检索结果-南通市图书馆

Bioengineering strategies for the treatment of peripheral arterial disease

Bioactive Materials 2021年第3期6卷 684-696页

作者： Cui Li Oliver Kitzerow Fujiao Nie Jingxuan Dai Xiaoyan Liu mark a.carlson George P.Casale Iraklis I.Pipinos Xiaowei Li Mary&Dick Holland Regenerative Medicine Program and Department of Neurological Sciences College of MedicineUniversity of Nebraska Medical CenterOmahaNE68198United States Department of Genetics Cell Biology and Anatomy College of MedicineUniversity of Nebraska Medical CenterOmahaNE68198United States Department of Surgery University of Nebraska Medical CenterOmahaNE68198United States Department of Genetics Cell Biology and AnatomyUniversity of Nebraska Medical CenterOmahaNE68198United States Omaha VA Medical Center OmahaNE68105United States

Peripheral arterial disease(PAD)is a progressive atherosclerotic disorder characterized by narrowing and occlusion of arteries supplying the lower *** 200 million people worldwide are affected by *** current standard of operative care is open or endovascular revascularization in which blood flow restoration is the ***,many patients are not appropriate candidates for these treatments and are subject to continuous ischemia of their lower *** research in the therapy of PAD involves developing modalities that induce angiogenesis,but the results of simple cell transplantation or growth factor delivery have been found to be relatively poor mainly due to difficulties in stem cell retention and survival and rapid diffusion and enzymolysis of growth factors following injection of these agents in the affected ***,including hydrogels,have the capability to protect stem cells during injection and to support cell *** can also provide a sustained release of growth factors at the injection *** review will focus on biomaterial systems currently being investigated as carriers for cell and growth factor delivery,and will also discuss biomaterials as a potential stand-alone method for the treatment of ***,the challenges of development and use of biomaterials systems for PAD treatment will be reviewed.

关键词： Hydrogels Growth factors Cell transplantation Peripheral arterial disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel fibrin-fibronectin matrix accelerates mice skin wound healing

引用

Bioactive Materials 2020年第4期5卷 949-962页

作者： Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso mark a.carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo Nursing School University of CampinasCampinasSPBrazil Laboratory of Cell Signaling University of CampinasCampinasSPBrazil Department of Chemical and Biomolecular Engineering University of NebraskaLincolnNEUSA Biomedical Engineering Program University of NebraskaLincolnNEUSA School of Biological Science University of NebraskaLincolnNEUSA Department of Surgery University of Nebraska Medical Center and the VA Nebraska-Western Iowa Health Care SystemUSA Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical CenterOmahaNEUSA Fred&Pamela Buffett Cancer Center University of Nebraska Medical CenterOmahaNEUSA

Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound *** 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN *** dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human *** in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN *** toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced *** study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing.

关键词： Fibrin Fibronectin Nanoclusters Wound healing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

改变的时机--令人焦虑的问题与趋势

引用

照明设计 2013年第2期 77-79页

作者： mark carlson Avalon Lighting Design Roseville加拿大/美国

人们有过这样的真实经历--暂时放下手上工作。审视自己并思考事情如何发展；依此检验照明行业你会发现，一些运作正处于危机之中。

关键词：照明行业认证标准品质

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bright spots for inland fish and fisheries to guide future hydropower development

引用

Water Biology and Security 2022年第1期1卷 81-99页

作者： William M.Twardek Ian G.Cowx Nicolas W.R.Lapointe Craig Paukert T.Douglas Beard Elena M.Bennett David Browne Andrew K.carlson Keith D.Clarke Zeb Hogan Kai Lorenzen Abigail J.Lynch Peter B.McIntyre Paulo Pompeu mark Rogers Alexis Sakas William W.Taylor Taylor D.Ward Zeenatul Basher Steven J.Cooke Fish Ecology and Conservation Physiology Laboratory Department of Biology and Institute for Environmental StudiesCarleton University1125 Colonel By DrOttawaON K1S 5B6Canada Fisheries Institute at the University of Hull Cottingham RdHullHU67RXUnited Kingdom Canadian Wildlife Federation 350 Michael Cowpland DrKanataONK2M 2W1Canada U.S.Geological Survey Missouri Cooperative Fish and Wildlife Research UnitUniversity of MissouriColumbiaMO65211United States U.S.Geological Survey National Climate Adaptation Science Center12201 Sunrise Valley DriveMS-516RestonVA20192United States McGill School of Environment McGill University845 Sherbrooke St WMontrealQuebec H3A 0G4Canada Princeton Environmental Institute and Department of Ecology and Evolutionary Biology Princeton UniversityM30 Guyot HallPrincetonNJ08544United States Ecological Sciences Section Science Branch Fisheries and Oceans CanadaCanadaPO Box/CP 5667St.John'sNewfoundland and LabradorA1C 5X1Canada University of Nevada Reno.4505 S Maryland PkwyLas VegasNV89154United States Fisheries and Aquatic Sciences School of Forest Resources and ConservationUniversity of Florida7922 NW 71st StreetGainesvilleFL32653United States Department of Natural Resources Cornell UniversityIthacaNY14853United States Departamento de Biologia Universidade Federal de LavrasAquenta SolLavrasState of Minas Gerais37200-900Brazil U.S.Geological Survey Tennessee Cooperative Fishery Research UnitTennessee tech UniversityCookevilleTN38505United States The Nature Conservancy 6375 Riverside DriveSuite 100DublinOH43017United States Michigan State University Department of Fisheries and WildlifeEast LansingMI48823United States

Hydropower production is one of the greatest threats to fluvial ecosystems and freshwater *** that we have entered the Anthropocene,there is an opportunity to reflect on what might constitute a‘sustainable’Anthropocene in the context of hydropower and riverine fish *** elements of existing practices that promote favorable social-ecological outcomes(i.e.,‘bright spots’)is timely given that there are plans to expand hydropower capacity in previously undammed rivers,intensify dam development in some of the world's largest river systems,and re-license existing *** approach this from a pragmatic perspective:for the foreseeable future,hydropower will likely remain an important source of renewable *** offer support for moving toward a more‘sustainable’Anthropocene,we provide syntheses of best practices during the siting,design,construction,operation,and compensation phases of hydropower development to minimize impacts on inland *** each phase,we offer positive examples(or what might be considered‘bright spots’)pertaining to some of the approaches described within our syntheses,acknowledging that these projects may not be viewed as without ecological and(or)societal detriment by all *** findings underscore the importance of protecting critical habitat and free-flowing river reaches through careful site selection and basinscale planning,infrastructure designs that minimize reservoir effects and facilitate safe passage of fish,construction of hydropower plants using best practices that minimize long-term damage,operating guidelines that mimic natural flow conditions,and compensation that is lasting,effective,inclusive,and locally *** from these‘bright spots’may require engagement of diverse stakeholders,professionals,and governments at scales that extend well beyond a given site,river,or even ***,environmental planning that integrates hydropower development into broader discussions

关键词： Migration Dams Salmon Hydroelectric Flow Socioecological Fish passage Barriers Ecosystems

来源：

维普期刊数据库评论