSpain Department of Chemical Engineering Delft University of TechnologyVan der Massweg 92629 HZ DelftThe Netherlands The Surface Analysis Laboratory Faculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU24DLUK

In this study,Ni catalysts supported on Pr-doped Ce O_(2) are studied for the CO_(2) methanation reaction and the effect of Pr doping on the physicochemical properties and the catalytic performance is thoroughly *** is shown,that Pr^(3+)ions can substitute Ce^(4+)ones in the support lattice,thereby introducing a high population of oxygen vacancies,which act as active sites for CO_(2) *** doping can also act to reduce the crystallite size of metallic Ni,thus promoting the active metal *** performance evaluation evidences the promoting effect of low Pr loadings(5 at%and 10 at%)towards a higher catalytic activity and lower CO_(2) activation *** the other hand,higher Pr contents negate the positive effects on the catalytic activity by decreasing the oxygen vacancy population,thereby creating a volcano-type trend towards an optimum amount of aliovalent substitution.

关键词： Power-to-gas CO_(2)methanation Ni-based catalyst Pr-doped CeO_(2) Oxygen vacancy Catalytic activity Activation energy

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Ultrasound responsive microcapsules for antibacterial nanodrug delivery

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Nano Research 2023年第2期16卷 2738-2748页

作者： jilin Fan Mingjun Xuan Pengkun Zhao mark Loznik junlin Chen Fabian Kiessling Lifei Zheng Andreas Herrmann Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China DWI—Leibniz Institute for Interactive Materials Forckenbeckstr.5052074 AachenGermany Institute of Technical and Macromolecular Chemistry RWTH Aachen UniversityWorringerweg 152074 AachenGermany Institute for Experimental Molecular Imaging University Hospital AachenForckenbeckstr.5552074 AachenGermany

The development of ultrasound-responsive microcapsule structures has resulted in several spatiotemporally controlled drug delivery systems for macromolecular cargoes,including proteins,nucleic acids,and even cells for biomedical ***,utilizing microcapsules to transport small molecular cargoes remains a challenge,because the leakage of drugs before ultrasound irradiation might cause side effects such as the undesired toxicity and the decrease of effective drug concentration at the target ***,we present a novel strategy to tackle these shortcomings by employing nanodrugs which refers to nanoparticles coated with small molecule *** showed that the drug leakage was prevented when encapsulating the nanodrug in ***,the fabricated drug delivery system was responsive not only to unfocused high-intensity ultrasound but also to the clinically relevant high-intensity focused ***,as a proof of concept,we showed that the antibacterial activity of the nanodrug@Microcapsules could be activated by applying ultrasound in *** results may provide new insights into the development of ultrasound triggered small molecule drug delivery assisted by metallic nanoparticles.

关键词： microcapsules vancomycin-nanodrug sonication drug release

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Impact of extended-infusion piperacillin-tazobactam in a Canadian community hospital

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Infectious Medicine 2023年第1期2卷 31-35页

作者： April j.Chan Gerald Lebovic Michael Wan Yan Chen Elizabeth Leung Bradley j.Langford jenny Seah Linda R.Taggart mark Downing Department of Pharmacy Unity Health TorontoTorontoOntarioCanada University of Toronto TorontoOntarioCanada Division of Infectious Diseases Unity Health TorontoTorontoOntarioCanada Public Health Ontario TorontoOntarioCanada Hotel Dieu Shaver Health and Rehabilitation Centre St.CatharinesOntarioCanada

Background:Studies have demonstrated improved clinical outcomes with extended infusion(EI)piperacillin/tazobactam(TZP)compared to standard infusion(SI).However,there is less evidence on its benefits in noncritically-ill ***-wide EI TZP was implemented at our site on February 21,*** objectives were to compare clinical,safety and economic outcomes between EI and SI ***:A retrospective cohort study of all adult patients who received EI TZP(3.375 g IV q8h infused over 4 hours and SI TZP for≥48 hours during 3 years pre-and postimplementation was *** primary study outcome was 14-day mortality while secondary outcomes included length of hospital stay(LOS),nursing plus pharmacy cost,occurrence of Clostridioides difficile infection,readmission within 30 days and change in Pseudomonas aeruginosa minimum inhibitory concentration(MIC)distribution for *** primary outcome and binary secondary outcomes were analyzed using a logistic regression *** was examined using time to event *** was examined using linear regression ***:Overall,2034 patients received EI TZP and 1364 patients received SI *** TZP was associated with lower odds of mortality(OR 0.76,95%CI 0.63-0.91),lower odds of *** infection(OR 0.59,95%CI 0.41-0.84)and 8%lower cost(estimate 0.92,95%CI 0.87-0.98)compared to SI ***:Hospital-wide implementation of EI TZP was associated with lower odds of 14-day mortality and incidence of *** infection with cost savings at our institution.

关键词： Antimicrobial stewardship Piperacillin/tazobactam Extended-infusion

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Overhead shoulder press - In-front of the head or behind the head？

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journal of Sport and Health Science 2015年第3期4卷 250-257页

作者： mark R. McKean Brendan j. Burkett Faculty of Science Health and Education School of Health and Sport Sciences University of the Sunshine Coast Sippy Downs Queensland 4556 A ustralia

背景:肩上举是一种常用练习,两种技术(头前式和头后式)可能会影响关节结构,因此需做客观分析。本研究旨在通过横向比较研究两种肩上举技术对肩部活动度和脊柱姿态的影响。方法:运用角度测量和三维生物力学测试方法研究33名受试者进行坐... 详细信息

背景:肩上举是一种常用练习,两种技术(头前式和头后式)可能会影响关节结构,因此需做客观分析。本研究旨在通过横向比较研究两种肩上举技术对肩部活动度和脊柱姿态的影响。方法:运用角度测量和三维生物力学测试方法研究33名受试者进行坐姿肩上举练习时肩关节的被动和主动活动幅度。结果:头前举在脊柱前凸的姿势下开始,头后举在脊柱后凸的姿势下开始。与头前举相比,头后举开始时的胸部伸展幅度更小。无论何种性别、何种肩上举技术,胸推均呈伸展状,且动作过程中的角度为12°-15°。两种肩上举技术在性别上表现出显著性差异。男性能保持正常的腰椎前凸,而女性则表现为腰椎后凸。结论:除头后式技术时男性肩关节产生外旋外,其余的肩关节动作幅度都在被动动作幅度之内。为避免可能出现的损伤,在头后式肩上举练习前应增加被动动作幅度。女性显现出更大的脊柱活动度,表明加强躯干力量有助于肩上举动作的完成。对具有正常躯干稳定性和理想肩关节动作幅度的受试者来说,无论头前式还是头后式,推举对于肩部和脊柱都最一种较为安全的练习。

关键词：只读存储器指标量化力学测量性别差异肩关节凸位置设计比较活动范围

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Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage

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Neural Regeneration Research 2018年第3期13卷 393-401页

作者： Nicole j.Scott-Hewitt Christopher j.Folts mark D.Noble Department of Biomedical Genetics University of Rochester School of Medicine and Dentistry

This review addresses two puzzling findings related to mutations in galactocerebrosidase （GALC） that cause Krabbe disease （KD）, a severe lysosomal storage disorder characterized by extensive myelin damage in children with mutations in both GALC alleles. First, heterozygous carriers of KD-causing mutations, which include the biological parents of children with KD, exhibit increased risk for developing other diseases. Second, variants in the GALC locus increase the risk of developing multiple sclerosis （MS）, another disease characterized by extensive myelin damage. What explains these correlations？ In studies on cuprizone-induced myelin damage in heterozygous （GALC＋/–） mice carrying one copy of a mutation that causes KD-like disease, the extent of damage was similar in GALC＋/– and wild-type （WT） mice. In contrast, GALC＋/- mice had striking defects in repair of cuprizone-induced damage. We further found unexpected microglial defects in myelin debris clearance and in the ability to up-regulate the Trem2 microglial protein critical for debris uptake. These defects were rescued by exposure to a lysosomal re-acidifying drug discovered in our studies on KD, and which provides multiple clinically relevant benefits in the twitcher （GALC＋/–） mouse model of KD. Thus, heterozygous GALC mutations cause effects on biological function that may help to understand the increased disease risk in heterozygous carriers of such mutations and to understand why GALC variations increase the risk of MS. Our findings indicate that while some genetic risk factors may contribute to complex diseases by increasing the risk of tissue damage, others may do so by compromising tissue repair.

关键词： vulnerability locus multiple sclerosis Krabbe disease galactocerebrosidase microglia myelin repair lysosomal storage disorders heterozygous carriers Trem2 demyelination

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The variable codons of H5N1 avian influenza A virus haemagglutinin genes

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Science China(Life Sciences) 2008年第11期51卷 987-993页

作者： mark j.GIBBS Robert W.MURPHY School of Botany and Zoology Faculty of ScienceAustralian National UniversityACT 0200Australia Department of Natural History Royal Ontario MuseumTorontoON M5S 2C6Canada

We investigated the selection pressures on the haemagglutinin genes of H5N1 avian influenza viruses using fixed effects likelihood models. We found evidence of positive selection in the sequences from isolates from 1997 to 2007, except viruses from 2000. The haemagglutinin sequences of viruses from southeast Asia, Hong Kong and China's Mainland were the most polymorphic and had similar nonsyn-onymous profiles. Some sites were positively selected in viruses from most regions and a few of these sites displayed different amino acid patterns. Selection appeared to produce different outcomes in vi-ruses from Europe, Africa and Russia and from different host types. One position was found to be positively selected for human isolates only. Although the functions of some positively selected posi-tions are unknown, our analysis provided evidence of different temporal, spatial and host adaptations for H5N1 avian influenza viruses.

关键词： positive selection pressure H5N1 avian influenza virus HA codon

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Exercise intolerance in heart failure with preserved ejection fraction： more than a heart problem

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journal of Geriatric Cardiology 2015年第3期12卷 294-304页

作者： Bharathi Upadhya mark j Haykowsky joel Eggebeen Dalane W Kitzman Cardiology and Geriatrics Wake Forest School of Medicine Medical Center Blvd Winston Salem NC USA Faculty of Rehabilitation Medicine University of Alberta Edmonton AB Canada

有保存喷射部分(HFpEF ) 的心失败(HF ) 是在更老的成年人的 HF 的最普通的形式，并且当人口变老，在流行正在增加。而且， HFpEF 正在增加与 HF 与不成比例当 HFrEF 的正在改善时，减少的 EF (HFrEF ) ，和它的预后正在变得更坏。尽管... 详细信息

有保存喷射部分(HFpEF ) 的心失败(HF ) 是在更老的成年人的 HF 的最普通的形式，并且当人口变老，在流行正在增加。而且， HFpEF 正在增加与 HF 与不成比例当 HFrEF 的正在改善时，减少的 EF (HFrEF ) ，和它的预后正在变得更坏。尽管有 HFpEF 的重要性，我们它的 pathophysiology 的理解不完全、最佳治疗仍然保持大部分未定义。HFpEF 的一个最重要的特征是减少的锻练忍耐，它象生活的减少的质量一样与症状相关。锻练限制的传统的概念集中了于与差的心脏的泵功能有关的中央机能障碍。然而，机制不对心和肺独占，并且这疾病的 pathophysiology 的理解演变。实质的注意集中了于定义与 HF 在病人之中位于减少的功能的能力和锻练忍耐下面的中央对外部的机制。事实上，物理训练能甚至当有利中央血液动力学的功能不在时经由外部适应机制改进锻练忍耐。另外，药试用在集中了于影响心血管的功能的 HFpEF 表现了到日期没改进锻练能力。这建议外部限制可以在限制锻练忍耐的 HF 起一个重要作用， HFpEF 的一个特点特征。

关键词：运动能力心力衰竭心脏分数病理生理学适应机制血流动力学心血管功能

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Differential effects of short term winter thermal stress on diapausing tiger swallowtail butterflies （Papilio spp.）

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Insect Science 2012年第3期19卷 277-285页

作者： j. mark Scriber Emily Maher Matthew L. Aardema Department of Entomology Michigan State University East Lansing MI McGuire Center for Lepidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville FL Department of Ecology and Evolutionary Biology Princeton University Princeton N J USA

It is generally thought that insects inhabiting lower latitudes are more severely impacted by changes in their thermal environment than are high latitude species. This is attributed to the wider range of temperatures to which high-latitude species are exposed. By contrast, low-latitude species have typically evolved in more thermally stable environments with a narrower range of temperature variation. However, deviation from this pattern can occur and here we report that under variable winter conditions a higher latitude species may be more sensitive to thermal variation than its lower latitude sister species. Using split broods, we examined the survival and adult emergence success of diapausing pupae of Papilio canadensis and P. glaucus, as well as a unique, recombinant hybrid population （＂late-flight＂） to short periods of mid-winter cold and heat stress. Our results indicate that the higher latitude, univoltine populations （P. canadensis and late-flights） exhibit lower pupal survival than the lower latitude, facultative diapauser （P. glaucus） for all mid-winter thermal stress treatments, both high and low. Size differences alone do not appear to account for the observed differences in survival or metabolic costs in these three pheno- types, as late-flight individuals are similar in size to R glaucus. We attribute the observed differences in survival and weight loss to potential metabolic differences and variation in the intensity of diapause, in addition to divergent adaptation to winter precipitation levels （e.g. snow cover） and the influences this may have on microhabitat temperature moderation.

关键词： climate change developmental threshold incipient hybrid species metabolic cost Papilionidae post-diapause delays thermal stress

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In Vivo and In Vitro Degradation Behavior of Magnesium Alloys as Biomaterials

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journal of Materials Science & Technology 2012年第3期28卷 261-267页

作者： Dingchuan Xue Yeoheung Yun Zongqing Tan Zhongyun Dong mark j. Schulz Department of Chemical and Materials Engineering University of Cincinnati OH 45221 USA Department of Bioengineering North Carolina A ＆ T State University Greensboro NC 27411 USA Department of Internal Medicine University of Cincinnati OH 45221 USA Department of Mechanical Engineering University of Cincinnati OH 45221 USA

The corrosion behavior of pure Mg,AZ31,and AZ91D were evaluated in various in vitro and in vivo environments to investigate the potential application of these metals as biodegradable implant *** polarization tests and immersion tests were performed in different simulated body solutions,such as distilled（DI） water,simulated body fluid（SBF） and phosphate buffered solution（PBS）.Mg/Mg alloys were also implanted in different places in a mouse for in vivo weight loss and biocompatibility *** in vivo subcutis bio-corrosion rate was lower than the corrosion rate for all of the in vitro simulated corrosive *** Mg/Mg alloys were biocompatible based on histology results for the liver,heart,kidney,skin and lung of the mouse during the two months *** microscopy and scanning electron microscopy were carried out to investigate the morphology and topography of Mg/Mg alloys after immersion testing and implantation to understand the corrosion mechanisms.

关键词： Mg/Mg alloys In vitro/in vivo testing Bio-degradation rate Biocompatibility

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Stepping up to meet the challenge of freezing of gait in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 589-600页

作者： Simon Lewis Stewart Factor Nir Giladi Alice Nieuwboer john Nutt mark Hallett ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of SydneySydneyNSWAustralia jean and Paul Amos Parkinson’s Disease and Movement Disorders Program Emory University School of MedicineAtlantaGAUSA Movement Disorders Unit Department of NeurologyTel-Aviv Sourasky Medical CenterSackler School of Medicine and Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael Department of Rehabilitation Sciences KU LeuvenLeuvenBelgium Movement Disorder Section Department of NeurologyOregon Health&Science UniversityPortlandORUSA Human Motor Control Section National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA.

There has been a growing appreciation for freezing of gait as a disabling symptom that causes a significant burden in Parkinson’s disease. Previous research has highlighted some of the key components that underlie the phenomenon, but these reductionist approaches have yet to lead to a paradigm shift resulting in the development of novel treatment strategies. Addressing this issue will require greater integration of multi-modal data with complex computational modeling, but there are a number of critical aspects that need to be considered before embarking on such an approach. This paper highlights where the field needs to address current gaps and shortcomings including the standardization of definitions and measurement, phenomenology and pathophysiology, as well as considering what available data exist and how future studies should be constructed to achieve the greatest potential to better understand and treat this devastating symptom.

关键词： Freezing of gait Computational modeling Standardized definitions and assessments Novel paradigms Phenomenology Pathophysiology Treatment

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