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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet Gauhar Khi Yung Fong mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman Gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,P<0.001).After 3 months,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

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A digital earth platform for sustainability

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International Journal of Digital Earth 2017年第4期10卷 342-355页

作者： mario Hernandez Engagement Committee Future EarthMexico CityMexico International Society for Digital Earth Mexico CityMexico

Based on the experience of the International Society for Digital Earth(ISDE),this paper describes some challenges foreseen in order to develop a Digital Earth platform that can support the implementation of the Sustainable Development *** use of ready-to-use derived geospatial information is *** Earth’s methodology of‘co-design’aims to bring together natural,social scientists and decision makers to plan and carry out research for *** implies transdisciplinary research,but in order for scientists of different disciplines to work together,they will need to be able to share,access and use common *** is by far not simple!While the good will to share data might exist,the associated technological,ethical and privacy issues are difficult to *** adequate e-infrastructure will be *** could consider to use the SDGs is the basis to develop the desired Digital Earth *** paper,by no means,covers everything for a Digital Earth platform,it aims to trigger research discussions and to have a good view about a starting point.

关键词： Digital earth platform sustainable development Sustainable Development Goals future earth

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Extravasated contrast volumetric assessment on computed tomography angiography in gastrointestinal bleeding:A useful predictor of positive angiographic findings

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World Journal of Radiology 2024年第5期16卷 115-127页

作者： Laura Maria Cacioppa Chiara Floridi Alessandra Bruno NicolòRossini Tommaso Valeri Alessandra Borgheresi Riccardo Inchingolo Francesco Cortese Giacomo Novelli Alessandro Felicioli mario Torresi Pietro Boscarato Letizia Ottaviani Andrea Giovagnoni Division of Interventional Radiology Department of Radiological SciencesUniversity Politecnica Delle MarcheAncona 60126Italy Department of Clinical Special and Dental SciencesUniversity Politecnica Delle MarcheAncona 60126Italy Division of Radiology Department of Radiological SciencesUniversity Hospital"Azienda Ospedaliero Universitaria Delle Marche"Ancona 60126Italy Interventional Radiology Unit "F Miulli"Regional General HospitalAcquaviva delle Fonti 70021Italy Department of Radiology IRCCS INRCAAncona 60126Italy

BACKGROUND Gastrointestinal bleeding(GIB)is a severe and potentially life-threatening condition,especially in cases of delayed *** tomography angiography(CTA)plays a pivotal role in the early identification of upper and lower GIB and in the prompt treatment of the *** To determine whether a volumetric estimation of the extravasated contrast at CTA in GIB may be a predictor of subsequent positive angiographic *** In this retrospective single-centre study,35 patients(22 men;median age 69 years;range 16-92 years)admitted to our institution for active GIB detected at CTA and further submitted to catheter angiography between January 2018 and February 2022 were ***-three(65.7%)patients underwent endoscopy before *** volumetry was evaluated in both arterial and venous phases via a semi-automated dedicated *** rate was obtained from volume change between the two phases and standardised for unit *** were divided into two groups,according to the angiographic signs and their concordance with *** Upper bleeding accounted for 42.9%and lower GIB for 57.1%.Mean haemoglobin value at the admission was 7.7 g/dL.A concordance between positive CTA and direct angiographic bleeding signs was found in 19(54.3%)*** no significant differences in terms of bleeding volume in the arterial phase(0.55 mL vs 0.33 mL,P=0.35),a statistically significant volume increase in the venous phase was identified in the group of patients with positive angiography(2.06 mL vs 0.9 mL,P=0.02).In the latter patient group,a significant increase in bleeding rate was also detected(2.18 mL/min vs 0.19 mL/min,P=0.02).CONCLUSION In GIB of any origin,extravasated contrast volumetric analysis at CTA could be a predictor of positive angiography and may help in avoiding further unnecessary procedures.

关键词： Gastrointestinal haemorrhage Computed tomography angiography Volumetric analysis Computer-assisted image interpretation Therapeutic embolization Transcatheter arterial embolization

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PROJECT REGULARITY： DEVELOPMENT AND EVALUATION OF A NEW PROJECT CHARACTERISTIC

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Journal of Systems Science and Systems Engineering 2017年第1期26卷 100-120页

作者： Jordy Batselier mario Vanhoucke Faculty of Economics and Business Administration Ghent Universit)/ Tweekerkenstraat 2 9000 Ghent Belgium Technology and Operations Management Area Vlerick Business School Reep 1 9000 Ghent Belgium UCL School of Management University College London Gower Street London WC1E 6BT United Kingdom

The ability to accurately characterize projects novel project characteristic is developed characteristic, called project regularity, is essential to good project management. Therefore, a reflects the value accrue within a project. This expressed in terms of the newly introduced regular/irregular-indicator RI. The widely accepted management system of earned value management （EVM） forms the basis for evaluation of the new characteristic. More concretely, the influence of project regularity on EVMforecasting accuracy is assessed, and is shown to be significant for both time and cost forecasting. Moreover, this effect appears to be stronger than that of the widely used characteristic of project seriality expressed by the serial/parallel-indicator SP. Therefore, project regularity could also be useful as an input parameter for project network generators. Furthermore, the introduction of project regularity can provide project managers with a more accurate indication of the time and cost forecasting accuracy that is to be expected for a certain project and, correspondingly, of how a project should be built up in order to obtain more reliable forecasts during project control.

关键词： Project management earned value management time and cost forecasting empirical database Monte Carlo simulation project control system

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Renewable Energy Penetration Strengthened Using a Reversible Solid Oxide Cell Installed in a Building

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 360-368页

作者： mario Lamagna Davide Astiaso Garcia Astronautical Electrical and Energy Engineering Department(DIAEE)Sapienza University of RomeItaly Planning DesignTechnology of Architecture Department(DPDTA)Sapienza University of RomeItaly

The renewable energy source(RES)penetration in end use must be strengthened to reach the prefixed decarbonization targets.A penetration obstacle is represented by the Power Grid,designed with an architecture disinclined to RES ***,different solutions are available to integrate these latter issues without affecting the Grid,among these,the reversible Solid Oxide Cell(rSOC)promises high efficiencies and the possibility to control energy fluxes in both production and *** this study,a series of hourly simulations based on real data were designed to evaluate the rSOC capacity to integrate a large number of RESs in the end use of three different buildings,through analyzing the possible congestion on the Power *** a rSOC model we chose the Smart Energy Hub proposed by Sylfen while for the buildings we selected a school,a hotel,and an office located in Procida,*** results show the rSOC capacity to integrate RES increased from 40%to 62%according to the storage capacity and the building’s hourly load curve and seasonal consumptions.

关键词： Green hydrogen RES integration rSOC power-to-power

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Biomaterials and additive manufacturing:osteochondral scaffold innovation applied to osteoarthritis(BAMOS project)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第4期19卷 329-330页

作者： mario MONZóN Departamento de Ingeniería Mecánica Universidad de Las Palmas de Gran CanariaEdificio de Fabricación Integrada

Osteoarthritis(OA)is a degenerative joint disease,typified by a loss of quality of cartilage and changes in bone at the interface of a joint,resulting in pain,stiffness,and reduced mobility."According to the World Hea... 详细信息

关键词：骨关节炎添加剂 ma 革新支架工程活动性疾病

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The first cavefish in the Dinaric Karst?Cave colonization made possible by phenotypic plasticity in Telestes karsticus

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Zoological Research 2023年第4期44卷 821-833页

作者： mateoČupić Zoran Marčić Marko Lukić Romana Gračan Helena Bilandžija Division of Molecular Biology Ruđer BoškovićInstituteZagreb 10000Croatia Department of Biology Faculty of ScienceZagreb 10000Croatia Croatian Biospeleological Society Zagreb 10000Croatia

Cave animals are an excellent model system for studying adaptive *** present,however,little is known about the mechanisms that enable surface colonizers to survive in the challenging environment of *** possibility is that these species have the necessary genetic background to respond with plastic changes to the pressures of underground *** gain insight into this process,we conducted a comparative study with the fish species Telestes karsticus,which occurs in a hydrological system consisting of an interconnected stream and a *** showed that *** resided year-round and spawned in Sušik cave,making it the first known cavefish in the Dinaric *** and surface populations differed in morphological and physiological characteristics,as well as in patterns of gene expression without any evidence of genetic *** test whether observed trait differences were plastic or genetic,we placed adult fish from both populations under light/dark or constant dark *** laboratory conditions erased all morphometric differences between the two morphs,suggesting phenotypic plasticity is driving the divergence of shape and size in wild *** pigmentation and increased fat deposition exhibited by cave individuals were also observed in surface fish kept in the dark in the *** study also revealed that specialized cave traits were not solely attributed to developmental plasticity,but also arose from adult responses,including ***,we conclude that *** can adapt to cave conditions,with phenotypic plasticity playing an important role in the process of cave colonization.

关键词： Maladaptive and adaptive phenotypic plasticity Troglobionts and stygobionts Endemic leuciscid fish Acclimatization European cavefish Cave adaptations Gene expression differences

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Cellular reprogramming and inherited peripheral neuropathies: perspectives and challenges

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Neural Regeneration Research 2015年第6期10卷 894-896页

作者： mario A.Saporta Department of Neurology Universidade Federal Fluminense

Inherited peripheral neuropathies （or Charcot-Marie-Tooth disease, CMT） are a phenotypically and genetically heterogeneous group of disorders, which are currently untreatable. They are the most common inherited neuromuscular disorder, affecting around 1 in every 2,500 people （over 120,000 people in the US）. Based on clinical neurophysiological and histopathological features, inherited neuropathies can be divided into two major forms： demyelinating （type 1） and axonal （type 2） CMT （Saporta, 2014）.

关键词： gene CMT Cellular reprogramming and inherited peripheral neuropathies perspectives and challenges LITAF

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Candidate Biomarkers of Liver Fibrosis: A Concise, Pathophysiology-oriented Review

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 317-325页

作者： Mattia Bellan Luigi mario Castello mario Pirisi Department of Translational Medicine Universita del Piemonte Orientale UPONovaraItaly Division of Internal Medicine “Sant'Andrea Hospital”VercelliItaly IRCAD Interdisciplinary Research Center of Autoimmune DiseasesNovaraItaly Emergency Medicine Department “AOU Maggiore della Carita”NovaraItaly Division of Internal Medicine “AOU Maggiore della Carita”NovaraItaly

Repair of sustained liver injury results in fibrosis(*** accumulation of extracellular matrix proteins),and ultimately the complete distortion of parenchymal architecture of the liver,which we call *** and staging of fibrosis is thus a mainstay in the management of chronic liver diseases,since many clinically relevant decisions,such as starting treatment and/or monitoring for complications including hepatocellular carcinoma,may depend on *** gold standard for fibrosis staging is liver biopsy,the role of which,however,is questioned nowadays because of cost,hazards and poor acceptance by *** the other hand,imaging techniques and/or measurement of direct and indirect serum markers have not proved to be completely satisfactory under all circumstances as alternatives to liver *** progress in this field is nowmore crucial than ever,since treatments for established fibrosis appear on the *** dissection of the pathways involved in the pathophysiology of liver diseases has put forward several novel candidate biomarkers of liver fibrosis,such as growth arrest-specific6,Mac-2-binding protein,osteopontin,placental growth factor,growth/differentiation factor 15 and hepatocyte growth *** molecules have been suggested to have potential to complement or substitute methods currently used to stage liver ***,we review the pros and cons for their use in this setting.

关键词： Liver fibrosis Staging Biomarkers Gas6 HGF PlGF

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Modeling the arc and ring structures in the HD 143006 disk

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 137-149页

作者： Yao Liu mario Flock Min Fang Purple Mountain Observatory&Key Laboratory for Radio Astronomy Chinese Academy of SciencesNanjing 210023China Max-Planck-Institut für Astronomie Heidelberg D-69117Germany

Rings and asymmetries in protoplanetary disks are considered as signposts of ongoing planet *** this work,we con-duct three-dimensional radiative transfer simulations to model the intriguing disk around HD143006 that has three dust rings and a bright arc.A complex geometric configuration,with a misaligned inner disk,is assumed to account for the asymmetric *** two-dimensional surface density is constructed by iteratively fitting the ALMA *** find that the dust tem-perature displays a notable discontinuity at the boundary of the *** ring masses range from 0.6 to 16 M⊕that are systematically lower than those inferred in the younger HL Tau *** arc occupies nearly 20%of the total dust *** a high mass fraction of dust grains concentrated in a local region is consistent with the mechanism of dust trapping into *** a gas-to-dust mass ratio of 30 that is constant throughout the disk,the dense and cold arc is close to the threshold of being gravitationally unstable,with the Toomre parameter Q∼***,our estimate of Q relies on the assumption for the unknown gas-to-dust mass *** a lower gas-to-dust mass ratio would increase the inferred Q ***-up high resolution observations of dust and gas lines are needed to clarify the origin of the substructures.

关键词： protoplanetary disks radiative transfer planet formation

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