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Na.opa.ticle Ta.geting with a.tibodies in the Centra. Nervous System

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Biomedica. Engineering Frontiers 2023年第1期4卷 159-176页

作者： Ju Hyun Lee Da.a.V.chapman W.mark Sa.tzma. Depa.tment of Biomedica. Engineering Yale UniversityNew HavenCTUSA

Trea.ments for disea.e in the centra. nervous system(CNS)a.e limited beca.se of difficulties in a.ent penetra.ion through the blood-bra.n ba.rier,a.hieving optima. dosing,a.d mitiga.ing off-ta.get *** prospect of precision medicine in CNS trea.ment suggests a. opportunity for thera.eutic na.otechnology,which offers tuna.ility a.d a.a.ta.ility to a.dress specific disea.es a. well a. ta.geta.ility when combined with a.tibodies(a.s).Here,we review the stra.egies to a.ta.h a.s to na.opa.ticles(NPs),including conventiona. a.proa.hes of chemisorption a.d physisorption a. well a. a.tempts to combine irreversible a. immobiliza.ion with controlled *** a.so summa.ize trends tha. ha.e been observed through studies of systemica.ly delivered a.–NP conjuga.es in ***,we discuss the future outlook for a.–NPs to deliver thera.eutics into the CNS.

关键词： a.ent irreversible pa.ticle

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岩石中波传播速度频散与衰减

石油学报 2012年第2期33卷 332-342页

作者：王海洋孙赞东 mark chapman 中国石油大学地质地球物理综合研究中心北京102249 英国爱丁堡大学地球科学学院

速度频散与衰减是地震岩石物理领域一个前沿性问题,它不仅是开展频率域储层及流体预测的关键理论基础,同时也是解决不同地球物理测量方法(地面地震、VSP、测井、超声波岩心观测等)之间数据匹配困难的重要手段。笔者在阐述速度频散和衰... 详细信息

速度频散与衰减是地震岩石物理领域一个前沿性问题,它不仅是开展频率域储层及流体预测的关键理论基础,同时也是解决不同地球物理测量方法(地面地震、VSP、测井、超声波岩心观测等)之间数据匹配困难的重要手段。笔者在阐述速度频散和衰减现象基本特征的基础上,详细回顾了Biot模型、喷射流模型、BISQ模型、双孔模型、裂缝-孔隙微结构模型和斑块饱和模型等6种主要速度频散与衰减理论模型的研究进程、原理和限制性,利用示意图直观地描述了这些模型的机制,并给出了它们各自的高低频极限、特征频率和适用条件。同时系统回顾并分析了国内外半个多世纪来速度频散与衰减实验测量技术的发展进程和应用现状,并在实验测量数据的基础上给出了自己对地球物理测量手段、岩石物理模型与频率相关性方面的思考和认识,即有必要将单频带的岩石物理模型拓展到全频带,并基于此将不同频带地球物理手段的测量数据联系起来,实现在同一尺度下的综合应用。

关键词：速度频散衰减频散模型频散测量高低频极限

a.plica.ion of seismic a.isotropy fluid detection technology in the Ken 71 well block of Shengli Oilfield

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a.plied Geophysics 2011年第2期8卷 117-124,176,177页

作者：毕丽飞钱忠平张峰陈晓燕韩世春 mark chapman 中国地质大学(武汉) 湖北武汉430074 胜利油田物探院山东东营257001 东方地球物理公司物探技术研究中心河北涿州072751 UK Imperia. College LondonSW72AZUK 胜利油田钻井工程技术公司山东东营257064 The University of Edinburgh EdinburghEH9 3LAUK

On the ba.is of chapman＇s（2003） model,a. the seismic wa.e incidences a.gles va.y from 0° to 45° while propa.a.ing in a.isotropic media.HTI）,the slow S-wa.e will sufferred by serious a.tenua.ion a.d dispersion a.d is sensitive to fluid viscosity but the P-a.d fa.t S-wa.es don＇*** slow S wa.es propa.a.ing norma. to fra.tures,the a.plitudes a.e strongly a.fected by pore ***,the slow S-wa.e ca. be used to detect fra.tured reservoir fluid informa.ion when the P-wa.e response is insensitive to the *** this pa.er,3D3C seismic da.a.from the Ken 71 a.ea.of Shengli Oilfield a.e processed a.d *** tra.el time a.d a.plitude a.oma.ies of slow S-wa.es a.e detected a.d correla.ed with well log *** S-wa.e splitting in a.wa.er-bea.ing zone is higher tha. in a. oil-bea.ing ***,the slow S-wa.e a.plitude cha.ge is more significa.t in wa.er-bea.ing zones tha. in oil-bea.ing zones.

关键词： a.isotropy slow S-wa.e fluid detection

Elucida.ing the genetic ba.is of a.tioxida.t sta.us in lettuce (La.tuca.sa.iva.

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Horticulture Resea.ch 2015年第1期2卷 47-59页

作者： a.na.elle Da.erum Sta.ey L Selmes Ga.a.F Biggi Gra.a. JJ Cla.kson Steve D Rothwell Ma.ia.JoséTruco Richa.d W Michelmore Robert D Ha.cock Connie Shellcock mark a.chapman Ga.l Ta.lor Centre for Biologica. Sciences University of SouthamptonLife SciencesUniversity RoadSouthamptonSO171BJUK Vita.ress Limited Lower Link FarmSt Mary BourneAndoverSP116DBHampshireUK The Genome Centre a.d the Depa.tment of Pla.t Sciences University of CaliforniaDavis95616CAUSA The Ja.es Hutton Institute InvergowrieDD25DADundeeUK

a.diet rich in phytonutrients from fruit a.d vegeta.les ha. been a.knowledged to a.ford protection a.a.nst a.ra.ge of huma. disea.es,but ma.y of the most popula. vegeta.les a.e low in *** rela.ives of crops ma. conta.n a.lelic va.ia.ion for genes determining the concentra.ions of these beneficia. phytonutrients,a.d therefore understa.ding the genetic ba.is of this va.ia.ion is importa.t for breeding efforts to enha.ce nutritiona. *** this study,lettuce recombina.t inbred lines,genera.ed from a.cross between wild a.d cultiva.ed lettuce(La.tuca.serriola.a.d La.tuca.sa.iva.respectively),were a.a.ysed for a.tioxida.t(a.)potentia. a.d importa.t phytonutrients including ca.otenoids,chlorophyll a.d phenolic *** grown in two environments,96 qua.tita.ive tra.t loci(QTL)were identified for these nutritiona. tra.ts:4 for a. potentia.,2 for ca.otenoid content,3 for tota. chlorophyll content a.d 87 for individua. phenolic compounds(two per compound on a.era.e).Most often,the *** a.leles conferred a. increa.e in tota. a.s a.d *** genes underlying these QTL were identified by BLa.Tn sea.ches;in severa. ca.es,these ha. functions suggesting involvement in phytonutrient biosynthetic *** of a.QTL on linka.e group 3,which a.counted for>30%of the va.ia.ion in a. potentia.,revea.ed severa. ca.dida.e genes encoding multiple MYB tra.scription fa.tors which regula.e fla.onoid biosynthesis a.d fla.a.one 3-hydroxyla.e,a. enzyme involved in the biosynthesis of the fla.onoids quercetin a.d ka.mpferol,which a.e known to ha.e powerful a. ***-up qua.tita.ive RT-PCR of these ca.dida.es revea.ed tha. 5 out of 10 genes investiga.ed were significa.tly differentia.ly expressed between the wild a.d cultiva.ed pa.ents,providing further evidence of their potentia. involvement in determining the contra.ting *** results offer exciting opportunities to improve the nutritiona. content a.d hea.th benefits of lettu

关键词： breeding crops La.tuca

Frequency-dependent seismic a.isotropy a.d its implica.ion for estima.ing fra.ture size in low porosity reservoirs

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Frequency-dependent seismic anisotropy and its implication f...

Genomic va.ia.ion,environmenta. a.a.ta.ion,a.d fera.iza.ion in ra.ie,a. a.cient fiber crop

中国科学院地质与地球物理研究所2003学术年会

作者： SONJa.Ma.LTZSCH mark chapman JOHN H.QUEEN Edinburgh a.isotropy Project EdinburghU.K. ConocoPhillips HoustonTexasU.S

The use of seismic a.isotropy for cha.a.terizing subsurfa.e fra.ture orienta.ions a.d intensity ha. become increa.ingly ***,the relucta.ce of reservoir engineers to a.cept seismic a.isotropy a. a.routine technique for fra.ture cha.a.teriza.ion is pa.tly beca.se of its ina.ility to provide informa.ion a.out sizes a.d volume of *** both gra.n-sca.e micro-cra.ks a.d forma.ion -sca.e ma.ro-fra.tures a.e considered ca.ses of *** a.isotropy, reservoir engineers a.e more interested in the la.ter a. permea.ility in ma.y

关键词：

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Pla.t Communica.ions 2024年第8期5卷 189-207页

作者： Zeng-Yua. Wu mark a.chapman Jie Liu Richa.d I.Milne Ying Zha. Ya.Hua.g Luo Gua.g-Fu Zhu Ma.c W.Ca.otte Ming-Ba. Lua. Peng-Zhen Fa. a.ex K.Monro Zhi-Peng Li Richa.d T.Corlett De-Zhu Li Germpla.m Ba.k of Wild Species&Yunna. Key La.ora.ory of Crop Wild Rela.ives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China School of Biologica. Sciences University of SouthamptonSouthampton SO171BJUK Ca. Key La.ora.ory for Pla.t Diversity a.d Biogeogra.hy of Ea.t a.ia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Institute of Molecula. Pla.t Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93JHUK Depa.tment of Biologica. Sciences University of Toronto-ScarboroughTorontoOntarioCanada Institute of Ba.t Fiber Crops Chinese Academy of Agricultural SciencesChangshaHunan 410205China Roya. Bota.ic Ga.dens Kew RichmondSurrey TW93AEUK Center for Integra.ive Conserva.ion a.d Yunna. Key La.ora.ory for the Conserva.ion of Tropica. Ra.nforests a.d a.ia. Elepha.ts Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunYunnan 666303China

Fera.iza.ion is a. importa.t evolutiona.y process,but the mecha.isms behind it rema.n poorly ***,we use the a.cient fiber crop ra.ie(Boehmeria.nivea.L.)Ga.dich.)a. a.model to investiga.e genomic cha.ges a.socia.ed with both domestica.ion a.d *** first produced a.chromosome-sca.e de novo genome a.sembly of fera. ra.ie a.d investiga.ed structura. va.ia.ions between fera. a.d domestica.ed ra.ie ***,we ga.hered 915 a.cessions from 23 countries,comprising cultiva.s,ma.or la.dra.es,fera. popula.ions,a.d the wild *** on whole-genome resequencing of these a.cessions,we constructed the most comprehensive ra.ie genomic va.ia.ion ma. to ***,demogra.hic,a.d a.mixture signa. detection a.a.yses indica.ed tha. fera. ra.ie is of exofera. or exo-endo origin,i.e.,descended from hybridiza.ion between domestica.ed ra.ie a.d the wild progenitor or a.cient *** ra.ie ha. higher genetic diversity tha. wild or domestica.ed ra.ie,a.d genomic regions a.fected by na.ura. selection during fera.iza.ion differ from those under selection during *** a.a.yses showed tha. fera. a.d domestica.ed ra.ie ha.e simila. ecologica. niches tha. differ substa.tia.ly from the niche of the wild progenitor,a.d three environmenta. va.ia.les a.e a.socia.ed with ha.ita.-specific a.a.ta.ion in fera. *** findings a.va.ce our understa.ding of fera.iza.ion,providing a.scientific ba.is for the exca.a.ion of new crop germpla.m resources a.d offering novel insights into the evolution of fera.iza.ion in na.ure.

关键词： ra.ie fiber offering

Genomic a.a.yses revea.ed the rich genetic va.ia.ions a.d potentia. ta.geted genes of selection during domestica.ion from a.perennia. woody tree to a. a.nua. semi-woody crop in ca.tor bea.

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Genomic analyses revealed the rich genetic variations and po...

Compa.a.ive a.d popula.ion genomics of buckwhea. species revea. key determina.ts of fla.or a.d fertility

中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Wei Xu Tia.qua. Ya.g Lijun Qiu mark a.chapman De-Zhu Li a.zhong Liu Depa.tment of Economic Pla.ts a.d Biotechnology and Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of Sciences Germpla.m Ba.k of Wild Species Kunming Institute of BotanyChinese Academy of Sciences Biologica. Sciences a.d Centre for Underutilised Crops University of Southampton Key La.ora.ory for Forest Resources Conserva.ion a.d Utiliza.ion in the Southwest Mounta.ns of China Ministry of EducationSouthwest Forestry University

Rela.ively little is known a.out the genetic va.ia.ion of woody trees during *** bea.（Ricinus communis L.,Euphorbia.ea.） is a. importa.t nonedible a.nua. semi-woody oilseed crop a.d its seed oils a.e widely used in *** cultiva.ed ca.tor bea. is evolved from its wild progenitors with perennia. woody *** ca.tor bea. wa. utilized by huma. da.ing ba.k more tha. 6000 yea.s,its domestica.ion origin,genomic va.ia.ion a.d potentia. ta.gets of selection underlying domestica.ion tra.ts rema.n ***,we performed a.phylogenetic a.a.ysis,resulting in tha. the wild a.cessions were distinctively sepa.a.ed from the cultiva.ed *** sequencing for three a.cessions（one ea.h wild,la.dra.e a.d cultiva.） a.d their genomic a.a.yses showed a.la.ge number of genetic va.ia.ts between wild a.d cultiva.ed ca.tor bea.,a.d rela.ively few between cultiva.s,suggesting tha. ca.tor bea. ha. undergone a.genetic bottleneck during *** genome a.a.ysis revea.ed tha. ma.y ca.dida.e genes of selection a.d key pa.hwa.s potentia.ly involved in the tra.sition from a.perennia. woody tree to a.nua. semi-woody ***,a.ong 16 oil-rela.ed genes only three showed evidence of selection a.d the rema.nder showed low or zero genetic va.ia.ion a. the popula.ion level,suggesting strong purifying selection in both the wild a.d domestica.ed gene *** results extend our understa.ding of the origin,genomic va.ia.ion a.d evolution,a.d woody tree domestica.ion of ca.tor *** genomic va.ia.ion identified within wild a.d cultiva.ed ca.tor bea. will provide a.va.ua.le resource for future gene-tra.t a.socia.ions a.d a. tools for ca.tor bea. breeding.

关键词： Ca.tor bea. genetic va.ia.ion domestica.ion woody tree perennia.ism a.nua.ism

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Molecula. Pla.t 2023年第9期16卷 1427-1444页

作者： Ka.xua. Zha.g Yuqi He Xia.g Lu Ya.ia.g Shi Hui Zha. Xia.bo Li Jinlong Li Ya.g Liu Yina. Ouya.g Yu Ta.g Xue Ren Xuemei Zha.g Weifei Ya.g Zha.xia.Sun Chunhua.Zha.g Muriel Quinet Zla.a.Lutha. Ma.eja.Germ Iva. Kreft Da.ma. Ja.ovska.Vla.imir Meglic Ba.ba.a.Pipa. Milen I.Georgiev Bruno Studer mark a.chapman Meilia.g Zhou Institute of Crop Sciences Chinese Academy of Agricultural SciencesNational Crop Genebank BuildingZhongguancun South Street No.12Haidian DistrictBeijing 100081China College of a.ronomy Sichuan Agricultural UniversityChengdu 611130China a.noroa. Gene Technology(Beijing)Co. LtdBeijing 100176China College of a.riculture Institute of Agricultural BioengineeringShanxi Agricultural UniversityTaigu 030801ShanxiChina Sha.xi Key La.ora.ory of Minor Crops Germpla.m Innova.ion a.d Molecula. Breeding Shanxi Agricultural UniversityTaiyuan 030031ShanxiChina Tonglia. Institute a.ricultura. a.d a.ima. Husba.dry Sciences Tongliao 028015Inner MongoliaChina Groupe de Recherche en Physiologie Ve´ge´ta.e(GRPV) Earth and Life Institute-Agronomy(ELI-A)Universite´Catholique de LouvainCroix du Sud 4-5bo^ıte L7.07.13B-1348Louvain-la-NeuveBelgium Biotechnica. Fa.ulty University of Ljubljana1000 LjubljanaSlovenia Nutrition Institute Trzaska 401000 LjubljanaSlovenia Gene Ba.k Crop Research InstituteDrnovska´507Prague 6Czech Republic a.ricultura. Institute of Slovenia Hacquetova ulicaLjubljanaSlovenia La.ora.ory of Meta.olomics Institute of MicrobiologyBulgarian Academy of SciencesPlovdivBulgaria Center of Pla.t Systems Biology a.d Biotechnology PlovdivBulgaria Molecula. Pla.t Breeding Institute of Agricultural SciencesETH ZurichUniversitaetstrasse 28092 ZurichSwitzerland Biologica. Sciences University of SouthamptonLife Sciences Building 85Highfield CampusSouthampton SO171BJUK

Common buckwhea.(Fa.opyrum esculentum)is a. a.cient crop with a.world-wide *** to its excellent nutritiona. qua.ity a.d high economic a.d ecologica. va.ue,common buckwhea. is becoming increa.ingly importa.t throughout the *** a.a.la.ility of a.high-qua.ity reference genome sequence a.d popula.ion genomic da.a.will a.celera.e the breeding of common buckwhea.,but the high heterozygosity due to the outcrossing na.ure ha. grea.ly hindered the genome *** we report the a.sembly of a.chromosome-sca.e high-qua.ity reference genome of *** ***,a.homozygous self-pollina.ing va.ia.t of common *** genomics revea.ed tha. two cultiva.ed buckwhea. species,common buckwhea.(***)a.d Ta.ta.y buckwhea.(***),underwent meta.olomic divergence a.d ecotype *** expa.sion of severa. gene fa.ilies in common buckwhea.,including FhFa. genes,is a.socia.ed with its wider distribution tha. Ta.ta.y *** number va.ia.ion of genes involved in the meta.olism of fla.onoids is a.socia.ed with the difference of rutin content between common a.d Ta.ta.y ***,we present a.comprehensive a.la. of genomic va.ia.ion ba.ed on whole-genome resequencing of 572 a.cessions of common *** a.d evolutiona.y genomics revea. genetic va.ia.ion a.socia.ed with environmenta. a.a.ta.ility a.d flora. development between Chinese a.d non-Chinese cultiva.ed ***-wide a.socia.ion a.a.yses of multi-yea. a.ronomic tra.ts with the content of fla.onoids revea.ed tha. Fh05G014970 is a.potentia. ma.or regula.or of flowering period,a.key a.ronomic tra.t controlling the yield of outcrossing crops,a.d tha. Fh06G015130 is a.crucia. gene underlying fla.or-a.socia.ed ***,we found tha. the gene tra.sloca.ion a.d sequence va.ia.ion of FhS-ELF3 contribute to the homomorphic self-compa.ibility of common ***,our results elucida.e the genetic ba.is of spe

关键词： buckwhea. genomics na.ura. va.ia.ion a.a.ta.ion fla.onoids Fa.opyrum

130～70ka.球冰量波动、北大西洋冰携事件和深海循环变化

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海洋地质动态 2000年第8期16卷 14-16页

作者： mark R.chapman 周立君张剑