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Open Journal of Rheumatology and Autoimmune Diseases 2014年第3期4卷 146-152页

作者： Damien Mikael Hansra mario ponce Francisco Socola Maria Helena Restrepo Department of Hematology/Oncology Sylvester Comprehensive Cancer Institute Jackson Memorial Hospit-al/University of Miami Miami Florida USA Department of Hematology/Oncology Sylvester Comprehensive Cancer Institute University of Miami Miami Florida USA Department of Medicine Jackson Memorial Hospital/University of Miami Miami Florida USA

A Pleural mass biopsy was performed showing an invasive thymoma. Computed tomography (CT) scan of the chest performed on admission revealed a left sided pleural mass, anterior mediastinal mass, lymphadenopathy and pericardial effusion. Pleural mass biopsy showed an invasive thymoma. Due to her clinical presentation, a complete work-up was performed revealing paraneoplastic systemic lupus erythematous (SLE), myasthenia gravis (MG) and hypogammaglobulinemia. We reviewed the literature regarding thymoma and its relationship with paraneoplastic SLE, MG and hypogammaglobulinemia.

关键词： Thymoma Paraneoplastic Systemic Lupus Erythematosus Myasthenia Gravis Hypogammaglobulinemia

Targeting autophagy by polyphenols to prevent glycative stress-toxicity in the brain

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Neural Regeneration Research 2024年第5期19卷 941-942页

作者： Alejandro ponce-Mora Eloy Bejarano Department of Biomedical Sciences School of Health Sciences and Veterinary SchoolUniversidad Cardenal Herrera-CEUCEU UniversitiesValenciaSpain

Glycative stress-a pathological hub in brain dysfunction:The nervous system is an intricate network that requires precise and complex *** recent years,growing evidence highlights the detrimental impact of glycative stress on brain homeostasis,which disables a network of vital processes,necessary for optimal function(Gómez et al.,2021).

关键词： homeostasis stress

Immigration of Post Larvae of Penaeid Shrimp to Terminos Lagoon,Campeche,Mexico:2013 Annual Cycle

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Open Journal of Ecology 2018年第9期8卷 522-535页

作者： Cesar Flores-Coto Daniel Embriz-Alba mario Alejandro Gomez-ponce Juana Lopez-Martinez Laura Sanvicente-Anorve Instituto de Ciencias del Mar y Limnologìa Universidad Nacional autonoma de MexicoMexico CityMexico Centro de Investigaciones Biologicas del Noroeste S.C. GuaymasMexico

Immigration density magnitude and entry sizes of shrimp postlarvae to Terminos Lagoon were analyzed through sixteen fortnightly sampling from March to November in 2013, in three levels in the deepest channel of the Puerto Real inlet. Trapezium nets were used with 1.5 m length, 50 cm mouth diameter and 505 μm mesh, during each sampling 12 casts of 15 minutes/each were made. It was determined the presence of two species Litopenaeus setiferus and Farfantepenaeus duorarum, with total densities of 41.284 and 37.558 Pls 100 m-3 respectively. The annual cycle of immigration of postlarvae was very similar for both species, with a clear pattern of immigration throughout the year, linked to climatic variation, with the highest densities (88%) during rainy season. There were two periods of maximum density, related to the periods of greatest reproduction of these species. The density variation among cast reflects the presence of at least two and probably more postlarvae banks, located some closer than others to the mouth of the lagoon and with different densities in them. The average sizes of the two species were 7.9 mm total length of L. setiferus and 9.0 mm of F. duorarum. The differences in income sizes of both species seem to indicate the habitat preference of adult populations, L. setiferus occurring in more coastal areas than F. duorarum. Considering the variation in density and sizes throughout each sampling period, it is evident that the larvae on the banks belong to different cohorts and that have coincided in their location in front of the mouth.

关键词： Shrimp Immigration Magnitude Sizes

Revisiting the theoretical prediction of the explosive performance found by the Trauzl test

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Defence Technology（防务技术） 2024年第6期36卷 163-174页

作者： Ivana Dobrilovic mario Dobrilovic Muhamed Suceska Faculty of Mining Geology and Petroleum EngineeringDepartment of Mining Engineering and GeotechnicsUniversity of ZagrebPierottijeva 6Zagreb10000Croatia

The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive charge in the cavity of a lead *** this paper,we reconsider the possibility of interpreting the Trauzl test results in terms of detonation parameters or *** detonation parameters used in the analysis are calculated using the thermochemical code EXPLO5,while the hydrocode AUTODYN is used to simulate the effect of explosive charge density and reaction rate on the results of the Trauzl *** increase in the volume of the lead block cavity was found to correlate best with the product of the detonation heat and the root of the volume of detonation *** simulation showed that the density of explosive charge and the rate of explosive decomposition affect the dynamics of the interaction of the detonation product and the lead block,and consequently the lead block cavity volume increase.

关键词： Trauzl lead block test Performance of explosives EXPLO5 AUTODYN Detonation heat

Machine learning applications in stroke medicine:advancements,challenges,and future prospectives

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Neural Regeneration Research 2024年第4期19卷 769-773页

作者： mario Daidone Sergio Ferrantelli Antonino Tuttolomondo Internal Medicine and Stroke Care Ward Department of Health PromotionMother and Child CareInternal Medicine and Medical SpecialtiesUniversity of Palermo Molecular and Clinical Medicine PhD Program University of Palermo

Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient *** recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine *** abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke *** introduced machine learning algorithms have been extensively employed in all the fields of stroke *** learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient *** the tremendous potential of machine learning in stroke medicine,several challenges must be *** include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and *** addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke *** learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved *** research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of *** review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic *** the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling dis

关键词： cerebrovascular disease deep learning machine learning reinforcement learning stroke stroke therapy supervised learning unsupervised learning

US Imperialism and its Legacies in East Asia:Thucydides Trap orThrasymachus Paradox?

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Fudan Journal of the Humanities and Social Sciences 2024年第3期17卷 417-436页

作者： mario Maritan International Relations and Global Affairs Social Science DivisionMahidol University International CollegeMahidol UniversitySalayaThailand

The US presence in East Asia is not simply a result of the victory over Japan in WW2,but a legacy of the US takeover of the Spanish overseas empire in ***,the threat of war between China and the US has little to do with Allison's Thucydides trap,which is based on a misreading of Thucydides'work:It originates from what in China is seen as a US imperial presence that mirrors Western inter-ference in Chinese affairs during the so-called“century of humiliation.”China is an authoritarian state with regional hegemonic ambitions,yet the West has been endorsing other authoritarian states,even absolute monarchies,that fit its geopoliti-cal *** the purported US support of“freedom”and“democ-racy,”the US in East Asia has been carrying out a foreign policy that,as an exten-sion of misinterpretations of the Monroe Doctrine,is a legacy of *** legacy is too often overlooked,while overseas interests are justified on the basis of secu-rity *** is relevant,but to compare the American and Athenian empires and their demise,not to drag China into US geopolitical discourse,when focus should have long been on ***-colonial theory shows how interstate relations,in particular in the East Asian context,are not defined by Thucydides trap,but Thrasymachus paradox.

关键词： US-Chinese relations Thucydides trap East Asia Cross-strait relations Imperialism

Research funding and citations in papers of Nobel Laureates in Physics, Chemistry and Medicine, 2019-2020

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Journal of Data and Information Science 2024年第2期9卷 56-80页

作者： mario Coccia Saeed Roshani CNR-National Research Council of Italy IRCRES-CNRTurin Research Area of the CNRStrada delle Cacce73-10135-TurinItaly Arizona State University School of Complex Adaptive Systems1031 S.Palm WalkTempeAZ 85281-2701USA Allameh Tabataba’i University Department of Technology and Entrepreneurship ManagementDehkadeh-ye-OTehran***Iran

Purpose:The goal of this study is a comparative analysis of the relation between funding(a main driver for scientific research)and citations in papers of Nobel Laureates in physics,chemistry and medicine over 2019-2020 and the same relation in these research fields as a ***/methodology/approach:This study utilizes a power law model to explore the relationship between research funding and citations of related *** study here analyzes 3,539 recorded documents by Nobel Laureates in physics,chemistry and medicine and a broader dataset of 183,016 documents related to the fields of physics,medicine,and chemistry recorded in the Web of Science ***:Results reveal that in chemistry and medicine,funded researches published in papers of Nobel Laureates have higher citations than unfunded studies published in articles;vice versa high citations of Nobel Laureates in physics are for unfunded studies published in ***,when overall data of publications and citations in physics,chemistry and medicine are analyzed,all papers based on funded researches show higher citations than unfunded ***/value:Results clarify the driving role of research funding for science diffusion that are systematized in general properties:a)articles concerning funded researches receive more citations than(un)funded studies published in papers of physics,chemistry and medicine sciences,generating a high Matthew effect(a higher growth of citations with the increase in the number of papers);b)research funding increases the citations of articles in fields oriented to applied research(e.g.,chemistry and medicine)more than fields oriented towards basic research(e.g.,physics).Practical implications:The results here explain some characteristics of scientific development and diffusion,highlighting the critical role of research funding in fostering citations and the expansion of scientific *** finding can support decision-making of policymakers and R&D mana

关键词： Research funding Citations Science diffusion Scientific change Science of Science Power-law distribution Basic research Applied research Matthew effect Nobel Laureates Nobel Prizes

Design and engineering of logic genetic-enzymatic gates based on the activity of the human CYP2C9 enzyme in permeabilized Saccharomyces cerevisiae cells

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Synthetic and Systems Biotechnology 2024年第3期9卷 406-415页

作者： Rana Azeem Ashraf Matthias Bureik mario Andrea Marchisio School of Pharmaceutical Science and Technology Tianjin University300072TianjinChina

Gene circuits allow cells to carry out complex functions such as the precise regulation of biological metabolic *** this study,we combined,in the yeast ***,genetic regulatory elements with the enzymatic reactions of the human CYP2C9 and its redox partner CPR on luciferin substrates and *** cells were permeabilized and used as enzyme bags in order to host these metabolic *** engineered three different(genetic)-enzymatic basic Boolean gates(YES,NOT,and N-IMPLY).In the YES and N-IMPLY gates,human CYP2C9 was expressed under the galactose-inducible GAL1 *** carbon monoxide releasing molecule CORM-401 was used as an input in the NOT and N-IMPLY gates to impair CYP2C9 activity through inhibition of the Fe+2-heme prosthetic group in the active site of the human *** study provides a new approach in designing synthetic bio-circuits and optimizing experimental conditions to favor the heterologous expression of human drug metabolic enzymes over their endogenous *** new approach will help study precise metabolic attributes of human P450s.

关键词： Cytochrome P450 Drug metabolism Budding yeast Diclofenac Synthetic biology CORM-401 Boolean gates

Application of flame-formed carbon nanoparticle films for ethanol sensing Author links open overlay panel

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Particuology 2024年第8期91卷 202-210页

作者： Pegah Darvehi Luca Basta mario Commodo Patrizia Minutolo Andrea D'Anna Istituto di Scienze e Tecnologie per l’Energia e la MobilitàSostenibili Consiglio Nazionale delle RicercheP.le Tecchio 8080125NapoliItaly Dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIP.le Tecchio 8080125NapoliItaly

Carbon nanoparticles(CNPs)have received considerable attention due to their exceptional qualities and *** unique physical and chemical characteristics make them extremely intriguing as materials for numerous high-potential applications,such as electronics and gas *** study focused on producing carbon-based nanomaterial devices by deposition of flame-formed carbon nanoparticles on a suitable substrate and investigating their gas-sensing *** were produced in a fuel-rich laminar premixed ethylene/air flame and the collected CNP film was morphologically and electrically *** electrical conductivity of the film was investigated as a function of ethanol concentration and amount of deposited ***,CNP films exhibited high sensitivity to ambient ethanol gas concentrations,and rapid recovery times at room temperature,and showed a sensitivity increasing with the amount of deposited material and the surface *** findings demonstrate the high potential of combustion-generated CNPs as building materials for low-cost and portable ethanol sensors.

关键词： Flame synthesis Carbon nanoparticles Soot Nanostructured thin film Optical and electrical characterization Atomic force microscopy Sensors

Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： Juan Jose Urquijo-ponce Carlos Alventosa-Mateu Mercedes Latorre-Sánchez Inmaculada Castelló-Miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant Systemic therapy