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Rifaximin in the treatment of inflammatory bowel disease

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World Journal of Gastroenterology 2011年第42期17卷 4643-4646页

作者： mario Guslandi Gastroenterology Unit S Raffaele University Hospital

The gut microbiota plays a role in promoting and maintaining inflammation in inflammatory bowel diseases （IBD）, hence the rationale for the use of antibiotics in the treatment of those disorders. Antibiotics, however, may induce untoward effects, especially during longterm therapy. Rifaximin α polymer is an antibacterial agent that is virtually unabsorbed after oral administration and is devoid of systemic side effects. Rifaximin has provided promising results in inducing remission of Crohn＇s disease （up to 69% in open studies and significantly higher rates than placebo in double blind trials） and ulcerative colitis （76% in open studies and significantly higher rates than placebo in controlled studies） and might also have a role in maintaining remission of ulcerative colitis and pouchitis. The potential therapeutic activity of rifaximin in IBD deserves to be further investigated and confirmed in larger, controlled studies. The optimal dosage still needs to be better defined.

关键词： Antibiotics Gut microbiota Inflammatorybowel disease Rifaximin

Endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction in Mexico

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World Journal of Surgical Procedures 2024年第3期14卷 15-20页

作者： Massiel Madelin Rosario-Morel Rodrigo Soto-Solis Katia Picazo-Ferrera Miriam Idalia Torres-Ruiz JoséAlberto Estradas-Trujillo mario Alberto Gallardo-Ramírez Gerardo Akram Darwich-del Moral Luis Ariel Waller-González Department of Endoscopy Centro Médico Nacional“20 de Noviembre”ISSSTEMexico City 03229Mexico Department of Gastroenterology HospitalÁngeles PedregalMexico City 10700Mexico Department of Endoscopy Centro Médico ABCMexico City 01120Mexico Department of Endoscopy Hospital General de México“Dr.Eduardo Liceaga”Mexico City 06720Mexico

BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has recently emerged as an alternative treatment for gastric outlet obstruction(GOO)in selected *** To report the initial experience of EUS-GE in patients with *** This study was a retrospective,observational,multicenter study in which the data from 10 patients who underwent EUS-GE due to GOO between September 2021 and May 2023 were *** analyzed technical success,clinical success,adverse events,and *** success was defined as adequate positioning and deployment of the *** success was defined as the patient’s ability to tolerate oral intake without vomiting 7 d after the *** adverse events were *** Eleven procedures in 10 patients with GOO were *** mean age of the patients was 67.5 years(range:56-77 years).Malignant GOO was present in 9 *** success was achieved in 9/11 procedures(82%).Among them,clinical success was achieved in 9 patients(100%).Adverse events occurred in 1 patient(9%).The median survival was 3 months(n=7;range:1-8 months).CONCLUSION EUS-GE is a feasible therapeutic option in the treatment of GOO.

关键词： Endoscopic ultrasound-guided gastroenterostomy Gastric outlet obstruction Lumen apposing metal stent Interventional endoscopic ultrasound Gastrojejunostomy Duodenal stenting

Remarks on the application of two-dimensional shape factors under severe wear conditions

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Friction 2016年第1期4卷 65-71页

作者： Giuseppe PINTAUDE mario COSEGLIO Programa de Pós-Gradua(a)(a)o em Engenharia Mec(a)nica e de Materiais UTFPR Curitiba PR Brazil University of Birmingham Birmingham UK

The use of two-dimensional shape parameters to characterize abrasive particles is a potential approach to express their angularity. Nevertheless, in sliding abrasion, especially in pin abrasion testing, these descriptors could not be suitable for characterizing severe wear of engineering materials such as steels and cast irons. This work compares the applicability of two-dimensional shape parameters in describing severe wear of metals in recent pin abrasion tests with cases where they could have been correlated with the wear rates. Considering these aspects, this work puts in evidence the importance of clogging occurrence and the coated paper structure for a carefully application of shape parameters. In addition, it is proposed a possible relation between the shape parameters and one of the components of the abrasion factor.

关键词： wear particle shape sliding abrasion coated papers

Exacerbation of inflammatory bowel disease by nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors:Fact or fiction?

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World Journal of Gastroenterology 2006年第10期12卷 1509-1510页

作者： mario Guslandi Gastroenterology Unit S.Raffaele University Hospital Via Olgettina 60Milano 20132Italy

The existence of a possible link between inflammatory bowel disease （IBD） and nonsteroidal anti-inflammatory drugs （NSAIDs） has been repeatedly suggested. Recently, a few studies have addressed the issue of a possible, similar effect by selective cyclooxygenase-2 inhibitors （COXIBs）. The present article reviews the available scientific evidence for this controversial subject.

关键词： COX-2 inhibitor Inflammatory bowel disease Non-steroidal anti-inflammatory drugs

Non-steroidal anti-inflammatory drugs-induced small intestinal injury and probiotic agents

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World Journal of Gastroenterology 2012年第31期18卷 4241-4242页

作者： mario Guslandi Gastroenterology Unit S.Raffaele University Hospital20132 MilanItaly

Intestinal bacteria play a role in the development of non-steroidal anti-inflammatory drugs （NSAID）-induced small intestinal injury. Agents such as probiotics, able to modi~ the gut ecology, might theoretically be useful in preventing small intestinal damage induced by NSAIDs. The clinical studies available so far do suggest that some probiotic agents can be effective in this respect.

关键词： Non-steroidal anti-inflammatory drugs Small intestine Intestinal bacteria Probiotics

Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles

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Neural Regeneration Research 2022年第7期17卷 1503-1504页

作者： Cristina Agliardi Franca R.Guerini mario Meloni mario Clerici IRCCS Fondazione Don Carlo Gnocchi MilanItaly Department of Pathophysiology and Transplantation University of MilanMilanItaly

The prevalence of Parkinson’s disease(PD)is rapidly increasing,and more than 12 million people are expected to suffer from PD by *** is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars *** main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies.

关键词： degeneration Alpha prevalence

Targeting intestinal microflora in inflammatory bowel disease

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World Journal of Gastroenterology 2006年第44期12卷 7225-7226页

作者： mario Guslandi Gastroenterology Unit S.Raffaele University Hospital Via Olgettina 60 Milan 20132 Italy

TOTHE EDITORIn their recent review article, Andoh and Fujiyama examined the various therapeutic approaches targeting intestinal microflora in patients with inflammatory bowel disease （IBD）. I would like to provide some additional data to complete and update their comments. First of all, when considering the role of probiotics in IBD treatment it must be emphasized that, in addition to Bifldobacteria, the Nissle 1917 E. coli strain and cocktails of microorganisms such as VSL # 3 mentioned in the article, other probiotic agents have been tested in the short- and long-term treatment of either ulcerative colitis and Crohn＇s disease, the results of those studies being reported in major international scientific journals.

关键词：肠疾病微生物疾病生命期 Crohn疾病

MPM simulations of dam-break floods

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Journal of Hydrodynamics 2017年第3期29卷 397-404页

作者： Xuanyu Zhao Dongfang Liang mario Martinelli Department of Engineering University of CambridgeCambridgeUK Deltares DelftThe Netherlands

Owing to its ability of modelling large deformations and the ease of dealing with moving boundary conditions,the material point method is gaining popularity in geotechnical engineering *** this paper,this promising Lagrangian method is applied to hydrodynamic problems to further explore its *** collapse of water columns with different initial aspect ratios is simulated by the material point *** order to test the accuracy and stability of the material point method,simulations are first validated using experimental data and results of mature numerical ***,the model is used to ascertain the critical aspect ratio for the widely-used shallow water equations to give satisfactory *** the comparisons between the simulations based on the material point method and the shallow water equations,the critical aspect ratio for the suitable use of the shallow water equations is found to be 1.

关键词： Material point method dam-break floods Lagrangian method shallow water equations

Study on the effect of landfill leachate on nutrient removal from municipal wastewater

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Journal of Environmental Sciences 2016年第5期28卷 153-158页

作者： Qiuyan Yuan Huijun Jia mario Poveda Department of Civil Engineering University of Manitoba

In this study, landfill leachate with and without pre-treatment was co-treated with municipal wastewater at different mixing ratios. The leachate pre-treatment was achieved by air stripping to removal ammonia. The objective of this study was to investigate the effect of landfill leachate on nutrient removal of the wastewater treatment process. It was demonstrated that when landfill leachate was co-treated with municipal wastewater, the high ammonia concentration in the leachate did not have a negative impact on the nitrification. The system was able to adapt to the environment and was able to improve nitrification capacity. The readily biodegradable portion of chemical oxygen demand（COD）in the leachate was utilized by the system to improve phosphorus and nitrate ***, this portion was small and majority of the COD ended up in the effluent thereby decreased the quality of the effluent. The study showed that the 2.5% mixing ratio of leachate with wastewater improved the overall biological nutrient removal process of the system without compromising the COD removal efficiency.

关键词： Leachate pre-treatment Biological nutrient removal Air stripping Mixing ratio Nitrification Phosphorus removal