检索结果-南通市图书馆

Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

引用

Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair j.G.Gray Marc Hanauer Kristina Hettne joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester mark D.Wilkinson Egon L.Willighagen Mascha jansen Barend Mons Marco Roos Annika jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

INCIDENCE MATRIX APPROACH FOR CALCULATING READINESS LEVELS

引用

journal of Systems Science and Systems Engineering 2014年第4期23卷 377-403页

作者： mark A.London Thomas H.Holzer Timothy j.Eveleigh Shahryar Sarkani School of Engineering and Applied Science George Washington University

Contemporary system maturity assessment approaches have failed to provide robust quantitative system evaluations resulting in increased program costs and developmental *** assessment metrics,such as Technology Readiness Levels（TRL）,do not sufficiently evaluate increasingly complex *** System Readiness Level（SRL）is a newly developed system development metric that is a mathematical function of TRL and Integration Readiness Level（IRL） values for the components and connections of a particular *** acceptance has been hindered because of concerns over SRL mathematical operations that may lead to inaccurate system readiness *** inaccurate system readiness assessments are called readiness reversals.A new SRL calculation method using incidence matrices is proposed to alleviate these mathematical *** presence of SRL readiness reversal is modeled for four SRL calculation methods across several system *** regression analysis demonstrates that the proposed Incidence Matrix SRL（IMSRL）method has a decreased presence of readiness reversal than other approaches suggested in the *** SRL methods will foster greater SRL adoption by systems engineering professionals and will support system development risk reduction goals.

关键词： Technology Readiness Level(TRL) integration readiness level(IRL) system readiness level(SRL) system readiness graph theory systems engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Senescence-specific Alteration of Hydrogen Peroxide Levels in Arabidopsis thaliana and Oilseed Rape Spring Variety Brassica napus ***

引用

journal of Integrative Plant Biology 2012年第8期54卷 540-554页

作者： Stefan Bieker Lena Riester mark Stahl jürgen Franzaring Ulrike Zentgraf ZMBP (Center for Plant Molecular Biology) University of TübingenAuf der Morgenstelle 2872076 Tübingen Germany Institute for Landscape and Plant Ecology kologiezentrum 2August-von-Hartmann-Str.370599 StuttgartGermany

In order to analyze the signaling function of hydrogen peroxide （H202） production in senescence in more detail, we manipulated intracellular H202 levels in Arabidopsis thaliala （L.） Heynh by using the hydrogen- peroxide-sensitive part of the Escherichia coil transcription regulator OxyR, which was directed to the cytoplasm as well as into the peroxisomes. H202 levels were lowered and senescence was delayed in both transgenic lines, but OxyR was found to be more effective in the cytoplasm. To transfer this knowledge to crop plants, we analyzed oilseed rape plants Brassica napus L. cv. Mozart for H20~ and its scavenging enzymes catalase （CAT） and ascorbate peroxidase （APX） during leaf and plant development. H202 levels were found to increase during bolting and flowering time, but no increase could be observed in the very late stages of senescence. With increasing H202 levels, CAT and APX activities declined, so it is likely that similar mechanisms are used in oilseed rape and Arabidopsis to control H202 levels. Under elevated CO2 conditions, oilseed rape senescence was accelerated and coincided with an earlier increase in H202 levels, indicating that H202 may be one of the signals to inducing senescence in a broader range of Brassicaceae.

关键词： Arabidopsis thaliana Brassica napus E. coil Oxy-RD intracellular hydrogen peroxide senescence phenotype catalase ascorbatePeroxidase elevated CO2.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alternatives for large-scale production of cultured beef: A review

引用

journal of Integrative Agriculture 2015年第2期14卷 208-216页

作者： Matilda S M Moritz Sanne E L Verbruggen mark j Post Department of Physiology Maastricht UniversityMaastricht 6229 ER The Netherlands Department of Physics Chemistry and Biology Linkping UniversityLinkping SE-581 83 Sweden

Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today＇s 2-dimensional（2D） standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef.

关键词： cultured beef microcarriers aggregated cells packed bed bioreactor cell culture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anatomic Correlates of Mitral Systolic Anterior Motion in Transposition of the Great Arteries Following Atrial Switch Operation

引用

Congenital Heart Disease 2023年第3期18卷 267-277页

作者： Norman Aiad mark V.Sherrid Adam j.Small Youssef Elnabawi jodi Feinberg Leon Axel Ralph Mosca T.K.Susheel Kumar Michael Argilla Dan G.Halpern Cardiovascular Division Leon H.Charney Division of CardiologyNYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Department of Cardiovascular Disease Medical SchoolThe University of MinnesotaMinneapolisUSA The Lillehei Heart Institute MinneapolisMNUSA Radiology Department NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Cardiothoracic Surgery Department NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Pediatric Cardiology Division NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Department of Internal Medicine NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA

Introduction:We sought to investigate whether the development of sub-pulmonic systolic anterior motion(SAM)may be inherent to the anatomy of the the mitral valve(MV)or affected by external factors,such as a dilated right ventricle or chest abnormalities in d-looped transposition of the great arteries post atrial switch operation(d-TGA/AtS).Methods:Analysis was performed of clinical and cardiac imaging studies acquired on 19 adult patients with d-TGA/AtS(age 42±6 years old,56%male)between 2015–*** data included mitral apparatus anatomy,and CT/MRI data included biventricular dimensions,function,and Haller index(HI)for pectus ***:Patients with leaflet SAM(n=6)compared to patients without SAM(n=13)had higher MV protrusion height(2.3±0.5 vs.1.5±0.4 cm,p≤0.01)and longer anterior MV leaflet length(3.1±0.4 cm vs.2.6±0.3 cm p≤0.05),when compared to those ***/MRI showed higher sub-pulmonic left ventricular ejection fraction(LVEF)in the SAM group(71%±8%vs.54%±7%,respectively).RV size and function,significant chest deformity(HI>3.5),presence of a ventricular lead pacemaker,and septal thickness did not play a role in development of ***:An elongated mitral apparatus is associated with the development of SAM,and the development of left ventricular outflow tract obstruction(LVOTO),in d-TGA/*** hyperkinesia is associated with *** RV dimensions,septal thickness,and degree of chest deformity did not differ significantly between subjects with SAM and those without.

关键词： d-loop transposition of the great arteries mustard operation senning operation systolic anterior motion of the mitral valve echocardiography cardiac MRI

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mobility of charge carriers in mineral oil and ester fluids

引用

High Voltage 2021年第6期6卷 1040-1050页

作者： Qingjiang Xue Igor Timoshkin mark PWilson Martin Given Scott j.MacGregor Department of Electronic and Electrical Engineering University of StrathclydeGlasgowUK

New,more stringent environmental requirements for electrical insulation liquids have led to the development of novel,more environment‐friendly liquid *** fluids,introduced several decades ago,provide a viable alternative to traditional mineral insu-lating *** order to expand the practical applications of these novel dielectric fluids,their dielectric and electrical parameters should be *** of the critical pa-rameters that affects and governs the development of pre‐breakdown processes in insulating liquids is the mobility of charge *** the present paper,the mobility of charge carriers in commercially available synthetic and natural insulating ester fluids and in a mineral insulating oil were obtained using two methods,the time of flight and the space charge saturation current *** mobility was obtained for a wide range of electrical field *** was found that the mobility of charge carriers is greater in the mineral oil than in both,the natural and synthetic,ester *** was also established that the mobility is higher for higher applied electric *** results of this work will help in characterizing liquid dielectrics and in optimizing high‐voltage systems in which liquid dielectrics,including natural and synthetic ester fluids,are used.

关键词： field. charge liquids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Chapman-Richards Distribution and its Relationship to the Generalized Beta

引用

Forest Ecosystems 2019年第3期6卷 219-235页

作者： jeffrey H.Gove Thomas B.Lynch mark j.Ducey USDA Forest Service Northern Research Station271 Mast Road Durham 03824NHUSA Professor Emeritus Department of Natural Resource Ecology and ManagementOklahoma State UniversityAg Hall Room 008CStillwater 74078OKUSA Department of Natural Resources and the Environment University of New Hampshire114 James Hall Durham 03824NHUSA

Background: The Chapman-Richards distribution is developed as a special case of the equilibrium solution to the McKendrick-Von Foerster equation. The Chapman-Richards distribution incorporates the vital rate assumptions of the Chapman-Richards growth function, constant mortality and recruitment into the mathematical form of the distribution. Therefore, unlike 'assumed' distribution models, it is intrinsically linked with the underlying vital rates for the forest area under consideration. Methods: It is shown that the Chapman-Richards distribution can be recast as a subset of the generalized beta distribution of the first kind, a rich family of assumed probability distribution models with known properties. These known properties for the generalized beta are then immediately available for the Chapman-Richards distribution, such as the form of the compatible basal area-size distribution. A simple two-stage procedure is proposed for the estimation of the model parameters and simulation experiments are conducted to validate the procedure for four different possible distribution shapes. Results: The simulations explore the efficacy of the two-stage estimation procedure;these cover the estimation of the growth equation and mortality-recruitment derives from the equilibrium assumption. The parameter estimates are shown to depend on both the sample size and the amount of noise imparted to the synthetic measurements. The results vary somewhat by distribution shape, with the smaller, noisier samples providing less reliable estimates of the vital rates and final distribution forms. Conclusions: The Chapman-Richards distribution in its original form, or recast as a generalized beta form, presents a potentially useful model integrating vital rates and stand diameters into a flexible family of resultant distributions shapes. The data requirements are modest, and parameter estimation is straightforward provided the minimal recommended sample sizes are obtained.

关键词： Diameter distributions Chapman-Richards growth Generalized beta distribution of the first kind Maximum likelihood McKendrick-Von Foerster equation Physiologically structured population model Size-structured distributions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Salicylic Acid Receptor NPR3 Is a Negative Regulator of the Transcriptional Defense Response during Early Flower Development in Arabidopsis

引用

Molecular Plant 2013年第3期6卷 802-816页

作者： Zi Shi Siela Maximova Yi Liu joseph Verica mark j. Guiltinan The Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA Department of Plant Science Pennsylvania State University University Park PA 16802 USA

Arabidopsis NON-EXPRESSOR OF PR1 （NPR1） is a transcription co-activator that plays a central role in regulating the transcriptional response to plant pathogens. The NPR family consists of NPR1 and five NPRl-like genes. The NPR1 paralog NPR3 has recently been shown to function as a receptor of the plant hormone salicylic acid and to mediate proteosomal degradation of NPR1. The function of NPR3 protein during early flower development was revealed through a detailed molecular-genetic analysis including promoter transcriptional fusion analysis, phenotype characterization of npr3-3 mutants/overexpressors, and whole-plant fitness analysis. The physical interaction between NPR3 and NPR1/ TGA2 was explored using bimolecular fluorescence complementation analysis in onion epidermal cells, Here, we show that NPR3 expression was strongest in the petals and sepals of developing flowers and declined after flower opening. Consistently with this observation, an npr3 knockout mutant displayed enhanced resistance to Pseudomonas syringae infection of immature flowers, but not leaves. Developing npr3 flowers exhibited increased levels of basal and induced PR1 transcript accumulation. However, the npr3 mutant showed lower fitness compared to Col-0 in the absence of pathogen. Moreover, NPR3 was shown to interact with NPR1 and TGA2 in vivo. Our data suggest that NPR3 is a negative regulator of defense responses during early flower development and it may function through the association with both NPR1 and TGA2.

关键词： plant defense NPR3 negative regulator Arabidopsis flower.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

jejunoileal bypass:A surgery of the past and a review of its complications

引用

World journal of Gastroenterology 2009年第18期15卷 2277-2279页

作者： Dushyant Singh Alexandra S Laya Wendell K Clarkston mark j Allen Department of Gastroenterology and Hepatology University of Missouri Kansas CityKansas City MO 64111United States

jejunoileal bypass(jIB),popular in the 1960s and 1970s,had remarkable success in achieving weight loss by creating a surgical short bowel *** patient had an unusual case of liver disease and provided no history of prior bariatric ***,it was recognized that he had a jIB in the 1970s,which was also responsible for the gamut of his *** with jIB are often not recognized,as they died of complications,or underwent reversal of their surgery or a liver-kidney *** identification with prompt reversal,and the recognition and treatment of the life-threatening consequences play a critical role in the management of such patients.

关键词：减肥手术并发症肝脏疾病短肠综合征肾移植手术体外循环早期识别扭转

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Breeding wheat for drought tolerance： Progress and technologies

引用

journal of Integrative Agriculture 2016年第5期15卷 935-943页

作者： Learnmore Mwadzingeni Hussein Shimelis Ernest Dube mark D Laing Toi j Tsilo College of Agriculture Engineering and Science University of KwaZulu-Natal/African Centre for Crop Improvement Scottsville 3209 South Africa Agricultural Research Council-Small Grain Institute (ARC-SGI) Bethlehem 9700 South Africa

Recurrent drought associated with climate change is among the principal constraints to global productivity of wheat（Triticum aestivum（L.） and T. turgidum（L.））. Numerous efforts to mitigate drought through breeding resilient varieties are underway across the world. Progress is, however, hampered because drought tolerance is a complex trait that is controlled by many genes and its full expression is affected by the environment. Furthermore, wheat has a structurally intricate and large genome. Consequently, breeding for drought tolerance requires the integration of various knowledge systems and methodologies from multiple disciplines in plant sciences. This review summarizes the progress made in dry land wheat improvement, advances in knowledge, complementary methodologies, and perspectives towards breeding for drought tolerance in the crop to create a coherent overview. Phenotypic, biochemical and genomics-assisted selection methodologies are discussed as leading research components used to exploit genetic variation. Advances in phenomic and genomic technologies are highlighted as options to circumvent existing bottlenecks in phenotypic and genomic selection, and gene transfer. The prospects of further integration of these technologies with other omics technologies are also provided.

关键词： drought tolerance genomic selection genotyping phenotyping wheat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：