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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

A 3R-Tau-mediated mechanism in oligodendrocytes:could it be the key for neuroprotection after stroke?

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Neural Regeneration Research 2021年第12期16卷 2401-2402页

作者： mario Villa Gonzalez Maria JoséPérez-Álvarez Departamento de Biología(Fisiología Animal) Facultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Biología Molecular“severo Ochoa” Departamento de Neuropatología Molecular CSIC-UAMMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Anoverview of cerebral ischemia:Cerebrovascular accident or stroke have a high global *** most common types of stroke are ischemic,accounting for 87%of the total number,and they are triggered by a reduction or interruption of blood flow to the central nervous system,usually caused by a thrombus,embolus or atherosclerotic *** severity of brain damage caused by this kind of stroke is directly related to the size of the vessel that is occluded and the duration of occlusion.

关键词： cerebral ischemia damage

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“severo Ochoa”(CsIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期 3209-3210页

作者： Marta García-Juan mario Villa Irene Benito-Cuesta Lara Ordó?ez-Gutiérrez Francisco Wandosell Centro de Biología Molecular “severo Ochoa” (CsIC-UAM) Nicolas Cabrera 1 Universidad Autónoma de Madrid Fisiología Animal Departamento de Biología Facultad de Ciencias Universidad Autónoma de Madrid Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset Solna Departamento de Bioquímica y Biología Molecular Universidad Complutense de Madrid Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called "autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

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Lipschitz Algebras and Peripherally-multiplicative Maps

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Acta Mathematica sinica,English series 2008年第8期24卷 1233-1242页

作者： A.JIM■NEZ-VARGAs moisés VILLEGAs-VALLECILLOs Departamento de■lgebray Análisis Matemático Universidad de Almería04071AlmeríaSpain

Let X be a compact metric space and let Lip（X） be the Banach algebra of all scalar- valued Lipschitz functions on X, endowed with a natural norm. For each f ∈ Lip（X）, σπ（f） denotes the peripheral spectrum of f. We state that any map Φ from Lip（X） onto Lip（Y） which preserves multiplicatively the peripheral spectrum： σπ（Φ（f）Φ（g）） = σπ（fg）, A↓f, g ∈ Lip（X） is a weighted composition operator of the form Φ（f） = τ· （f °φ） for all f ∈ Lip（X）, where τ ： Y → {-1, 1} is a Lipschitz function and φ ： Y→ X is a Lipschitz homeomorphism. As a consequence of this result, any multiplicatively spectrum-preserving surjective map between Lip（X）-algebras is of the form above.

关键词： Lipschitz algebra peripherally-multiplicative map spectrum-preserving map peaking function peripheral spectrum

Application of nanotechnology to dentistry:Impact of graphene nanocomposites on clinical air quality

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World Journal of Clinical Cases 2025年第8期13卷 1-7页

作者： Ruth Rodríguez Montaño mario A Alarcón-sánchez Melissa Martínez Nieto Juan J Varela Hernández sarah M LomelíMartínez Department of Health and Illness as an Individual and Collective Process University Center of TlajomulcoUniversity of GuadalajaraTlajomulco de Zuñiga 45641JaliscoMexico Institute of Research in Dentistry Department of Integral Dental ClinicsUniversity Center of Health SciencesUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biomedical science Faculty of Chemical-Biological SciencesAutonomous University of GuerreroGuerrero 39090Mexico Instituto Odontológico del Pacífico sur Chilpancingo de los Bravo 39022Mexico Independent Researcher Tijuana 22116Baja CaliforniaMexico Department of Medical and Life sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlan 47810JaliscoMexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraOcotlan 46200JaliscoMexico

Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection *** editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene *** potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains *** recent study by Ju et al which was published in World Journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental *** study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional *** these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical ***,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.

关键词： Graphene Nanocomposites Antibacterial activity Biomedical applications Air disinfection

Anthropogenic mineral generation and its potential resource supply:The case of niobium

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science China Earth sciences 2024年第8期67卷 2583-2591页

作者： Xianlai ZENG moisés Gómez Mahmoud BAKRY Yong GENG Jinhui LI school of Environment Tsinghua UniversityBeijing 100084China school of Environmental science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China school of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China

The strategy of carbon neutrality is reshaping the global landscape of resource flow and *** the final sink of geological minerals,the proliferated anthropogenic minerals,also called secondary resources,play an increasingly important role in resource supply *** is a critical metal that lacks full concern for its *** fundamental principle of niobium circularity is to recycle and maintain the material as close to the manufacturing process as *** we estimate the niobium-containing applications lost at their end-of-life,underscoring the imperative to minimize such ***,we elucidate the extraction processes for scrap and alloy quantities throughout the industry's *** from anticipated waste generated by the majority of niobium applications,a forecast indicates a potential loss of approximately 168 kt by 2090 in the absence of ***,with a recycling efficiency of 90%for niobium,the projected loss diminishes to approximately 16 *** delve into the significance of niobium's circular economy and explore various aspects that demand further investigation for a seamless transition from linear to circular practices.

关键词： Niobium Anthropogenic mineral Circular economy Recycling sustainability

A study of fire propagation in coal seam with numerical simulation of heat transfer and chemical reaction rate in mining field

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International Journal of Mining science and Technology 2019年第6期29卷 873-879页

作者： moisés Oswaldo Bustamante Rúa Alan José Daza Aragón Pablo Bustamante Baena National University of Colombia Cr 65 # 63 20 CIMEX Minerals Institute

spontaneous combustion of coal is a problem that affects the mining operation and generates environ-mental,economic,social and geotechnical *** phenomenon has been divided into two pro-cesses:ignition and *** propagation develops in coal seams because of a set of factors such as direction and wind speed,fracturing and *** this work,heat transfer and chemical kinetics are studied from conservation equations of energy and species,respectively,using the software COMsOL Multiphysics to simulate the propagation of fires in coal *** possible scenarios were analyzed that usually occur in the walls of the coal seams,such as fire focus and fire complete *** was found that the propagation kinetics of the fire changes depending on the temperature,the fractur-ing of rock mass and the area of fire *** temperature values lower than 300℃,there is con-sumption around 250 cm^3/h,values around 700℃,the consumption is 1500 cm^3/h,and for fires of 1200℃ have values of 3000 cm^3/*** on the speed of propagation can vary from 4 to 17cm/day,considering on the level and fracturing of the final wall of the open pit.

关键词： spontaneous combustion of coal Open pit mines simulation Heat transfer Chemical reaction COMsOL

On the Perturbation of semi-Fredholm Relations with Complemented Ranges and Null spaces

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Acta Mathematica sinica,English series 2010年第8期26卷 1545-1554页

作者： Teresa lvarez Department of Mathematics University of Oviedo

Multivalued semi-Fredholm type linear operators with complemented ranges and null spaces are introduced. Conditions are obtained under which the classes given are stable under compact, strictly singular and strictly c... 详细信息

关键词： Left-Atkinson relation right-Atkinson relation strictly singular strictly cosingular perturbation