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Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

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Open Journal of Veterinary Medicine 2024年第7期14卷 163-179页

作者： Lucia garcia-Delgado Mariana Monserrath Verdía-Venegas Jacinto Bañuelos-Pineda Esther Albarrán-Rodríguez Guillermo Nolasco-Rodriguez José Ricardo Cuellar-Pérez Sergio Fausto-Guerra Manuel Rosales-Cortés Master in Behavioral Sciences Institute of Neurosciences University of Guadalajara Zapopan Mexico Department of Veterinary Medicine Division of Veterinary Sciences CUCBA University of Guadalajara Zapopan Mexico Botany and Zoology Laboratory CUCBA University of Guadalajara Zapopan Mexico

Various studies indicate that low levels of estradiol negatively impact cognitive abilities. Extracts from the fungus Hericium erinaceus (HE) contain bioactive components that promote the proper functioning of the nervous system and potential effects on protection against neurodegenerative diseases, including dementia and motor dysfunctions. The objective was to evaluate the effects of the administration of the HE mushroom extract on visuospatial memory and morphology of neurons in the CA1 and CA3 regions of the hippocampus in ovariectomized rats. 40 young Wistar rats weighing 90 ± 10 g BW were used, which were distributed into four groups of 10 animals;Control Group, non-ovariectomized and untreated rats;Group E2, ovariectomized rats treated with estradiol (2 μg/kg/body weight);Group HE, ovariectomized rats treated with the extract of the fungus Hericium erinaceus (0.5 mg/kg body weight) and Group Ovx/ST, ovariectomized rats, without treatment. The animals were tested in the Barnes and Open Field maze, then they were sacrificed, and their brains were obtained to perform a histological analysis of neuronal morphology in the CA1 and CA3 areas of the hippocampus. The most outstanding results showed that the Ovx/ST group recorded the longest time to arrive at the escape box and stay in the Barnes maze. A correlation was observed between neuronal damage and function;in the groups that did not present satisfactory performance in the maze tests, morphological alterations were identified such as the presence of some neuronal somata with degeneration characteristics such as pyknosis, nuclear basophilia and shrinkage of the cells. Its soma, as well as a decrease in the nuclear area of CA1 and CA3 neurons. It is concluded that the fungus Hericium erinaceus exerted a neuroprotective effect on the neuronal bodies of the hippocampus, associated with better performance in the visuospatial recognition memory test.

关键词： Ovariectomized Rats Ovarian Hypofunction Estradiol Hericium erinaceus Barnes Circular Labyrinth Open Field Labyrinth

Spatiotemporal mode decomposition of ultrashort pulses in linear and nonlinear graded-index multimode fibers

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Photonics Research 2023年第5期11卷 750-756页

作者： mario ZITELLI VINCENT COUDERC mario FERRARO FABIO MANGINI PEDRO PARRA-RIVAS YIFAN SUN STEFAN WABNITZ Department of Information Engineering Electronics and TelecommunicationsUniversitàdegli Studi di Roma Sapienza00184 RomeItaly Universitéde Limoges XLIMUMR CNRS 725287060 LimogesFrance CNR-INO Istituto Nazionale di Ottica80078 PozzuoliItaly

We develop a spatiotemporal mode decomposition technique to study the spatial and temporal mode power distribution of ultrashort pulses in long spans of graded-index multimode fiber,for different input laser *** find that the beam mode power content in the dispersive pulse propagation regime can be described by the Bose-Einstein law,as a result of the process of power diffusion from linear and nonlinear mode coupling among nondegenerate mode *** the soliton regime,the output mode power distribution approaches the Rayleigh-Jeans law.

关键词： ultrashort multimode mode

Versatile chip-based nanoscopy becomes ready for histopathology assessment

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Light(Science & Applications) 2022年第5期11卷 730-732页

作者： Martin Lopez-garcia Natural and Artificial Photonic Structures Group International Iberian Nanotechnology LaboratoryBraga 4715-330Portugal

Nanoscopy is a mature technology used routinely in life science to obtain images well below the optical diffraction *** the use of nanoscopy in histopathology assessment is very limited mostly due to the low throughput of traditional nanoscopic *** far,Chip-nanoscopy,nanoscopy in which sample illumination is performed by an integrated photonic chip instead of bulk optics,has been shown to provide an enhanced field of view and throughput for cell ***,a new development shows that chip-nanoscopy also offers interesting progress for the study of histological samples offering a complementary technique to electron microscopy for histopathology assessment.

关键词： nanos offering illumination

SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer

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Genes & Diseases 2022年第6期9卷 1419-1422页

作者： Francisco Gallardo-Chamizo Nieves Lara-Urena Juan F.Correa-Vazquez Jose C.Reyes Benoit R.Gauthier mario garcia-Dominguez Cell Dynamics and Signaling Department CABIMERCSICUniversidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Genome Biology Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Cell Therapy and Regeneration Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabo´licas Asociadas(CIBERDEM) Madrid 28029Spain

To the Editor,Constricted oxygen and glucose supplies are common conditions that healthy cells following a stress such an ischemic insult as well as cancer cells within a solid tumor need to overcome in order to *** conditions are a serious challenge for cells,which accurately measure the impact to make a life or death *** cancer cells,aberrant gene expression and/or protein regulation,frequently linked to appearing mutations,may confer selective advantages to survive under these adverse *** the past years,cumulative evidence indicates that protein modification by covalent attachment of the Small Ubiquitin-like MOdifier(SUMO)plays a role in cell survival after oxygen and glucose deprivation(OGD).

关键词： cancer deprivation colon

Potential use of magnesium industrial waste for synthesis of Li and Mg co-doped LiMn_(2)O_(4)nanoparticles as cathode material for Li-ion batteries:Effect of sintering temperature

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Nano Research 2022年第5期15卷 4500-4516页

作者： Aleksei Llusco Luis Rojas Svetlana Ushak mario Grageda Department of Chemical Engineering and Mineral Processing and Center for Advanced Study of Lithium and Industrial Minerals(CELiMIN) Universidad de AntofagastaAntofagasta 1270300Chile

Potential advantages of active electrode nanomaterials have led to development of high energy and power density lithium-ion(Li-ion)***,under increasing demand for critical resources such as lithium and cobalt,it is necessary to use abundant raw materials,which can be obtained from industrial *** this work,purified Mg(OH)_(2)from waste generated in the production of Li2CO3 with natural brines from the Salar de Atacama(Chile)is used as a doping agent for synthesis of LiMn_(2)O_(4)(LMO)spinel octahedral nanoparticles co-doped with excess Li and *** of a pure cubic spinel phase(Fd3m)takes place at 500℃and sintering temperature effect at 580 and 750℃,thus the elemental composition and the structural,morphological,and electrochemical properties are studied in *** electrochemical performance at room temperature is obtained for Li_(1.03)Mg_(0.05)Mn_(1.92)O_(4)spinel sintered at 750℃with an initial discharge capacity of 121.3 mAh·g^(-1)and capacity retention of 94.0%after 100 cycles at C/3.A locally ordered spinel structure is obtained at 750℃,and doping with Mg^(2+)improves structural *** between both effects resulted in a high Li^(+)diffusion rate(1.29×10^(-9)cm^(2)·s^(-1))significantly improving cycling performance at elevated C-rates in 50℃.

关键词： LiMn_(2)O_(4)(LMO)spinel Mg doped excess Li octahedral nanoparticle industrial waste lithium-ion(Li-ion)batteries

Proper progression of neurogenesis relies on a defined pattern of SUMO-modified proteins

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Neural Regeneration Research 2022年第8期17卷 1731-1732页

作者： mario García-Domínguez Andalusian Centre for Molecular Biology and Regenerative Medicine-CABIMER CSIC-Universidad de Sevilla-Universidad Pablo de Olavide SevilleSpain

Neurogenesis is a complex process involving the orchestration of many transcription factors and other *** regulation of their activities is crucial for proper progression of neurogenesis.A few decades ago,covalent attachment of Small Ubiquitin-like MOdifier(SUMO)to other proteins was revealed as a major regulator of protein activities,constituting an essential posttranslational modification system in *** then,hundreds of proteins have been shown to be targets of SUMO,which is implicated in controlling many relevant processes in eukaryotic *** include the development and function of the nervous system,with SUMO tightly linked to synapsis and to neurodegenerative diseases(Yau et al.,2020).The SUMO protease SENP7 has been involved in neurogenesis(Juárez-Vicente et al.,2016),while sumoylation of BRAF35,a subunit of the LSD1 histone demethylase complex,assures the undifferentiated state of neural progenitors(Ceballos-Chávez et al.,2012).In addition,increased sumoylation in mouse brain-derived neural stem cells results in enhanced neuronal differentiation(Bernstock et al.,2019).

关键词： pattern diseases

Long-term experimental study on gravitational sedimentation of water aluminum oxide nanofluid at different volumetric concentrations

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International Journal of Sediment Research 2023年第3期38卷 303-315页

作者： mario Misale Johan Augusto Bocanegra Annalisa Marchitto DIME-Department of Mechanics Energetics Management and Transportation Thermal Engineering and Environmental Conditioning Division University of Genoa

The stability of nanofluids is critical in engineering applications. The sedimentation of the nanoparticles in the base fluid limits the stability of the nanofluid. By measuring the absorbance of a visible laser through water aluminum oxide nanofluids it is possible to observe the evolution of the sedimentation process. A simple experimental setup consisting of a thin closed test cavity（0.8 mm or 1.5 mm thickness）filled with nanofluid and a set of laser diodes-photodiodes pairs was used in the experiments to determine the absorbance and the local volumetric concentration. The evolution of the local volumetric concentration of the nanofluid was measured at 13 height positions along the test cavity. Five initial volumetric concentrations of aluminum oxide（Al2O3; 0.5%, 1.0%, 1.5%, 2.0%, 3.0% and 4.0%） were considered. Data and digital photos were acquired for a total time lapse of 260 days. The results were independent of the container thickness. The same general trend was consistent for all the initial volumetric concentrations, i.e., the sedimentation rate decreases in time. The time evolution of the volumetric concentration was compared with results from a modified Mason-Weaver model. The comparison was possible by setting a variable sedimentation velocity in the model, suggesting that the sedimentation is affected by the dynamics of nanoparticle clusters with diverse sizes produced by agglomeration.

关键词： Pure nanofluid Aluminum oxide Nanoscale alumina particles Colloid sedimentation Nanoparticle settling Mason-Weaver model

Driver Intent Prediction and Collision Avoidance With Barrier Functions

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 365-375页

作者： Yousaf Rahman Abhishek Sharma Mrdjan Jankovic mario Santillo Michael Hafner the Ford Motor Company DearbornMichigan 48121 USA IEEE

For autonomous vehicles and driver assist systems,path planning and collision avoidance algorithms benefit from accurate predictions of future location of other vehicles and intent of their *** the literature,the algorithms that provide driver intent belong to two categories:those that use physics based models with some type of filtering,and machine learning based *** this paper we employ barrier functions(BF)to decide driver *** are typically used to prove safety by establishing forward invariance of an admissible ***,we decide if the“target”vehicle is violating one or more possibly fictitious(i.e.,non-physical)barrier constraints determined based on the context provided by the road *** algorithm has a very small computational footprint and better false positive and negative rates than some of the *** predicted intent is then used by a control barrier function(CBF)based collision avoidance system to prevent unnecessary interventions,for either an autonomous or human-driven vehicle.

关键词： Driver Intent Prediction and Collision Avoidance With Barrier Functions Intent

Nitrogen use in double cropping soybean with non-fertilized winter oilseed crops

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 159-164页

作者： Ronghao Liu Stephen Gregg Axel garcia y garcia College of Water Resources Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Province Key Laboratory of Soil Environment and Nutrient Resources Taiyuan 030031China Department of Agronomy and Plant Genetics University of MinnesotaSt.PaulMN 55108USA Southwest Research and Outreach Center University of MinnesotaLambertonMN 56152USA

Sustainable intensification of cropping systems is a strategy to increase productivity and reduce disservices of conventional ***[Camelina sativa(L.)Crantz]and field pennycress(Thlaspi arvense L.)are winter annual oilseed crops well suited to fill the fallow period between corn(Zea mays L.)and soybean[Glycine max(L.)Merr.]in the *** Corn Belt,but their inclusion may be limited by resource use limitations.A 2-year study was conducted from 2015 to 2017 in the *** Midwest to evaluate the effect of double cropping on winter oilseed crops and soybean productivity and economic *** included relay-and sequential-cropped soybean with winter camelina and field pennycress,and monocrop soybean as *** and grain yield of winter oilseed crops were not affected by cropping *** over years and cropping systems,winter camelina resulted in more biomass,nitrogen(N)uptake and grain yield by 240,186 and 139% respectively,compared to field *** biomass,N uptake and yield were higher in relay relative to sequential *** soybean resulted in similar total grain yield(soybean+winter oilseed crop)compared to monocropped *** cropping soybean could maintain net return compared to monocropped *** indicate that double cropping winter oilseed crops with soybean can be economically viable in the *** ***,research aimed at optimizing yield through N and water use while improving ecosystem services is needed.

关键词： camelina pennycress relay cropping multiple cropping winter oilseed