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Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles

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Neural Regeneration Research 2022年第7期17卷 1503-1504页

作者： Cristina Agliardi Franca R.Guerini mario Meloni mario clerici IRCCS Fondazione Don Carlo Gnocchi MilanItaly Department of Pathophysiology and Transplantation University of MilanMilanItaly

The prevalence of Parkinson’s disease(PD)is rapidly increasing,and more than 12 million people are expected to suffer from PD by *** is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars *** main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies.

关键词： degeneration Alpha prevalence

Immune Activation in HIV-Infected Patients Treated with Different ARV Regimens

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World Journal of AIDS 2012年第2期2卷 97-102页

作者： Alessia Uglietti Sergio Lo Caputo Marinella Lauriola Michele De Gennaro Elisabetta Chiesa Massimo Coen Roberta Terzi Dorothy H. Bray Renato Maserati Daria Trabattoni mario clerici Departments of Infectious Diseases of the Campo di Marte Hospital Milano Italy Departments of Infectious Diseases of the Chair of Immunology University of Milano Milano Italy Departments of Infectious Diseases of the Chair of Immunology University of Milano Milano Italy Departments of Infectious Diseases of the Fondazione Don C. Gnocchi Scientific Institute for Patient Care and Research Milano Italy Departments of Infectious Diseases of the Foundation IRCCS Policlinico San Matteo Hospital Milano Italy Departments of Infectious Diseases of the Immunoclin Ltd. Paris France Milano Italy Departments of Infectious Diseases of the Luigi Sacco Hospital Milano Italy Departments of Infectious Diseases of the Santa Maria Annunziata Hospital Milano Italy

Objectives: To evaluate the effects of starting therapy with either Truvada (TVD) or Combivir (CBV) in combination with Efavirenz (EFV) or a boosted Protease Inhibitor (LPV/r, ATV/r, fAPV/r and SQV/r) on clinical, immunological, and virological parameters in HIV-infected antiretroviral (ARV) naive patients. Methods: Twenty-seven patients were prospectively enrolled and received TVD-EFV, 32 TVD-PI/r, 24 CBV-EFV, and 23 CBV-PI/r. Immunovirological analyses were performed at baseline and after 3, 6, 9 and 12 months after initiation of therapy;a full set of data is available for 51 patients. Results: Median CD4+ cell counts and HIV-RNA plasma viremia were comparable in the four groups of patients (TVD-EFV, TVD-PI/r, CBV-EFV, CBV-PI/r) at baseline. At month 12 HIV RNA plasma viremia was <50 cps/ml in all patients. Median CD4 cell counts increases were higher, although not significantly, in CBV-EFV and TVD-EFV patients. Finally, CD8+/CD38+/CDRO+T lymphocytes were significantly decreased after 12 months of therapy in all patients with, possibly, a faster effect seen in the EFV groups. Conclusions: Immunologic parameters are similarly affected by different ARV combinations, even if EFV-associated immunomodulation might be marginally better.

关键词： HIV Immune Activation Antiretroviral Therapy

Therapeutic termination of pregnancy and women’s mental health:Determinants and consequences

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World Journal of Psychiatry 2021年第11期11卷 937-953页

作者： Ester di Giacomo Rodolfo Pessina mario Santorelli Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo clerici School of Medicine and Surgery University Milan BicoccaMonza 20900LombardyItaly Department of Psychiatric ASST MonzaMonza 20900LombardyItaly Psychiatric Residency Training Program University Milan BicoccaMonza 20900LombardyItaly PhD Program in Psychology Linguistics and Cognitive NeuroscienceUniversity Milan BicoccaMilano 20126LombardyItaly Psychiatric Residency Training Program University of GenovaGenova 16126LiguriaItaly

The therapeutic termination of pregnancy(TToP)is an induced abortion following a diagnosis of medical *** is applied to avoid the risk of substantial harm to the mother or in cases of fetal *** type of induced abortion is provided after the second semester of gestation if fetal illness or the pregnancy cause physical danger or pathological mental distress to the *** and economic determinants could influence the desire for children and family planning in couples,as well as the use of effective contraception and the choice to perform an induced ***,pre-existing mental health problems could affect the decision between carrying on a problematic pregnancy or having ***,the TToP is a reproductive event with an important traumatic burden,but also with an intrinsic therapeutic effect and it can produce different psychological and psychopathological effects on women and *** aim of this review is to evaluate what demographic,reproductive and psychopathological determinants are involved in the choice of undergoing a TToP in ***,we will examine both positive and negative consequences of this procedure on women’s mental health,underlying which factors are related to a worse outcome in order to provide the best clinical support to vulnerable groups.

关键词： Therapeutic abortion Women’s health Depression PostTraumatic stress disorder Perinatal care Psychiatry

Child abuse and psychopathy: Interplay, gender differences and biological correlates

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World Journal of Psychiatry 2021年第12期11卷 1167-1176页

作者： Ester di Giacomo mario Santorelli Rodolfo Pessina Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo clerici School of Medicine and Surgery University of Milano BicoccaMonza 20900Italy Department of Psychiatry ASST MonzaMonza 20090Italy School of Medicine and Surgery Psychiatric Residency Training ProgramUniversity of Milano BicoccaMonza 20900Italy Department of Psychology Linguistics and Cognitive NeuroscienceUniversity of Milano BicoccaMonza 20900Italy Department of Psychiatric Residency Training Program University of GenovaGenova 16126Italy Department of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy

Child abuse is an important source of mental and physical adverse consequences for victims,their family,and their *** impact of violence during childhood on the development of the victim is a very sensitive *** than internalizing symptoms,it is interesting to analyze the possibility that a victim may assume the role of *** this aim,we evaluate Literature and examine the interplay among different types of child abuse(emotional neglect,emotional abuse,physical neglect,physical abuse and sexual abuse)and the development of *** consider the role of post-traumatic stress disorder and that of personal environment as potential mediators between abuse and ***,an in-depth analysis on possible differences due to the victim's gender is ***,analysis focused on genetic variants,such as the polymorphism of 5HTT and MAO-A,or a biological alteration,like the difference in daily cortisol levels that could be related to the development of psychopathy after a trauma.

关键词： Child abuse Sexual abuse Physical abuse Psychopathy Neglect Intergenerational transmission

Dispersion of particles in the coatings characterized by laser scanning confocal micrscopy(LSCM) I:Vertical dispersion of particles in the coatings and the weathering property studied by orthogonal analysis method of LSCM

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Science China(Technological Sciences) 2010年第8期53卷 2247-2251页

作者： HAN Charles C. SUNG Li-Piin clerici Cyril State Key Laboratory of Polymer Physics and Chemistry Institute of ChemistryChinese Academy of Sciences Polymeric Materials Group Building and Fire Research LaboratoryNational Institute of Standards and TechnologyGaithersburgMD 200899USA

Two kinds of TiO2 filled epoxy coatings were designed and prepared to obtain pigments with different dispersion degrees of TiO2 *** scanning confocal microscope（LSCM）was used to investigate both the horizontal and vertical distributions of TiO2 particles in the *** results indicated that TiO2 in the two samples shared considerable similarity in horizental dispersion,but exhibited great difference in vertical ***2 showed uniform vertical distribution in disp coating,wheras a gap about 1.1μm was found in the non-disp coating,which significantly influenced the surface optical properties of the coatings during *** on the confocal data,the model of dispersion of pigments in the coatings was proposed and the change of surface properties during weathering was predicted:the surface optical properties showed an initial decrease followed by a subsequent increase,which was in good agreement with the weathering data.

关键词： laser scanning confocal microscope(LSCM) TiO 2 epoxy coatings vertical dispersion of particles

A Set of GRASS GIS-Based Shell Scripts for the Calculation and Graphical Display of the Main Morphometric Parameters of a River Channel

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International Journal of Geosciences 2016年第2期7卷 135-143页

作者： Aldo clerici Susanna Perego Dipartimento di Fisica e Scienze della Terra “M. Melloni” University of Parma Parma Italy

For the analysis of river evolution, the use of quantitative parameters can be quite useful in order to assess changes in the channel planform. Among the several parameters proposed by different authors in a number of papers, channel length and width, braiding and sinuosity indexes, and channel lateral shifting are proved to be the most effective ones for a quantitative analysis of river changes. However, the calculation of these parameters is time-consuming, tedious and error-prone, even where made in a GIS environment. This work describes four shell scripts that perform fast and automatic calculation of the morphometric parameters and draw curves showing the variation of the calculated parameters along the entire channel development. The scripts are based on commands of the GRASS GIS free and open source software and, as input, they require a simple vector map containing the essential features of a river channel, i.e. bankfull channel limits and longitudinal and lateral bars.

关键词： GRASS GIS Shell Script River Morphometry

Year-round multi-scale habitat selection by Crested Tit(Lophophanes cristatus)in lowland mixed forests(northern Italy)

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Avian Research 2022年第4期13卷 461-467页

作者： Alessandro Berlusconi Alessio Martinoli Lucas AWauters Giulia Tesoro Stefania Martini Erminio clerici Gualtiero Guenzani Gabriele Pozzi Diego Rubolini Michelangelo Morganti Adriano Martinoli Environment Analysis and Management Unit-Guido Tosi Research Group-Department of Theoretical and Applied Sciences Universita degli Studi dell’InsubriaVia J.H.Dunant 321100VareseItaly CNR-IRSA National Research Council–Water Research Institute Via del Mulino 1920861BrugherioMBItaly Gruppo Insubrico di Ornitologia c/o Civico Museo Insubrico di Storia Naturale di Clivio e Induno OlonaVia Manzoni21050ClivioVAItaly Parco Pineta di Appiano Gentile e Tradate Via Alessandro Manzoni1122070Castelnuovo BozzenteCOItaly e Dipartimento di Scienze della Vita Biologia dei Sistemi Universita degli Studi di TorinoVia Accademia Albertina 1310123TurinItaly Conservation Department LIPU-Birdlife Italia Via Udine 3/a43122ParmaItaly Department of Environmental Science and Policy Universita degli Studi di MilanoVia Celoria 2620122MilanItaly

Determining how animals respond to resource availability across spatial and temporal extents is crucial to understand ecological processes underpinning habitat ***,we used a multi-scale approach to study the year-round habitat selection of the Crested Tit(Lophophanes cristatus)in a semi-natural lowland woodland of northern Italy,analysing different habitat features at each *** performed Crested Tit censuses at three different spatial *** the macrohabitat scale,we used geolocalized observations of individuals to compute Manly's habitat selection index,based on a detailed land-use map of the study *** the microhabitat scale,the trees features were compared between presence and absence *** the foraging habitat scale,individual foraging birds and their specific position on trees were recorded using focal animal *** were performed during both the breeding(March to May)and wintering(December to January)*** the macrohabitat scale,the Crested Tits significantly selected pure and mixed pine forests and avoided woods of alien plant species,farmlands and urban *** the microhabitat scale,old pine woods with dense cover were selected,with no significant difference in the features of tree selection between the two phenological *** the foraging habitat scale,the species was observed spending more time foraging in the canopies than in the understorey,using mostly the portion of Scots Pine(Pinus sylvestris)canopies closer to the trunk in winter,while during the breeding period,the whole canopy was ***,breeding and wintering habitats largely overlapped in the Crested *** on our findings,lowland Crested Tits can be well defined as true habitat specialists:they are strictly related to some specific coniferous woodland ***,compared to other tit species,which normally show generalist habits during winter,the Crested Tit behaves as a habitat specialist also out of the breeding ***

关键词： Crested tit Functional response Habitat selection Multi-scale approach Scots pine

Stem Cell Regulation by Arabidopsis WOX Genes

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Molecular Plant 2016年第7期9卷 1028-1039页

作者： Alicja Dolzblasz Judith Nardmann Elena clerici Barry Causier Eric van der Graaff Jinhui Chen Brendan Davies Wolfgang Werr Thomas Laux BIOSS Centre for Biological Signalling Studies Faculty of Biology Albert-Ludwigs-University Freiburg 79104 Freiburg Germany Institute of Developmental Biology Biocenter Cologne University zu KoIn Zulpicher Street 47b 50674 K61n Germany Centre for Plant Sciences University of Leeds Leeds LS2 9JT UK present address: Department of Plant Developmental Biology Institute of Experimental Biology Faculty of Biological Sciences University of Wroclaw50-328 Wroclaw Poland present address: Department of Plant and Environmental Sciences Copenhagen Plant Science Center University of Copenhagen 1871 Taastrup Denmark Present address: Key Laboratory of Forest Genetics & Biotechnology Ministry of Education Nanjing Forestry University 210037 Nanjing China

Gene amplification followed by functional diversification is a major force in evolution. A typical example of this is seen in the WUSCHEL-RELATED HOMEOBOX （WOX） gene family, named after the Arabidopsis stem cell regulator WUSCHEL. Here we analyze functional divergence in the WOX gene family. Members of the WUS clade, except the cambium stem cell regulator WOX4, can substitute for WUS function in shoot and floral stem cell maintenance to different degrees. Stem cell function of WUS requires a canonical WUS-box, essential for interaction with TPL/TPR co-repressors, whereas the repressive EAR domain is dispensable and the acidic domain seems only to be required for female fertility. In contrast to the WUS clade, members of the ancient WOX13 and the WOX9 clades cannot support stem cell maintenance. Although the homeodomains are interchangeable between WUS and WOX9 clade members, a WUS- compatible homeodomain together with canonical WUS-box is not sufficient for stem cell maintenance. Our results suggest that WOX function in shoot and floral meristems of Arabidopsis is restricted to the modern WUS clade, suggesting that stem cell control is a derived function. Yet undiscovered functional domains in addition to the homeodomain and the WUS-box are necessary for this function.

关键词： Arabidopsis thaliana shoot meristem stem cells WOX genes WUSCHEL

Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies

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World Journal of Gastroenterology 2007年第30期13卷 4035-4041页

作者： Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Italy 2nd Pathology Department Spedali Civili Brescia Italy Department of Surgery Liestal Hospital Switzerland Department of Pathology Liestal Hospital Switzerland

The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies.

关键词： Enteric glia Glial cells Gastrointestinal motility