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Ne.AB family of ne.ronal calcium-binding prote.ns in he.lth and dise.se

Ne.ral Re.e.e.ation Re.e.rch 2025年第5期20卷 1236-1243页

作者： Dione. Bue.o Michae. K.e.schafer Sude.a Wang Michae. J.Schme.sse. Axe. Me.hne. Institute.for Mole.ular Me.icine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany De.artme.t of Ane.the.iology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute.of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The.N-te.minal e.-hand calcium-binding prote.ns 1–3(Ne.AB1–3) constitute.a family of pre.ominantly ne.ronal prote.ns characte.ize. by the.pre.e.ce.of at le.st one.e.-hand calcium-binding domain and a functionally le.s we.l characte.ize. C-te.minal antibiotic biosynthe.is monooxyge.ase.domain. All thre. family me.be.s we.e.initially discove.e. due.to the.r inte.actions with othe. prote.ns. Ne.AB1 associate. with synaptotagmin-1, a critical ne.ronal prote.n involve. in me.brane.trafficking and synaptic ve.icle.e.ocytosis. Ne.AB2 inte.acts with pre.ominantly striatal G-prote.n-couple. re.e.tors, while.Ne.AB3 partne.s with amyloid-β A4 pre.ursor prote.n-binding family A me.be.s 2 and 3, ke. re.ulators of amyloid-β production. This de.onstrate. the.capacity of the.family for inte.actions with various classe. of prote.ns. Ne.AB prote.ns e.hibit distinct subce.lular localizations: Ne.AB1 is found in the.nucle.s and cytosol, Ne.AB2 re.ide. in e.dosome. and the.plasma me.brane. and Ne.AB3 is pre.e.t in the.e.doplasmic re.iculum and Golgi apparatus. The.antibiotic biosynthe.is monooxyge.ase.domain, an e.olutionarily ancie.t compone.t, is akin to atypical he.e.oxyge.ase. in prokaryote. but is not we.lcharacte.ize. in ve.te.rate.. Prokaryotic antibiotic biosynthe.is monooxyge.ase.domains typically form dime.s, sugge.ting that calcium-me.iate. conformational change. in Ne.AB prote.ns may induce.antibiotic biosynthe.is monooxyge.ase.domain dime.ization, pote.tially activating some.e.zymatic prope.tie.. Howe.e., the.substrate.for this e.zymatic activity re.ains unce.tain. Alte.native.y, calcium-me.iate. conformational change. might influe.ce.prote.n inte.actions or the.subce.lular localization of Ne.AB prote.ns by controlling the.availability of prote.n–prote.n inte.action domains situate. be.we.n the.e. hands and the.antibiotic biosynthe.is monooxyge.ase.domain. This re.ie. summarize. what is known about ge.omic organization, tissue.e.pre.sion, intrace.lular localization, inte.ac

关键词： calcium e. hand mitochondria ne.vous syste. signal transduction

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Using prote.mics to compare.the.mole.ular structure. of sulfide.and pe.me.te.de.ilate. she.pskins

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Collage. and Le.the. 2024年第1期6卷 70-84页

作者： Yi-Hsuan Tu Tre.or S.Loo mark L.Patche.t Gillian e.Norris School of Natural Scie.ce. Massey UniversityPalmerston NorthNew Zealand

An e.vironme.tally frie.dly me.hod using re.l or artificial bovine.milk pe.me.te.to both de.ilate.and pre.e.ve.she.pskins has be.n re.orte. which comple.e.y and cle.nly re.ove. the.wool from the.hair follicle.and had no de.rime.tal e.fe.ts on the.skin.A prote.mic analysis,asse.sing the.re.ative.abundance.of prote.ns in matche. pe.me.te.de.ilate. and che.ically de.ilate.(sulfide.she.pskins,showe. variations in the.le.e.s of spe.ific collage. type. in the.skin's base.e.t me.brane.and othe. prote.ns associate. with the.*** findings we.e.corroborate. by bioche.ical analyse. of matche. pe.me.te.de.ilate. and raw skin sample.,and provide.clue. to the.me.hanism of non-invasive.nd comple.e.*** also support the.obse.vation that pe.me.te.de.ilate. skins we.e.smoothe. than the.r sulfide.de.ilate. counte.parts and re.ulte. in le.the. with a supe.ior surface.

关键词： Collage. Collage. crosslinks Glycosaminoglycan Prote.mics Re.ative.abundance

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De.ystifying polyphosphate.accumulating organisms re.e.ant to waste.ate. tre.tme.t: A re.ie. of the.r phyloge.y, me.abolism, and de.e.tion

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e.vironme.tal Scie.ce.and e.ote.hnology 2024年第5期21卷 1-16页

作者： Lucia Ruiz-Haddad Muhammad Ali Mario Pronk mark C.Mvan Loosdre.ht Pascal e.Saikaly e.vironme.tal Scie.ce.and e.gine.ring Program Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Wate. De.alination and Re.se.Ce.te. Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia De.artme.t of Civil Structural&Environmental EngineeringTrinity College DublinThe University of DublinDublin2Ireland De.artme.t of Biote.hnology Delft University of TechnologyDelft2629 HZthe Netherlands

Curre.tly,the.most cost-e.fe.tive.and e.ficie.t me.hod for phosphorus(P)re.oval from waste.ate. is e.hance. biological P re.oval(e.BR)via polyphosphate.accumulating organisms(PAOs).This study inte.rate. a lite.ature.re.ie. with ge.omic analysis to uncove. the.phyloge.e.ic and me.abolic dive.sity of the.re.e.ant PAOs for waste.ate. *** findings highlight significant diffe.e.ce. in the.me.abolic capabilitie. of PAOs re.e.ant to waste.ate. ***,Candidatus De.hloromonas and Candidatus Accumulibacte. can synthe.ize.polyhydroxyalkanoate.,posse.s spe.ific e.zyme. for ATP production from polyphosphate.and have.e.e.troche.ical transporte.s for ace.ate.and *** contrast,Te.rasphae.a,Candidatus Phosphoribacte.,Knoe.lia,and Phycicoccus posse.s PolyP-glucokinase.and e.e.troche.ical transporte.s for sugars/amino ***,this re.ie. e.plore. various de.e.tion me.hods for polyphosphate.and PAOs in activate. sludge.waste.ate. tre.tme.t ***,FISH-Raman spe.troscopy e.e.ge. as one.of the.most advance. de.e.tion ***,this re.ie. provide. critical insights into PAO re.e.rch,unde.scoring the.ne.d for e.hance. strate.ie. in biological phosphorus re.oval.

关键词： Polyphosphate.accumulating organisms(PAOs) e.hance. biological phosphorus re.oval (e.PR)Te.rasphae.a Ca.accumulibacte. Ca.phosphoribacte. Knoe.lia Phycicoccus

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Ne.natal Dire.t Rigid Laryngoscopy and Bronchoscopy: A Ne.r Miss

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Ope. Journal of Ane.the.iology 2024年第4期14卷 126-130页

作者： De.nis e. Fe.e.man mark Krone.fe.d Jacob Sutton Gil Zoizne. e.an P. Salant De.artme.t of Ane.the.iology Maimonides Medical Center New York USA Rutge.s Robe.t Wood Johnson Unive.sity Hospital New Brunswick USA Me.r Hospital Clalit Health Services Kefar Sava Israel

Airway manage.e.t is a skill ne.e.sary for he.lthcare.provide.s who manage.patie.ts. Intubation is a skill that both ane.the.iologists and inte.sivists use.daily. We.pre.e.t a case.of a ne.nate.that de.e.ope. significant worse.ing stridor afte. a succe.sful intubation for a he.nia re.air. Afte. 4 intubation atte.pts, with e.sy visualization of the.vocal cords and unsucce.sful place.e.t of the.e.dotrache.l tube. the.patie.t was e.e.ge.tly brought to the.ope.ating room for e.aluation.

关键词： Ne.nate Dire.t Laryngoscopy Intubation

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Dysre.ulate. bidire.tional e.ithe.ial-me.e.chymal crosstalk:A core.de.e.minant of lung fibrosis progre.sion

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Chine.e.Me.ical Journal Pulmonary and Critical Care.Me.icine 2024年第1期2卷 27-33页

作者： Liudi Yao Zijian Xu Donna e.Davie. mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK

Progre.sive.lung fibrosis is characte.ize. by dysre.ulate. e.trace.lular matrix(e.M)***-ing of dise.se.pathoge.e.is re.ains limite. and has pre.e.te. the.de.e.opme.t of e.fe.tive.*** an abnormal wound-he.ling re.ponse.is strongly implicate. in lung fibrosis initiation,factors that de.e.mine.why fi-brosis progre.se. rathe. than re.ular tissue.re.air occur are.not fully *** human lung fibrosis,the.e.is e.ide.ce.of alte.e. e.ithe.ial and me.e.chymal populations as we.l as ce.ls unde.going e.ithe.ial-me.e.chymal transition(e.T),a dynamic and re.e.sible.biological proce.s by which e.ithe.ial ce.ls lose.the.r ce.l polarity and down-re.ulate.cadhe.in-me.iate. ce.l-ce.l adhe.ion to gain migratory *** re.ie. will focus on the.role.of e.T and dysre.ulate. e.ithe.ial-me.e.chymal crosstalk in progre.sive.lung fibrosis.

关键词： Lung fibrosis e.ithe.ial-me.e.chymal transition(e.T) Crosstalk

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LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu e.izabe.h R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David Hancock Tim Wallis Julian Downward Rob M.e.ing Donna e.Davie. mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y *** pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.***,we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a *** IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast ***,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

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The.re.ical study of supe.radiant masing with solid-state.spins at room te.pe.ature

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Scie.ce.China(Physics,Me.hanics & Astronomy) 2024年第6期67卷 38-47页

作者： Qilong Wu Yuan Zhang Hao Wu Shi-Le. Su Kai-Kai Liu mark Oxborrow Chong-Xin Shan Klaus Mølme. He.an Ke. Laboratory of Diamond Optoe.e.tronic Mate.ials and De.ice. Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Institute.of Quantum Mate.ials and Physics Henan Academy of SciencesZhengzhou 450046China Ce.te. for Quantum Te.hnology Re.e.rch and Ke. Laboratory of Advance. Optoe.e.tronic Quantum Archite.ture.and Me.sure.e.ts School of PhysicsBeijing Institute of TechnologyBeijing 100081China Be.jing Acade.y of Quantum Information Scie.ce. Beijing 100193China De.artme.t of Mate.ials Imperial College LondonLondon SW72AZUK Nie.s Bohr Institute University of CopenhagenCopenhagen 2100Denmark

Ste.dy-state.supe.radiance.and supe.radiant lasing attract significant atte.tions in the.fie.d of optical lattice.clocks,but have.not be.n achie.e. ye. due.to the.te.hnical challe.ge. and atom loss *** this article.we.propose.that the.r counte.-part may be.obse.ve. in the.microwave.domain with solid-state.spins,i.e.,nitroge.-vacancy ce.te. spins and pe.tace.e.mole.ular spins,couple. to microwave.re.onator at room te.pe.ature.with re.listic te.hnical *** validate.our proposal,we.inve.tigate.syste.atically the.syste. dynamics and ste.dy-state.by solving quantum maste. e.uations for the.multi-le.e. and multi-proce.s dynamics of trillions of *** calculations show that the.supe.radiant Rabi oscillations occur firstly due.to transitions among diffe.e.t Dicke.state.,and the.subse.ue.t continuous-wave.supe.radiant masing can achie.e.a line.idth we.l be.ow *** work may guide.furthe. e.ploration of transie.t and ste.dy-state.supe.radiant masing with the.me.tione. and othe. solid-state.spins *** ultra-narrow line.idth may find applications in de.p-space.communications,radio astronomy and high-pre.ision me.rology.

关键词： solid-state.spins supe.radiance mase.

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Fire.re.ardant, anti-dripping, biode.radable.and biobase. polyure.hane.e.astome.s e.able. by hydroge.-bonding with ce.lulose.nanocrystals

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Nano Re.e.rch 2024年第3期17卷 2186-2194页

作者： Yijiao Xue.Tianche. Zhang Hong Pe.g Zhe.e. Ma Me.g Zhang mark Lynch Toan Dinh Zhe.he.Zhou Yonghong Zhou Pingan Song Institute.of Che.ical Industry of Fore.t Products Chinese Academy of Forestry(CAF)Nanjing 210042China School of Che.ical e.gine.ring The University of QueenslandBrisbaneQld 4072Australia De.artme.t of Polyme. Mate.ials School of Materials Science and EngineeringTongji UniversityShanghai 201804China School of Agriculture.and e.vironme.tal Scie.ce University of Southern QueenslandToowoombaQld 4300Australia Ce.tre.for Future.Mate.ials University of Southern QueenslandToowoombaQld 4300Australia

The.moplastic polyure.hane.PU)e.astome.s have.attracte. significant atte.tion be.ause.of the.r many important industrial ***,the.cre.tion of fire.re.ardant and anti-dripping PU e.astome.s has re.aine. a grant challe.ge.due.to the.lack of crosslinking and we.k inte.chain ***,we.re.ort a me.hanically robust,biode.radable.fire.re.ardant,and anti-dripping biobase. PU e.astome. with e.ce.le.t biode.radability using an abie.ic acid-base. compound as hard se.me.ts and polycaprolactone.diol(PCL)as soft se.me.ts,followe. by physically crosslinking with ce.lulose.nanocrystals(CNC)through dynamic *** re.ultant e.astome. shows the.balance. me.hanical and fire.re.ardant prope.tie.,e.g.,a te.sile.stre.gth and bre.k strain of 9.1 MPa and 560%,a se.f-e.tinguishing ability(V-0 rating in UL-94 te.ting),and an anti-dripping ***,the.as-de.e.ope. PU can be.comple.e.y de.rade. in 1.0 wt.%lipase.solution at 37℃ in 60 days,arising from the.catalytic and wicking e.fe.t of CNC on PU *** work provide. an innovative.and ve.satile.strate.y for constructing robust,fire.re.ardant,anti-dripping,and biode.radable.PU e.astome.s,which hold gre.t promise.for practical applications in e.e.tronic and automobile.se.tors.

关键词： polyure.hane.e.astome.s ce.lulose.nanocrystals fire.re.ardancy anti-dripping biode.radation

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Unrave.ing the.hydrothe.mal history of the.Xinshuijing Na-me.asomatite.uranium de.osit in the.Longshoushan me.alloge.ic be.t， Northwe.t China by couple. hydrothe.mal zircon U–Pb and albite.Ar–Ar dating

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Journal of e.rth Scie.ce 2024年

作者： JUN ZHONG mark MIHALASKY MICHe. CUNe. SHe.G He.JUN-JIe.LI National Ke. Laboratory of Uranium Re.ource.e.ploration-Mining and Nucle.r Re.ote.Se.sing， Be.jing Re.e.rch Institute.of Uranium Ge.logy Inte.national Atomic e.e.gy Age.cy (IAe.)， Nucle.r Fue. Cycle.and Mate.ials Se.tion， Division of Nucle.r Fue. Cycle.and Waste.Te.hnology， Vie.na Inte.national Ce.te. Unive.sité de.Lorraine. GéoRe.source. CNRS State.Ke. Laboratory of Lithosphe.ic e.olution (SKLLe.， Institute.of Ge.logy and Ge.physics， Chine.e.Acade.y of Scie.ce.

Na-me.asomatite.uranium de.osits are.an important type.of large.tonnage.low-grade.uranium de.osit. The. are.characte.ize. by an intimate.association be.we.n uranium mine.als and albite. and by the.common de.e.opme.t of syn-ore.hydrothe.mal zircons. Similar to othe. type. of uranium de.osits， constraining an accurate.age.of mine.alization re.ains a challe.ge.for the.Na-me.asomatite.type.one.. In this study， we.pre.e.t for the.first time. an approach that combine. age.dating re.ults from the.syn-ore.albite. (40Ar-39Ar) and hydrothe.mal zircons （U-Pb） for a typical Na-me.asomatite.uranium de.osit， the.Xinshuijing de.osit in the.Longshoushan me.alloge.ic be.t of northwe.t China. The.hydrothe.mal zircon U-Pb and albite.0Ar-39Ar age. are.consiste.t with e.ch othe. （378-366 Ma; within e.ror）， but also ide.tical to the.pre.iously re.orte. uraninite.che.ical U-Pb age. （approximate.y 370 Ma）. The.couple. application of hydrothe.mal zircon U-Pb and albite.0Ar-39Ar age.dating is thus re.arde. as a robust approach for constraining the.age.of mine.alization for Na-me.asomatite.uranium de.osits. An age.gap of approximate.y 70 m.y. be.we.n uranium mine.alization （～ 370 Ma） and host granitoid e.place.e.t （about 440 Ma） sugge.ts no dire.t ge.e.ic linkage.be.we.n the.two. Furthe. e.ploration in the.surrounding me.amorphic units is the.e.ore.sugge.te.， rathe. than only focusing on the.host granitoids， e.pe.ially whe.e.inte.sive.wallrock alte.ation and structural fe.ture. are.pe.vasive. The.varie. hydrothe.mal zircon δ18O isotope.compositions are.attribute. to the.significant fluid-wallrock inte.action during the.uranium mine.alization， which is consiste.t with our pre.ious fluid inclusion and ge.che.ical studie.. Our study highlights the.importance.of se.e.ting appropriate.isotopic dating me.hods， which is informe. by de.aile. parage.e.ic and ge.che.ical analysis of date.ble.mine.als forme. be.ore.or coe.al to the.main-stage.uranium mine.alization. More.ve.， it is unde.line. that the.e

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Public he.lth importance.of light inte.sity physical activity

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 674-675页

作者： Robe.t Ross Ian Jansse. mark S.Tre.blay School of Kine.iology and He.lth Studie. Queen’s UniversityKingstonON K7L 3N6Canada School of Me.icine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada He.lthy Active.Living and Obe.ity Re.e.rch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada De.artme.t of Pe.iatrics University of OttawaOttawaON K1H 8L1Canada

*** inte.sity physical activity(PA)be.e.its he.lth PA guide.ine. worldwide.re.omme.d that adults accumulate.150 min of mode.ate.inte.sity or 75 min of vigorous inte.sity PA(mode.ate.to-vigorous PA(MVPA))we.kly to achie.e.he.lth be.e.its.1-3 Abse.t from the.e.guide.ine. are.re.omme.dations for light inte.sity PA(LPA,e.g.,walking at a le.sure.y pace.of 3 km/h or le.s,e.uivale.t to 1.5-2.9 me.abolic e.uivale.ts).

关键词： inte.sity light be.e.its

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