Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health ***:An umbre...
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Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health ***:An umbrella review of systematic reviews with meta-analyses of observational studies was *** assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess *** graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 ***,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing *** associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as *** further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.
1. Overview The 2016 Quadrennial Ozone Symposium (QOS-2016) was held on 4-9 September 2016 in Edinburgh, UK. The Symposium was organized by the International Ozone Commission (IO3C), the NERC Centre for Ecology &...
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1. Overview The 2016 Quadrennial Ozone Symposium (QOS-2016) was held on 4-9 September 2016 in Edinburgh, UK. The Symposium was organized by the International Ozone Commission (IO3C), the NERC Centre for Ecology & Hydrology and the University of Edinburgh, and was co-sponsored by the International Union of Geodesy and Geophysics, the International Association of Meteorology and Atmospheric Sciences, and the World Meteorological Organization.
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