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Human Wharton’s jelly mesenchymal stem cells inhibit cytokine storm in acute respiratory distress syndrome in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2022年第8期12卷 343-350页

作者： Wahyu Widowati Teresa Liliana Wargasetia Fanny Rahardja Rimonta F Gunanegara Didik Priyandoko marisca evalina gondokesumo Ervi Afifah Cahyaning Riski Wijayanti Rizal Rizal Faculty of Medicine Maranatha Christian UniversityJl.Surya Sumantri no 65Bandung 40164Indonesia Faculty of Mathematic and Natural Science Education Indonesia University of EducationJl.Dr.Setiabudi no 229Bandung 40154Indonesia Faculty of Pharmacy University of SurabayaUniversitas SurabayaJl.Raya KalirungkutSurabaya 60293Indonesia Biomolecular and Biomedical Research Center Aretha Medika UtamaJl.Babakan Jeruk 2 no 9Bandung 40163Indonesia Biomedical Engineering Department of Electrical EngineeringFaculty of EngineeringUniversitas IndonesiaJl.Margonda RayaDepok 1642Indonesia

Objective:To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells(hWJMSCs)on acute respiratory distress syndrome in lipopolysaccharide(LPS)-induced ***:The hWJMSCs(5×10^(4)/mL,5×10^(5)/mL,5×10^(6)/mL)were administered to rats on day 1 and day 8 after being induced by LPS(5 mg/kg body weight).TNF-αlevels in the lung and IL-18 and IL-1βlevels in the serum were measured using *** addition,caspase-1 expression in lung tissues was quantified using qRT-PCR,and NF-κB and IL-6 expressions were assessed using ***:The hWJMSCs decreased TNF-αlevels in the lung and plasma IL-18 and IL-1β***,the hWJMSCs downregulated the expressions of caspase-1,IL-6,and NF-κB in lung ***:The hWJMSCs can decrease inflammatory markers of acute respiratory distress syndrome in a rat model and may be further investigated for the treatment of acute respiratory distress syndrome.

关键词： Human Wharton’s jelly mesenchymal stem cells Acute respiratory distress syndrome TNF-α IL-18 NF-κB Inflammatory marker

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Different types of mechanical complications after surgical correction of adult spine deformity with osteotomy

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World Journal of Meta-Analysis 2017年第6期5卷 132-149页

作者： Cameron Barton Andriy Noshchenko Vikas V Patel Christopher M J Cain Christopher Kleck evalina L Burger Department of Orthopedics and Rehabilitation University of Iowa Department of Orthopedics University of ColoradoAnschutz Medical Campus

AIM To determine the incidence and risk factors for mechanical complications （MC） after surgical correction of adult spinal deformity （ASD） with *** retrospective study was performed. Inclusion criteria： Surgical correction of ASD using osteotomy; male or female; 〉 20 years old; follow-up ≥ 24 mo or revision. The MC of spine and spinal instrumentation were studied separately. Risk analysis included assessment of the association between more than 50 different characteristics （demographic, clinical, radiographic, and instrumentation） with different types of *** medical records of 94 operations in 88 subjects were analyzed： Female （68%）, mean age 58.6 （SD, 12.7） years. Cumulative incidence of MC at 2 year follow-up was 43.6%. Of these, 78% required revision （ P 〈 0.001）. The following characteristics had significant （ P ≤ 0.05） association with MC：（1） Preoperative： osteoporosis, smoking, previous spinal operation, sagittal vertical axis （SVA）〉 100 mm, lumbar lordosis （LL）〈 34°; （2） postoperative： SVA 〉 75 mm; operative correction： SVA 〉 75 mm, LL 〉 30°, thoracic kyphosis 〉 25°, and pelvic tilt 〉 9°; a fall; pseudarthrosis; and （3） device and surgical technique： use of previously implanted instrumentation; use of domino and/or parallel connectors; type of osteotomy （PSO vs SPO） if preoperative SVA 〈 100 mm; lumbar osteotomy location; in-situ rod contouring 〉 60°; and fxation to sacrum/*** of MC after surgical correction of ASD is substantial. To decrease this risk over- and/or insuffcient correction of the sagittal imbalance should be avoided.

关键词： Adult spinal deformity Osteotomy Risk factors Mechanical complications

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Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis

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World Journal of Orthopedics 2015年第7期6卷 537-558页

作者： Andriy Noshchenko Lilian Hoffecker Emily M Lindley evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford Department of Orthopaedics University of Colorado Anschutz Medical Campus Health Sciences Library University of Colorado Anschutz Medical Campus Department of Orthopaedics and Gyneco-logy University of Colorado Anschutz Medical Campus

AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of ***: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of mela

关键词： Orthopedics Scoliosis Adolescent idiopathic scoliosis Spine deformity Predictors

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