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Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1193-1208页

作者： Brigkita Venardou John VO’Doherty Shane Maher marion tryan Vivian Gath Rajeev Ravindran Claire Kiely Gaurav Rajauria Marco Garcia-Vaquero Torres Sweeney School of Veterinary Medicine University College DublinBelfield Dublin 4Ireland School of Agriculture and Food Science University College DublinBelfield Dublin 4Ireland.

Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in *** objectives of this study were to:1)evaluate the *** activity of ANE(containing 46.6%fucoidan,18.6%laminarin,10.7%mannitol,4.6%alginate)in vitro,and;2)compare the effects of dietary supplementation with ANE and Zinc oxide(ZnO)on growth performance,Salmonella shedding and selected gut parameters in naturally infected *** was established post-weaning(newly weaned pig experiment)and following regrouping of post-weaned pigs and experimental re-infection with ***(challenge experiment).Results:In the in vitro assay,increasing ANE concentrations led to a linear reduction in *** counts(P0.05).ANE supplementation decreased the Enterobacteriaceae counts compared to the *** counts were also reduced in the ZnO-residual group compared to the control(P<0.05).ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control(P<0.05).Conclusions:ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,Salmonella sh

关键词： Ascophyllum nodosum Gastrointestinal microbiota Inflammation Pig Salmonella Seaweed extract Zinc oxide

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Calibration of Modified Spalart-Ailmaras Model Parameters for Linear Compressor Cascade Corner Flow

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Journal of Thermal Science 2022年第1期31卷 163-172页

作者： MATSUI Kotaro PEREZ Ethan KELLY tryan TANI Naoki JEMCOV Aleksandar IHI Corporation Akishima 196-8686Japan Notre Dame Turbomachinery Laboratory South Bend 46601USA Department of Aerospace and Mechanical Engineering University of Notre DameNotre Dame 46556USA

In this study,Bayesian parameter calibration is applied to Saplart-Allmaras(SA)turbulence model,and the prediction improvement by the calibrated model is *** quantity of interest(QOI)is the pitch-wise distribution of Mach number in the comer separation flow *** 10 model parameters included in the SA model with Rotation-Curvature correction are considered as random variables obeying uniform prior probability *** order of generalized Polynomial Chaos(gPC)used for sensitivity analysis and surrogate model in calibration is incrementally increased during the calibration *** convergence is obtained at the 3rd order expansion level in this *** this final level,sensitivity analysis indicates 3 model parameters,cbl,k and cr3 are the most influential random variables,and 3-parameter Bayesian calibration is *** likelihood function in the Bayesian theorem is specified in the form of Gaussian distribution,including experimental *** combination of prior and likelihood brings the posterior distribution of model parameters,and Maximum A Posterior(MAP)value is selected as a calibrated parameter *** flow simulation with calibrated parameters shows a significant increase in the accuracy of the Mach number profile in the comer separation *** increase in accuracy is attributed to enlarged turbulent viscosity due to the parameter modification of the turbulent viscosity source *** calibrated parameter is also tested in the off-design flow field,not included in the calibration *** calibrated CFD again shows improved accuracy for comer separation prediction,and the effectiveness of the parameter set outside of the calibration field is demonstrated.

关键词： compressor corner flow turbulence model calibration

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