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Targeting intestinal microflora in inflammatory bowel disease

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World Journal of Gastroenterology 2006年第44期12卷 7225-7226页

作者： mario Guslandi Gastroenterology Unit S.Raffaele University Hospital Via Olgettina 60 Milan 20132 Italy

TOTHE EDITORIn their recent review article, Andoh and Fujiyama examined the various therapeutic approaches targeting intestinal microflora in patients with inflammatory bowel disease （IBD）. I would like to provide some additional data to complete and update their comments. First of all, when considering the role of probiotics in IBD treatment it must be emphasized that, in addition to Bifldobacteria, the Nissle 1917 E. coli strain and cocktails of microorganisms such as VSL # 3 mentioned in the article, other probiotic agents have been tested in the short- and long-term treatment of either ulcerative colitis and Crohn＇s disease, the results of those studies being reported in major international scientific journals.

关键词：肠疾病微生物疾病生命期 Crohn疾病

Modulation of valosin-containing protein by Kyoto University Substances(KUS) as a novel therapeutic strategy for ischemic neuronal diseases

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Neural Regeneration Research 2017年第8期12卷 1252-1255页

作者： Masayuki Hata Hanako Ohashi ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Neuroprotective Treatment Project for Ocular Diseases Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate（ATP） depletion and subsequent induced endoplasmic reticulum（ER） stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity. Based on the chemical structure, we developed novel valosin-containing protein modulators, Kyoto University Substances（KUSs）, that not only inhibit intracellular ATP depletion, but also ameliorate ER stress. Suppressing ER stress by KUSs is associated with neural cell survival in animal models of several neurodegenerative diseases, such as glaucoma and retinal degeneration. Given that a major pathology of ischemic retinal diseases, other than intracellular ATP depletion, is ER stress-induced cell death, KUSs may provide a novel strategy for cell protection in ischemic conditions. Hence, we investigated the efficacy of KUS121 in a rat model of retinal ischemic injury. Intravitreal injections of KUS121, which is clinically preferable route of drug administration in retinal diseases, significantly suppressed inner retinal thinning and retinal cell death, and maintained visual functions. Valosin-containing protein modulation by KUS is a promising novel therapeutic strategy for ischemic retinal diseases.

关键词： adenosine triphosphatase C/EBP homologous protein central retinal artery occlusion endoplasmicreticulum stress neuroprotective therapy retinal ganglion cell

MPM simulations of dam-break floods

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Journal of Hydrodynamics 2017年第3期29卷 397-404页

作者： Xuanyu Zhao Dongfang Liang mario Martinelli Department of Engineering University of CambridgeCambridgeUK Deltares DelftThe Netherlands

Owing to its ability of modelling large deformations and the ease of dealing with moving boundary conditions,the material point method is gaining popularity in geotechnical engineering *** this paper,this promising Lagrangian method is applied to hydrodynamic problems to further explore its *** collapse of water columns with different initial aspect ratios is simulated by the material point *** order to test the accuracy and stability of the material point method,simulations are first validated using experimental data and results of mature numerical ***,the model is used to ascertain the critical aspect ratio for the widely-used shallow water equations to give satisfactory *** the comparisons between the simulations based on the material point method and the shallow water equations,the critical aspect ratio for the suitable use of the shallow water equations is found to be 1.

关键词： Material point method dam-break floods Lagrangian method shallow water equations

Study on the effect of landfill leachate on nutrient removal from municipal wastewater

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Journal of Environmental Sciences 2016年第5期28卷 153-158页

作者： Qiuyan Yuan Huijun Jia mario Poveda Department of Civil Engineering University of Manitoba

In this study, landfill leachate with and without pre-treatment was co-treated with municipal wastewater at different mixing ratios. The leachate pre-treatment was achieved by air stripping to removal ammonia. The objective of this study was to investigate the effect of landfill leachate on nutrient removal of the wastewater treatment process. It was demonstrated that when landfill leachate was co-treated with municipal wastewater, the high ammonia concentration in the leachate did not have a negative impact on the nitrification. The system was able to adapt to the environment and was able to improve nitrification capacity. The readily biodegradable portion of chemical oxygen demand（COD）in the leachate was utilized by the system to improve phosphorus and nitrate ***, this portion was small and majority of the COD ended up in the effluent thereby decreased the quality of the effluent. The study showed that the 2.5% mixing ratio of leachate with wastewater improved the overall biological nutrient removal process of the system without compromising the COD removal efficiency.

关键词： Leachate pre-treatment Biological nutrient removal Air stripping Mixing ratio Nitrification Phosphorus removal

Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases

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Neural Regeneration Research 2019年第1期14卷 82-84页

作者： Tomoko Hasegawa Hanako Ohashi ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Department of Experimental Therapeutics Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa(RP)and glaucoma,which are leading causes of adult *** RP,progressive loss of photoreceptor cells leads to visual *** established treatments are available to date for this condition,although potential treatments,including regenerative medicine,gene therapy,and neurotropic factor therapy are being *** glaucoma。

关键词：眼睛疾病视网膜氨基酸基因治疗腺苷分叉维护光敏电阻器

First-principles screening of structural properties of intermetallic compounds on martensitic transformation

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npj Computational Materials 2017年第1期3卷 23-36页

作者： Joohwi Lee Yuji ikeda Isao Tanaka Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Elements Strategy Initiative for Structure Materials(ESISM) Kyoto UniversityKyoto 606-8501Japan Center for Materials Research by Information Integration National Institute for Materials Science(NIMS)Tsukuba 305-0047 IbarakiJapan Nanostructures Research Laboratory Japan Fine Ceramics CenterNagoya 456-8587 AichiJapan Toyota Central R&D Laboratories Inc.Nagakute 480-1192 AichiJapan

Martensitic transformation with good structural compatibility between parent and martensitic phases are required for shape memory alloys(SMAs)in terms of functional *** this study,first-principles-based materials screening is systematically performed to investigate the intermetallic compounds with the martensitic phases by focusing on energetic and dynamical stabilities as well as structural compatibility with the parent *** B2,D0_(3),and L2_(1) crystal structures are considered as the parent phases,and the 2H and 6M structures are considered as the martensitic *** total,3384 binary and 3243 ternary alloys with stoichiometric composition ratios are *** is found that 187 alloys survive after the *** of the surviving alloys are constituted by the chemical elements already widely used in SMAs,but other various metallic elements are also found in the surviving *** energetic stability of the surviving alloys is further analyzed by comparison with the data in Materials Project Database(MPD)to examine the alloys whose martensitic structures may cause further phase separation or transition to the other structures.

关键词： martensitic intermetallic alloys

Design of an Interpolated Controller for Stabilization of a Plant with Variable Operating Condition

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Journal of Systems Engineering and Electronics 2000年第2期11卷 39-47页

作者： Yuan, Xiangyang Shi, Songjiao ikeda, Masao Shanghai Jiaotong Univ Shanghai China

In this paper, the stabilization of a linear SISO plant with variable operating condition is considered. The plant is described by a linear interpolation of proper stable co-prime factorizations of the transfer functions at two representative operating points. An interpolation of the stabilizing controllers for the representative models is designed to stabilize the plant, and the necessary and sufficient condition for the plant to be stabilized by the proposed controller is presented using the Nevanlinna-Pick interpolation theory. It is shown that the class of stabilization plants via the proposed controller in the paper is larger than that by the controller in reference. An example is also given to illustrate this fact.

关键词： Closed loop control systems Control system analysis Interpolation System stability Transfer functions

Estimating the Lost Economic Production Caused by Internal Displacement Because of Disasters

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International Journal of Disaster Risk Science 2018年第4期9卷 496-506页

作者： mario A.Salgado-Gálvez Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) 08034 BarcelonaSpain

Disasters are a large cause of internal displacement at the global level, in 2017 alone affecting more than19 million people. This dimension of disaster risk is usually overlooked in many disaster risk management strategies and assessments. It is only very recently that efforts to quantify displacement risk and integrate that dimension into existing physical risk models have been made. A key component of internal displacement assessment is the quantification of its economic impacts, both direct and indirect, not only to make a figure available but to raise awareness and increase accountability among governments, stakeholders, policymakers, and decision *** article presents a novel and peril-agnostic methodology with which to estimate, using a scenario-based approach, the economic production lost because of internal population displacement. The methodology is applied by using as a triggering event the April 2015 Gorkha, Nepal M7.8 earthquake. The method quantifies the indirect cost caused by internal population displacement because of that event in terms of lost economic production and estimates the loss to be between USD 400 and 850 million.

关键词： Disability adjusted life years Disaster risk Internally displaced people Lost economic production Disaster risk assessment

Thermomemory in shoot apical meristem: Regulation of carbohydrate metabolism and stem cell identity

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Molecular Plant 2021年第9期14卷 1427-1429页

作者： Miho ikeda Hironori Takasaki Nobutaka Mitsuda Graduate School of Science and Engineering Saitama UniversitySaitama 338-8570Japan Bioproduction Research Institute National Institute of Advanced Industrial Science and Technology(AIST)Central 6Tsukuba 305-8566Japan

Adaptation to the environment is essential for sessile organisms,such as plants,as they cannot move away from adverse *** stress(HS)is one of the most serious environmental stresses in terms of its effect on crop growth and yield,especially in this era of global ***,research on heat re-sponses and acclimation in plants is becoming increasingly *** have evolved complex systems to respond to HS for their *** general,heat shock transcription factors(Hsfs)are involved in the acquisition of thermotolerance.

关键词： metabolism becoming effect