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Renal transplants from older deceased donors: Is preimplantation biopsy useful? A monocentric observational clinical study

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World Journal of Transplantation 2018年第4期8卷 110-121页

作者： Giacomo Colussi Costanza Casati Valeriana Giuseppina Colombo mario livio pietro camozzi Fabio Rosario Salerno Division of Nephrology Dialysis and Renal Transplantatation ASST Grande Ospedale Territoriale Niguarda Division of Pathology ASST Grande Ospedale Territoriale Niguarda School of Nephrology Milano-Bicocca University

AIM To compare survival of kidney transplants from deceased extended criteria donors(ECD) according to:(1) donor graft histological score; and(2) allocation of high score grafts either to single(SKT) or dual(DKT) *** Renal biopsy was performed as part of either a newly adopted DKT protocol, or of surveillance protocol in the past. A total 185 ECD graft recipients were categorized according to pre-implantation graft biopsy into 3 groups: SKT with graft score 1 to 4 [SKT(1-4), n = 102]; SKT with donor graft score 5 to 8 [SKT(> 4), n = 30]; DKT with donor graft score 5 to 7(DKT, n = 53). Graft and patient survival were analyzed by Kaplan-Meier curves and compared by log-rank test. Mean number of functioning graft years by transplant reference, and mean number of dialysis-free life years by donor reference in recipients were also calculated at 1, 3 and 6 years from transplantation. RESULTS There were no statistically significant differences in graft and patient survival between SKT(1-4) and SKT(> 4), and between SKT(> 4) and DKT. Recipient renal function(plasma creatinine and creatinine clearance) at 1 years did not differ in SKT(1-4) and SKT(> 4)(plasma creatinine 1.71 ± 0.69 and 1.69 ± 0.63 mg/dL; creatinine clearance 49.6 + 18.5 and 52.6 + 18.8 m L/min, respectively); DKT showed statistically lower plasma creatinine(1.46 ± 0.57, P 4)]. CONCLUSION In transplan

关键词： Dual kidney transplant Extended criteria donor Graft survival Pre-implantation biopsy score Renal transplantation Single kidney transplant

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Erectile dysfunction as a predictor of asymptomatic coronary artery disease in elderly men with type 2 diabetes

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Journal of Geriatric Cardiology 2016年第6期13卷 552-556页

作者： Carmine Gazzaruso Adriana Coppola Arturo Pujia Colomba Falcone Silvia Collaviti Mariangela Fodaro pietro Gallotti Sebastiano B Solerte Andrea Giustina Gabriele Pelissero livio Luzi Tiziana Montalcini Internal medicine diabetes endocrine-metabolic diseases Unit and the Centre for Applied Clinical Research (Ce.R.CA.) Clinical Institute 'Beato Matteo Vigevano Italy Department of Clinical and Experimental Medicine University of Catanzaro Catanzaro Italy Cardiology Unit Clinical Institute 'Citta di Pavia ' University of Pavia Pavia Italy Department of lnternal Medicine University of Pavia Pavia Italy Department of Medical and Surgical Sciences University of Brescia Brescia Italy IRCCS Policlinico San Donato and University of Pavia Pavia Italy IRCCS Policlinico San Donato and University of Milan Milan Italy

1 Introduction Erectile dysfunction （ED） and coronary artery disease （CAD） are closely linked, as both conditions share the same cardiovascular risk factors. Indeed, these risk factors can determine endothelial dysfunction that represents the common underlying mechanism of both ED and CAD. The prevalence of ED is about three-fold higher among diabetic patients than in the general population and a higher prevalence of CAD has been observed in people with diabetes when compared to non-diabetic *** studies showed that ED can be a powerful marker of silent CAD and a strong predictor of cardiovascular events in apparently uncomplicated type 2 diabetic patients Therefore ED is now considered as a sentinel symptom of silent CAD, as ED often precedes the onset of myocardial ischemia itself by many years.

关键词： Aging male Diabetes mellitus Erectile dysfunction Silent coronary artery disease

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