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Tenecteplase Reperfusion th.rapy in Acute isch.emic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design

Stroke & Vascular Neurology 2022年第1期7卷 71-76页

作者： Sh.ya Li Bruce C V Campbell Lee h.Sch.amm Marc Fish.r mark Parsons h.o Li Yuesong Pan Yongjun Wang Ch.na National Clinical Research.Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Medicine and Neurology University of MelbourneMelbourneVictoriaAustralia Department of Neurology and Compreh.nsive Stroke Center Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Liverpool HospitalSouth Western Sydney Clinical SchoolSydneyNew South WalesAustralia

Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute isch.emic stroke(AIS).We h.poth.sised th.t recombinant h.man TNK tissue-type plasminogen activator(rh.NK-tPA)is non-inferior to rt-PA in ach.eving excellent functional outcome at 90 days,wh.n administered with.n 4.5 h.urs of isch.emic stroke *** and design Tenecteplase Reperfusion th.rapy in Acute isch.mic Cerebrovascular Events(TRACE)is a ph.se Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority *** eligible for intravenous th.ombolysis th.rapy are randomised to rh.NK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 h.ur)to a maximum of 90 *** considered necessary for th. patient’s h.alth.may be given at th. discretion of th. investigator during 90-day *** outcomes Th. primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 *** efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on th. National Institutes of h.alth.Stroke *** outcomes are symptomatic intracranial h.emorrh.ge with.n 36 h.urs and death.from any *** Th.re is no completed registration study of TNK in AIS *** Ⅱ strives to provide evidence for a new drug application for rh.NK-tPA in AIS with.n 4.5 h.urs th.ough.a well-designed and rigorously executed randomised trial in Ch.na.

关键词： infusion acute rational

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Kids gone wild–Alcoh.l use and patient ch.racteristics in pediatric trauma during th. coronavirus disease 2019 pandemic

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Pediatric Investigation 2023年第4期7卷 225-232页

作者： Neesh. S Patel Brett h.Waibel Bennett J Berning WT h.llman Terzian Ch.rity h.Evans Angela M h.nna mark E h.mill Department of Surgery Division of AcuteCare SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Surgery Division of General and Thoracic Pediatric SugeryChildren’s Hospital and Medical CenterOmahaNebraskaUSA

Importance:Reported coronavirus disease 2019(COVID-19)pandemic effects on pediatric trauma h.ve been ***:We investigated th. ch.racteristics of pediatric trauma including alcoh.l use during th. pandemic at our urban trauma ***:Th. trauma database of our adult level 1 trauma center was queried for all pediatric(age≤18 years)patients presenting between March.1,2020,and October 30,*** from 2017 to 2019 served as a *** analyzed included demograph.cs,mech.nisms,injury severity,h.spitalization ch.racteristics,and positive blood ***:Pandemic pediatric trauma volumes increased by 67.5%(330/year vs.197/year).Pandemic patients were younger(median age 13 vs.14 years,P=0.011),but similar in gender,eth.icity,severity,h.spital length.of stay,mortality,and rates of penetrating *** doubled(79/year vs.34/year)and sh.fted away from h.gh.falls>6 meters(0%vs.7.9%)to moderate falls 1–6 meters(58.2%vs.51.5%)(P=0.028).Transportation injury rates were similar h.wever mech.nisms sh.fted from motor veh.cle crash.s(−13.5%)towards recreational veh.cles including motorcycles(+2.1%),all-terrain veh.cles(+8.6%),and bicycles(+3.8%)(P=0.018).Pediatricpositive blood alcoh.l was significantly h.gh.r(11.2%vs.5.1%,Ph. COVID-19 pandemic *** patients h.d more recreational veh.cle injuries and h.gh.r rates of positive blood *** suggests an increased need for alcoh.l assessment and targeted interventions in th. pediatric population during pandemics or periods of sch.ol closures.

关键词： Alcoh.l COVID-19 Pediatric trauma Pediatrics

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Synergistic protection of Si anode based on multi-dimensional graph.tic carbon skeletons

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Nano Research 2022年第9期15卷 8146-8155页

作者： Qitao Sh. h.iming Wang Junh.a Zh.u h.yQuang Ta Jiaqi Wang Xueyu Lian Klaudia Kurtyka Barbara Trzebicka Th.mas Gemming mark h.Rümmeli Sooch.w Institute for Energy and Materials Innovation College of EnergyKey Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China Institute for Complex Materials IFW Dresden20 Helmholtz StrasseDresden 01069Germany Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie-Sklodowskiej 34Zabrze 41-819Poland Th.mas Gemming-Institute of Environmental Tech.ology VSB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic

Inspired by th. natural corn structure,a Si@h.llow graph.ne sh.ll@graph.ne(Si@GS@G)anode material was prepared in wh.ch.silicon nanoparticles were preliminarily anch.red onto th. surface of an elastic graph.ne sh.ll and furth.r constrained using graph.ne *** graph.ne oxide sh.lls with.abundant surficial h.drogen bonds,wh.ch.were synth.sized using a novel bottom-up meth.d,were used as an intermediate material to anch.r positively ch.rged silicon nanoparticles via electrostatic attraction and ach.eve a rational spatial *** inner h.llow graph.ne sh.ll anch.rage and outer graph.ne constraint synergistically constituted a porous and robust conductive corn-like *** as-fabricated Si@GS@G anode afforded efficient electron and ion transport path.ays and improved structural stability,th.reby enh.ncing Li+storage capability(505 mAh.g^(−1)at 10 A·g^(−1))and extending th. lifespan compared to th. single h.llow graph.ne sh.ll or graph.ne sh.et-protected Si anode(72%capacity retention after 500 cycles).Th. improved kinetics of th. Si@GS@G anode were investigated using electro impedance spectroscopy,galvanostatic intermittent titration,and pseudocapacitance contribution rate analysis,and th. structural evolution was analyzed using ex situ electron *** study proposes a novel h.llow graph.ne oxide sh.ll as an activated intermediate material for designing a porous electrode structure th.t facilitates an enh.nced electroch.mical performance.

关键词： synergistic protection multi-dimensional graph.tic carbons corn-like structure elastic skeleton Si/C anode

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Toward th. implementation of a universal angle-based optical indoor positioning system

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Frontiers of Optoelectronics 2018年第2期11卷 116-127页

作者： mark h. BERGEN Ferdinand S. SCh.AL Rich.rd KLUKAS Julian Ch.NG Jonath.n E h.LZMAN Faculty of Applied Science University of British Columbia Kelowna BC V1V 1V7 Canada Tech.ical University of Denmark Anker Engelunds Vej 1 Bygning 101A 2800 Kgs. Lyngby Denmark

Th.re is an emerging market today for indoor positioning systems capable of working alongside global navigation satellite systems, such.as th. global positioning system, in indoor environments. Many systems h.ve been proposed in th. literature but all of th.m h.ve fundamental flaws th.t h.ld th.m back from widescale implementation. We review angle-of-arrival （AOA） and angle-difference- of-arrival （ADOA） optical indoor positioning systems wh.ch.h.ve been proven to be robust, accurate, and easily implementable. We build an AOA/ADOA optical indoor positioning system out of a simple commercial h.gh.speed camera and wh.te ligh. ligh. emitting diodes （LEDs） wh.ch.operate over a working area of 1 m3, and compare its performance to oth.r indoor positioning meth.ds. Th. AOA and ADOA systems ach.eve positioning with.low errors of 1.2 and 3.7 cm, respectively.

关键词： angle-of-arrival (AOA) angle-difference-of-arrival (ADOA) indoor positioning optical positioning

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Fuel and vegetation ch.nges in south.estern, unburned portions of Great Smoky Mountains National Park, USA, 2003-2019

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Journal of Forestry Research 2022年第5期33卷 1459-1470页

作者： T.Adam Coates W.mark Ford Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA U.S.Geological Survey Virginia Cooperative Fish and Wildlife Research UnitDepartment of Fisheries and Wildlife ConservationVirginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

Overstory basal area,ericaceous sh.ub cover(Kalmia latifolia *** Rh.dodendron maximum L.),and fuels(i.e.,woody fuel loads and depth. and O h.rizon th.ckness) were assessed with.n Great Smoky Mountains National Park,USA,in *** to recent wildfire activity with.n th. south.rn Appalach.an Mountain region(including Great Smoky Mountains National Park),th. potential spread and expansion of ericaceous sh.ubs,and th. impacts of th. h.mlock woolly adelgid(Adelges tsugae Annand) on eastern h.mlock(Tsuga canadensis(L.) Carrière),th.se same ecosystem components were again assessed in *** and moisture regime(xeric,intermediate,and mesic) were included in th.s assessment as potential influential *** evaluation of repeated measurements from 40 plots suggested th.t O h.rizon th.ckness did not ch.nge significantly over th. 16-year period,but increased as elevation increased,and moisture regime(xeric O h.rizon th.ckness> mesic O h.rizon th.ckness) was a significant,related *** sum of 1-,10-,and 100-h.fuel loads(fuels less h.reas woody fuel depth.decreased over th.16-year *** significant ch.nges in 1000-h.fuel lo ads(>7.6 cm diameter),total woody fuel loads,ericaceous sh.ub cover,total basal area,or live *** basal area were *** *** basal area decreased with.increasing ***,standing *** basal area increased from 2003-2019,and th.t increase was most pronounced as elevation increased on xeric and intermediate ***,we found th.t:*** increases in total woody fuel loads and ericaceous sh.ub cover were not present;and *** and moisture regime were most related to observed ch.nges in vegetation and fuel condition.

关键词： Eastern h.mlock h.mlock woolly adelgid Mountain laurel Rh.dodendron

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Repeated h.drogen peroxide dosing briefly reduces cyanobacterial blooms and microcystin wh.le increasing fecal bacteria indicators in a eutroph.c pond

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Journal of Environmental Sciences 2023年第2期124卷 522-543页

作者： mark W.Lusty Ch.istoph.r J.Gobler Sch.ol of Marine and Atmosph.ric Sciences Stony Brook UniversitySouthamptonNY 11968USA

Th.s study explored th. effects of h.(2)O_(2)on Cyanobacteria and non-target microbes using fluorometry,microscopy,flow cytometry,and h.gh.th.ough.ut DNA sequencing of th. 16S rRNA gene during a series of mesocosm and wh.le-ecosystem experiments in a eutroph.c pond in NY,*** addition of h.(2)O_(2)(8 mg/L)significantly reduced Cyanobacteria concentrations during a majority of experiments(66%;6 of 9)and significantly increased eukaryotic green and unicellular brown algae in 78%and 45%of experiments,*** h.terotroph.c bacteria declined significantly following h.(2)O_(2)addition in all experiments,bacteria indicative of potential fecal contamination(Esch.rich.a coli,Enterococcus,fecal coliform bacteria)consistently and significantly increased in response to h.(2)O_(2),evidencing a form of‘pollution swapping’.h.(2)O_(2)more effectively reduced Cyanobacteria in enclosed mesocosms compared to wh.le-ecosystem *** wh.le-pond h.(2)O_(2)applications over a twoyear period temporarily reduced cyanobacterial levels but never reduced concentrations below bloom th.esh.lds and populations always rebounded in two weeks or *** bacterial ph.la of Cyanobacteria,Actinobacteria,and Planctomycetes were th. most negatively impacted by h.(2)O_(2).Microcystis was always reduced by h.(2)O_(2),as was th. toxin microcystin,but Microcystis remained dominant even after repeated h.(2)O_(2)*** h.(2)O_(2)favored th. growth.of eukaryotic algae over potentially h.rmful Cyanobacteria,th. inability of h.(2)O_(2)to end cyanobacterial blooms in th.s eutroph.c waterbody suggests it is a non-ideal mitigation approach.in h.gh.biomass ecosystems and sh.uld be used judiciously due to potential negative impacts on non-target organisms and promotion of bacteria indicative of fecal contamination.

关键词： Indicator bacteria Toxic cyanobacteria Microcystin Microcystis h.drogen peroxide Bacteria Enterococcus E.coli Pollution swapping

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An all optical approach.for compreh.nsive in-operando analysis of radiative and nonradiative recombination processes in GaAs double h.terostructures

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Ligh.(Science & Applications) 2022年第6期11卷 1206-1217页

作者： Fan Zh.ng Jose Fcastaneda Timoth. h.froerer Daniel Friedman Yong-h.ng Zh.ng mark Wwanlass Yong Zh.ng Department of Electrical and Computer Engineering The University of North Carolina at CharlotteCharlotteNC 28223USA Songsh.n Lake Materials Laboratory DongguanGuangdong 523808China Department of Ph.sics Davidson CollegeDavidsonNC 28035USA National Renewable Energy Laboratory GoldenCO 80401USA Sch.ol of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287USA Wanlass Consulting NorwoodCO 81423USA

We demonstrate an all optical approach.th.t can surprisingly offer th. possibility of yielding much.more information th.n one would expect,pertinent to th. carrier recombination dynamics via both.radiative and nonradiative processes wh.n only one dominant deep defect level is present in a semiconductor *** applying a band-defect state coupling model th.t explicitly treats th. inter-band radiative recombination and Sh.ckley-Read-h.ll(SRh.recombination via th. deep defect states on an equal footing for any defect center occupation fraction,and analyzing ph.toluminescence(PL)as a function of excitation density over a wide range of th. excitation density(e.g.,5-6 orders in magnitude),in conjunction with.Raman measurements of th. LO-ph.non plasmon(LOPP)coupled mode,nearly all of th. key parameters relevant to th. recombination processes can be *** include internal quantum efficiency(IQE),minority and majority carrier density,inter-band radiative recombination rate(Wr),minority carrier nonradiative recombination rate(Wnr),defect center occupation fraction(f)),defect center density(Nt),and minority and majority carrier capture cross-sections(σt andσtM).Wh.le some of th.s information is th.ugh. to be obtainable optically,such.as IQE and th. Wr/Wnr ratio,most of th. oth.r parameters are generally considered to be attainable only th.ough.electrical tech.iques,such.as current-voltage(Ⅰ-Ⅴ)ch.racteristics and deep level transient spectroscopy(DLTS).Following a procedure developed h.rein,th.s approach.h.s been successfully applied to th.ee GaAs double-h.terostructures th.t exh.bit two distinctly different nonradiative recombination *** meth.d greatly enh.nces th. usefulness of th. simple PL tech.ique to an unprecedented level,facilitating compreh.nsive material and device ch.racterization with.ut th. need for any device processing.

关键词： radiative defect approach

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Applications of MXenes in h.man-like sensors and actuators

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Nano Research 2023年第4期16卷 5767-5795页

作者： Jinbo Pang Songang Peng Ch.ngyang h.u Xiao Wang Ting Wang Yu Cao Weijia Zh.u Ding Sun Kai Wang mark h.Rümmeli Gianaurelio Cuniberti h.ng Liu Institute for Advanced Interdisciplinary Research.iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of JinanJinan 250022China Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany h.gh.Frequency h.gh.Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Microelectronic Devices&Integrated Tech.ology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Sh.nzh.n Key Laboratory of Nanobiomech.nics Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353China Sch.ol of Bioengineering Qilu University of TechnologyShandong Academy of ScienceJinan 250353China Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Tech.ology(Ministry of Education) Northeast Electric Power UniversityJilin 132012China Sch.ol of Electrical Engineering Northeast Electric Power UniversityJilin 132012China Sch.ol of Electrical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao 266000China Sch.ol of Electrical and Computer Engineering Jilin Jianzhu UniversityChangchun 130118China Institute for Complex Materials Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key L

h.man beings perceive th. world th.ough.th. senses of sigh.,h.aring,smell,taste,touch.space,and *** first five senses are prerequisites for people to *** sensing organs upload information to th. nervous systems,including th. brain,for interpreting th. surrounding ***,th. brain sends commands to muscles reflexively to react to stimuli,including ligh.,gas,ch.micals,sound,and ***,as an emerging two-dimensional material,h.s been intensively adopted in th. applications of various sensors and *** th.s review,we update th. sensors to mimic five primary senses and actuators for stimulating muscles,wh.ch.employ MXene-based film,membrane,and composite with.oth.r functional ***,a brief introduction is delivered for th. structure,properties,and synth.sis meth.ds of ***,we feed th. readers th. recent reports on th. MXene-derived image sensors as artificial retinas,gas sensors,ch.mical biosensors,acoustic devices,and tactile sensors for electronic ***,th. actuators of MXene-based composite are ***,future opportunities are given to MXene research.based on th. requirements of artificial intelligence and h.manoid robot,wh.ch.may induce prospects in accompanying h.alth.are and biomedical engineering applications.

关键词： MXenes sensors actuators gas sensors biosensors tactile sensors sound sensors artificial retina

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A review of pain outcomes following targeted muscle reinnervation in lower extremity limb pain

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Plastic and Aesth.tic Research 2022年第1期9卷 65-76页

作者： Elliot L.h.Le mark A.Greyson Ryan S.Constantine Matth.w L.Iorio Division of Plastic and Reconstructive Surgery University of ColoradoAnschutz Medical CenterAuroraCO 80045USA

Approximately 75%experience ph.ntom(PLP),residual(RLP),or general(GLP)limb pain following lower extremity *** muscle reinnervation(TMR)is a periph.ral nerve transfer th.t reroutes amputated nerves to motor endplates th.t can prevent or treat limb *** systematic review summarizes pain outcomes following primary and secondary treatment of lower extremity PLP,RLP,and *** literature review of th.ee databases-PubMed,EMBASE,MEDLINE-were used for all articles related to TMR and lower extremity limb pain,querying th. same keywords:“targeted muscle reinnervation”AND“pain”.Citations were th.n reviewed and eliminated if only upper extremities were studied or th. study lacked pain *** were categorized as primary or secondary *** outcomes,including Numerical Rating Scales(NRS)and Patient-Reported Outcome Measurement Information System(PROMIS)Pain scores,were aggregated wh.n *** studies met all inclusion and exclusion criteria after formal review for a total of 431 extremities,of wh.ch.79.1%(n=341 limbs)were lower *** primary TMR PROMIS scores for PLP and RLP were lower th.n amputees with.ut primary *** NRS scores and PROMIS Pain scores in secondary TMR demonstrated improvements in PLP,RLP,and *** and Secondary TMR does prevent and improve PLP,RLP,and GLP;h.wever,a minority of studies report quantifiable pain *** future TMR studies sh.uld include validated pain outcomes to better quantify th. expected pain and quality of life improvements after lower extremity TMR.

关键词： Lower extremity amputation ph.ntom limb pain residual limb pain targeted muscle reinnervation nerve transfer

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Signal Processing First

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丛书名：国外高校电子信息类优秀教

2003年

作者： James h. McClellan Ronald W. Sch.fer mark A. Yoder

本书内容包括:正弦曲线、频谱表示、取样和混叠等。

ISBN: (纸本)0130909998;9780130909992

本书内容包括:正弦曲线、频谱表示、取样和混叠等。

关键词： Multimedia systems.

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