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Psychiatric aspects of brain tumors:A review

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World Journal of Psychiatry 2015年第3期5卷 273-285页

作者： Subramoniam Madhusoodanan mark bryan ting Tara Farah Umran Ugur Department of Psychiatry St.John’s Episcopal Hospital Department of Psychiatry SUNY Downstate Medical Center Community Behavioral Health Center Bio-Behavioral Medical Clinics Fresno Medical Student Ⅳ Medical University of Lublin Medical Student Ⅳ Ross University School of Medicine

Infrequently, psychiatric symptoms may be the only manifestation of brain tumors. They may present with mood symptoms, psychosis, memory problems, personality changes, anxiety, or anorexia. Symptoms may be misleading, complicating the clinical picture. A comprehensive review of the literature was conducted regarding reports of brain tumors and psychiatric symptoms from 1956-2014. Search engines used include Pub Med, Ovid, Psych Info, MEDLINE, and Med Scape. Search terms included psychiatric manifestations/symptoms, brain tumors/neoplasms. Our literature search yielded case reports, case studies, and case series. There are no double blind studies except for post-diagnosis/-surgery studies. Early diagnosis is critical for improved quality of life. Symptoms that suggest work-up with neuroimaging include: new-onset psychosis, mood/memory symptoms, occurrence of new or atypical symptoms, personality changes, and anorexia without body dysmorphic symptoms. This article reviews the existing literature regarding the diagnosis and management of this clinically complex condition.

关键词： Brain tumors Psychiatric symptoms Neuropsychiatric Behavioral symptoms Diagnosis Management Neuroimaging

Local Variability in Temperature, Humidity and Radiation in the BaekduDaegan Mountain Protected Area of Korea

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Journal of Mountain Science 2012年第5期9卷 613-627页

作者： CHAE Heemun LEE Hyunju LEE Sangsin CHEONG Yukyong UM Gijeung mark bryan PATRICK Nathan Department of Forest Environment Protection College of Forest and Environmental ScienceKangwon National University Department of Geography and Byrd Polar Research Center Ohio State University

A novel embedded sensor network records changes in key climatic-environmental variables over a range of altitude in the BaekduDaegan Mountain （BDM） of Gangwon Province in Korea, a protected mountain region with unique biodiversity undergoing climate change research. The investigated area is subdivided into three horizontal north-south study areas. Three variables, temperature （T, °C）, relative humidity （RH, %）, and light intensity （LI, lumens m-2, or lux, lx）, have been continuously measured at hourly intervals from June, 2olo to September, 2011 using HOBO H8 devices at lO fixed study sites. These hourly observations are aggregated to monthly, seasonal and annual mean values, and results are summarized to inaugurate a long-term climate change investigation. A region wide T difference in accordance with altitude, or lapse rate, over the interval is calculated as o.4°C l00 m-1. T lapse rates change seasonally, with winter lapse rates being greater than those of summer. RH is elevated in summer compared to other seasons. LI within forestland is lower during summer and higher during other seasons. The obtained results could closely relate to the vegetation type and structure and the terrain state since data loggers were located in forestland.

关键词： Embedded sensors Temperature lapserates Relative humidity Light intensity Forest Climate change BaekduDaegan Mountain

Agricultural water conservation in China:plastic mulch and traditional irrigation

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Ecosystem Health and Sustainability 2015年第4期1卷 1-12页

作者： mark Ingman Mary V.Santelmann bryan Tilt Water Resources Graduate Program Oregon State UniversityCorvallisOregon 97331 USA Department of Anthropology Oregon State UniversityCorvallisOregon 97331 USA Oregon Department of Environmental Quality 811 SW 6th AvenuePortlandOregon 97204 USA

Plastic mulch is commonly used with micro-irrigation in developed countries;however,Chinese farmers use plastic mulch on a vast scale independent of *** the past three decades,China’s land area in plastic mulch has exceeded the world’s total land area in *** report results from the water-scarce region of Minqin County,where 87%of Chinese farmers interviewed responded that they use plastic mulch to conserve water and 53%to increase *** results indicated the desire to conserve water through the use of plastic mulch to be statistically equivalent to the desire to increase *** to interviews and surveys indicate that farmers perceive water savings of 24-26%when plastic mulch is *** and survey responses suggest farming families are shifting to purchasing wheat from outside the region;a potential import of"virtual water"into this water-scarce region.

关键词： agriculture cash cropping China irrigation plastic mulch virtual water water conservation

Clostridium difficile-associated disease:Adherence with current guidelines at a tertiary medical center

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World Journal of Gastroenterology 2013年第46期19卷 8647-8651页

作者： bryan F Curtin Yousef Zarbalian mark H Flasar Erik von Rosenvinge Resident in Internal Medicine Department of Medicine University of Maryland School of Medicine Baltimore Division of Gastroenterology and Hepatology Department of Medicine University of Maryland School of Medicine and VA Maryland Health Care System Baltimore

AIM:To assess adherence with the the Society for Healthcare Epidemiology of America(SHEA)/the Infectious Diseases Society of America(IDSA)guidelines for management of Clostridium difficile(***)-associated disease(CDAD)at a tertiary medical ***:All positive *** stool toxin assays in adults between May 2010 and May 2011 at the University of Maryland Medical Center were *** episodes were classified as guideline adherent or nonadherent and these two groups were compared to determine demographic and clinical factors predictive of *** regression analysis was performed to assess the effect of multiple predictors on guideline ***:320 positive *** stool tests were identified in 290 *** by disease severity criteria set forth by the SHEA/IDSA guidelines,42.2%of cases were mild-moderate,48.1%severe,and 9.7%*** adherence with the guidelines was observed in only 43.4%of *** was65.9%for mild-moderate CDAD,which was significantly better than in severe cases(25.3%)or severe-complicated cases(35.5%)(P<0.001).There was no difference in demographics,hospitalization,ICU exposure,recurrence or 30-d mortality between adherent and non-adherent groups.A multivariate model revealed significantly decreased adherence for severe or severecomplicated episodes(OR=0.18,95%CI:0.11-0.30)and recurrent episodes(OR=0.46,95%CI:0.23-0.95).CONCLUSION:Overall adherence with the SHEA/IDSA guidelines for management of CDAD at a tertiary medical center was poor;this was most pronounced in severe,severe-complicated and recurrent *** interventions aimed at improving guideline adherence are warranted.

关键词： Clostridium difficile Metronidazole Vanco-mycin Adherence to the Infectious Diseases Society of America Guidelines Hospital Acquired Infections

Deep subwavelength nanometric image reconstruction using Fourier domain optical normalization

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Light(Science & Applications) 2016年第1期5卷 632-640页

作者： Jing Qin Richard M Silver bryan M Barnes Hui Zhou Ronald G Dixson mark-Alexander Henn Engineering Physics Division Physical Measurement LaboratoryNational Institute of Standards and Technology100 Bureau Dr MS 8212GaithersburgMD 20899-8212USA

Quantitative optical measurements of deep subwavelength,three-dimensional(3D),nanometric structures with sensitivity to sub-nanometer details address a ubiquitous measurement challenge.A Fourier domain normalization approach is used in the Fourier optical imaging code to simulate the full 3D scattered light field of nominally 15 nm-sized structures,accurately replicating the light field as a function of the focus *** the full 3D light field,nanometer scale details such as a 2 nm thin conformal oxide and nanometer topography are rigorously fitted for features less than one-thirtieth of the wavelength in *** densely packed structures are positioned nearly an order of magnitude closer than the conventional Rayleigh resolution limit and can be measured with sub-nanometer parametric *** approach enables a practical measurement sensitivity to size variations of only a few atoms in size using a high-throughput optical configuration with broad application in measuring nanometric structures and nanoelectronic devices.

关键词： computational microscopy light scattering metrology quantitative nanoscale microscopy sub-nanometer uncertainties

“Listening to the Sounds of the Water”:Bringing Together Local Knowledge and Biophysical Data to Understand Climate-Related Hazard Dynamics

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International Journal of Disaster Risk Science 2021年第3期12卷 326-340页

作者： Natasha Pauli mark Williams Savuti Henningsen Kevin Davies Chanchhaya Chhom Floris van Ogtrop Sochanny Hak bryan Boruff Andreas Neef UWA School of Agriculture and Environment The University of Western AustraliaCrawleyWestern Australia 6009Australia Department of Geography and Planning School of Social SciencesThe University of Western AustraliaCrawleyWestern Australia 6009Australia School of Geosciences The University of SydneySydneyNew South Wales 2006Australia Faculty of Development Studies Royal University of Phnom PenhPhnom Penh 12150Cambodia School of Life and Environmental Sciences The University of SydneySydneyNew South Wales 2006Australia Development Studies School of Social SciencesThe University of AucklandAuckland 1142New Zealand

Integrating local knowledge and scientific information can aid in co-developing locally relevant approaches for climate change adaptation and disaster risk *** along the Mekong River have adapted to variability in temperature,rainfall,and flooding patterns over *** environmental change in the Mekong Basin presents a new set of challenges related to drought,altered seasonal rainfall,more frequent high-flow flood events,and water withdrawals for hydropower and *** present a multi-method approach to understand how local knowledge of the spatial and temporalpatterns of floods,droughts,and rainfall can be integrated with scientific information along a flood-prone section of the lower Mekong River in Kratie Province,*** hazard mapping of community members’knowledge of the movement of floodwaters through the landscape enabled interpretation of flood extent mapping using Synthetic Aperture Radar images from the Sentinel-1A *** calendars of weather patterns and livelihood activities,together with local indicators of flooding,rainfall,and drought were compared with trends in 35 years of rainfall data,and highlighted"pressure points"at the beginning and end of the rainy season where agriculture may be particularly impacted by climate *** discuss potential applications of our findings for adaptation and hazard planning.

关键词： Cambodia Local knowledge Mekong River Natural hazards Participatory mapping Remote sensing

Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia

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World Journal of Clinical Oncology 2017年第5期8卷 398-404页

作者： Kamini Shah bryan F Curtin Christopher Chu Daniel Hwang mark H Flasar Erik von Rosenvinge Division of Infectious Diseases Department of MedicineUniversity of Maryland School of Medicine Digestive Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases Department of Medicine University of Maryland School of Medicine Division of Gastro-enterology and Hepatology Department of MedicineUniversity of Maryland School of Medicine and VA Maryland Health Care System

AIM To evaluate factors associated with Clostridium difficile infection (CDI) and outcomes of CDI in the myelodysplastic syndrome(MDS) and acute myeloid leukemia (AML) *** After IRB approval,all MDS/AML patients hospitalized at the University of Maryland Greenebaum Comprehensive Cancer Center between August 2011 and December 2013 were *** charts were reviewed for demographics,clinical information,development of CDI,complications of CDI,and *** with CDI,defined as having a positive stool PCR done for clinical suspicion of CDI,were compared to those without CDI in order to identify predictors of disease.A t-test was used for comparison of continuous variables and chisquare or Fisher's exact tests were used for categorical variables,as *** Two hundred and twenty-three patients (60.1% male,mean age 61.3 years,13% MDS,87% AML) had 594 unique hospitalizations during the study *** patients (15.2%) were diagnosed with *** significantly associated with CDI included lower albumin at time of hospitalization (P ting agent-based chemotherapy (P = 0.92) were not significantly associated with *** CDI is common in the MDS/AML *** significantly associated with CDI in this population include low albumin,prior CDI,use of cytarabine-based chemotherapy,and prolonged *** this study,we have identified a subset of patients in which prophylaxis studies could be targeted.

关键词： Clostridium difficile Acute myeloid leukemia Cytarabine-based chemotherapy Myelodysplastic syndrome Neutropenia

The Use of Item Response Theory in Survey Methodology: Application in Seat Belt Data

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American Journal of Operations Research 2018年第1期8卷 17-32页

作者： mark K. Ledbetter Norou Diawara bryan E. Porter Mathematics and Statistics Department Old Dominion University Norfolk VA USA Department of Psychology Old Dominion University Norfolk VA USA

Problem: Several approaches to analyze survey data have been proposed in the literature. One method that is not popular in survey research methodology is the use of item response theory (IRT). Since accurate methods to make prediction behaviors are based upon observed data, the design model must overcome computation challenges, but also consideration towards calibration and proficiency estimation. The IRT model deems to be offered those latter options. We review that model and apply it to an observational survey data. We then compare the findings with the more popular weighted logistic regression. Method: Apply IRT model to the observed data from 136 sites within the Commonwealth of Virginia over five years collected in a two stage systematic stratified proportional to size sampling plan. Results: A relationship within data is found and is confirmed using the weighted logistic regression model selection. Practical Application: The IRT method may allow simplicity and better fit in the prediction within complex methodology: the model provides tools for survey analysis.

关键词： Item Response Theory Logistic Regression Sampling Weight

Hemodynamic investigations in intracranial aneurysms:a commentary

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Biomedical Engineering Communications 2023年第1期2卷 1-3页

作者： Hang Yi mark Johnson Luke Bramlage Zifeng Yang bryan Ludwig Department of Mechanical and Material Engineering Wright State University3640 Colonel Glenn Hwy.DaytonOH 45435USA Division of NeuroInterventional Surgery Department of NeurologyWright State University/Premier Health–Clinical Neuroscience Institute30E.Apple StDaytonOH 45409USA Boonshoft School of Medicine Wright State UniversityDaytonOH 45435USA

Intracranial aneurysms(IAs)are abnormal bulges in a blood vessel in the brain that have a potential to rupture and even causing a stroke,which can lead to lasting brain damage,long-term disability,or even loss of *** has been widely acknowledged that hemodynamic factors,e.g.,instantaneous wall shear stress,time-averaged wall shear stress,wall shear stress gradient,gradient oscillatory number,oscillatory shear index,pulsatile blood flow waveform(flow rate magnitude and shape,physical flow period),relative residence time/turnover time,blood pressure.

关键词： aneurysm rupture flow