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Cyanobacteria Growth in Nitrogen- &Phosphorus-Spiked Water from a Hypereutrophic Reservoir in Kentucky, USA

Journal of Environmental Protection 2021年第2期12卷 75-89页

作者： Sarah E. Hughes Jason W. marion Department of Environmental Health Science College of Health Sciences Eastern Kentucky University Richmond KY USA

Cyanobacteria may adversely impact aquatic ecosystems through oxygen depletion and cyanotoxin production. These cyanotoxins can also harm human health and livestock. In recent years, cyanobacterial blooms have been observed in several drinking water reservoirs in Kentucky, United States. In Kentucky, the paradigm is that phosphorous is the limiting nutrient for cyanobacteria growth. To explore this paradigm, an indoor microcosm study was conducted using hypereutrophic Guist Creek Lake water. Samples were collected and spiked with various combinations of locally used agricultural grade fertilizers, including ammonium nitrate, urea, and triple phosphate (calcium dihydrogen phosphate). Samples were incubated indoors for the photoperiod-specific to the time of the year. Cyanobacteria density, measured by phycocyanin, did not demonstrate increased growth with the addition of phosphate fertilizer alone. Cyanobacteria growth was enhanced in these conditions by the combined addition of ammonium nitrate, urea, and phosphorus fertilizer. Growth also occurred when using either ammonium nitrate or urea fertilizer with no additional phosphorus input, suggesting that phosphorus was not limiting the cyanobacteria at the time of sample collection. The addition of both nitrogen fertilizers (ammonium nitrate and urea) at the concentrations used in this study, in the absence of phosphorus, was deleterious to both the Chlorophyta and cyanobacteria. The results suggest further studies using more robust experimental designs are needed to explore lake-specific dual nutrient management strategies for preventing cyanobacterial blooms in this phosphorus-rich hypereutrophic lake and possibly other hypereutrophic lakes.

关键词： Nutrient Limitation Eutrophication Harmful Algal Bloom Fertilization Primary Productivity Phosphorous Loading Nitrate Loading Cyanobacteria Bloom

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Mucosal healing progression after acute colitis in mice

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World Journal of Gastroenterology 2019年第27期25卷 3572-3589页

作者： Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon marion Leclerc Francois Blachier Annaig Lan UMR PNCA AgroParisTechINRAUniversite Paris-SaclayParis 75005France UMR MICALIS INRAUniversite Paris-SaclayJouy-en-Josas 78350France

BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little *** To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced *** C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA *** The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammat

关键词： Colon luminal environment Dextran sodium sulfate-induced colitis Dysbiosis Epithelial repair Acute colitis

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Treatment options for the wet form of age-related macular degeneration--a perspective

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眼科学报：英文版 2016年第4期31卷 266-271页

作者： marion R.Munk Rene Rückert Department of Ophthalmology InselspitalUniversity Hospital BernBernSwitzerland Department of Ophthalmology Northwestern UniversityFeinberg School of MedicineChicagoILUSA Eyegnos Consulting BernSwitzerland

Treatment of the wet form of age-related macular degeneration(wet AMD) has been revolutionized a decade ago with the introduction of vascular endothelial growth factor(VEGF) blockers that reduce neovascularization and macular edema. Two approved drugs are marketed for the treatment of wet AMD—ranibizumab and aflibercept, but there is a third drug, bevacizumab, which is widely used offlabel; a cancer drug that also blocks VEGF but was never tested in pivotal trials and never approved for ophthalmic indications including wet AMD. Similarity of bevacizumab to ranibizumab led to off-label use and even to government-sponsored studies comparison the approved ranibizumab head-to-head to the offlabel cancer drug bevacizumab in wet AMD, like the Comparison of Age-related Macular Degeneration Treatments Trials(CATT) study, discussed in this perspective paper. Recent publication of 5-year follow-up from the initial 2-year CATT study provided the occasion to discuss the similarities and differences between these two drugs and the lessons learned from the last decade of anti-VEGF therapy for wet AMD. Clinical efficacy is comparable, with an advantage for ranibizumab. Likewise, safety finding favor ranibizumab over bevacizumab in some aspects. The latest addition of approved anti-VEGF drugs for wet AMD, aflibercept, may provide even more benefit to patients. In this perspective we discuss results of CATT and other longterm follow-up and comparative studies. While all demonstrate clinical benefit of anti-VEGF, all reveal that most patients' loose visual acuity(VA) in real-life situations over 5–7 years. This loss is based on—what we believe—significant under-treatment of wet AMD patients, due to economic or practical limitations and overestimation of perceived risks as geographic atrophy. We compare own data that showed more intensive treatment(more than twice the CATT-follow-up injections) with ranibizumab or aflibercept can maintain a sustained gain in VA in wet AMD patients aft

关键词：治疗头老年性黄斑变性湿型血管内皮生长因子 VEGF 抗癌药物

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Suspended Solids from Drained Peatlands in the East Coastal Zone of New Brunswick： Point Estimates and Climate Effects on the Environment

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Journal of Environmental Science and Engineering(A) 2015年第1期4卷 1-13页

作者： Mathieu Quenum marion Tetegan Papa Malick Sail Department of Peat Peatlands and Sustainable Development Coastal Zones Research Institute Shippagan E8S1J2 Canada

Peatlands represent one of the most important economic resources and abandoned peatlands after mining can be considered as ecological resources by re-vegetation restoration or management. However, some environmental problems like particles from peatlands and their effects in the water system have to be characterized. Since centuries, artificial drainage has been a current practice for the mining of peatlands. Mainly mined for horticultural purpose, New Brunswick＇s peatlands--predominantly located in the eastern of the province--cover about 140,000 ha. At the downstream end of the drainage system, the water from peatlands flow into sedimentation basins. Drainage waters are often laden with solid particles. Once they have flowed through the ponds to allow sediment settling, the water is released into the water system. This paper describes the spatio-temporal evolution of suspended solids from 12 New Brunswick drained peatlands. The studied sites were characterized by some heterogeneity in the concentration of suspended solids. This study also provides knowledge on the suspended solids amount that can be released by drained peatlands, and it proposes a function to estimate the concentration of suspended solids by using climate variables; and identifies some potential ecological risks.

关键词： Peatlands drainage sedimentation ponds suspended matters water system.

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Attractive males have faster sperm in three-spined sticklebacks Gasterosteus aculeatus

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Current Zoology 2013年第6期59卷 761-768页

作者： marion MEHLIS Lukas K. HILKE Theo C. M. BAKKER Institute for Evolutionary Biology and Ecology University of Bonn An der Immenburg 1 D-53121 Bonn Germany Department of Behavioural Ecology Institute of Ecology and Evolution University of Bern Wohlenstrasse 50a CH-3032 Hinterkappelen Switzerland

Recent studies have revealed that sexually selected traits may signal sperm quality and hence male fertilisation ability. There is also evidence that the expression of male sexual ornamentation and associated sperm characteristics depend on an indi- vidual＇s ability to cope with oxidative stress. Carotenoids are known for their antioxidant properties and carotenoid-based orna- ments might represent honest signals as these pigments can be traded offbetween the investment in sexual ornamentation, sperm function as well as immune response. In this study, we examined the relationship between sexual ornamentation （breeding colo- ration） and sperm characteristics （e.g., velocity and morphology） in the three-spined stickleback Gasterosteus aeuleatus, an ex- ternally fertilising fish species, in which sperm competition commonly occurs. During the breeding season males are sperm limi- ted and develop a conspicuous carotenoid-based coloration, which is under strong pre-copulatory sexual selection due to female mate choice and male-male competition. The results of the present study show that the expression of stickleback male breeding coloration is significantly positively associated with the linearity of sperm movement, whereas sperm morphology （head length to tail length ratio） is significantly negatively related to the trajectory of sperm movement. Moreover, there is some support for the phenotype-linked fertility hypothesis as the intensity of male red breeding coloration is significantly positively correlated with sperm velocity, which is supposed to be an important determinant of fertilisation success in external fertilisers, indicating the honesty of the sexually selected nuptial red coloration.

关键词： Mate choice Sperm competition Carotenoids Oxidative stress Reproductive success CASA ImageJ

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IT精英职场英语口语 5

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2012年

作者：司炳月（加）marion Wyse

本书分IT新人宝典、IT精英职场、IT项目开发流程专场三大部分，其内容包括：面试阶段、上班第一周、通晓办公环境等。

ISBN: (数字)9787561173503

ISBN: (纸本)9787561173503

本书分IT新人宝典、IT精英职场、IT项目开发流程专场三大部分，其内容包括：面试阶段、上班第一周、通晓办公环境等。

关键词：口语英语

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Cost-effectiveness of patient specific vs conventional instrumentation for total knee arthroplasty:A systematic review and meta-analysis

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World Journal of Orthopedics 2023年第6期14卷 458-470页

作者： Isobel M Dorling Lars Geenen marion J L F Heymans Jasper Most Bert Boonen Martijn G M Schotanus Department of Orthopaedic Surgery and Traumatology Zuyderland Medical CenterSittard-Geleen 6162 BGLimburgNetherlands Zuyderland Academy Zuyderland Medical CenterSittard-Geleen 6155 NHLimburgNetherlands School of Care and Public Health Research Institute(CAPHRI) Faculty of HealthMedicine and Life SciencesMaastricht 6229 ERLimburgNetherlands Department of Orthopaedic Surgery and Traumatology Maastricht University Medical CenterMaastricht 6229 HXLimburgNetherlands

BACKGROUND Over the past years,patient specific instrumentation(PSI)for total knee arthroplasty(TKA)has been implemented and routinely *** clear answer has been given on its associated cost and cost-effectiveness when compared to conventional instrumentation(CI)for *** To compare the cost and cost-effectiveness of PSI TKA compared to CI *** A literature search was performed in healthcare,economical healthcare,and medical databases(MEDLINE,EMBASE,CINAHL,Web of Science,Cochrane Library,EconLit).It was conducted in April 2021 and again in January *** literature included randomised controlled trials,retrospective studies,prospective studies,observational studies,and case control *** studies were assessed on methodological *** outcomes included incremental cost-effectiveness ratio,quality-adjusted life years,total costs,imaging costs,production costs,sterilization associated costs,surgery duration costs and readmission rate *** eligible studies were assessed for risk of ***-analysis was performed for outcomes with sufficient *** Thirty-two studies were included into the systematic *** were included in the metaanalysis.3994 PSI TKAs and 13267 CI TKAs were included in the sample *** methodological quality of the included studies,based on Consensus on Health Economic Criteria-scores and risk of bias,ranged from average to *** TKA costs less than CI TKA when considering mean operating room time and its associated costs and tray sterilization per patient *** TKA costs more compared to CI TKA when considering imaging and production *** total costs per patient case,PSI TKA is more expensive in comparison to CI ***-analysis comparing total costs for PSI TKA,and CI TKA showed a significant higher cost for PSI *** Cost for PSI and CI TKA can differ when considering distinct aspects of their *** costs per patient case are increased for PSI TKA whe

关键词： Total knee arthroplasty Patient specific instrumentation Instrumentation for total knee arthroplasty Cost-effectiveness Systematic review

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The Plastid Envelope CHLOROPLAST MANGANESE TRANSPORTER1 Is Essential for Manganese Homeostasis in Arabidopsis

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Molecular Plant 2018年第7期11卷 955-969页

作者： marion Eisenhut Natalie Hoecker Sidsel Birkelund Schmidt Rubek Merina Basgaran Samantha Flachbart Peter Jahns Tabea Eser Stefan Geimer Seren Husted Andreas P.M. Weber Dario Leister Anja Schneider Biochemie der Pflanzen Cluster of Excellence on Plant Science (CEPLAS) Heinrich-Heine-University Di3sseldorf 40225 Desseldorf Germany Molekularbiologie der Pflanzen (Botanik) Department Biologie I Ludwig-Maximilians-University Mernchen 82152 Martinsried Germany Department of Plant and Environmental Sciences and Copenhagen Plant Science Centre (CPSC) Faculty of Science University of Copenhagen 1871 Frederiksberg Denmark Zellbiologie/Elektronenmikroskopie NW I/B1 Universit&t Bayreuth 95447 Bayreuth Germany These authors contributed equally to this article.

The transition metal manganese （Mn） is indispensable for photoautotrophic growth since photosystem II （PSII） employs an inorganic Mn4CaOs cluster for water splitting. Here, we show that the Arabidopsis membrane protein CHLOROPLAST MANGANESE TRANSPORTER1 （CMT1） is involved in chloroplast Mn homeostasis. CMT1 is the closest homolog of the previously characterized thylakoid Mn transporter PHOTOSYNTHESIS-AFFECTED MUTANT71 （PAM71）. In contrast to PAM71, CMT1 resides at the chloro- plast envelope and is ubiquitously expressed. Nonetheless, like PAM71, the expression of CMT1 can also alleviate the Mn-sensitive phenotype of yeast mutant qomrl. The cmtl mutant is severely suppressed in growth, chloroplast ultrastructure, and PSII activity owing to a decrease in the amounts of pigments and thylakoid membrane proteins. The importance of CMT1 for chloroplast Mn homeostasis is demonstratedby the significant reduction in chloroplast Mn concentrations in cmtl-1, which exhibited reduced Mn binding in PSII complexes. Moreover, CMT1 expression is downregulated in Mn-surplus conditions. The pam71 cmtl-ldouble mutant resembles the cmtl-f single mutant rather than pare71 in most respects. Taken together, our results suggest that CMT1 mediates Mn2 uptake into the chloroplast stroma, and that CMT1 and PAM71 function sequentially in Mn delivery to PSII across the chloroplast envelope and the thylakoid membrane.

关键词： manganese transporter envelope chloroplast photosynthesis Arabidopsis

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LO-RAY-LIGH@ Diffraction Gratings in UV-VIS Spectroscopy

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Journal of Chemistry and Chemical Engineering 2013年第12期7卷 1117-1120页

作者： Uwe Oppermann marion Egelkraut-Holtus Tatsuyoshi Fujiwara Shimadzu Europa GmbI-L Duisburg D-47269 Germany Shimadzu Device Corporation Tokyo 101-8448 Japan

It has been more than half a century since the release of the first Shimadzu UV-VIS （UV-visible） spectrophotometer QB-50 in 1952, and during this time more than 160,000 UV-VIS spectrometers have been produced and installed in a wide variety of different applications. A lot of technical innovations have been implemented to improve the performance and significantly reduce the stray light levels. The latest innovation during development of sophisticated spectrophotometers is based on a new holographic exposure method and optimized etching process which has made it possible to produce both high-efficient and exceptionally low stray light gratings. These LO-RAY-LIGH~ gratings have guaranteed values of stray light at the intermediate position between zero-order and first-order lights. The values are measured by Shimadzu＇s laser stray-light-measuring system. The latest development in the series of UV-VIS spectrophotometers is the UV-2700 which is a true double beam double monochromator system in a compact design for high-precision spectral analysis of a wide range of samples including organic and inorganic compounds, biological samples, optical materials and photovoltaics. The high performance optical system is designed with ＂LO-RAY-LIGH＂ diffraction gratings, featuring highest efficiency and exceptionally low stray light. The spectrophotometer operates in the wavelength range from 185 nm to 900 nm and allows highly sophisticated applications such as direct measurement of high density samples up to 8 absorbance units without dilution.

关键词： LO-RAY-LIGH stray light diffraction grating spectrophotometer single monochromator holographic grating highefficiency double monochromator.

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Clinical spectrum of ocular manifestations in COVID-19:a case series

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Infectious Medicine 2023年第2期2卷 148-152页

作者： Souheil Zayet Ayoub Mihoubi marion Chatain Nour Sreiri Malek Bouzaien Trimech Vincent Gendrin Fatiha Benjelloun Timothée Klopfenstein Department of Infectious Diseases Nord Franche-Comte Hospital90400 TrevenansFrance Department of Ophthalmology Nord Franche-Comte Hospital90400 TrevenansFrance

In this current case series,all Coronavirus disease 2019 patients had predominant ophthalmological *** one patient sough care for concomitant respiratory *** reported herein 2 cases with cranial oculomotor nerve palsy,one patient with confirmed diagnosis of branch retinal vein occlusion,and the last one patient presenting for acute kareto-conjunctivitis with several recurrences,which was unsuccessfully treated with steroids and requiring *** case series highlights the importance of collecting a careful history of ocular presentation,including exposures to possible infected patients with *** this will lead to an early diagnosis and treatment and to make appropriate infection control measures.

关键词： SARS-CoV-2 COVID-19 Diplopia Ophtalmoplegia Neuro-ophtalmology

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