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Reversing gastric mucosal alterations during ethanol-induced chronic gastritis in rats by oral administration of Opuntia ficus-indica mucilage

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World Journal of Gastroenterology 2006年第27期12卷 4318-4324页

作者： Ricardo Vázquez-Ramírez marisela olguín-martínez Carlos Kubli-Garfias Rolando Hernández-Mu■oz Depto.de Biología Celular y Fisiología Instituto de Investigaciones Biomédicas. Universidad Nacional Autónoma de México. Apdo. Postal 70-243México D.F. 04510Mexico Depto.de Biología Celular Instituto de Fisiología Celular. Universidad Nacional Autónoma de México. Apdo. Postal 70-243México D.F. 04510Mxico Depto. de Biología Celular Institute de Fisiología Celular. Universidad Nacional Autónoma de México. Apdo. Postal 70-243México D.F. 04510Mxico

AIM： To study the effect of mucilage obtained from cladodes of Opuntia ficus-indica （Cactaceae） on the healing of ethanol-induced gastritis in rats. METHODS： Chronic gastric mucosa injury was treated with mucilage （5 mg/kg per day） after it was induced by ethanol. Lipid composition, activity of 5＇-nucleotidase （a membrane-associated ectoenzyme） and cytosolic activities of lactate and alcohol dehydrogenases in the plasma membrane of gastric mucosa were determined. Histological studies of gastric samples from the experimental groups were included. RESULTS： Ethanol elicited the histological profile of gastritis characterized by loss of the surface epithelium and infiltration of polymorphonuclear leukocytes. Phosphatidylcholine （PC） decreased and cholesterol content increased in plasma membranes of the gastric mucosa. In addition, cytosolic activity increased while the activity of alcohol dehydrogenases decreased. The administration of mucilage promptly corrected these enzymatic changes. In fact, mucilage readily accelerated restoration of the ethanol-induced histological alterations and the disturbances in plasma membranes of gastric mucosa, showing a univocal anti-inflammatory effect. The activity of 5＇-nucleotidase correlated with the changes in lipid composition and the fluidity of gastric mucosal plasma membranes. COnCLUSIOn： The beneficial action of mucilage seems correlated with stabilization of plasma membranes of damaged gastric mucosa. Molecular interactions between mucilage monosaccharides and membrane phospholipids, mainly PC and phosphatidylethanolamine （PE）, may be the relevant features responsible for changing activities of membrane-attached proteins during the healing process after chronic gastric mucosal damage.

关键词： Gastritis Mucilage Chronic gastric mucosal injury Ethanol

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The Social Conditions in the Genesis of Preeclampsia

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Open Journal of Epidemiology 2014年第3期4卷 115-121页

作者： Jaime Salvador-Moysén Yolanda martínez-López José M. Ramírez-Aranda marisela Aguilar-Durán Miguel A. Reyes-Romero Department of Family Medicine University Hospital Dr. José Eleuterio González Universidad Autónoma de Nuevo León Monterrey México Faculty of Medicine and nutrition Universidad Juárezdel Estado de Durango Durango México Scientific Research Institute Universidad Juárez del Estado de Durango Durango México

This article highlights the importance of preeclampsia as a global public health problem and the lack of a satisfactory model to explain its genesis. Scientific advances relevant to the placental pathophysiology, which have resulted in a deeper understanding of the immunological mechanisms associated to preeclampsia and have been translated into better treatment options, are also highlighted, although to date these approaches cannot explain the origin of the disease. From a theoretical approach underpinned by the concepts related to the social determinants of the health, and specifically from current psychosocial epidemiology, an alternative approach that gives account for the genesis of preeclampsia is proposed. The proposal is based in the scientific literature as well as in the work of the authors;it takes as references unfavorable socioeconomic and psychosocial conditions in pregnant women, linking these conditions to a series of failed adaptive biological processes closely related to an ineffective allostatic response by the body, which ultimately determines the occurrence of the disease.

关键词： Preeclampsia Psychosocial Epidemiology Social Inequality Allostasis neighborhood

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neuropsychological and Electrophysiological Evaluation after Rape: A Case Study of a Teenage Girl

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Journal of Behavioral and Brain Science 2014年第6期4卷 256-267页

作者： Lucía Ester Rizo-martínez Miguel ángel Guevara Luis Francisco Cerdán Francisco Abelardo Robles-Aguirre Araceli Sanz-martin marisela Hernández-González Centro Universitario del norte Universidad de Guadalajara Colotlán México Instituto de neurociencias CUCBA Universidad de Guadalajara Guadalajara Jalisco México

Although rape is an event with a high incidence worldwide, there is currently no single consensus about both the general effects and the diagnosis and treatment of this. To evaluate the consequences of rape, a teenage girl was evaluated at two moments: a month-and-a-half and then a year-and-a-half after being raped. Clinical measurements, neuropsychological testing and electroencephalographic recording (EEG) were conducted in four conditions: eyes closed, eyes open, and during performance of two tasks: Towers of Hanoi and Wisconsin. Observations showed subsyndromal symptoms of post-traumatic stress on the first evaluation, and close-to-normal scores on the neuropsychological and cognitive tests in both assessments. Decreased cortical EEG synchronization, mainly in the fast frequencies and in almost all conditions, was obtained in the second evaluation. The results obtained in this study may indicate an early development in the brain, which is discussed in light of current literature on this topic.

关键词： Rape Adolescence EEG Clinical Evaluation neuropsychological Testing

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EEG Correlations during WCST Performance in Female Adolescents with Sexual Abuse-Related Post-Traumatic Stress Disorder

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Journal of Behavioral and Brain Science 2015年第7期5卷 239-250页

作者： Lucía Ester Rizo-martínez Araceli Sanz-martin Miguel ángel Guevara marisela Hernández-González Olga Inozemtseva Francisco Abelardo Robles-Aguirre Instituto de neurociencias CUCBA Universidad de Guadalajara Guadalajara México Centro Universitario del norte Universidad de Guadalajara Colotlán México

Child sexual abuse (CSA) survivors can present post-traumatic stress disorder (PTSD) and alterations in EEG activity and cognition. The aim of this study was to evaluate EEG correlations in female adolescents with CSA-related PTSD during performance of the Wisconsin Card-Sorting Test (WSCT). Inter- and intrahemispheric EEG correlations (InTERr and InTRAr) of those subjects were calculated at rest and during performance of WCST. On this task, the PTSD group obtained higher scores than the control group for the number of correct responses and failure to maintain set. In the between-groups comparisons, the PTSD group presented a higher InTERr between frontal areas in the gamma and slow bands, as well as a higher correlation in the delta band at Fp1-F3;however, this group presented a lower InTRAr between Fp1-P3 and Fp2-P4 in the theta and alpha1 bands. In the comparison between conditions, the PTSD group presented an increased correlation during execution of the WCST, mainly in the gamma band, while the control group showed a decrease of InTRAr in the slow bands. Results are discussed with respect to the influence of CSA- related PTSD on the development of cognition and functional connectivity in the brain.

关键词： Child Sexual Abuse Post-Traumatic Stress Disorder EEG Correlation WCST Adolescents

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Prefrontal-Parietal Correlation during Performance of a Visuospatial Working Memory Task in Children, Adolescents and Young Adults

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Journal of Behavioral and Brain Science 2015年第10期5卷 448-457页

作者： Miguel Angel Guevara Jorge Carlos Hevia-Orozco Araceli Sanz-martin Lucía Ester Rizo-martínez marisela Hernández-González Mayra Linné Almanza-Sepúlveda Instituto de neurociencias CUCBA Universidad de Guadalajara Guadalajara México

Development of the prefrontal cortex and its connectivity with different cortical areas has strong implications for the improvement of working memory. The aim of this research was to characterize the interhemispheric (InTER) prefrontal and hemispheric (InTRA) frontopolar-dorsolateral prefrontal and dorsolateral prefrontal-parietal correlation (r) in children, adolescents and adults during performance of a visuospatial working memory task (VSWM). InTERr and InTRAr of 36 different aged male participants (11 - 13, 18 - 20 and 26 - 30 years old) were calculated during performance of the Corsi Block-Tapping task, which assessed VSWM. On this task, children showed lower correct responses than adolescents and adults. Adults also showed lower total execution times than children and adolescents, with a more efficient performance. On the EEGs, the older groups showed both higher interfrontal correlations and left and right prefronto-parietal correlations than children. According to our results, the progressive efficiency in VSWM is related to differences in EEG patterns among children, adolescents and adults.

关键词： Corsi Block-Tapping Task EEG Correlations Development Visuospatial Working Memory

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EEGbands: A Computer Program to Statistically Analyze Parameters of Electroencephalographic Signals

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Journal of Behavioral and Brain Science 2014年第7期4卷 308-324页

作者： Miguel Angel Guevara Araceli Sanz-martin marisela Hernández-González Instituto de neurociencias CUCBA Universidad de Guadalajara Guadalajara Jalisco México

The quantitative analysis of electroencephalographic activity (EEG) is a useful tool for the study of changes in brain electrical activity during cognitive and behavioral functions in several experimental conditions. Their recording and analysis are currently carried out primarily through the use of computer programs. This paper presents a computerized program (EEGbands) created for Windows operating systems using the Delphi language, and designed to analyze EEG signals and facilitate their quantitative exploration. EEGbands applies Rapid Fourier Transformation to the EEG signals of one or more groups of subjects to obtain absolute and relative power spectra. It also calculates both interhemispheric and intrahemispheric correlation and coherence spectra and, finally, applies parametrical statistical analysis to these spectral parameters calculated for wide frequency EEG bands. Unlike other programs, EEGbands is simple and inexpensive, and rapidly and precisely generates results files with the corresponding statistical significances. The efficacy and versatility of EEGbands allow it to be easily adapted to different experimental and clinical needs.

关键词： EEG Correlation EEG Coherence Relative Power Absolute Power EEG Software EEG Signal Analysis

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EEGcorco: a computer program to simultaneously calculate and statistically analyze EEG coherence and correlation

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Journal of Biomedical Science and Engineering 2011年第12期4卷 774-787页

作者： Miguel Angel Guevara marisela Hernández-González Araceli Sanz-martin Claudia Amezcua 不详

EEGcorco is a computer program designed to analyze the degree of synchronization between two electroencephalographic signals (EEG) by mean the analysis of correlation and coherence index. The correlation and coherence values permit the quantitative determination of the similarity among EEG signals from homologous areas of the cerebral hemispheres (interhemispheric), and among localized areas within one cerebral hemisphere (intrahemispheric). EEG coherence is a function of frequency;thus it is commonly presented in a spectral manner (coherence values in every frequency of the spectrum), in contrast, the correlation function has been employed mainly to search periodic components of bioelectrical signals, and normally appears as punctual values defined in time, hence it is not common calculate correlation spectra. EEGcorco offers an easy and novel way to calculate correlation spectra by mean the application of the Fast Fourier Transformation (FFT) to digitized EEG signals. Both, correlation and coherence spectra are obtained in both independent frequencies and frequencies grouped in wide bands. Moreover, the program applies parametric statistical analyses to those coherence and correlation spectra also, for each individual frequency and for the frequencies grouped in bands. The program functions on any PC-compatible computer equipped with a Pentium or superior processor and a minimum of 512 Mb of RAM memory (though the higher the capacity the better). The space required on the hard disk depends on the signals to be analyzed, as the output takes the form of files in text format that occupy very little space. The program has been elaborated completely in the Delphi environment for the Windows operating system. The efficacy and versatility of EEGcorco allow it to be easily adapted to different experimental and clinical needs.

关键词： EEG EEG Coherence EEG Correlation

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Electroencephalographic Correlates of Sexual Arousal Induced by Sexually-Explicit Reading in Human Females

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Journal of Behavioral and Brain Science 2018年第11期8卷 599-614页

作者： Miguel Angel Guevara Carolina Gomez-navarro Claudia Amezcua-Gutierrez marisela Hernandez-Gonzalez Anders Agmo Institute of neuroscience CUCBAUniversity of GuadalajaraGuadalajaraJaliscoMexico Psychology Department Tromso UniversityTromsoNorway

This study explored the cortical functionality in young women while reading a sexually-explicit text. Electroencephalographic activity (EEG) was recorded in heterosexual women while reading either a sexually-explicit text or one with neutral content. Absolute power (AP) and the degree of EEG synchronization among the prefrontal, temporal and parietal cortices were analyzed for the different EEG bands. To evaluate sexual arousal, valence and general activation, Likert-type and Manikin scales were applied. Subjects scored the sexually-explicit text as more pleasurable, and reported greater general activation and sexual arousal than while reading the neutral one. During reading of the sexually-explicit text only, they showed a higher AP in the beta and gamma bands in temporal areas in both hemispheres, and in the theta band in parietal ones, with a lower degree of EEG synchronization between prefronto-temporal areas in the fast bands. Results show that both hemispheres were activated in these sexually-aroused women. The low bilateral synchronization between prefrontal and temporal regions indicates the independent functionality of these cortices, which could be a requirement for inducing and maintaining sexual arousal during reading of sexually-explicit texts in women. These data should broaden our knowledge of the cortical mechanisms that underlie sexual arousal in women.

关键词： Sexual Arousal EEG Sexually-Explicit Reading Erotic Reading Women

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Aluminum Contents in Dry Leaves and Infusions of Commercial Black and Green Tea Leaves: Effects of Sucrose and Ascorbic Acid Added to Infusions

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natural Resources 2011年第3期2卷 141-145页

作者： Diego Armando Bárcena-Padilla marisela Bernal-González Amalia Panizza-de-León Rolando Salvaor García-Gómez Carmen Durán-Domínguez-de-Bazúa 不详

Tea consumption has increased due to its beneficial effects. Results from a lab study on the effect of sucrose (5 g per cup, 150 mL) and/or ascorbic acid (2 mL per cup, 150 mL) on dissolved aluminum compounds during the infusion of two commercial types of dry tea leaves (black, green) with boiling water (5, 15 min infusion time) are presented. Factors influencing the presence of dissolved aluminum in the infusions of both tea leaves were infusion time and sugar contents, as well as the interaction between ascorbic acid and sucrose (p num contents found after 15 min of infusion were 0.7 mg L–1 for black tea infusions added with sugar, and 0.69 mg L–1 for green tea added with both sugar and ascorbic acid. Both concentrations are higher than the level accepted in Mexico for drinking water (there is no act concerning tea infusions), that is 0.2 mg L–1.

关键词： Aluminum Contents Commercial Black and Green Tea Dry Leaves Infusions Sucrose Ascorbic Acid

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Ethanol Effects on Cortical EEG Correlation and Sexual Behavior in Male Rats

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Journal of Behavioral and Brain Science 2014年第2期4卷 92-98页

作者： Miguel Angel Guevara marisela Hernández-González Mayra Linné Almanza-Sepúlveda Diego Radberto Chapa García Abascal Pilar Durán Carolina Sotelo Tapia Fabricio Luna Torres Departamento de Biología Celular Facultad de Ciencias Universidad Nacional Autónoma de México México DF México Instituto de neurociencias Universidad de Guadalajara Guadalajara Jalisco México

Ethanol affects sexual behavior drastically, as much as its execution as well as its motivation. Ethanol is a central nervous system depressant and the prefrontal cortex (PFC) is one of the cortical areas most sensitive to its effects. This prefrontal area participates in the modulation of the cognitive control, and furthermore, by mean of connections with the parietal cortex (PC) plays an important role in the processing of sexually relevant stimuli. Considering that it has been reported that the ethanol affects the proper functioning of these cortical areas, particularly decreasing the degree of electroencephalographic (EEG) coupling or correlation between them, the aim of this study was to characterize the effect of a low dose of ethanol on EEG correlation, as well determining if this effect is associated with impaired sexual behavior in male rats. nine male rats unilaterally implanted were simultaneously recorded the EEG from the PFC and PC to calculate the degree of EEG synchronization (correlation, r) between both cortices during the first 40 minutes post administration of 0.75 g/kg of ethanol. At the end of the EEG recording, the males were submitted to copulatory behavior with a receptive female rat. The ethanol administration was associated with a decreased intrahemispheric correlation of the fast bands between PFC and PC, as well as with an increased mount and intromission latency. This data showed that ethanol in moderate doses decreased the coupling degree between cortices. It is likely that this functional disconnection between the PFC and PC after the ethanol administration could be associated with the difficulty in discriminating incentive value of the sexual stimuli so that decreased the sexual motivation but not the performance of the copulatory parameters in the male rat.

关键词： Ethanol Sexual Behavior EEG Prefrontal Cortex Parietal Cortex Rat

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