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Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma

World Journal of Gastroenterology 2004年第4期10卷 598-601页

作者： RinaldoPellicano mariorizzetto AntonioPonzetto Vincenzo Mazzaferro Walter Franco Grigioni MiguelAngelCutufia SharmilaFagoonee LorenzoSilengo Department of Gastro-Hepatology Ospedale S. Giovanni Battista(Molinette)TorinoItaly Surgery and Liver Transplantation Centre Istituto Nazionale dei TumoriMilanoItaly Department of Pathology Istituto AddariiBolognaItaly Department of Biology Biochemistry and GeneticsUniversity of TodnoItaly

AIM:Only a minority of patients carrying a defined viral aetiologic agent develop cirrhosis and ultimately hepatocellular carcinoma(HCC),the mechanism underlying the worsening is still *** infection by Helicobacter hepaticus in mice causes chronic hepatitis and HCC and recently,more Helicobacterspecies(Helicobacter spp.)have been detected in the liver of patients suffering from cholestatic diseases and HCC arising from non-cirrhotic *** investigated whether *** could be detected in the liver of patients with cirrhosis and HCC compared to subjects with metastasis to liver from colon cancer. METHODS:Twenty-three liver samples from patients operated upon for HCC superimposed on hepatitis C virus (HCV)-related cirrhosis and 6 from patients with resected metastases from colorectal cancer,were tested by polymerase chain reaction for presence of genomic 16S rRNA of Helicobacter genus using specific *** sequencing and cag A gene analysis were also performed. RESULTS:Genornic sequences of Helicobacter *** found in 17 of 20(85%)liver samples from patients with HCC and in 2 of 6 samples from patients with liver metastasis. In three samples of the first group the result was uncertain. Hpyloriwas revealed in 16 out of 17 positive samples and Helicobacter pullorum in the other. CONCLUSION:Helicobacter spp.,carcinogenic in mice, were found at a higher frequency in the liver of patients with HCV-related cirrhosis and HCC than those in patients without primary liver disease.

关键词： Carcinoma, Hepatocellular Colonic Neoplasms DNA, Bacterial Helicobacter Infections Helicobacter pylori purification Humans Liver Cirrhosis Liver Neoplasms Research Support, Non-U.S. Gov't

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