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微藻EPA和DHA的研究现状及前景

水产学报 2000年第3期24卷 289-296页

作者：梁英麦康森青岛海洋大学水产学院!山东青岛266003

高度不饱和脂肪酸(PUFA)在营养和医学上的重要作用,已引起人们广泛的兴趣,特别是二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)两者对防治心脏疾病、动脉硬化、癌症、风湿关节炎、气喘和糖尿病等人类疾病有明显效果[1～3],已成为研究开发的热... 详细信息

高度不饱和脂肪酸(PUFA)在营养和医学上的重要作用,已引起人们广泛的兴趣,特别是二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)两者对防治心脏疾病、动脉硬化、癌症、风湿关节炎、气喘和糖尿病等人类疾病有明显效果[1～3],已成为研究开发的热点.在水产上,EPA和DHA是许多鱼类幼体、对虾幼体、双壳类幼虫的必需脂肪酸,关系到幼虫和幼体的生长发育和存活.EPA和DHA虽然对有些动物不是必需的,但在饵料中适当添加这些物质,可提高投喂动物的生长速度和存活率[4～6].目前国内外对微藻中的EPA和DHA已进行了大量研究,取得了不少成就.

关键词：微藻二十碳五烯酸二十二碳六烯酸

Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

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Science China(Life Sciences) 2016年第4期59卷 340-348页

作者： Bing-Lan Zhang Di-Yuan Qin Ze-Ming mo Yi Li Wei Wei Yong-Sheng Wang Wei Wang Yu-Quan Wei State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Department of Emergency West China Hospital Sichuan University

Recent reports on the impressive efficacy of chimeric antigen receptor(CAR)-modified T cells against hematologic malignancies have inspired oncologists to extend these efforts for the treatment of solid tumors. Clinical trials of CAR-T-based cancer immunotherapy for solid tumors showed that the efficacies are not as remarkable as in the case of hematologic malignancies. There are several challenges that researchers must face when treating solid cancers with CAR-T cells, these include choosing an ideal target, promoting efficient trafficking and infiltration, overcoming the immunosuppressive microenvironment, and avoiding associated toxicity. In this review, we discuss the obstacles imposed by solid tumors on CAR-T cell-based immunotherapy and strategies adopted to improve the therapeutic potential of this approach. continued investigations are necessary to improve therapeutic outcomes and decrease the adverse effects of CAR-T cell therapy in patients with solid malignancies in the future.

关键词： chimeric antigen receptor T cells solid tumors

青少年近视患者配戴角膜塑形镜引起角膜感染的影响因素分析

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中国社区医师 2024年第11期40卷 60-62页

作者：吴雁玲莫垸湘张婷婷扶城宾赵禾苗东莞爱尔眼科医院广东东莞523000

目的:分析青少年近视患者配戴角膜塑形镜引起角膜感染的影响因素。方法:选取2022年8月-2023年12月于东莞爱尔眼科医院配戴角膜塑形镜的青少年近视患者1 600例作为研究对象。收集患者资料,分析青少年近视患者配戴角膜塑形镜引起角膜感染... 详细信息

目的:分析青少年近视患者配戴角膜塑形镜引起角膜感染的影响因素。方法:选取2022年8月-2023年12月于东莞爱尔眼科医院配戴角膜塑形镜的青少年近视患者1 600例作为研究对象。收集患者资料,分析青少年近视患者配戴角膜塑形镜引起角膜感染影响因素。结果:1 600例青少年近视患者中,发生感染20例。根据配戴期间是否发生角膜感染分别纳入感染组(n=20)和未感染组(n=1 580)。感染组住校、父母文化程度中等、配戴卫生情况差、护理液更换时间>2 d、手指甲修剪时间>1周、洗手不规范、未定期复查占比高于未感染组,差异有统计学意义(P0.05)。住校、父母文化程度中等、配戴卫生情况差、护理液更换时间>2 d、手指甲修剪时间>1周、洗手不规范、未定期复查是青少年近视患者配戴角膜塑形镜引起角膜感染的独立危险因素(P0.05)。结论:青少年近视患者配戴角膜塑形镜存在一定感染风险,临床需根据危险因素采取针对性的应对措施。

关键词：青少年角膜塑形镜感染

Glycosylation on proteins of the intestine and perimicrovillar membrane of Triatoma (Meccus) pallidipennis, under different feeding conditions

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Insect Science 2019年第5期26卷 796-808页

作者： Ana E.Gutierrez-Cabrera Wesley F.Zandberg Edgar Zenteno mario H.Rodriguez Bertha Espinoza Carl Lowenberger coNACyT-Centro de Investigacion Sobre Enfermedades Infecciosas Instituto Nacional de Salud PublicaCuernavacaMorelosMexico Department of Chemistry Simon Fraser UniversityBurnabyBCCanada Department of Chemistry The University of British Columbia OkanaganKelownaBCCanada Facultad de Medicina Departamento de BioquimicaUniversidad Nacional Autdmoma de Mexico Mexico CityDFMexico Centro de Investigacion Sobre Enfermedades Infecciosas Instituto Nacional de Salud PublicaCuernavaca MorelosMexico Departamento de Inmunologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de Mexico Ciudad UniversitariaMexico CityDFMexico Department of Biological Sciences Simon Fraser UniversityBurnabyBCCanada

Trypanosoma cruzi,the causative agent of Chagas disease, interacts with molecules in the midgut of its insect vector to multiply and reach the infective stage. Many studies suggest that the parasite binds to midgut-specific glycans. We identified several glycoproteins expressed in the intestine and perimicrovillar membrane (PMM) of Triatoma (Meccus) pallidipennis under different feeding conditions. In order to assess changes in protein-linked glycans, we performed lectin and immunoblot analyses on glycoprotein extracts from these intestinal tissues using well-characterized lectins, and an antibody, which collectively recognize a wide range of different glycans epitopes. We observed that the amount and composition of proteins and glycoproteins associated with different glycans structures changed over time in the intestines and PMM under different physiological conditions. PMM extracts contained a wide variety of glycoproteins with different sugar residues, including abundant high-mannose and complex sialylated glycans. We propose that these molecules could be involved in the process of parasite-vector interactions.

关键词： feeding conditions glycoproteins lectins perimicrovillar membrane triatomine vector-parasite interactions

Effects of hypokalemia on transmural dispersion of ventricular repolarization in left ventricular myocardium

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Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 485-488页

作者： Jiang-Hua Zhong Shi-Juan Lu mo-Shui Chen Zi-Bin Chen Liu Wang Ping-Sheng Wu Department of Cardiology Affiliated South Hospital of South Medical University Department of Cardiology Haikou People's Hospital

Objective:To observe effects of hypokalemia on transmural heterogeneity of ventricular repolarization in left ventricular myocardium of rabbit,and explore the role of hypokalemia in malignant ventricular arrhythmia（MVA）.Methods:A total of 20 rabbits were randomly divided into control group and hypokalemic *** hearts in the control group were simply perfused with modified Tyrode’s solution,and were perfused with hypokalemic Tyrode’s solution in hypokalemic *** fibrillation threshold（VFT）,90%monophasic action potential repolarization duration(APD90) of subepicardial,midmyocardial and subendocardial myocardium,transmural dispersion of repolarization（TDR） and Cx43 protein expression in three layers of myocardium were measured in both ***:VFT in the control group and the hypokalemic group were（13.40±2.95） V,and（7.00±1.49） V,*** was a significant difference between two groups（P90 of three myocardial layers in the hypokalemic group were significantly prolonged than those in the control group（/’90in the hypokalemic group and the control group were（38.10±10\29） ms and（23.7015.68） ms,and TDR were（52.90r 14.55） ms and（36.10±12.44） ms,respectively.△APD90 and TDR in the hypokalemic group were significantly higher than those in the control group(P90 of midmyocardium was more significant in the hypokalemic ***43 protein expression of all three myocardial layers were decreased significantly in the hypokalemic group（P90 was significantly increased {Pmore significant in the ***:Hypokalemic can increase transmural heterogeneity of Cx43 expression and repolarization in left ventricular myocardium of rabbit,and decrease VFT and can induce MVA more easily.

关键词： Hypokalemia Gap junction Repolarization heterogeneity Midmyocardium

河北省《民用建筑节能工程施工质量验收标准》修订及编制要点

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建设科技 2024年第1期 18-21页

作者：李永刘伟斌庄炜赵彦彦李沫刘建林河北省建筑科学研究院有限公司石家庄050000 河北建研工程技术有限公司石家庄050227 青县住房和城乡建设局青县062650

阐述了目前国内和河北省节能设计标准的现状,包括该标准的制定背景、编写思路和重点。该标准与我国现行标准《建筑节能工程施工质量验收标准》GB 50411、《建筑节能与可再生能源利用通用规范》GB 55015、河北省《超低能耗居住建筑节能... 详细信息

阐述了目前国内和河北省节能设计标准的现状,包括该标准的制定背景、编写思路和重点。该标准与我国现行标准《建筑节能工程施工质量验收标准》GB 50411、《建筑节能与可再生能源利用通用规范》GB 55015、河北省《超低能耗居住建筑节能设计标准》DB13(J)/T 8506-2022和河北省《超低能耗公共建筑节能设计标准》DB13(J)/T 8503-2022相协调。

关键词：建筑节能工程验收保温结构一体化

Transcriptome changes in seeds during coleorhiza hair formation in rice

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The Crop Journal 2022年第3期10卷 692-703页

作者： Tao Song ANMRubaiyath Bin Rahman Debatosh Das Neng-Hui Ye Feng Yang Fu-Yuan Zhu mo-Xian Chen Jian-Hua Zhang co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037JiangsuChina Shenzhen Research Institute The Chinese University of Hong Kon6Shenzhen 518057Guangdon6China Southern Regional collaborative Innovation Center for Grain and Oil Crops in China College of AgricultureHunan Agricultural UniversityChangsha 410128HunanChina Department of Biology Hong Kong Baptist UniversityKowloon 999077Hong Kon6China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055Guangdon6China School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kon6Shatin 999077Hong Kon6China

coleorhiza hairs are hairlike structures in seeds of the grass family(Poaceae).The molecular mechanisms underlying its formation are largely unknown,study on this topic will expand our understanding of the effects of water status on germination during rice(Oryza sativa L.)direct *** of Nipponbare were treated under two water conditions:in one,half of the seed surface was immersed in water and the other half was embryo side in air(EIA),and in the other,the whole seed was covered by water(CBW).coleorhiza hairs formed only in EIA *** was used to identify the gene regulation during coleorhiza hair formation in EIA(***)embryos and *** displayed more transcriptome modulation even though smaller in size than the *** expressed genes(DEGs)were enriched in both primary and secondary metabolism and showed changes in abscisic acid,auxin,jasmonic acid,and salicylic acid *** enrichment data were positively correlated with gene expression changes in the affected metabolic functional *** presence of shorter coleorhiza hairs in an Os RHL1(Os06 g0184000,a coleorhiza hair formation regulation candidate gene)knockout mutant suggested that root hair-associated DEGs share molecular regulators that control the formation of coleorhiza hairs.

关键词： Embryo Endosperm Transcriptomics Metabolomics Hormone coleorhiza hair

不同混交比例桉树—红锥混交林对林下植被和土壤肥力的影响研究

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林业与环境科学 2024年第4期40卷 70-79页

作者：朱琪邓海燕马安琪申琳琳丁晓纲莫晓勇华南农业大学林学与风景园林学院广东广州510642 广东省林业科学研究院广东广州510520 广东省林业调查规划院广东广州510520

为探究不同混交比例的桉树Eucalyptus robusta、红锥Castanopsis hystrx混交林对土壤肥力和林下植被多样性的影响,以广东省廉江市石岭林场4种混交比例的桉树—红锥混交林(桉树为华桉一号,红锥为当年生盆栽实生苗)为研究对象,通过野外调... 详细信息

为探究不同混交比例的桉树Eucalyptus robusta、红锥Castanopsis hystrx混交林对土壤肥力和林下植被多样性的影响,以广东省廉江市石岭林场4种混交比例的桉树—红锥混交林(桉树为华桉一号,红锥为当年生盆栽实生苗)为研究对象,通过野外调查、取样、分析以及综合比较,对不同混交比例下的桉树—红锥混交林的土壤理化性质、林下植被组成和植物多样性进行分析。结果表明,桉树—红锥5∶1混交林林下灌木和草本植物最多,1∶1混交林林下灌木物种组成最少,3∶3混交林林下草本物种组成最少。4种桉树—红锥混交林林下植被Patrick丰富度指数存在显著差异(P0.05),表现为5∶1混交林显著高于3∶3混交林。3∶1混交林林地的土壤最大持水量最大,其次为5∶1混交林;3∶1混交林的土壤最大持水量在0~20 cm,20~40 cm,40~60 cm,3个土层均显著高于1∶1混交林,在20~60 cm土层均显著高于3∶3混交林;5∶1混交林林地的最大持水量仅在0~20 cm土层显著高于1∶1混交林,在20~40 cm土层显著高于3∶3混交林。桉树—红锥混交林林下植被的Simpson多样性指数在5∶1混交林和1∶1混交林与全磷含量显著负相关;Shannon-Wiener变化度指数在3∶3混交林与全磷含量显著负相关,在1∶1混交林与全磷含量显著负相关;Patrick丰富度指数在3∶3混交林与土壤非毛管孔隙度显著正相关,在3∶3混交林与全氮含量显著负相关;Pielou均匀度指数在3∶1混交林与土壤非毛管孔隙度和土壤通气度均显著负相关,在5∶1混交林与与全磷含量显著正相关。综上所述,5∶1混交比例更适合林下植物的生长,但1∶1的混交比例更适合土壤肥力的保存。

关键词：林下植被土壤肥力混交桉树

Non-contact biomimetic mechanism for selective hydrogenation of nitroaromatics on heterogeneous metal nanocatalysts

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Science China Chemistry 2022年第4期65卷 726-732页

作者： Wenting Zhou Laiyang Li Ruixuan Qin Jiaxin Zhu Shengjie Liu Shiguang mo Zaifa Shi Huihuang Fang Pengpeng Ruan Jun Cheng Gang Fu Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

While the enzymatic reduction of unsaturated compounds usually has high specificity,highly selective reduction processes are hardly realized by heterogeneous industrial catalysts,which is critical for the green production of many fine ***,we report an unexpected discovery of a biomimetic behavior of dicyandiamide(DICY)-modified Pt nanocatalysts for the green hydrogenation of a wide range of *** demonstrate that the surface modification by DICY not only prevents the direct contact of nitroaromatic reactants with Pt surface but also induces an effective non-contact hydrogenation mechanism mediated by protons and *** such a process,the DICY layer serves as a“semi-permeable membrane”to allow the permeation of H_(2) molecules for being activated into electrons and protons at the Pt-DICY *** the generation of separated protons and electrons,the nitro group with strong electrophilic properties can be hydrogenated through the electron transfer followed by the proton transfer,which is facilitated by the hydrogen bonding network formed by protonated *** unique mechanism makes it highly directional toward the hydrogenation of nitro groups without side *** to its capability to largely eliminate the waste generation,the developed Pt-DICY catalysts have been successfully applied for the green industrial production of many important aniline intermediates.

关键词： hydrogenation catalysis nitroaromatics proton/electron separation non-contact hydrogenation biomimetic mechanism