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Repeated hydrogen peroxide dosing briefly reduces cyanobacterial blooms and microcystin while increasing fecal bacteria indicators in a eutrophic pond

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journal of Environmental Sciences 2023年第2期124卷 522-543页

作者： mark W.Lusty Christopher j.Gobler School of Marine and Atmospheric Sciences Stony Brook UniversitySouthamptonNY 11968USA

This study explored the effects of H_(2)O_(2)on Cyanobacteria and non-target microbes using fluorometry,microscopy,flow cytometry,and high throughput DNA sequencing of the 16S rRNA gene during a series of mesocosm and whole-ecosystem experiments in a eutrophic pond in NY,*** addition of H_(2)O_(2)(8 mg/L)significantly reduced Cyanobacteria concentrations during a majority of experiments(66%;6 of 9)and significantly increased eukaryotic green and unicellular brown algae in 78%and 45%of experiments,*** heterotrophic bacteria declined significantly following H_(2)O_(2)addition in all experiments,bacteria indicative of potential fecal contamination(Escherichia coli,Enterococcus,fecal coliform bacteria)consistently and significantly increased in response to H_(2)O_(2),evidencing a form of‘pollution swapping’.H_(2)O_(2)more effectively reduced Cyanobacteria in enclosed mesocosms compared to whole-ecosystem *** whole-pond H_(2)O_(2)applications over a twoyear period temporarily reduced cyanobacterial levels but never reduced concentrations below bloom thresholds and populations always rebounded in two weeks or *** bacterial phyla of Cyanobacteria,Actinobacteria,and Planctomycetes were the most negatively impacted by H_(2)O_(2).Microcystis was always reduced by H_(2)O_(2),as was the toxin microcystin,but Microcystis remained dominant even after repeated H_(2)O_(2)*** H_(2)O_(2)favored the growth of eukaryotic algae over potentially harmful Cyanobacteria,the inability of H_(2)O_(2)to end cyanobacterial blooms in this eutrophic waterbody suggests it is a non-ideal mitigation approach in high biomass ecosystems and should be used judiciously due to potential negative impacts on non-target organisms and promotion of bacteria indicative of fecal contamination.

关键词： Indicator bacteria Toxic cyanobacteria Microcystin Microcystis Hydrogen peroxide Bacteria Enterococcus E.coli Pollution swapping

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Alternative expressions for stand diameter in complex forests

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Forest Ecosystems 2023年第3期10卷 328-336页

作者： mark j.Ducey john A.Kershaw jr. Department of Natural Resources and the Environment University of New HampshireDurhamNHUSA Faculty of Forestry and Environmental Management University of New BrunswickFrederictonNBCanada

Quadratic mean diameter is the most frequently reported descriptor of the diameter distribution of *** such,it is often used as an indicator of forest stand structure,developmental stage,and ecological and economic ***,quadratic mean diameter can be heavily influenced by the presence or absence of large numbers of small stems in lower canopy strata,and it is also sensitive to left-truncation of the diameter distribution,making its interpretation across inventories with different protocols ***,we examine three alternative expressions of stand diameter:the arithmetic and quadratic mean diameter of the thickest 100 trees per hectare,and the basal area-weighted mean *** data from the United States Forest Inventory and Analysis program for New York and New England,these alternative expressions showed closer correlation with multiple stand structural variables than did quadratic mean diameter,including merchantable cubic and board foot volume per hectare,aboveground live tree carbon per hectare,and total number of live and dead standing trees greater than 40 cm diameter at breast height per hectare(previously proposed as an index of old-growth structure).Arithmetic and quadratic mean diameter of the thickest 100 trees per hectare showed nearly identical performance,and the strongest correlations across the *** develop closed-form expressions for these variables when the diameter distribution is a Weibull,and illustrate their behavior relative to quadratic mean diameter for that *** the reasons for prevalence of quadratic mean diameter as an indicator remain valid,we suggest that these alternative measures should be more widely reported and analyzed to give a more informative depiction of stand structure and development in complex forests.

关键词： Forest structure Diameter at breast height Weibull distribution

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c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions

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World journal of Gastroenterology 2022年第13期28卷 1338-1346页

作者： Grant Halliday Ross j Porter Catherine j Black mark j Arends Shahida Din Department of Pathology Western General HospitalNHS LothianScotland EH42XUUnited Kingdom Centre for Inflammation Research Queen’s Medical Research InstituteUniversity of EdinburghEdinburgh EH164TJUnited Kingdom Edinburgh Inflammatory Bowel Disease Unit Western General HospitalNHS LothianEdinburgh EH42XUUnited Kingdom Cancer Research UK Edinburgh Centre Institute of Cancer&GeneticsWestern General HospitalUniversity of EdinburghEdinburgh EH42XUUnited Kingdom

BACKGROUND Post-colonoscopy colorectal cancer(CRC)rates for patients with inflammatory bowel disease(IBD)are unacceptably *** colonoscopy,an intravenous fluorescent anti-c-MET probe may improve endoscopic detection of ***,c-MET expression in IBD lesions is poorly defined,limiting translational *** To comprehensively define c-MET expression in sporadic and IBD-associated colorectal *** c-MET expression was immunohistochemically assessed in 319 formalin-fixed paraffin-embedded tissue specimens,colonoscopically or surgically retrieved between *** included:30 normal colorectal biopsies,30 hyperplastic polyps(HP),31 sessile serrated lesions(SSL),55 tubular/tubulovillous adenomas with low(TA-LGD,n=32)or high grade dysplasia(TA-HGD,n=23),26 sporadic(s)-CRCs,16 quiescent IBD biopsies,11 active/inflamed IBD biopsies,18 IBDassociated dysplastic lesions(IBD-dys),and 102 *** was scored by two independent observers as:0=absent,1=weak,2=moderate or 3=***-Whitney U and Kruskal-Wallis tests were used to assess *** Positive epithelial cytoplasmic and membranous c-MET expression was observed in all tissues,indicating there is ubiquitous expression in the colorectum.c-MET expression was weak in normal colonic epithelium compared with each of the sporadic colonic lesions,including TA-LGD(P<0.001),TA-HGD(P=0.004),HP(P<0.001),SSL(P<0.001),and s-CRC(P<0.001).Specifically,in sporadic(non-IBD)lesions,expression was stronger in TA-LGD compared with normal mucosa(P<0.001),and stronger in s-CRC compared with TA-HGD(P=0.004).However,there was no significant difference between TA-LGD and TA-HGD(P=0.852).Further,there was no difference in c-MET expression between HP and SSL(P=0.065).In IBD,expression was weaker in quiescent colonic mucosa compared with inflamed colonic mucosa(P<0.001).There was no difference between inflamed colonic mucosa and IBD-dys(P=0.512)or IBD-CRC(P=0.296).However,expression

关键词： Inflammatory bowel diseases Colorectal cancer Surveillance Detection c-MET Immunohistochemistry

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The effect of temperature on the wear behaviour of dental composites

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Biosurface and Biotribology 2022年第4期8卷 329-336页

作者： joseph A.Arsecularatne Serena Tran mark j.Hoffman School of Materials Science and Engineering UNSW SydneySydneyNew South WalesAustralia School of Mechanical and Manufacturing Engineering UNSW SydneySydneyNew South WalesAustralia School of Engineering University of NewcastleCallaghanNew South WalesAustralia

Despite numerous published studies on the wear of dental composites,few have considered the influence of temperature on the two-body wear ***,no previous work has considered the influence of temperature on dominant wear mecha-nisms during the consumption of hot substances,hence the focus of this ***-rocating wear tests were carried out at varying artificial saliva lubricant temperatures(37 and 57℃)and material loss was quantified using *** wear tracks were analysed using FIB/SEM/*** reveal that the wear rate of a dental composite can significantly increase with temperature,with fatigue/delamination and ploughing acting as dominant mechanisms.

关键词： dental composite temperature tribological performance wear mechanism

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Evolution of interventional endoscopic ultrasound

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Gastroenterology Report 2023年第1期11卷 131-139页

作者： mark j.Radlinski Daniel S.Strand Vanessa M.Shami Division of Gastroenterology and Hepatology University of VirginiaCharlottesvilleVAUSA

Endoscopic ultrasound(EUS)has become an indispensable modality for the assessment of the gastrointestinal tract and adjacent structures since its origin in the *** the development of the linear echoendoscope,EUS has evolved from a purely diagnostic modality to a sophisticated tool for intervention,with numerous luminal,pancreaticobiliary,and hepatic ***,these applications may be subdivided into three categories:transluminal drainage or access procedures,injection therapy,and EUS-guided liver *** drainage or access procedures include management of pancreatic fluid collection,EUS-guided biliary drainage,EUS-guided bile duct drainage,EUS-guided pancreatic duct drainage,and enteral anastomosis *** therapies include therapeutic EUS-guided injections for management of malignancies accessible by ***-guided liver applications include EUS-guided liver biopsy,EUS-guided portal pressure gradient measurement,and EUS-guided vascular *** this review,we discuss the origins of each of these EUS applications,evolution of techniques leading to the current status,and future directions of EUS-guided interventional therapy.

关键词： endoscopic ultrasound interventional endoscopic ultrasound biliary drainage gastrojejunostomy pancreatic pseudocyst drainage

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Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke

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Neural Regeneration Research 2022年第1期17卷 91-92页

作者： Rayudu Gopalakrishna Charlotte Lin mark S.Kindy William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Pharmaceutical Sciences College of PharmacyUniversity of South FloridaTampaFLUSA

Currently,there are no clinically proven drugs for recovery from stroke and other neuronal injuries such as traumatic brain injury and spinal cord *** therapy requires axonal regeneration,which is inhibited by diverse axonal growth inhibitors,such as Nogo-A,myelin-associated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp),and chondroitin sulfate proteoglycans(CSPGs)(Chaudhry and Filbin,2007;Carmichael,2010;Schwab and Strittmatter,2014).

关键词： axonal injuries inhibited

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Fluidization and bubbling behavior of potash particles in a deep fluidized bed

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Particuology 2023年第9期80卷 103-114页

作者： Mojtaba Nabipoor Hassankiadeh jingsi Yang mark Berrey Dave jordison Lifeng Zhang Donald Bergstrom Raymond j.Spiteri Department of Chemical and Biological Engineering University of SaskatchewanSKS7N 5A9SaskatoonCanada The Mosaic Company Belle PlaineSKCanada Department of Mechanical Engineering University of SaskatchewanSaskatoonCanada Department of Computer Science University of SaskatchewanSaskatoonSKCanada

Most existing models for predicting bubble size and bubble frequency have been developed for freely bubbling fluidized *** prediction of bubbling behavior in deep fluidized beds,however,has been a challenge due to the higher degree of bubble coalescence and break up,high probability of the slugging regime,partial fluidization,and chaotic behavior in the bubbling *** this work,the bubbling and fluidization behavior of potash particles was investigated in a deep fluidized bed employing a twin-plane electrical capacitance tomography(ECT)*** volume fraction,average bubble velocity,average bubble diameter,and bubble frequency in both bubbling and slugging regimes were measured at two different bed height ratios(H/D=3.5 and H/D=3.78).This work is the first to illustrate a sequential view of bubbles at different superficial gas velocities in a fluidized *** results show that both the bubble diameter and rising velocity increased with increasing the superficial gas velocity for the two bed heights,with larger values observed in the deeper bed compared to the shallower *** values for bubble diameter,bubble rise velocity and bubble frequency from different models are compared with the experimental data obtained from the ECT system in this *** agreement has been achieved between the values predicted by the previous models and the experimental data for the bubble diameter and bubble rise velocity with an average absolute deviation of 16%and 15%for the bed height of 49 cm and 13%and 8%for the bed height of 53 cm,respectively.

关键词： Deep fluidized bed Potash particle Electrical capacitance tomography Image reconstruction Bubbling and slugging regime

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A diagnosis with a twist:Ultrasonographic sensitivity and predictors of pediatric ovarian torsion within a large pediatric hospital

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World journal of Emergency Medicine 2022年第3期13卷 229-231页

作者： mark K.Hewitt jesse E.Marshall-Sheppard April j.Kam Department of Medicine Division of Emergency MedicineMcMaster UniversityHamilton L8S 4L8Canada Department of Family Medicine University of TorontoToronto M5S1A1Canada Department of Pediatrics Division of Pediatric Emergency MedicineMcMaster UniversityHamilton 8S 4L8Canada

The diagnosis of ovarian torsion(OT)in girls is challenging compared to that of testicular torsion in boys for many reasons,but it behooves the medical community to continue to strive to better identify this uncommon but clinically important pathology^([1]) OT occurs when the ovary and associated structures rotate around its vascular pedicle,leading to eventually irreversible necrosis.^([2,3])Studies attempting to identify clinical features for early diagnosis have not reached a consensus on the best clinical predictors of this condition,making radiographic imaging of the ovaries even more crucial.^([4,5])

关键词： diagnosis pediatric torsion

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Updates on the pathologic diagnosis and classification of mesothelioma

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journal of Cancer Metastasis and Treatment 2022年第1期8卷 197-209页

作者： julia R.Farkas mark Sharobim jefree j.Schulte Department of Pathology and Laboratory Medicine University of WisconsinMadisonWI 53792USA

Mesothelioma is a rare malignant tumor of the serosal membranes that can be challenging to diagnose,especially on small biopsy *** are updated guidelines on the diagnosis and classification of mesothelioma,which incorporate advancements in understanding mesothelioma biology published in the literature over recent *** review will discuss marked developments and/or improvements that have been made,including:(1)to the histologic classifications of mesothelioma;(2)the use of such classifications and nuclear grading in prognosis;(3)the indispensability of ancillary studies in the diagnosis of mesothelioma;(4)the application of these pleural based classifications and diagnostic schemes in peritoneal mesothelioma;and(5)the potential for diagnosis of mesothelioma in situ.

关键词： Mesothelioma BRCA associated peptide 1(BAP1) methylthioadenosine phosphorylase(MTAP) nuclear grading mesothelioma in situ

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Eight decades of compositional change in a managed northern hardwood landscape

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Forest Ecosystems 2023年第3期10卷 398-410页

作者： mark j.Ducey Olivia L.Fraser Mariko Yamasaki Ethan P.Belair William B.Leak University of New Hampshire Department of Natural Resources and the Environment114 James HallDurhamNH03824USA U.S.D.A.Forest Service White Mountain National Forest71 White Mountain DriveCamptonNH03223USA U.S.D.A.Forest Service Northern Research Station271 Mast RoadDurhamNH03824USA The Nature Conservancy Natural Climate SolutionsAfrica Regional Portland Office45 Exchange StSuite 303PortlandME04101USA

We analyzed over 8 decades of change in forest composition(represented by species proportion of basal area)and size class from more than 400 permanent plots located on the Bartlett Experimental Forest in the White Mountains of New *** data represent one of the longest-term landscape-scale records of forest change based on permanent plots in North *** analyzed the plots based on elevation class,land type indicating assumed successional direction(grouped into coniferous and deciduous),and inventory period within managed and unmanaged portions of the *** ongoing shift from small-to large-diameter stems is clear across all species,in response to the overall aging of the forest following exploitative harvesting in the 19th *** compositional changes include a continuing decline in shade-intolerant species(paper birch and aspen),along with the mid-tolerant yellow *** increase in red maple abundance through the early 1990s has leveled off or *** shade-tolerant species,increases in beech and red spruce were largely consistent with assumed land type on unmanaged plots,but heavy marking against diseased beech on managed plots restricted increase of that *** maple declined in abundance except where silvicultural intervention helped maintain *** contrast,eastern hemlock showed a continuing expansion at all elevations below 600 *** data continue to show little or no evidence of upward migration of species,despite evidence of recent regional change in ***,the BEF is poised for substantial changes when emerald ash borer and hemlock woolly adelgid,both of which are known to infest nearby areas,do arrive.

关键词： Northern hardwoods Succession Stand dynamics Silviculture

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