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外扩张联合自体脂肪移植隆乳术是一种安全、有效的选择：6年81例患者前瞻性、多中心研究

中华医学会整形外科学分会第十一次全国会议、中国人民解放军整形外科学专业委员会学术交流会、中国中西医结合学会医学美容专业委员会全国会议

作者： marita eisenmann-klein Department of Plastic Aesthetic Hand- and Reconstructive Surgery Caritas Krankenhaus St.Josef Regensburg

Fat grafting has been performed successfully for various indications since more than 30 *** injection into breast tissue frequently lead to disastrous results. Only a few years ago new techniques have been developed using the concept of strictly limited injections into the subcutaneous tissue of the breast or into the space between gland and the fascia of the pectoralis *** of these techniques use adipose tissue derived stem cells or a stem cell rich environment.

关键词： Reconstruction with Fat Grafts and Vacuum Assisted Bra

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中国美容整形外科杂志 2012年第12期23卷 I0009-I0022页

作者： Roger K. Khouri marita eisenmann-klein Eufemiano Cardoso Brian C. Cooley Daniel Kacher Eva Gombos 魏峰(译) 高景恒(译) 张晨(译) 美国佛罗里达州迈阿密市佛罗里达国际大学整形外科中心迈阿密乳房中心德国雷格斯堡圣约瑟夫明爱医院整形美容与手外科部威斯康星州密尔沃基市维斯康星医学院骨科马萨诸塞州波士顿市哈佛大学医学院布莱根妇女医院手术规划实验室及乳房放射线科迈阿密大学外科部《中国美容整形外科杂志》编辑部大连大学附属新华医院

研究背景自体脂肪移植隆乳术是一个有待科学验证的吸引人的选择. 方法本研究为前瞻性、多通道研究,81例女性患者（年龄17～63岁）穿戴Brava装置（一个类似乳罩的真空外扩张器）4周,然后在每侧乳房选择10～14 个入针点三维扇形地进行自... 详细信息

研究背景自体脂肪移植隆乳术是一个有待科学验证的吸引人的选择. 方法本研究为前瞻性、多通道研究,81例女性患者（年龄17～63岁）穿戴Brava装置（一个类似乳罩的真空外扩张器）4周,然后在每侧乳房选择10～14 个入针点三维扇形地进行自体脂肪注射（每侧乳房平均注射277ml）.然后,患者再次全天穿戴Brava装置7d或更久.利用MRI成像扫描三维体积重建测量治疗前、后乳房体积,并将治疗效果与近期报道的6篇未扩张的自体脂肪移植隆乳术的Meta分析结果进行对比.本组患者随访观察12个月至6年（平均 3.7年）.结果乳房体积在3～6个月间无变化.本组有71例患者顺应Brava装置的穿戴,且12个月时每侧乳房体积增加233ml,而文献中报道的未穿戴Brava的每侧增加量为134ml（P ＜0.00001）.穿戴Brava与未穿戴Brava的脂肪移植成活率分别为82%±18%及55%±18%（P ＜0.00001）.移植前Brava预扩张与脂肪移植隆乳术效果间有强烈的线性关联（R2=0.87）.无可疑的脂肪肿块或硬结.术后1年的乳房影像学分析可以很容易地通过MRI检查到16%的脂肪坏死发生率.结论自体脂肪移植隆乳术中引入Brava扩张可疑通过增加脂肪置入空间、提高移植成活率、减少移植坏死和并发症的发生来增加脂肪增大的量,证实其为安全、有效的措施.（循证医学证据等级：Ⅳ级,疗法）

关键词：自体脂肪移植女性患者隆乳术多中心研究安全自体脂肪注射乳房体积 MRI成像

Brava和自体脂肪移植是一种安全有效的隆乳选择：一项6年，81例多中心前瞻性研究结果（摘要）

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中国美容整形外科杂志 2012年第7期23卷 I0003-I0003页

作者： Roger K. Khouri marita eisenmann-klein Eufemiano. Cardoso Brian C. Cooley Daniel. Kacher Eva Gombos Thomas J. Baker 朱利娜魏峰高景恒张晨迈阿密乳房中心美国佛罗里达州比斯坎湾《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的隆乳术中采用自体脂肪移植是经科学认证的有吸引力的选择。方法多中心前瞻性研究中，纳入81例女性，年龄17—63岁，均使用Brava设备4周。Brava是一个类似乳罩装置、负压体外组织扩张器。而后利用10～14个针刺位点以三维扇形... 详细信息

背景与目的隆乳术中采用自体脂肪移植是经科学认证的有吸引力的选择。方法多中心前瞻性研究中，纳入81例女性，年龄17—63岁，均使用Brava设备4周。Brava是一个类似乳罩装置、负压体外组织扩张器。而后利用10～14个针刺位点以三维扇形模式对每个乳房注射自体脂肪（平均每个乳房注射277ml）。受试者在注射后24h内重新使用Brava，并使用7d以上。利用磁共振成像技术扫描治疗前和治疗后的乳房体积，并与6篇已报道的自体脂肪隆乳术（未使用扩张器）报道的Meta分析结果相比较。随访期为1～6年（平均为3．7年）。结果3—6个月内乳房体积没有变化。接受治疗的女性中有71例按要求使用Brava，其结果是1年内每个乳房体积增加233ml，而之前报道的没有使用Brava的女性乳房体积只增加134ml（P〈0．00001）。使用Brava扩张的移植存活率为（82±18）％，而未使用Brava的移植存活率为（55±18）％（P〈0．00001）。且移植前的Brava扩张与乳房增大的体积有强烈的线性相关性（R2=0．87）。未发现可疑的乳房肿块或结节。1年后影像评估时，磁共振成像技术发现脂肪坏死的发生率为16％。结论自体脂肪移植术前使用Brava扩张器可使乳房体积明显增大，且脂肪植入点更多，移植成活率更高，移植物坏死和并发症最少，证明该方法具有很高的安全性和有效性。临床问题／证据等级：疗法，Ⅳ级。

关键词：多中心前瞻性研究自体脂肪移植隆乳术安全性磁共振成像技术组织扩张器乳房体积移植存活率

Hydration lubrication

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Friction 2013年第1期1卷 1-23页

作者： Jacob klein Department of Materials&Interfaces Weizmann Institute of ScienceRehovot76100Israel

The hydration lubrication paradigm,whereby hydration layers are both strongly held by the charges they surround,and so can support large pressures without being squeezed out,and at the same time remain very rapidly relaxing and so have a fluid response to shear,provides a framework for understanding,controlling,and designing very efficient boundary lubrication systems in aqueous and biological *** review discusses the properties of confined water,which-unlike organic solvents-retains its fluidity down to molecularly thin *** then describes lubrication by hydrated ions trapped between charged surfaces,and by other hydrated boundary species including charged and zwitterionic polymer brushes,surfactant monolayers,liposomes,and biological macromolecules implicated in synovial joint ***,challenges and prospects for future development of this new boundary lubrication approach are considered.

关键词： hydration lubrication biolubrication boundary lubrication liposomes polymer brushes hydration repulsion hydration layers

MICROSTRUCTURE CHARACTERIZATION OF LiCoO_2 COATINGS FOR MOLTEN CARBONATE FUEL CELLS COMPONENTS

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Chinese Journal of Mechanical Engineering 2002年第2期15卷 182-185页

作者： klein Lisa College of Materials Science and Engineering Fuzhou University Fuzhou 350002 Rutgers University 美国 Evercel Co. Connecticut 美国

The sol-gel process, sing aqueous solutions, is used for dip coating ontosubstrates of 316L stainless steel. A suitable coating of Li CoO_2 is achieved by varying thethickness and heat treating at 650 deg C for 3 h. Thermal analysis, X-ray diffraction analysis andSEM are carried out to characterize the microstructure of the coatings. The results show that thecoating transforms from an amorphous gel to crystalline phases above 350 deg C, and show a porousstructure. The phase transition mechanism is discussed.

关键词： Molten carbonate fuel cells Sol-gel LiCoO_2 coating Crystalline phasetransition

Converging links between adult-onset neurodegenerative Alzheimer’s disease and early life neurodegenerative neuronal ceroid lipofuscinosis?

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Neural Regeneration Research 2023年第7期18卷 1463-1471页

作者： Marcel klein Guido Hermey Institute for Molecular and Cellular Cognition Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburgGermany

Evidence from genetics and from analyzing cellular and animal models have converged to suggest links between neurodegenerative disorders of early and late ***,we summarize emerging links between the most common late life neurodegenerative disease,Alzheimer’s disease,and the most common early life neurodegenerative diseases,neuronal ceroid *** studies reported an overlap of clinically diagnosed Alzheimer’s disease and mutations in genes known to cause neuronal ceroid *** data strongly suggest dysfunction of intracellular trafficking mechanisms and the autophagy-endolysosome system in both types of neurodegenerative *** suggests shared cytopathological processes underlying these different types of neurodegenerative diseases.A better understanding of the common mechanisms underlying the different diseases is important as this might lead to the identification of novel targets for therapeutic concepts,the transfer of therapeutic strategies from one disease to the other and therapeutic approaches tailored to patients with specific ***,we review dysfunctions of the endolysosomal autophagy pathway in Alzheimer’s disease and neuronal ceroid lipofuscinoses and summarize emerging etiologic and genetic overlaps.

关键词： Alzheimer’s disease autophagy Batten disease CLN3 disease dementia endosome lysosome neurodegeneration neuronal ceroid lipofuscinosis presenilin

Disruption of bone and skeletal muscle in severe burns

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Bone Research 2015年第1期3卷 6-10页

作者： Gordon L klein Department of Orthopaedic Surgery and Rehabilitation University of Texas Medical Branch and Shriners Hospitals for Children

Severe burn injury triggers the body＇s nonspecific adaptive responses to acute insult, including the systemic inflammatory and stress responses, as well as the sympathetic response to immobilization. These responses trigger inflammatory bone resorption followed by glucocorticoid-induced apoptosis of osteoblasts and probably osteocytes. Because these patients are catabolic, they suffer concomitant muscle wasting and negative nitrogen balance. The use of anabolic agents such as recombinant human growth hormone and oxandrolone results in improved bone mineral content and muscle strength after approximately I year. Use of bisphosphonates within the first 10 days of a severe burn completely blocks the resorptive bone loss and has the added advantage of appearing to preserve muscle protein from excessive breakdown. The mechanism for the protective effect on muscle is not currently known. However, if the effect of bisphosphonates on muscle can be confirmed, it raises the possibility that bone communicates with muscle.

关键词： bone Disruption of bone and skeletal muscle in severe burns

Function of lateral line canal morphology

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Integrative Zoology 2015年第1期10卷 111-121页

作者： Adrian klein Horst BLECKMANN Institute for Zoology University of BonnPoppelsdorfer SchlossBonnGermany

Fish perceive water motions and pressure gradients with their lateral *** line information is used for prey detection,spatial orientation,predator avoidance,schooling behavior,intraspecific communication and station *** lateral line of most fishes consists of superficial neuromasts(SNs)and canal neuromasts(CNs).The distribution of SNs and CNs shows a high degree of variation among *** have speculated for decades about the functional significance of this diversity,often without any conclusive *** et al.(2013)examined how tubules,pore number and pore patterns affect the filter properties of lateral line canals in a marine teleost,the black prickleback(Xiphister atropurpureus).A preliminary mathematical model was formulated and biomimetic sensors were *** the present study the mathematical model was extended to understand the major underlying principle of how canal dimensions influence the filter properties of the lateral *** the extended mathematical model and the sensor experiments show that the number and distribution of pores determine the spatial filter properties of the lateral *** an environment with little hydrodynamic noise,simple and complex lateral line canals have comparable response ***,if exposed to highly turbulent conditions,canals with numerous widely spaced pores increase the signal to noise ratio significantly.

关键词： filter lateral line morphology noise sensor

A genomic approach to active surveillance： a step toward precision medicine

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Asian Journal of Andrology 2013年第3期15卷 340-341页

作者： Eric A klein Glickman Urological and Kidney Institute Cleveland Clinic Cleveland OH 44195 USA

In the last 25 years, Prostate Specific Antigen （PSA） screening has resulted ina large gap between the likelihood of being diagnosed with and of dying of prostate cancer, leading to the clinical problems of overdiagnosis and overtreatment. Despite the favorable outcomes reported for active surveil- lance, its clinical use is limited, with 〉90% of men in the US diagnosed with potentially indol- ent disease undergoing immediate treatment with radiation or surgery. We have designed a novel strategy of molecular profiling of prostate cancers, allowing an assessment of tumor aggres- siveness to be based on tumor tissue obtained at biopsy.

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