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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong university NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Temperature-insensitive micro-displacement sensor with spindle-shaped structure single mode fiber

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Optoelectronics Letters 2025年

作者： ZHANG Weihua mu Jinlin WANG Hao WANG Dong Yu Haozheng TAO Yipeng Engineering Research Center of Optoelectronic Devices and Communication Technology，Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin university of Technology Engineering Infrastructure Department，Autonomous Driving Department Xiaomi EV Company Ltd

A temperature-insensitive micro-displacement sensor based on a spindle-shaped single mode fiber (SMF) is presented and demonstrated. The SMF is bent into a balloon-shaped SMF and burned into a spindle-shaped SMF by a flame. Due to the bending of the fiber， part of the incident light leaks from the fiber core into the fiber cladding， which excites higher order cladding modes. Therefore， modal interference occurs. The experimental results show that the maximum sensitivity of the sensors is -203 pm/μm when micro-displacement varies from 0 to 80 μm. The sensors are insensitive to temperature in the range of 20-70℃. In addition， the sensors have the advantages of simple structure， low cost， small volume， high sensitivity and stability， which can be widely used in numerous high-precision industrial measurements and civil engineering structure monitoring fields.

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黑死病与奥斯曼帝国的兴起(1347-1453)

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古代文明（中英文） 2025年第1期19卷 50-58,M0004,M0005页

作者：母仕洪西南大学历史文化学院、伊朗研究中心重庆400715

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧... 详细信息

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧残加速了对外扩张进程,实现了国力的持续提升。黑死病之所以对奥斯曼帝国与敌对政权的冲击效应大相径庭,主要缘于帝国位居内陆的地理位置、游牧社会组织形式以及相对有效的防疫举措。总之,黑死病肆虐对以拜占庭帝国为主的东地中海诸政权产生了严重负面效应,一定程度上为奥斯曼早期扩张铺平了道路,成为促进帝国兴起不可忽视的重要因素。

关键词：黑死病奥斯曼帝国拜占庭帝国瘟疫大流行

Narrow versus broad:sexual dimorphism in the wing form of western European species of the subgenus Avaritia(Culicoides,Ceratopogonidae)

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Integrative Zoology 2021年第5期16卷 769-784页

作者： Francesc muÑOZ-muÑOZ Nonito PAGÈS Ana.F.DuRAO marion ENGLAND Doreen WERNER Sandra TALAVERA Departament de Biologia Animal de Biologia Vegetal i d’EcologiaFacultat de BiociènciesUniversitat Autònoma de BarcelonaBarcelonaSpain Centre de Recerca en Sanitat Animal(CReSA) UAB-IRTACampus de la Universitat Autònoma de BarcelonaBarcelonaSpain CIRAD UMR ASTREGuadeloupeFrance ASTRE CIRADINRAeUniversitéde MontpellierMontpellierFrance The Pirbright Institute SurreyUK Leibniz-Centre for Agricultural Landscape Research MünchebergGermany

While wing form is known to differ between males and females of the genus Culicoides,detailed studies of sexual dimorphism are *** this study,we analyze sex-specific differences in the wing form of 5 species of the subgenus Avaritia,using geometric morphometrics and comparative phylogenetic *** results confirm the existence of marked sexual dimorphism in the wing form of the studied species and reveal for the first time that while there is a shared general pattern of sexual shape dimorphism within the subgenus,sexual size dimorphism,and particular features of sexual shape dimorphism differ among *** shape dimorphism was found to be poorly associated to size and the evolutionary history of the *** tight association of sexual shape dimorphism with aspect ratio suggests that the shape of the wing is optimized for the type of flight of each sex,that is,dispersal flight in females versus aerobatic flight in ***,the fact that interspecific shape differences are greater and more strongly associated to aspect ratio in males than in females might be indicating that in males the selective pressures affecting flight performance characteristics are more heterogeneous and/or stronger than in females among the studied species.

关键词： aspect ratio geometric morphometrics phylogenetic signal shape size

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Surface characteristics of HA coated Ti-Hf binary alloys after nanotube formation

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中国有色金属学会会刊：英文版 2009年第4期19卷 852-856页

作者： Yong-Hoon JEONG Won-gi KIM Geun-Hyeong PARK Han-Cheol CHOE Yeong-mu KO Department of Dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University Research Center for Oral Disease Regulation of the Aged College of DentistryChosun University

Ti-Hf binary alloys contained 10%,20%,30% and 40%(mass fraction)Hf were manufactured in the vacuum furnace *** then,specimens were homogenized for 24 h at 1 000 ℃ in argon *** formation of oxide nanotubes was conducted by anodic oxidation on the Ti-Hf alloy in 1 mol/L H3PO4 electrolytes containing small amounts of NaF at room *** hydroxyapatite(HA) coating made of tooth ash prepared by electron-beam physical vapor deposition(EB-PVD) *** corrosion behaviors of the specimens were examined through potentiodynamic test in 0.9% NaCl solution by *** microstructures of the alloys were examined by field emission scanning electron microscopy(FE-SEM) and x-ray diffractometer(XRD).It was observed that the lamellar structure translated to needle-like structure with Hf *** formed and HA coated Ti-xHf alloys had a good corrosion resistance.

关键词：二元合金 HA涂层纳米管表面特性管形 0.9%NaCl溶液物理气相沉积铪

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轨道交通钢混组合连续梁及剪力件设计探讨

价值工程 2025年第1期44卷 71-73页

作者：李牧中铁上海设计院集团有限公司上海200040

由于钢混组合梁结构可以充分发挥混凝土和钢结构的性能优势,因此在轨道交通桥梁设计中逐步得到推广。目前对于轨道交通组合梁上部结构构造设计及计算参考较少,不同设计标准、规范针对剪力件的计算仍存在区别,因此有必要对上述问题进行... 详细信息

由于钢混组合梁结构可以充分发挥混凝土和钢结构的性能优势,因此在轨道交通桥梁设计中逐步得到推广。目前对于轨道交通组合梁上部结构构造设计及计算参考较少,不同设计标准、规范针对剪力件的计算仍存在区别,因此有必要对上述问题进行分析探讨。本文结合国内某轨道交通项目(45+70+45)m钢混组合连续梁的设计,通过有限元软件建模计算,分析钢混组合梁的受力特点,并针对国内外不同规范对于钢混组合梁剪力件的抗剪承载力计算公式进行比较及探讨,以期为同类型桥梁设计计算提供一定参考。

关键词：轨道交通桥梁钢混组合连续梁剪力连接件焊钉结构分析

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