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Experience of Patients Undergoing Mini-Arthroscopy Compared to MRI in the Earliest Phases of Arthritis

International Journal of Clinical Medicine 2013年第12期4卷 1-5页

作者： Maria J. H. de Hair Marleen G. H. van de Sande mario maas Danielle M. Gerlag Paul P. Tak Department of Clinical Immunology and Rheumatology Aca-demic Medical Center University of Amsterdam Amsterdam The Netherlands Department of Radiology Academic Medical Center University of Amsterdam Amsterdam The Netherlands

Objective: To evaluate the expectations and experience of patients undergoing mini-arthroscopy compared to contrast enhanced MRI for research purposes. Methods: Seventeen patients with early, active arthritis (Group A) and 21 autoantibody-positive individuals without any evidence of arthritis upon physical examination (Group B) were included. All subjects underwent both contrast enhanced MRI and synovial biopsy sampling by mini-arthroscopy of the same joint within one week. At inclusion and after both procedures, subjects filled in questionnaires with items about expectations and experience with regard to the procedures. Results: Before procedures, subjects in group B had a higher fear of and reluctance to undergo mini-arthroscopy compared to MRI (p < 0.0001 and p = 0.001, respectively). Before procedures, 42% of the subjects preferred MRI, 11% of the subjects preferred mini-arthroscopy and 47% had no preference for either procedure. After both procedures, subjects preferences changed to 39% for MRI, 32% for mini-arthroscopy and 29% for no preference for one or the other procedure. When comparing Group A with Group B, there were no significant differences in preference before and after the procedures. Conclusion: Synovial biopsy sampling by mini-arthroscopy for analysis of synovial inflammation is a well-experienced procedure when compared to contrast enhanced MRI. These results support the use of mini-arthroscopy in a research setting from a patient perspective.

关键词： Arthritis Rheumatoid Synovium Arthroscopy MRI

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Describing gluons at zero and finite temperature

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Chinese Physics C 2010年第9期34卷 1328-1330页

作者： A.maas Institute of Physics Karl-Franzens University Graz

Any description of gluons requires a well-defined *** is complicated non-perturbatively by Gribov copies.A possible method-independent gauge definition to resolve this problem is presented and afterwards used to study the properties of gluons at any *** is found that only chromo-electric properties reflect the phase *** these the gauge-invariant phase transition temperature is determined for SU（2） and SU（3） Yang-Mills theory independently.

关键词： gluons gauge-fixing temperature Yang-Mills theory Gribov-Singer obstruction confinementIf

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A digital earth platform for sustainability

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International Journal of Digital Earth 2017年第4期10卷 342-355页

作者： mario Hernandez Engagement Committee Future EarthMexico CityMexico International Society for Digital Earth Mexico CityMexico

Based on the experience of the International Society for Digital Earth(ISDE),this paper describes some challenges foreseen in order to develop a Digital Earth platform that can support the implementation of the Sustainable Development *** use of ready-to-use derived geospatial information is *** Earth’s methodology of‘co-design’aims to bring together natural,social scientists and decision makers to plan and carry out research for *** implies transdisciplinary research,but in order for scientists of different disciplines to work together,they will need to be able to share,access and use common *** is by far not simple!While the good will to share data might exist,the associated technological,ethical and privacy issues are difficult to *** adequate e-infrastructure will be *** could consider to use the SDGs is the basis to develop the desired Digital Earth *** paper,by no means,covers everything for a Digital Earth platform,it aims to trigger research discussions and to have a good view about a starting point.

关键词： Digital earth platform sustainable development Sustainable Development Goals future earth

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Anisotropic brittle-ductile transition of monocrystalline sapphire during orthogonal cutting and nanoindentation experiments

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Nanotechnology and Precision Engineering 2018年第3期1卷 157-171页

作者： Philipp maas Yuta Mizumoto Yasuhiro Kakinuma Sangkee Min Department of System Design Engineering Faculty of Science & TechnologyKeio University Department of Mechanical Engineering University of Wisconsin-Madison

Single-crystal sapphire is utilized as a high-performance engineering material,especially in extreme and harsh ***,due to its extreme hardness and brittleness,the machinability of sapphire is still a *** means of nanoindentation and plunge-cut experiments,the anisotropic brittle-ductile transition of the prismatic M-plane and rhombohedral R-plane is examined by analyzing crack morphologies and the critical depth-of-cut(CDC).The experimental results of the nanoindentation tests are correlated to the plunge-cut *** the prism plane and the rhombohedral crystal plane exhibit a two-fold symmetry of ductility with various crack patterns along the machined *** direction-dependent plasticity of the hexagonal sapphire crystal is mainly connected to a twinning process accompanied by slip dislocation.

关键词： Sapphire Anisotropy Brittle-ductile transition Orthogonal cutting

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PROJECT REGULARITY： DEVELOPMENT AND EVALUATION OF A NEW PROJECT CHARACTERISTIC

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Journal of Systems Science and Systems Engineering 2017年第1期26卷 100-120页

作者： Jordy Batselier mario Vanhoucke Faculty of Economics and Business Administration Ghent Universit)/ Tweekerkenstraat 2 9000 Ghent Belgium Technology and Operations Management Area Vlerick Business School Reep 1 9000 Ghent Belgium UCL School of Management University College London Gower Street London WC1E 6BT United Kingdom

The ability to accurately characterize projects novel project characteristic is developed characteristic, called project regularity, is essential to good project management. Therefore, a reflects the value accrue within a project. This expressed in terms of the newly introduced regular/irregular-indicator RI. The widely accepted management system of earned value management （EVM） forms the basis for evaluation of the new characteristic. More concretely, the influence of project regularity on EVMforecasting accuracy is assessed, and is shown to be significant for both time and cost forecasting. Moreover, this effect appears to be stronger than that of the widely used characteristic of project seriality expressed by the serial/parallel-indicator SP. Therefore, project regularity could also be useful as an input parameter for project network generators. Furthermore, the introduction of project regularity can provide project managers with a more accurate indication of the time and cost forecasting accuracy that is to be expected for a certain project and, correspondingly, of how a project should be built up in order to obtain more reliable forecasts during project control.

关键词： Project management earned value management time and cost forecasting empirical database Monte Carlo simulation project control system

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Arsenic and sulfur nanoparticle synthesis mimicking environmental conditions of submarine shallow-water hydrothermal vents

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Journal of Environmental Sciences 2022年第1期34卷 301-312页

作者： Vicente Durán-Toro Kurosch Rezwan Solveig I.Bühring Michael maas MARUM–Center for Marine Environmental Sciences University of BremenBremen 28359Germany Advanced Ceramics University of BremenBremen 28359Germany MAPEX-Center for Materials and Processes University of BremenBremen 28359Germany

Arsenic and sulfur mineralization is a natural phenomenon occurring in hydrothermal systems where parameters like temperature and organic matter(OM)can influence the mobilization of the toxic metalloid in marine *** the present study we analyze the influence of temperature and OM(particularly sulfur-containing additives)on As and S precipitation based on the recent discovery of As-rich nanoparticles in the hydrothermal system near the coast of the Greek island *** this end,we experimentally recreate the formation of amorphous colloidal particles rich in As and S via acidification(pH 3–4)of aqueous precursors at various *** higher temperatures,we observe the formation of monodisperse particles within the first 24 h of the experiment,generating colloidal particles with diameters close to 160 *** S:As ratio and particle size of the synthetized particles closely correlates with values for As_(x)S_(y)particles detected in the hydrothermal system off ***,organic sulfur containing additives(cysteine and glutathione,GSH)are a key factor in the process of nucleation and growth of amorphous colloidal As_(x)S_(y)particles and,together with the temperature gradient present in shallow hydrothermal vents,dictate the stabilization of As-bearing nanomaterials in the *** on these findings,we present a simple model that summarizes our new insights into the formation and mobility of colloidal As in aquatic *** this context,amorphous As_(x)S_(y)particles can present harmful effects to micro-and macro-biota not foreseen in bulk As material.

关键词： Biomineralization Milos Hydrothermal vent Arsenic Sulfur Nanoparticles Ecotoxicology

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Renewable Energy Penetration Strengthened Using a Reversible Solid Oxide Cell Installed in a Building

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 360-368页

作者： mario Lamagna Davide Astiaso Garcia Astronautical Electrical and Energy Engineering Department(DIAEE)Sapienza University of RomeItaly Planning DesignTechnology of Architecture Department(DPDTA)Sapienza University of RomeItaly

The renewable energy source(RES)penetration in end use must be strengthened to reach the prefixed decarbonization targets.A penetration obstacle is represented by the Power Grid,designed with an architecture disinclined to RES ***,different solutions are available to integrate these latter issues without affecting the Grid,among these,the reversible Solid Oxide Cell(rSOC)promises high efficiencies and the possibility to control energy fluxes in both production and *** this study,a series of hourly simulations based on real data were designed to evaluate the rSOC capacity to integrate a large number of RESs in the end use of three different buildings,through analyzing the possible congestion on the Power *** a rSOC model we chose the Smart Energy Hub proposed by Sylfen while for the buildings we selected a school,a hotel,and an office located in Procida,*** results show the rSOC capacity to integrate RES increased from 40%to 62%according to the storage capacity and the building’s hourly load curve and seasonal consumptions.

关键词： Green hydrogen RES integration rSOC power-to-power

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Biomaterials and additive manufacturing:osteochondral scaffold innovation applied to osteoarthritis(BAMOS project)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第4期19卷 329-330页

作者： mario MONZóN Departamento de Ingeniería Mecánica Universidad de Las Palmas de Gran CanariaEdificio de Fabricación Integrada

Osteoarthritis(OA)is a degenerative joint disease,typified by a loss of quality of cartilage and changes in bone at the interface of a joint,resulting in pain,stiffness,and reduced mobility."According to the World Hea... 详细信息

关键词：骨关节炎添加剂 ma 革新支架工程活动性疾病

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Revisiting the theoretical prediction of the explosive performance found by the Trauzl test

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Defence Technology（防务技术） 2024年第6期36卷 163-174页

作者： Ivana Dobrilovic mario Dobrilovic Muhamed Suceska Faculty of Mining Geology and Petroleum EngineeringDepartment of Mining Engineering and GeotechnicsUniversity of ZagrebPierottijeva 6Zagreb10000Croatia

The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive charge in the cavity of a lead *** this paper,we reconsider the possibility of interpreting the Trauzl test results in terms of detonation parameters or *** detonation parameters used in the analysis are calculated using the thermochemical code EXPLO5,while the hydrocode AUTODYN is used to simulate the effect of explosive charge density and reaction rate on the results of the Trauzl *** increase in the volume of the lead block cavity was found to correlate best with the product of the detonation heat and the root of the volume of detonation *** simulation showed that the density of explosive charge and the rate of explosive decomposition affect the dynamics of the interaction of the detonation product and the lead block,and consequently the lead block cavity volume increase.

关键词： Trauzl lead block test Performance of explosives EXPLO5 AUTODYN Detonation heat

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