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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“severo Ochoa”(CsIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

structural and biological engineering of 3D hydrogels for wound healing

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Bioactive Materials 2023年第6期24卷 197-235页

作者： Mohammad Hadi Norahan sara Cristina Pedroza-González Mónica Gabriela sánchez-salazar mario moisés Álvarez Grissel Trujillo de santiago Escuela de Ingeniería y Ciencias Tecnológico de MonterreyMonterreyNL64849Mexico Centro de Biotecnología-FEMsA Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico Departamento de Bioingeniería Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause of death *** dressings are necessary to facilitate wound *** wound dressings may substantially reduce healing time,reduce the risk of recurrent infections,and reduce the disability and costs *** the path of engineering of an ideal wound dressing,hydrogels have played a leading *** are 3D hydrophilic polymeric structures that can provide a protective barrier,mimic the native extracellular matrix(ECM),and provide a humid *** to their advantages,hydrogels(with different architectural,physical,mechanical,and biological properties)have been extensively explored as wound dressing *** we describe recent studies on hydrogels for wound healing applications with a strong focus on the interplay between the fabrication method used and the architectural,mechanical,and biological performance ***,we review different categories of additives which can enhance wound regeneration using 3D hydrogel *** engineering for wound healing applications promises the generation of smart solutions to solve this pressing problem,enabling key functionalities such as bacterial growth inhibition,enhanced re-epithelialization,vascularization,improved recovery of the tissue functionality,and overall,accelerated and effective wound healing.

关键词： Wound healing Wound dressing Hydrogel Tissue engineering 3D culture

Lipschitz Algebras and Peripherally-multiplicative Maps

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Acta Mathematica sinica,English series 2008年第8期24卷 1233-1242页

作者： A.JIM■NEZ-VARGAs moisés VILLEGAs-VALLECILLOs Departamento de■lgebray Análisis Matemático Universidad de Almería04071AlmeríaSpain

Let X be a compact metric space and let Lip（X） be the Banach algebra of all scalar- valued Lipschitz functions on X, endowed with a natural norm. For each f ∈ Lip（X）, σπ（f） denotes the peripheral spectrum of f. We state that any map Φ from Lip（X） onto Lip（Y） which preserves multiplicatively the peripheral spectrum： σπ（Φ（f）Φ（g）） = σπ（fg）, A↓f, g ∈ Lip（X） is a weighted composition operator of the form Φ（f） = τ· （f °φ） for all f ∈ Lip（X）, where τ ： Y → {-1, 1} is a Lipschitz function and φ ： Y→ X is a Lipschitz homeomorphism. As a consequence of this result, any multiplicatively spectrum-preserving surjective map between Lip（X）-algebras is of the form above.

关键词： Lipschitz algebra peripherally-multiplicative map spectrum-preserving map peaking function peripheral spectrum

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Anthropogenic mineral generation and its potential resource supply:The case of niobium

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science China Earth sciences 2024年第8期67卷 2583-2591页

作者： Xianlai ZENG moisés Gómez Mahmoud BAKRY Yong GENG Jinhui LI school of Environment Tsinghua UniversityBeijing 100084China school of Environmental science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China school of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China

The strategy of carbon neutrality is reshaping the global landscape of resource flow and *** the final sink of geological minerals,the proliferated anthropogenic minerals,also called secondary resources,play an increasingly important role in resource supply *** is a critical metal that lacks full concern for its *** fundamental principle of niobium circularity is to recycle and maintain the material as close to the manufacturing process as *** we estimate the niobium-containing applications lost at their end-of-life,underscoring the imperative to minimize such ***,we elucidate the extraction processes for scrap and alloy quantities throughout the industry's *** from anticipated waste generated by the majority of niobium applications,a forecast indicates a potential loss of approximately 168 kt by 2090 in the absence of ***,with a recycling efficiency of 90%for niobium,the projected loss diminishes to approximately 16 *** delve into the significance of niobium's circular economy and explore various aspects that demand further investigation for a seamless transition from linear to circular practices.

关键词： Niobium Anthropogenic mineral Circular economy Recycling sustainability

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Rupture area analysis of the Ecuador (Musine) Mw = 7.8 thrust earthquake on April 16, 2016, using GOCE derived gradients

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Geodesy and Geodynamics 2017年第1期8卷 49-58页

作者： Orlando alvarez Andres Folguera mario Gimenez lnstituto Geofisico y sismologico lng Volponi Universidad Nacional de San Juan Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Argentina indean-instituto de Estudios Andinos "Don Pablo Groeber" Departamento de Cs. Geologicas FCEN Universidad de Buenos Aires Argentina

The Ecuador Mw - 7.8 earthquake on April 16, 2016, ruptured a nearly 200 km long zone along the plate interface between Nazca and south American plates which is coincident with a seismic gap since 1942, when a Mw - 7.8 earthquake happened. This earthquake occurred at a margin characterized by moderately big to giant earthquakes such as the 1906 （Mw 8.8）. A heavily sedimented trench explains the abnormal lengths of the rupture zones in this system as inhibits the role of natural barriers on the propagation of rupture zones. High amount of sediment thickness is associated with tropical climates, high erosion rates and eastward Pacific dominant winds that provoke orographic rainfalls over the Pacific slope of the Ecuatorian Andes. Offshore sediment dispersion off the oceanic trench is controlled by a close arrangement of two aseismic ridges that hit the Costa Rico and south Ecuador margin respectively and a mid ocean ridge that separates the Cocos and Nazca plate trapping sediments. Gravity field and Ocean Circulation Explorer （GOCE） satellite data are used in this work to test the possible relationship between gravity signal and earthquake rupture structure as well as registered aftershock seismic activity. Reduced vertical gravity gradient shows a good correlation with rupture structure for certain degrees of the harmonic expansion and related depth of the causative mass; indicating, such as in other analyzed cases along the subduction margin, that fore-arc structure derived from density heterogeneities explains at a certain extent propagation of the rupture zones. In this analysis the rupture zone of the April 2016 Ecuador earthquake developed through a relatively low density zone of the fore-arc sliver. Finally, aftershock sequence nucleated around the area of maximum slips in the rupture zone, suggesting that heterogeneous density structure of the fore-arc determined from gravity data could be used in forecasting potential damaged zones associated with big rupture

关键词： Gravity field and Ocean Circulation Explorer(GOCE)Vertical gravity gradientEcuador earthquakeTrench sedimentsRupture zone