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A potential clinical based score in hepatitis C viruscirrhotic patients to exclude small hepatocellular carcinoma

Hepatoma Research 2018年第4期4卷 14-24页

作者： Denise Cerqueira Paranaguá-Vezozzo Celso Eduardo Lourenco Matielo Daniel Ferraz de Campos Mazo Lucas Souto Nacif mario guimaraes pessoa Gleicy Luz Reinoso Pereira Roque Gabriel Rezende de Lima Patricia Momoyo Yoshimura Zitelli Suzane Kioko Ono Flair JoséCarrilho Division of Gastroenterology and Hepatology Department of GastroenterologyUniversity of Sao Paulo School of MedicineSao Paulo 05403-900Brazil Sao Paulo Clínicas Liver Cancer Group Sao PauloCancer Institute of Sao PauloUniversity of Sao Paulo School of MedicineSao Paulo 01246-000Brazil Division of Gastroenterology(Gastrocentro) School of Medical SciencesUniversity of CampinasCampinas 13083-878Brazil

Aim: Hepatitis C virus (HCV) cirrhosis is an important cause of hepatocellular carcinoma (HCC). This study aimed to identify factors of HCC presence among HCV cirrhotic patients with and without small diameter HCC (≤ 3 cm). Methods: A case control transversal study between 1998 and 2003 including 93 patients: 31 with small diameter HCC and 62 without HCC. Groups were matched by age and gender. Multiple logistic regression analysis using Akaike Information Criteria to estimate the probability of HCC was performed. A model score was generated and bootstrap analysis was performed for internal validation. Results: Three significant laboratorial variables for HCC presence were found: alanine aminotransferase > 37 U/L [odds ratio (OR): 7.43 (1.61-34.19),P = 0.01], alpha-fetoprotein > 20 ng/mL [OR: 16.2 (4.17-63.01),P < 0.001] and platelet count < 100,000/mm3 (OR: 3.62 (1.43-9.14),P = 0.007)A model score with an area under curve of 0.79 (95% CI: 0.7-0.89) was built based on these variables. The negative predictive value of those classified as at low risk of HCC was 99.1%. Conclusion: An easy and practical model score was generated. It may be an auxiliary tool for identification of HCV patients with low probability of small diameter HCC at initial evaluation composed of three serum examinations used in routine outpatient clinical practice.

关键词： Clinical score hepatocellular carcinoma hepatitis C

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SC Hemoglobinopathy(HbSC) with Osteoarticular Complications:Case Report

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Health 2017年第7期9卷 1075-1080页

作者： Filipe Bezerra Macedo Jucier Goncalves Júnior Fabiana Gouveia guimaraes Raphael Cisne Tomaz Débora Valentim Monte Alto Paula pessoa Pinheiro Jácia Maria Neves Coelho Department of Pediatric Hospital Maternidade Sao Vicente de Paulo(HMSVP)BarbalhaBrazil School of Medicine Federal University of Cariri(UFCA)BarbalhaBrazil Residence in Pediatrics Federal University of Cariri(UFCA)BarbalhaBrazil

Background: Among hemoglobinopathies, the most prevalent in our population are hemoglobins S and C, which are capable of producing disease when homozygous. In cases of double heterozygotes with sickle hemoglobin C (SC), the disease is less expressive in its clinical condition and rarer. Case report: Patient has a previous hospitalization with pain in the joints in knee and hip and several febrile peaks. Upon physical examination, the patient had difficulty in walking, without edema, pedal and tibial posterior pulses present, with no signs of compartment syndrome. Complementary exams revealed anemia, leukocytosis and lymphopenia. The hemoglobin electrophoresis showed the SC Hemoglobinopathy. The treatment with antibiotic therapy according to the protocol (Oxacillin and Ceftriaxone) was restarted and submitted to joint drainage in affected limb. Conclusion: Osteomyelitis and septic arthritis in patients in the pediatric age group should be considered as serious infections that deserve hospitalization and more expressive treatment.

关键词： SC Hemoglobinopathy Paediatrics Case Report

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Influence of Environmental and Microclimate Factors on the Coffee Beans Quality (C. canephora): Correlation between Chemical Analysis and Stable Free Radicals

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Agricultural Sciences 2018年第9期9卷 1173-1187页

作者： AndréLuíz Alves Marcio Solino pessoa Paulo Eduardo Narcizo de Souza Fábio Luís Partelli Paulo Sérgio Moscon Edson Correa da Silva André Oliveira guimaraes Eduardo Perini Muniz Patrícia Fontes Pinheiro Flávio Meira Borém Paulo César Morais Departamento de Ciências Naturais Universidade Federal do Espírito SantoCentro Universitário Norte do Espírito SantoSao MateusBrazil Universidade de Brasília Instituto de FísicaNúcleo de Física AplicadaBrasília DFBrazil Laboratório de Ciências Físicas Centro de Ciências e TecnologiaUniversidade Estadual Norte FluminenseCampos dos GoytacasesBrazil Departamento de Química e Física Universidade Federal do Espírito SantoAlto UniversitárioAlegreBrazil Departamento de Engenharia Universidade Federal de LavrasLavrasBrazil School of Chemistry and Chemical Engineering Anhui UniversityHefeiChina

The present study reports a physicochemical comparison of shade-grown and sun-grown coffee beans, under unripe, rip and roasted-ripe conditions, using electrical conductivity measurements, electron paramagnetic resonance (EPR), infrared spectroscopy (FTIR), and high performance liquid chromatography (HPLC). Moreover, the assessed physicochemical parameters were compared with organoleptic evaluations based on the Coffee Quality Institute protocol. The values found for electrical conductivity, leached potassium, and stable free radicals were respectively 29%, 31%, and 350% higher for shade-grown coffee beans, whereas polyphenol oxidase enzymatic activity was 23% lower. By contrast, FTIR and HPLC measurements identified higher chlorogenic acid and lipid contents in sun-grown coffee beans. Importantly, the sensorial grade attributed to roasted-ripe grains was 12% higher for sun-grown coffee. Our findings suggest that shade-grown coffee beans have undergone microorganismal activity and undesired fermentation during cultivation, which resulted in lower coffee quality. A correlation between a set of selected physicochemical properties and organoleptic properties was robustly established and could be used in the development of future coffee bean quality control protocols.

关键词： Sun-Grown Coffee Shade-Grown Coffee Fermentation EPR FTIR HPLC

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Oral Cancer:Health Promotion and Visual Screening—A Study Report

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Journal of Cancer Therapy 2013年第8期4卷 1313-1320页

作者： Augusta P.Silveira Augusta Marques Miguel Pavao Eurico Monteiro Gabriela Pereira Joaquim Goncalves Luís Castro Maria Ines guimaraes Bernardete Carvalho Claudia Ribeiro Teresa Sequeira Faculty of Heath Sciences Fernando Pessoa UniversityPortoPortugal Centre of Health Studies and Research Coimbra UniversityCoimbraPortugal Non-Governmental Organization(NGO):Mundo A Sorrir PortoPortugal Portuguese Institute for Oncology PortoPortugal Instituto Politecnico do Cavado e do Ave BarcelosPortugal Porto Portugal Well Medical Spa PortoPortugal Health Sciences Department Portuguese Catholic UniversityViseuPortugal

Background: Oral cancer presents a heterogeneous geographic incidence. Annually, more than 275,000 new cases are diagnosed worldwide. In spite of the easy accessibility of oral cavity during physical examination, most malignancies are not diagnosed until late stages of disease. Methods: Oral health promotion was our main objective, risk factors were identified and oral cavity self-examination was promoted. The population considered (n = 1117) was divided in two main age groups—a youngest (individuals under 25 years old) mostly targeted for oral cancer awareness and oral cavity self examination promotion, and an older group having accumulated potential risk exposure. Results: The results obtained revealed smoking habits and fruits-vegetables consumption deficit as the highest risks factors found. Considering a Risk Factor Exposure Index analysis, individuals with secondary level of instruction and living in sub-urban areas assumed the highest risk exposure. Alcohol consumption had also contributed as a significant risk exposure. Conclusions: Some of these risk factors work as biological reward of quality of life deficit. A wide comprehension of the problem requires a multidisciplinary approach necessarily involving Health and Social Sciences in order to target the core of oral cancer health promotion. An effective epidemiological strategy must thus support three major aspects: population knowledge, sensitization and visual screening.

关键词： Oral Cancer Visual Screening Oral Health Promotion Epidemiological Strategies

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Use of Color Doppler Ultrasound for the Diagnosis of Subarachnoid Hemorrhage in Asymptomatic Full-Term Neonate:A Case Report

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International Journal of Clinical Medicine 2012年第2期3卷 151-153页

作者： Helio A.guimaraes Filho Janett J.Liberalino Ana T.P.Mendonca Carlos V.S.B.Leite Filho Leonardo F.Felipe Carlos F.Melo Júnior CETRIM-Imaginology Training Center Joao PessoaBrazil Departament of Ultrasound Frei Damiao MaternityJoao PessoaBrazil Department of Radiology Federal University of ParaibaJoao PessoaBrazil

Cerebral hemorrhages are fairly common in full-term neonates with no history of traumatic birth, mostly limited, and with benign evolution. We report a case of a full-term neonate from vaginal birth with caput succedaneum in the right parietal area. The neonate underwent cranial ultrasonography and color Doppler which showed extra-axial blood effusion. Color Doppler showed vessels crossing the collection area, which allowed the diagnosis of subarachnoid hematoma.

关键词： Cerebral Hemorrhage Subarachnoid Hematoma Cranial Ultrasound Color Doppler

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Pressure Ulcers in Institutionalized Elderly People:Association of Sociodemographic and Clinical Characteristics and Risk Factors

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Open Journal of Nursing 2017年第1期7卷 111-122页

作者： Suellen Duarte de Oliveira Matos Iraktania Vitorino Diniz Adriana Lira Rufino de Lucena Smalyanna Sgren da Costa Andrade Karen Krystine Goncalves de Brito Elizabeth Souza Silva de Aguiar Emanuelle Malzac Freire de Santana Mailson Marques de Sousa Ana Paula Marques Andrade de Souza Hemílio Fernandes Campos Coelho Mirian Alves da Silva Marta Miriam Lopes Costa Maria Julia guimaraes Oliveira Soares Simone Helena dos Santos Oliveira Graduate Program in Nursing Universidade Federal da ParaíbaJoao PessoaBrazil Departament of Statistics Universidade Federal da ParaíbaParaíbaBrazil

Objective: To evaluate the association of socio-demographic and clinical characteristics, and risk factors with occurrence of pressure ulcers in institutionalized elderly people. Method: This cross-sectional, analytical study, in quantitative approach, performed from the database analysis linked to the project “Pressure Ulcer in institutionalized elderly people: Association of incidence with the risk factors to functional and nutritional assessment” developed in six long-stay institutions for the elderly people in João pessoa. Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0. Associations were made through chi square test and Odds Ratio. Results: The clinical conditions of significant associations with the occurrence of pressure ulcers were the variables neurological disorders (p = 0.011) and visual impairment (p = 0.005). As for risk factors, the most important was fecal incontinence (p Conclusion: The analysis of the associations pointed out problems that require intervention in order to prevent health implications of the elderly people and to minimize the risk and occurrence of this injury.

关键词： Elderly People Institutions for the Elderly People Pressure Ulcer Health Profile Risk Factors

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