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How to recognize late-onset hypogonadism in men wit sexual dysfunction

Asian Journal of Andrology 2012年第2期14卷 251-259页

作者： Giovanni Corona Giulia Rastrelli Linda Vignozzi Edoardo Mannucci mario Maggi Sexual Medicine and Andrology Unit Department of Clinical Physiopathology University of Florence Florence 50139 Italy Endocrinology Unit Maggiore-Bellaria Hospital Medical Department Azienda-Usl Bologna Bologna 40133 Italy Diabetes Section Geriatric Unit Department of Critical Care University of Florence Florence 50139 Italy

Late-onset hypogonadism （LOH） has been considered the most common form of male hypogonadism with a prevalence of approximately 1 in 100 men. Diagnosis of LOH should be made in symptomatic men with unequivocally low serum testosterone （T） levels. However, its clinical presentation is often insidious and difficult to recognize because it is characterized by nonspecific symptoms that make differential diagnosis with physiological ageing problematic. Sexual dysfunction is the most important determinant for medical consultation and the most specific symptom associated with low T. We therefore analysed a consecutive series of 1734 subjects who attended our unit for sexual dysfunction to investigate the associations between low T （different thresholds）, sexual parameters, medical history data （delayed puberty, pituitary disease or cryptorchidism） and their physical exam results. Metabolic parameters, in particular waist circumference, display the greatest accuracy in detecting low T. We found that only the association of several symptoms and signs could significantly raise the clinical suspicion of low T. Structured inventories, which cluster together symptoms and signs of hypogonadism, can help clinicians suspect androgen deficiency. In particular, structured interviews, such as ANDROTEST, have been demonstrated to have a greater accuracy when compared to self reported questionnaires in detecting low T levels.

关键词： late-onset hypogonadism (LOH) male hypogonadism testosterone sexual dysfunction

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Role of preoperative CT colonography in patients with colorectal cancer

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World Journal of Gastroenterology 2014年第14期20卷 3795-3803页

作者： Lapo Sali Massimo Falchini Antonio Taddei mario Mascalchi Department of Experimental and Clinical Biomedical Sciences University of Florence Department of Surgery and Translational Medicine University of Florence

In patients with colorectal cancer (CRC), accurate preoperative evaluation is essential for a correct therapeutic plan. Colonoscopy and intravenous contrast-enhanced computed tomography (CT) are currently recommended in the preoperative work-up for CRC. Preoperative colonoscopy has some limitations such as misdiagnosis of synchronous cancers in cases of incomplete exploration of the colon and inaccurate tumor localization. Intravenous contrast-enhanced CT successfully documents distant metastases although it sometimes enables unsatisfactory locoregional staging. Computed tomography colonography (CTC) is obtained after gas insufflation of the colon and offers a comprehensive preoperative evaluation in patients with CRC, including a definition of the segmental location of the tumor, presence of synchronous lesions or lack thereof, and fairly accurate locoregional staging. CTC has some limitations, including a lack of biopsy capability, suboptimal sensitivity for synchronous small polyps, and unsatisfactory nodal staging. Bearing in mind these limitations, CTC could be employed as a “one-stop-shop” examination for preoperative assessment in patients with CRC.

关键词： Colorectal cancer Colonoscopy Computed tomography colonography Synchronous cancer Cancer staging

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3-D crustal-scale gravity model of the San Rafael Block and Payenia volcanic province in Mendoza,Argentina

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Geoscience Frontiers 2018年第1期9卷 239-248页

作者： Daniel Richarte Marianela Lupari Agustina Pesce Silvina Nacif mario Gimenez Instituto Geofísico-Sismológico Volponi Universidad Nacional de San JuanArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Argentina

The San Rafael Block(SRB)is part of one of the main retroarc volcanic provinces in southern Central Andes in Mendoza,*** block is located in the Andean foothills between the orogenic front and foreland basement uplifts of late Miocene *** order to analyze the geochronological evolution of the Quaternary volcanism in the region,several geologic and geophysical studies have been ***,the crust,where the SRB is located,has not been well characterized *** on gravimetric and magnetic data,together with isostatic and elastic thickness analyses,we modeled the crustal structure of the *** obtained has allowed us to understand the crust where the SRB and the Payenia volcanic province are *** anomalies indicate that the SRB presents higher densities to the North of Cerro Nevado and Moho calculations suggest depths for this block between 40 and 50 *** of elastic thickness would indicate that the crust supporting the San Rafael Block presents values of approximately 10 km,being enough to support the block ***,in the Payenia region,elastic thickness values are close to zero due to the regional temperature increase.

关键词： San Rafael Block Payenia 3-D crustal model Asthenospheric wedge

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Subregion graph: A path planning acceleration structure for characters with various motion types in very large environments

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Computational Visual Media 2015年第2期1卷 105-118页

作者： Nicholas mario Wardhana Henry Johan Hock Soon Seah Multi-plAtform Game Innovation Centre(MAGIC) Nanyang Technological University School of Computer Engineering Nanyang Technological University Fraunhofer IDM NTU Nanyang Technological University

Modern computer graphics applications commonly feature very large virtual environments and diverse characters which perform different kinds of motions. To accelerate path planning in such a scenario, we propose the subregion graph data structure. It consists of subregions, which are clusters of locally connected waypoints inside a region, as well as subregion connectivities. We also present a fast algorithm to automatically generate a subregion graph from an enhanced waypoint graph map representation,which also supports various motion types and can be created from large virtual environments. Nevertheless,a subregion graph can be generated from any graphbased map representation. Our experiments show that a subregion graph is very compact relative to the input waypoint graph. By firstly planning a subregion path, and then limiting waypoint-level planning to this subregion path, over 8 times average speedup can be achieved, while average length ratios remain as low as102.5%.

关键词： path planning acceleration very large environments motion types abstraction

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Preliminary assessment of nasopharyngeal carcinoma incidence in the Philippines: a second look at published data from four centers

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Chinese Journal of Cancer 2014年第3期33卷 159-164页

作者： mario Paulus Cesar B.Sarmiento Michael Benedict A.Mejia Department of Radiation Oncology Benavides Cancer InstituteUniversity of Santo Tomas Hospital

In endemic regions such as southern China and Southeast Asia, the annual incidence of nasopharyngeal carcinoma(NPC) ranges from 3 to 30 per 100,000. In the Philippines, the estimated incidence in 2010 was 1.2 per 100,000. However, this rate is based on data collected from registries covering only two regions in the country. Here, we report the findings from our study to better approximate the incidence of NPC in the Philippines. Between September 1, 2011 and August 31, 2012, data were collected from 49 patients from 4 different institutions—University of Santo Tomas, Makati Medical Center, Philippine Oncology Center Corporation, and Cardinal Santos Memorial Medical Center—using a NPC screening questionnaire. Crude incidence was 0.09 per 100,000. Age-standardized incidences using Segi and WHO standards were 2.08 and 1.79 per 100,000, respectively. Of the 49 patients, 31 were males and 18 were females, and 71% of patients were between 30 and 59 years old. WHO types II and III represented 22% and 78% of the subjects, respectively, and 75.5% of cases were locally advanced(stages III–IVB). Although the age-standardized incidence from the 4 institutions was numerically higher than the published age-standardized incidence(2.07 per 100,000 vs. 1.2 per 100,000), two-proportion z-test showed no significant difference between them(P = 0.68). A more concerted effort is needed for a better approximation of the country's NPC disease burden.

关键词： Nasopharyngeal carcinoma incidence Philippines

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Application of Natural Antioxidants from Strawberry Tree(Arbutus unedo L.) and Dog Rose(Rosa canina L.) to Frankfurters Subjected to Refrigerated Storage

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Journal of Integrative Agriculture 2013年第11期12卷 1972-1981页

作者： Mónica Armenteros David Morcuende Sonia Ventanas mario Estévez Animal Production and Food Science University of ExtremaduraAv.de la Universidad s/n

The effect of the addition of natural antioxidants from strawberry tree （Arbutus unedo L.; AU） and dog rose （Rosa canina L.; RC）, in frankfurters elaborated with or without the addition of antioxidant additives （sodium ascorbate and nitrite） was studied. Six different types of experimental frankfurters were prepared depending on the addition of phenolic-rich extracts from RC and AU and the presence （P） or absence （C） of antioxidant additives. Thiobarbituric acid reactive substances （TBARS）-numbers signiifcantly increased during chilled storage of C-frankfurters while additives and fruit phenolics inhibited lipid oxidation in P-frankfurters. The amount of protein carbonyls signiifcantly increased in all treatments except in P-AU frankfurters. The discoloration process that occurred during the chilled storage was reduced by the addition of substances with proven antioxidant activity （P-frankfurters）. Texture characteristics as hardness, springiness, cohesiveness and gumminess also suffered a signiifcant deterioration in C-frankfurters. The use of phenolic fruit extracts in combination with traditional antioxidant additives is a successful strategy to enhance the oxidative stability of frankfurters without modifying their color and texture properties.

关键词： fruit phenolics protein oxidation lipid oxidation nitrite ascorbate

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Helicobacter pylori virulence genes

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World Journal of Gastroenterology 2019年第33期25卷 4870-4884页

作者： Anja Sterbenc Erika Jarc mario Poljak Matjaz Homan Institute of Microbiology and Immunology Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Gastroenterology Hepatology and NutritionUniversity Children’s HospitalFaculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia

Helicobacter pylori(***)is one of the most important human pathogens,infecting approximately half of the global *** its high prevalence,only a subset of *** infected individuals develop serious gastroduodenal *** pathogenesis of *** infection and disease outcome is thus thought to be mediated by an intricate interplay between host,environmental and bacterial virulence *** has adapted to the harsh milieu of the human stomach through possession of various virulence genes that enable survival of the bacteria in the acidic environment,movement towards the gastric epithelium,and attachment to gastric epithelial *** virulence factors enable successful colonization of the gastric mucosa and sustain persistent *** infection,causing chronic inflammation and tissue damage,which may eventually lead to the development of peptic ulcers and gastric *** studies have focused on the prevalence and role of putative *** virulence genes in disease *** several virulence factors with various functions have been identified,disease associations appear to be less evident,especially among different study *** review presents key findings on the most important *** virulence genes,including several bacterial adhesins and toxins,in children and adults,and focuses on their prevalence,clinical significance and potential relationships.

关键词： Helicobacter pylori Virulence genes Disease association Children Adults Outer membrane proteins Bacterial toxins

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Validation of material point method for soil fluidisation analysis

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Journal of Hydrodynamics 2017年第3期29卷 431-437页

作者： Marco Bolognin mario Martinelli Klaas J.Bakker Sebastiaan N.Jonkman Delft University of Technology DelftThe Netherlands Deltares DelftThe Netherlands

The main aim of this paper is to describe and analyse the modelling of vertical column tests that undergo fluidisation by the application of a hydraulic gradient.A recent advancement of the material point method（MPM）,allows studying both stationary and non-stationary fluid flow while interacting with the solid *** fluidisation initiation and post-fluidisation processes of the soil will be investigated with an advanced MPM formulation（Double Point）in which the behavior of the solid and the liquid phase is evaluated separately,assigning to each of them a set of material points（MPs）.The result of these simulations are compared to analytic solutions and measurements from laboratory *** work is used as a benchmark test for the MPM double point formulation in the Anura3D software and to verify the feasibility of the software for possible future engineering applications.

关键词： Material point method fluidization liquefaction

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Ethernet based time synchronization for Raspberry Pi network improving network model verification for distributed active turbulent flow control

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Control Theory and Technology 2015年第2期13卷 204-210页

作者： Marcel DUECK mario SCHLOESSER Stefan van WAASEN Michael SCHIEK Central Institute of Engineering Electronics and Analytics ZEA-2: Electronic SystemsForschungszentrum Juelich Gmb H ZEA-2 Wilhelm-Johnen-Straβe University of Duisburg-Essen Faculty of Engineering

Friction drag primarily determines the total drag of transport systems. A promising approach to reduce drag at high Reynolds numbers(> 104) are active transversal surface waves in combination with passive methods like a riblet surface. For the application in transportation systems with large surfaces such as airplanes, ships or trains, a large scale distributed real-time actuator and sensor network is required. This network is responsible for providing connections between a global flow control and distributed actuators and sensors. For the development of this network we established at first a small scale network model based on Simulink and True Time. To determine timescales for network events on different package sizes we set up a Raspberry Pi based testbed as a physical representation of our first model. These timescales are reduced to time differences between the deterministic network events to verify the behavior of our model. Experimental results were improved by synchronizing the testbed with sufficient precision. With this approach we assure a link between the large scale model and the later constructed microcontroller based real-time actuator and sensor network for distributed active turbulent flow control.

关键词： Raspberry Pi True Time distributed actuator and sensor network network model

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The AMS measurement of ^236U at CIRCE

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Nuclear Science and Techniques 2017年第7期28卷 47-51页

作者： Yong-Jing Guan Hui-Juan Wang mario De Cesare Filippo Terrasi Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science & Technology Guangxi University Nanning 530004 China Department of Diagnostic Methodologies and Measurement Techniques Italian Aerospace Research Centre (CIRA) 81043 Capua (CE) Italy INFN 80126 Naples Italy CIRCE Department of Mathematic and Physics Ⅱ University of Naples 81100 Caserta Italy

Accelerator mass spectrometry(AMS) is an ultrasensitive technique for measuring long-lived actinides,e.g.,^(236)U,^(237)Np and Pu *** order to improve the detection limit for actinides abundance,and to increase the detection efficiency in actinides AMS measurement,a 16-strip silicon detector was used to identify actinides at the Center for Isotopic Research on Cultural and Environmental heritage in Caserta,*** sensitivity of ^(236)U/^(238)U was 1×10^(-11) by special resolution and 5.0×10^(-12) by time *** pulse height defect of^(236)U in an ion-implanted silicon detector in the low-energy range with 17.26 MeV is presented.

关键词： AMS 测量锕系元素钚同位素硅探测器加速器质谱时间分辨率元素丰度

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