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Controlling Osteogenic Differentiation through Nanoporous Alumina

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Journal of Biomaterials and Nanobiotechnology 2014年第2期5卷 98-104页

作者： Shiuli Pujari-Palmer Thomas Lind Wei Xia Liping Tang marjam Karlsson ott Applied Material Science Department of Engineering SciencesThe Angstrom LaboratoryUppsala UniversityUppsalaSweden Department of Medical Sciences Uppsala UniversityUppsalaSweden Bioengineering Department University of Texas at ArlingtonArlingtonUSA

Nanotopographical features are found to have significant effects on bone behavior. In the present study, nanoporous aluminas with different pore sizes (20, 100 and 200 nm in diameter), were evaluated for their osteoinductive and drug eluting properties. W20-17 marrow stromal cells were seeded on nanoporous alumina with and without the addition of BMP-2. Although cell proliferation was not affected by pore size, osteogenic differentiation was 200 nm as compared to 20 and 100 nm pores induced higher alkaline phosphatase activity (ALP) and osteocalcin expression levels, thus indicating osteoblastic differentiation. Cell morphology revealed that cells cultured on 20 nm pores adopted a rounded shape, while larger pores (200 nm) elicited an elongated morphology. Furthermore, ALP expression levels were consistently higher on BMP-2 loaded nanoporous alumina surfaces compared to unloaded surfaces, indicating that not only is nanoporous alumina osteoinductive, but also has the potential to be used as a drug eluting bone-implant coating.

关键词： Nanotopography Nanoporous Alumina Osteogenic Differentiation Marrow Stromal Cells

Multitarget Thiol-Activated Tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer Therapy

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CCS Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian Türck Maxime ASiegler Uttara Basu Ingo ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig Department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 Division of Drug Discovery&Safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(TrxR)inhibition,which disturbs the redox balance of cancer ***,in this model,the role of the ligand(s)coordinated to gold is often *** this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl *** formation of a free Au(Ⅰ)center is responsible for the expected TrxR ***,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium ***,these ligands ended up in the lysosomes,resulting in significant lysosome ***,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2D monolayers and 3D tumor *** suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

Multiple phenotypes in genome-wide genetic mapping studies

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Protein & Cell 2011年第7期2卷 519-522页

作者： Jurg ott Jing Wang Key Laboratory of Mental Health Institute of Psychology Chinese Academy of SciencesBeijing 100101China

For many psychiatric and other traits,diagnoses are based on a number of different criteria or *** than carrying out genetic analyses on the final diagnosis,it has been suggested that relevant phenotypes should be analyzed *** provide an overview of statistical methods for the joint analysis of multiple phenotypes in case-control association studies.

关键词： multiple phenotypes genetic mapping case-control statistical method

Investigation of the heat distribution in dry friction systems during fade and recovery using fiber-optic sensing and infrared technology

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Friction 2022年第3期10卷 422-435页

作者： Albert ALBERS Thomas KLOTZ Chris FINK Sascha ott IPEK–Institute of Product Engineering Karlsruhe Institute of TechnologyBaden Wurttemberg 76131Germany

The design of dry-running friction pairings and systems determines not only their installation space and costs,but also their reliability under critical load conditions,for example in emergencies,in the case of faults,and in the event of *** knowledge of the contact pattern is highly important for the development of clutches and brakes,the contact-related measurement of the temperature of these systems has not yet been solved in a satisfactory *** its importance,the temperature distribution has only been measured in a few ***,temperature measurements of complete clutches and brakes are carried out using thermocouples *** this study,a new innovative test setup is *** setup is able to measure the heat distribution of the lining and the steel disk of a brake with high spatial resolution by means of fiber optic sensing technology and *** a novelty,it enables measurement of the heat distribution and allows to correlate it with the fade and recovery *** to the expectations,the contact pattern is heterogeneous in circumferential *** causes are discussed using simulation *** with surface analysis,the new setup contributes to the investigation of the causes of fade and recovery.

关键词： dry-running clutch and brake fade and recovery high-resolution spatial temperature distribution measurement

A Comparative Study of the Local Heat Transfer Distributions Around Various Surface Mounted Obstacles

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Journal of Thermal Science 2014年第2期23卷 169-176页

作者： Robert Wyssmann Dirk Ullmer Alexandros Terzis Peter ott Group of Thermal Turbomachinery(GTT) cole Polytechnique Fédérale de Lausanne (EPFL)SCI-STI-POCH-1015LausanneSwitzerland

In many engineering applications,heat transfer enhancement techniques are of vital importance in order to ensure reliable thermal designs of convective heat transfer *** study examines experimentally the heat transfer characteristics on the base plate around various surface mounted *** convection coefficients are evaluated in the vicinity of each individual protruding body with great spatial resolution using the transient liquid crystal *** different obstacles of constant height-to-hydraulic diameter ratio(~1.3) are *** include:a cylinder,a square,a triangle,a diamond and a vortex generator of delta wing shape *** experiments were carried out over a range of freestream Reynolds numbers,based on the hydraulic diameter of each obstacle,varying from 4,000 to 13,*** results indicate a negligible effect of the flow speed on the heat transfer topological structure and a considerable effect of the obstacle geometry on the level and distribution of heat transfer enhancement.

关键词： surface obstacles heat transfer enhancement transient liquid crystal technique

Heat Transfer and Performance Characteristics of Axial Cooling Fans with Downstream Guide Vanes

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Journal of Thermal Science 2012年第2期21卷 162-171页

作者： Alexandros Terzis Ioannis Stylianou Anestis I. Kalfas Peter ott Group of Thermal Turbomachinery (GTT) School of Engineering EPFL-SCI-STI-PO CH-1015 Lausanne Switzerland Laboratory of Fluid Mechanics and Turbomachinery Dept. of Mechanical Engineering School of Engineering Aristotle University of Thessaloniki (AUTH) GR-54124 Thessaloniki Greece

This study examines experimentally the effect of stators on the performance and heat transfer characteristics of small axial cooling fans. A single fan impeller, followed by nine stator blades in the case of a complete stage, was used for all the experimental configurations. Performance measurements were carried out in a constant speed stage performance test rig while the transient liquid crystal technique was used for the heat transfer measurements. Full surface heat transfer coefficient distributions were obtained by recording the temperature history of liquid crystals on a target plate. The experimental data indicated that the results are highly affected by the flow conditions at the fan outlet. Stators can be beneficial in terms of pressure drop and efficiency, and thus more economical operation, as well as, in the local heat transfer distribution at the wake of the stator blades if the fan is installed very close to the cooling object. However, as the separation distance increases, enhanced heat transfer rate in the order of 25% is observed in the case of the fan impeller.

关键词： axial fans stators performance thermochromic liquid crystals transient heat transfer

Eccentric error and compensation in rotationally symmetric laser triangulation

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仪器仪表学报 2007年第9期28卷 1548-1553页

作者： Wang Lei Gao Jun Wang Xiaojia Johannes Eckstein Peter ott Lab of Image Information Processing School of Computer and Information Hefei University of Technology Hefei 230009 China Optical Engineering Lab. Heilbronn University Heilbronn D-74081 Germany Dep. of Mechanical and Electrical Engineering Xiamen University Xiamen 361005 China

Rotationally symmetric triangulation(RST)sensor has more flexibility and less uncertainty limits because of the abaxial rotationally symmetric optical *** if the incident laser is eccentric,the symmetry of the image will descend,and it will result in the eccentric error especially when some part of the imaged ring is *** model of rotationally symmetric triangulation that meets the Schimpflug condition is presented in this *** error from eccentric incident laser is *** is pointed out that the eccentric error is composed of two parts,one is a cosine in circumference and proportional to the eccentric departure factor,and the other is a much smaller quadric factor of the *** the ring is complete,the first error factor is zero because it is integrated in whole ring, but if some part of the ring is blocked,the first factor will be the main *** verifies the result of the a- *** last,a compensation method to the error when some part of the ring is lost is presented based on neural *** results of experiment show that the compensation will make the absolute maximum error descend to half,and the standard deviation of error descends to 1/3.

关键词：补偿作用旋转对称激光三角测量法偏心因子视力测量神经网络

Feasibility of Using Wood Chips to Regulate Relative Humidity Inside a Building: A Numerical Study

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Journal of Renewable Materials 2019年第6期7卷 505-516页

作者： Dimitri Bigot Cyril ott Stéphane Guichard Bruno Malet-Damour University of La Réunion-40 avenue de Soweto-Terre Sainte-BP 373-97455 Saint-Pierre CedexLa RéunionFrance

The use of bio-based materials in buildings has become more and more significant last *** most of the cases,their health properties and natural provenance have made them a great solution to face global climate warming and the new policies to reduce building energy *** many thermal problems,biobased materials can allow to optimize the building thermal behavior according to its energy consumption and inside comfort *** it is when they are used as an insulation material in the ***,it is not the case in this *** fact,the bio-based matter is rather used as a desiccant wheel to control air conditioning inside the *** aim of this paper is to numerically verify if it is possible to use a bed of wood chips as a hygroscopic material(or a desiccant matter)in order to modify the relative humidity inside the building in Reunion Island and so improve thermal comfort.A simple model of heat and mass transfer between a bed of wood chips and building inside air has been set up and implemented into a validated building simulation code named *** simulations were set up for the four climate zones of the island regulations and a focus has been made on the low altitude one(with high,solar irradiation,temperature and relative humidity).Simulation results give the thermal behavior of the building particularly the temperature and relative humidity of inside air temperature,and temperature and moisture content of wood *** obtained results lead to determine if the wood chips bed is suitable for the reference building and to verify its technical feasibility(wood species,size of the bed,integration to the building,etc.).The results show that the use of a WCB help to decrease the building inside air temperature and water content up to 10°C less and 11.6 ***-1 *** are the ways to improve inside comfort ***,comfort analysis have shown the possibility to significantly increase building users’thermal comfort

关键词： Wood chips bed building inside comfort bio-based material desiccant relative humidity temperature building thermal modelling

Mixed is beautiful Cellulose rheology modifiers for modern architectural paints

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涂料工业 2007年第B7期37卷 50-52页

作者： Jürgen ott the dispersion systems team at Wolff Cellulosics

Cellulose mixed ethers are multifunctional rheological additives that play a significant role in determining the flow behavior,pigment suspension and water retention of dispersion ***-viscosity methyl hydroxyethyl celluloses,in particular,have further ex panded the performance spectrum of modern,solvent-free paints in recent years.

关键词：建筑涂料纤维素流变性添加剂混合醚辅助物料