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Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

Acta Pharmaceutica Sinica B 2017年第4期7卷 517-522页

作者： mark a.doll Raúl A.Salazar-González Srineil Bodduluri David W.Hein Department of Pharmacology and Toxicology and James Graham Brown Cancer Center University of LouisvilleLouisvilleKY 40202USA

Cryopreserved human hepatocytes were used to investigate the role of arylamine N-acetyltransferase 2 (NAT2; EC 2.***.1.5) polymorphism on the N-acetylation of isoniazid (INH). NAT2 genotype was determined by Taqman allelic discrimination assay and INH N-acetylation was measured by high performance liquid chromatography. INH N-acetylation rates in vitro exhibited a robust and highly significant (P<0.005) NAT2 phenotype-dependent metabolism. N-acetylation rates in situ were INH concentration- and time-dependent. Following incubation for 24 h with 12.5 or 100 µmol/L INH, acetyl-INH concentrations varied significantly (P = 0.0023 and P = 0.0002) across cryopreserved human hepatocytes samples from rapid, intermediate, and slow acetylators, respectively. The clear association between NAT2 genotype and phenotype supports use of NAT2 genotype to guide INH dosing strategies in the treatment and prevention of tuberculosis.

关键词： Isoniazid N-Acetyltransferase 2 Acetylation polymorphism Human hepatocytes Genotype Phenotype

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全球资源服务中国市场——访Business Objects高级副总裁mark doll

每周电脑报

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每周电脑报 2006年第24期 50-50页

作者：杨超 mark doll Business Objects 高级副总裁

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UV-laser-machined stretchable multi-modal sensor network for soft robot interaction

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npj Flexible Electronics 2022年第1期6卷 899-907页

作者： Jooyeun Ham Amy Kyungwon Han mark R.Cutkosky Zhenan Bao Department of Mechanical Engineering Stanford University450 Serra MallStanfordCA 94305USA Department of Mechanical Engineering Seoul National University1 Gwanak-ro Gwanak-guSeoul 08826Korea Department of Chemical Engineering Stanford University443 Via OrtegaStanfordCA 94305USA

Soft robotic hands can facilitate human-robot interaction by allowing robots to grasp a wide range of objects safely and ***,their performance has been hampered by a lack of suitable sensing *** present a flexible and stretchable multimodal sensor network integrated with a soft robotic *** design of wired sensors on a flexible metalized film was embodied through a manufacturing approach that uses both UV laser metal ablation and plastic cutting simultaneously to create sensor electrode and stretchable conductive wires in a Kirigami pattern into a single *** evaluated the interconnects and sensors by measuring an impedance change to each external stimulus and showed that are not substantially affected by stretching the *** the sensor sheet wrapped around a soft robotic gripper,we demonstrated several interaction scenarios,including a warm burrito for food handling,and a warm baby doll for medical applications.

关键词： robot interaction network

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