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SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 129-146页

作者： Jes-Niels Boeckel Maximilian Mobius-Winkler marion Muller Sabine Rebs Nicole Eger Laura Schoppe Rewati Tappu Karoline E.Kokot Jasmin M.Kneuer Susanne Gaul Diana M.Bordalo Alan Lai Jan Haas Mahsa Ghanbari Philipp Drewe-Boss Martin Liss Hugo A.Katus Uwe Ohler Michael Gotthardt Ulrich Laufs Katrin Streckfuss-Bomeke Benjamin Meder Department of Cardiology Angiology and PneumologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany Klinik und Poliklinik fur Kardiologie Universitatskrankenhaus LeipzigD-04103 LeipzigGermany German Center for Cardiovascular Research(DZHK) Partner site HeidelbergD-69120 HeidelbergGermany Clinic for General and Interventional Cardiology/Angiology Herz-und Diabeteszentrum NRWRuhr-Universitat BochumD-32545 Bad OeynhausenGermany Department of Cardiology and Pneumology University HospitalGeorg-August University GoettingenD-37075 GoettingenGermany German Center for Cardiovascular Research(DZHK) Partner site GoettingenD-37075 GoettingenGermany Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-10115 BerlinGermany Institute of Biology Humboldt Universitat zu BerlinD-10099 BerlinGermany Neuromuscular and Cardiovascular Cell Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-13092 BerlinGermany German Center for Cardiovascular Research(DZHK) Partner site BerlinD-10117 BerlinGermany Stanford Genome Technology Center Department of GeneticsStanford Medical SchoolPalo AltoCA 94304USA

Alternative mRNA splicing is a fundamental process to increase the versatility of the *** humans,cardiac mRNA splicing is involved in the pathophysiology of heart *** in the splicing factor RNA binding motif protein 20(RBM20) cause severe forms of *** identify novel cardiomyopathy-associated splicing factors,RNA-seq and tissue-enrichment analyses were performed,which identified up-regulated expression of Sam68-Like mammalian protein 2(SLM2) in the left ventricle of dilated cardiomyopathy(DCM) *** the human heart,SLM2 binds to important transcripts of sarcomere constituents,such as those encoding myosin light chain2(MYL2),troponin 13(TNNI3),troponin T2(TNNT2),tropomyosin 1/2(TPM1/2),and titin(TTN).Mechanistically,SLM2 mediates intron retention,prevents exon exclusion,and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-,glutamate-,valine-,and lysine-rich(PEVK) domain and another part of the I-band region of *** summary,SLM2 is a novel cardiac splicing regulator with essential functions for maintaining cardiomyocyte integrity by binding to and processing the mRNAs of essential cardiac constituents such as titin.

关键词： Splicing Titin Dilated cardiomyopathy KHDRBS3 SLM2

Inverted Apical CD24 and Weak EZH2 Expressions Are Phenotypic Characteristics of Pure Invasive Micropapillary Carcinoma of the Breast

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Open Journal of Pathology 2013年第2期3卷 85-95页

作者： Nadège Gruel Aurélie Cédenot marion Richardson Paul Fréneaux Jaydutt Bhalshankar Thierry Dubois Xavier Sastre-Garau Olivier Delattre Anne Vincent-Salomon INSERM Unit 830 Institut Curie Paris France

Invasive micropapillary carcinomas (IMPC) of the breast account for less than 2% of all breast cancers and have been recently described as luminal B carcinomas. CD24, CD44, ALDH1 and EZH2 are commonly used as stem-cell markers that display differential expression as a function of stage and molecular type, but their pattern of expression according to this rare histological type remains poorly defined and unknown for EZH2. We assessed expression of these markers in a series of 28 micropapillary breast carcinomas and compared the results with those obtained in a series of luminal A (27 cases) and B (34 cases) invasive carcinomas not otherwise specified (IC-NST). CD24 and CD44 were expressed in most cases. However, CD24 was expressed at the inverted apical membrane in 85% of invasive micropapillary carcinoma and at the apical pole of gland-forming cells in 45% of luminal A (p-val = 6.8 × 10-4) and 13% of luminal B cases (p-val = 1.1 × 10-7). ALDH1 was expressed in the stroma in most tumors, but in only 25%, 11% and 15% in epithelial cells of IMPC, luminal A and B IC-NST, respectively. Nuclear expression of EZH2 was not observed in luminal A tumors, and was detected in 35% (12/34) of luminal B carcinomas (p-val = 6.1 × 10-3) and only 4% (1/28) of invasive micropapillary carcinomas. This series shows that invasive micropapillary carcinomas harbor a CD24-positive inverted apical pole associated with weak EZH2 expression, phenotypical characteristics that distinguish this entity from other luminal carcinomas.

关键词： CD44 CD24 ALDH1 EZH2 Invasive Micropapillary Breast Carcinoma

Does food addiction distinguish a specific subgroup of overweight/obese overeating women?

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Health 2012年第12期4卷 1492-1499页

作者： Catherine Bégin Marie-ève St-Louis Sophie Turmel Béatrice Tousignant Louis-Philippe marion Francine Ferland Nadine Blanchette-Martin Marie-Pierre Gagnon-Girouard Rehabilitation Center for Dependency Quebec City Canada School of Psychology Laval University Quebec Canada

Neurophysiological and behavioral similarities have been evidenced between excessive food consumption leading to obesity and addiction to other substances. In accordance, food addiction was defined following the DSM-IV diagnostic criteria for substance dependence. The aim of this pilot study was to identify a subgroup of women suffering from food addiction (n = 11), and to compare them to women suffering from substance-use disorder (n = 23), and to women seeking treatment for compulsive overeating but free from food addiction (n = 12) on addiction-related characteristics (reward sensitivity, impulsivity, personality traits, depression, emotion dysregulation). We hypothesized that women with food addiction would be similar to women with substance-use disorders, and different from women with compulsive overeating without food addiction. Participants completed self-reported questionnaires assessing food addiction and other variables related to addiction. Almost half (47.8%) of women with compulsive overeating fulfilled the criteria for food addiction. Although food addiction does not account for every case of compulsive overeating, it characterizes a specific subgroup of overweight/obese women who show more severe overeating. Women with food addiction seem to be more similar to women suffering from substance-use disorders than to other women with overeating difficulties, particularly regarding impulsivity and self-directedness.

关键词： Food addiction Compulsive Overeating Binge Eating Addiction

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牙周状况不良患者的复杂修复治疗

中国口腔医学继续教育杂志 2009年第2期12卷 25-32页

作者： marion E. Kreissl Dr med dent 曹烨（译）姜婷（审）不详北京大学口腔医学院修复科 100081

这是一个系列报道的第二部分．围绕1例牙周存在严重问题的女性患者的修复重建进行讨论。在第一部分中．已经讨论了诊断和治疗计划。而在第二部分中，将根据以往研究的结果提出具体治疗方法并进行详细的讨论。主要讨论3个比较复杂的部位... 详细信息

这是一个系列报道的第二部分．围绕1例牙周存在严重问题的女性患者的修复重建进行讨论。在第一部分中．已经讨论了诊断和治疗计划。而在第二部分中，将根据以往研究的结果提出具体治疗方法并进行详细的讨论。主要讨论3个比较复杂的部位的治疗方法：上颌前部、上颌后部以及下颌前部。最后展示最终的修复效果，并且与修复前的情况进行对比。

关键词：牙周状况修复治疗治疗方法修复重建女性患者治疗计划上颌前部上颌后部

Effect of Microwave Power on the Zn2SnO4 Synthesis and Its Use for Photodegradation of Phenol

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Journal of Chemistry and Chemical Engineering 2014年第8期8卷 794-799页

作者： Edson Luiz Foletto Marcio Antonio Mazutti Adriano Cancelier Erico marion de Moraes Flores Edson Irineu Muller Leticia Severo Fagundes Pereira Osvaldo Chiavone-Filho Andre Gundel Department of Chemical Engineering Federal University of Santa Maria Santa Maria 97105-900 Brazil Department of Chemistry. Federal University of Santa Maria Santa Maria 97105-900 Brazil Department of Chemical Engineering Federal University of Rio Grande do Norte Natal 59066-800 Brazil Department of Physics Federal University of Pampa Bage 96413-170 Brazil

Spinel structure Zn2SnO4 was successfully synthesized by microwave-assisted hydrothermal process. The effects of the microwave power on the formation and physical properties of the Zn2SnO4 particles are discussed. The products were characterized by X-ray diffraction, atomic force microscopy, infrared spectroscopy, and N2 adsorption. The results indicated that the microwave power had important influence on the formation of the spinel phase. The results also revealed that the physical properties of Zn2SnO4 particles did not change with the increase of the microwave power above 600 W, with 20 min of reaction time. Furthermore, the photocatalytic activity of the Zn2SnO4 particles for the phenol degradation under sunlight was also investigated.

关键词： Zn2SnO4 zinc stannate synthesis microwave porous material photocatalysis.

Aims and First Assessments of the French Hydrogen Pathways Project HyFrance3

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Journal of Energy and Power Engineering 2012年第1期6卷 34-40页

作者： Alain Le Duigou Marie-Marguerite Quemere Pierre marion Philippe Menanteau Pascal Houel LaureSinegre Lionel Nadau Aline Rastetter Aude Cuni Philippe Mulard Loic Antoine Thierry Alleau I-Tese CEA Gif-Sur-Yvette Cedex 91191 France Departement EPI-ECUELLES EDF R＆D Moret Sur Loing Cedex 77818 France IFP Energies nouvelles 1 et 4 avenue de Bois Preau Rueil Malmaison Cedex 92852 France LEPII Universit# de Grenoble - CNRS Grenoble Cedex 9 BP 47 38040 France DRI GDF SUEZ 361 av du pdt WILSON Saint Denis La Plaine Cedex BP 33 93211 France ALPHEA EURODEV CENTER 4 rue Jules Verne Eurozone Forbach 57600 France AIR LIQUIDE 1 chemin de la porte des loges Jouy-en-Josas BP 126 78354 France TOTAL RAFFINAGE MARKETING La Defense 10 Paris la Defense Cedex 92069 France ADEME 20 avenue du Gresille Angers Cedex 01 BP 90406 49004 France AFH2 28 rue Saint Dominique Paris 75007 France

The HyFrance Group was originally formed in France to support the European project HyWays, by providing （former projects HyFrancel and HyFrance2） the French data and possible hydrogen pathways according to national specificities. HyFrance3 is a new project that focuses on the economic competitiveness of different steps of the hydrogen chain, from the production to end usage, at the time horizon of 2030 in France. The project is coordinated by CEA with the other partners being： ADEME （co-funding）, AFH2, CNRS, IFP, Air Liquide, EdF, GdF Suez, TOTAL, ALPHEA. The project is divided into 4 sub-projects, that address present and future French hydrogen industrial markets for chemical ＆ refinery uses, the analysis of the interplay between wind energy production and storage of hydrogen for different automotive requirements （refuelling stations, BtL plants, H2/NG mix）, massive hydrogen storage to balance various offer and demand characteristics, and the supply network （pipeline option competitiveness vs. trucked in supply） to distribute hydrogen in a French region for automotive applications. Technical and economical issues, as well as GHG emissions, are addressed.

关键词： HyFrance hydrogen industrial techno-economy storage wind energy infrastructure.

Bat pluripotent stem cells reveal unusual entanglement between host and viruses

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四川生理科学杂志 2023年第3期45卷 259-259页

作者： marion Déjosez 不详

Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However,there are currently no reliable cellular models for studying bat biology or their response to viral infections. Here, we createdinduced pluripotent stem cells (iPSCs) from two species of bats: the wild greater horseshoe bat (Rhinolophus ferrumequinum) andthe greater mouse-eared bat (Myotis myotis). The iPSCs from both bat species showed similar characteristics and had a geneexpression profile resembling that of cells attacked by viruses. They also had a high number of endogenous viral sequences,particularly retroviruses. These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences andmay have a more intertwined relationship with viruses than previously thought. Further study of bat iPSCs and their differentiatedprogeny will provide insights into bat biology, virus host relationships, and the molecular basis of bats' special traits.

关键词： endogenous unusual viruses

优化施肥和传统施肥对夏玉米生长发育及产量的影响

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玉米科学 2003年第3期11卷 90-93,97页

作者：李志勇王璞 marion Boening-Zilkens W.Claupein 河南科技大学农学院河南洛阳471003 中国农业大学北京100094 德国霍恩海姆大学

中国农业大学和德国霍恩海姆大学(HohenheimUniversityofGermany)中德合作项目“华北平原作物高产高生产力条件下环境可承受的持续农业研究”2000～2001年度北京试验基地研究结果的一部分。试验结果表明,优化施肥和秸秆还田优化施肥夏... 详细信息

中国农业大学和德国霍恩海姆大学(HohenheimUniversityofGermany)中德合作项目“华北平原作物高产高生产力条件下环境可承受的持续农业研究”2000～2001年度北京试验基地研究结果的一部分。试验结果表明,优化施肥和秸秆还田优化施肥夏玉米株高、基部节间直径、同一时期叶面积指数、干物质积累量、穗部基本性状,如穗长、穗粗、秃尖长、产量结构及产量与传统施肥无显著性差异,而氮肥利用率显著提高。在优化施肥条件下,夏玉米棒三叶总叶面积略微减少,生育后期穗位叶叶绿素含量下降稍快,吐丝至收获干物质积累量略有下降。秸秆还田有利于改善夏玉米的生育状况和提高产量。

关键词：施肥夏玉米生长发育产量影响因素株高节间生长节间顺序收获

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上海德国、法国联合学校新校舍

世界建筑 2006年第8期 114-120页

作者：玛丽昂·海特普拉茨翟宇彤(译) 德国“建筑品”事务不详

上海德国，法国联合学校的新校址位于上海市西区，毗临虹桥国际机场。在基地的北面和西面有江南典型的河道，东面目前还保留着工厂厂区。幼儿园与学校的两个主要入口布置在临街的建筑体内。学校的中心（室内广场）以及音乐室，戏剧排练... 详细信息

上海德国，法国联合学校的新校址位于上海市西区，毗临虹桥国际机场。在基地的北面和西面有江南典型的河道，东面目前还保留着工厂厂区。幼儿园与学校的两个主要入口布置在临街的建筑体内。学校的中心（室内广场）以及音乐室，戏剧排练室也集中布置在这一建筑体中，从这一条状建筑起以鱼骨形并列布置了幼儿园，小学以及中学这3个主要部分。

关键词：上海市学校德国法国校舍集中布置国际机场幼儿园