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Combinatorial therapies for spinal cord inj.ry repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord inj.ries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord inj.ry recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord inj.ry pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord inj.ry pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord inj.ry

Taurine:an essential amino sulfonic acid for retinal health

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Neural Regeneration Research 2023年第4期18卷 807-808页

作者： j.hnny Di pierdomenico Ana martínez-Vacas Serge picaud maría p.Villegas-pérez Diego García-Ayuso Departamento de Oftalmología Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria Hospital Virgen de la Arrixaca(IMIB-Virgen de la Arrixaca)MurciaSpain(Di Pierdomenico JMartínez-Vacas AVillegas-Pérez MPGarcía-Ayuso D)INSERMCNRSInstitut de la VisionSorbonne UniversitéParisFrance(Picaud S)

Taurine(2-amino-ethanesulfonic acid)is a naturally occurring amino sulfonic acid derived from cysteine and methionine *** common name derives from the ox,as it was first isolated from the bile of an ox(Froger et al.,2014).The molecular structure of taurine differs from that of amino acids by the presence of a sulfonic acid,instead of the more common carboxylic acid group in the structure of amino acids.

关键词： sulfonic structure ethane

Commuting Structure j.cobi Operator for Real Hypersurfaces in Complex Two-plane Grassmannians

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Acta mathematica Sinica,English Series 2015年第1期31卷 111-122页

作者： Carlos j.G.mACHADO j.an de Dios prez Young j.n SUH Departamento de Geometria y Topologia Universidad de Granada Kyungpook National University Department of Mathematics

We classify real hypersurfaces in complex two-plane Grassmannians whose structure j.cobi operator commutes either with any other j.cobi operator or with the normal j.cobi operator.

关键词： Real hypersurfaces complex two-plane Grassmannians structure j.cobi operator normal j.cobi operator

Reservoir stress path and induced seismic anisotropy： results from linking coupled fluid-flow/geomechanical simulation with seismic modelling

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petroleum Science 2016年第4期13卷 669-684页

作者： D.A.Angus Q.j.Fisher j.m.Segura j.p.Verdon j.-m.Kendall m.Dutko A.j.L.Crook School of Earth and Environment University of LeedsLeeds UK Formerly School of Earth and Environment University of Leeds Leeds UK Department of Earth Sciences University of Bristol BristolUK Rockfield Software Ltd. Swansea UK Three Cliffs Geomechanics Swansea UK Repsol Madrid Spain ESG Solutions Kingston Canada

We present a workflow linking coupled fluid-flow and geomechanical simulation with seismic modelling to predict seismic anisotropy induced by non-hydrostatic stress changes. We generate seismic models from coupled simulations to examine the relationship between reservoir geometry, stress path and seismic anisotropy. The results indicate that geometry influences the evolution of stress,which leads to stress-induced seismic anisotropy. Although stress anisotropy is high for the small reservoir, the effect of stress arching and the ability of the side-burden to support the excess load limit the overall change in effective stress and hence seismic anisotropy. For the extensive reservoir, stress anisotropy and induced seismic anisotropy are high. The extensive and elongate reservoirs experience significant compaction, where the inefficiency of the developed stress arching in the side-burden cannot support the excess *** elongate reservoir displays significant stress asymmetry,with seismic anisotropy developing predominantly along the long-edge of the reservoir. We show that the link betweenstress path parameters and seismic anisotropy is complex,where the anisotropic symmetry is controlled not only by model geometry but also the nonlinear rock physics model used. Nevertheless, a workflow has been developed to model seismic anisotropy induced by non-hydrostatic stress changes, allowing field observations of anisotropy to be linked with geomechanical models.

关键词： Coupled fluid-flow/geomechanics Reservoir characterization Seismic anisotropy Stress path

modified activated carbon with interconnected fibrils of iron-oxyhydroxides using mn^(2+) as morphology regulator, for a superior arsenic removal from water

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j.urnal of Environmental Sciences 2019年第2期31卷 403-414页

作者： Cesar Nieto-Delgado j.el Gutiérrez-martínez j.Rene Rangel-méndez Environmental Sciences Division Potosino Institute of Scientific and Technological ResearchIPICyT

The arsenic removal efficiency of iron-modified activated carbons depends greatly on the number of available iron oxide surface sites, which are given by the surface area of the anchored particles. In this sense, aiming the generation of an adsorbent with superior arsenic adsorption capacity, we developed a protocol to anchor interconnected fibrils of iron oxyhydroxides, using mn^(2+) as a morphology regulator. The protocol was based on a microwave-assisted hydrothermal method, using bituminous based activated carbon and both Fe^(2+) and mn^(2+) ions in the hydrolysis solution. The elemental analysis of modified carbons revealed that mn does not anchor to the carbon. However, when mn is included in the hydrolysis solution, the iron content in the activated carbon increased up to 3.5 wt%,without considerable decreasing the adsorbent surface area. Under specific hydrothermal conditions, the mn^(2+) promoted the formation of iron oxide nanoparticles shaped as interconnected fibrils. This material showed a superior arsenic adsorption capacity in comparison to similar iron modified activated carbons(5 mg As/g carbon, at 2 mg As/L),attributed to the increase in quantity and availability of active sites located on the novel interconnected fibrils of iron oxyhydroxides nanostructures.

关键词： Iron oxide nanostructures Hydrothermal synthesis microwave Adsorption capacity Kinetics

photoluminescence characteristics of soft pZT 53/47 ceramic doped at A and/or B sites

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j.urnal of Advanced Ceramics 2018年第2期7卷 109-116页

作者： m.D.DURRUTHY-RODRíGUEZ j.j.GERVACIO-ARCINIEGA m.HERNáNDEZ-GARCíA j.m.Yánez-LImóN Universidad Nacional Evangélica Departamento de Física Aplicada Instituto de CibernéticaMatemáticay FísicaCITMA Catedrático CONACYT-Facultad de Ciencias Físico matemáticas Benemérita Universidad Autónoma de Puebla CINVESTAV-Unidad Querétaro del IpN Libramiento Norponiente 2000Fracc.Real de Juriquilla

This study presents the photoluminescence characteristics of the pZT 53/47 system doped at A and/or B sites, with Nb(pZTN), La(pLZT), and Nb–La(pLZTN) in the concentration range from 0.2 to 1.0 molar fraction. The intensity of the emission bands of the system pZTN is two orders higher than the intensity of the emission bands of the systems pLZT and pLZTN, and these emission bands are located at 1.73 eV(718 nm), 2.56 eV(485 nm), and 2.93 eV(424 nm). The origin of the luminescence in these systems is associated with lead and oxygen vacancies produced during the sintering process. The results from X-ray diffraction(XRD) show a mixture of rhombohedral and tetragonal phases. The system pZTN shows a higher tetragonal phase concentration, while pLZT and pLZTN systems show a higher rhombohedral phase concentration. The cell volume shows an increase with dopant concentration only in the case of the pLZTN system. The band gap energy shows a small variation in the pZTN and pLZTN cases around 3.0 eV, a close value to the band gap energy of the pure pZT 53/47 sample. The system pLZT shows an increasing behavior until 4.41 eV for the higher dopant concentration.

关键词： photoluminescence pZT ceramics band structure X-ray diffraction(XRD)

Factors Affecting Distribution of Vegetation Types on Abandoned Cropland in the Hilly-Gullied Loess plateau Region of China

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pedosphere 2008年第1期18卷 24-33页

作者： j.AO j.-Ying j. TZANOpOULOS p. XOFIS j. mITCHLEY Institute of Soil and Water Conservation Northwest Sci-Technology University of Agriculture and Forestry Yangling Shaanxi 712100 (China) Centre for Agro-Environmental Research Department of Agriculture The University of Reading Barley Gate PO Box237 Reading RG6 6.4 R (UK) Imperial College London Department of Agricultural Sciences Wye Campus Wye Ashford Kent TN25 5AH (UK) nstitute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water Resources Yangling Shaanxi 712100 (China)

A study was conducted in the forest-steppe region of the Loess plateau to provide insight into the factors affecting the process of vegetation establishment,and to provide recommendations for the selection of indigenous species in order to speed up the succession process and to allow the establishment of vegetation more resistant to soil *** distinctive vegetation types were identified,and their distribution was affected not only by the time since abandonment but also by other environmental factors,mainly soil water and total p in the upper soil *** of the vegetation types,dominated by Artemisia scoparia,formed the early successional stage after abandonment while the other three types formed later successional stages with their distribution determined by the soil water content and total *** can be concluded that the selection of appropriate species for introduction to accelerate succession should be determined by the local conditions and especially the total p concentration and soil water content.

关键词： abandoned cropland Loess plateau soil erosion vegetation variation

Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： m.p.SALAImANImAGUDAm j.j.YApRAKASH Department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,inj.ction concrete 3D printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subj.ctive and obj.ctive weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3D printing

Formation of High-quality Advanced High-k Oxide Layers at Low Temperature by Excimer UV Lamp-assisted photo-CVD and Sol-gel processing

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Chemical Research in Chinese Universities 2004年第4期20卷 396-402页

作者： YU j. j. Electronic & Electrical Engineering University College London

We have successfully demonstrated that high quality and high dielectric constant layers can be fabricated by low temperature photo-induced or -assisted processing. Ta_2O_5 and ZrO_2 have been deposited at tmeans of a UV photo-CVD technique and HfO_2 by photo-assisted sol-gel processing with the aid of excimer lamps. The UV annealing of as-grown layers was found to significantly improve their electrical properties. Low leakage current densities on the order of 10 -8 A/cm 2 at 1 mV/cm for deposited ultrathin Ta_2O_5 films and ca.10 -6 A/cm 2 for the photo-CVD ZrO_2 layers and photo-irradiated sol-gel HfO_2 layers have been readily achieved. The improvement in the leakage properties of these layers is attributed to the UV-generated active oxygen species O( 1D) which strongly oxidize any suboxides to form more stoichiometric oxides on removing certain defects, oxygen vacancies and impurities present in the as-prepared layers. The photo-CVD Ta_2O_5 films deposited across 10.16-cm Si wafers exhibit a high thickness uniformity with a variation of less than \{±2.0%\} being obtained for ultrathin ca.10 nm thick films. The lamp technology can in principle be extended to larger area wafers, providing a promising low temperature route to the fabrication of a range of high quality thin films for future ULSI technology.

关键词： Excimer lamp High-kdielectrics Thin film Chemical vapour deposition(CVD) Sol-gel processing