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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Estimating the Lost Economic Production Caused by Internal Displacement Because of Disasters

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International Journal of Disaster Risk Science 2018年第4期9卷 496-506页

作者： mario A.Salgado-gálvez Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) 08034 BarcelonaSpain

Disasters are a large cause of internal displacement at the global level, in 2017 alone affecting more than19 million people. This dimension of disaster risk is usually overlooked in many disaster risk management strategies and assessments. It is only very recently that efforts to quantify displacement risk and integrate that dimension into existing physical risk models have been made. A key component of internal displacement assessment is the quantification of its economic impacts, both direct and indirect, not only to make a figure available but to raise awareness and increase accountability among governments, stakeholders, policymakers, and decision *** article presents a novel and peril-agnostic methodology with which to estimate, using a scenario-based approach, the economic production lost because of internal population displacement. The methodology is applied by using as a triggering event the April 2015 gorkha, Nepal M7.8 earthquake. The method quantifies the indirect cost caused by internal population displacement because of that event in terms of lost economic production and estimates the loss to be between USD 400 and 850 million.

关键词： Disability adjusted life years Disaster risk Internally displaced people Lost economic production Disaster risk assessment

Accelerating gW calculations through machine-learned dielectric matrices

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npj Computational Materials 2023年第1期9卷 437-445页

作者： mario g.Zauchner Andrew Horsfield Johannes Lischner Department of Materials Thomas Young CentreImperial College LondonSouth Kensington CampusLondon SW72AZUK

The gW approach produces highly accurate quasiparticle energies,but its application to large systems is computationally challenging due to the difficulty in computing the inverse dielectric *** address this challenge,we develop a machine learning approach to efficiently predict density–density response functions(DDRF)in *** atomic decomposition of the DDRF is introduced,as well as the neighborhood density–matrix descriptor,both of which transform in the same way under *** resulting DDRFs are then used to evaluate quasiparticle energies via the gW *** assess the accuracy of this method,we apply it to hydrogenated silicon clusters and find that it reliably reproduces HOMO–LUMO gaps and quasiparticle energy *** accuracy of the predictions deteriorates when the approach is applied to larger clusters than those in the training *** advances pave the way for gW calculations of complex systems,such as disordered materials,liquids,interfaces,and nanoparticles.

关键词： materials dielectric quasi

STUDY ON THE CATALYTIC REACTION OF ACETONE TO DIACETONE ALCOHOL

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催化学报 1996年第5期17卷 466-471页

作者： Sun Hongwei He fe DepartmentofChemicalEngineering TianjinUviversity DepartmentofChemicalEngineeri

ＳＴＵＤＹＯＮＴＨＥＣＡＴＡＬＹＴＩＣＲＥＡＣＴＩＯＮＯＦＡＣＥＴＯＮＥＴＯＤＩＡＣＥＴＯＮＥＡＬＣＯＨＯＬＳｕｎＨｏｎｇｗｅｉ，ＨｅＦｅｉ，ＸｕＧｅｎｈｕｉ＊，ＭａＸｉｎｂｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃ... 详细信息

ＳＴＵＤＹＯＮＴＨＥＣＡＴＡＬＹＴＩＣＲＥＡＣＴＩＯＮＯＦＡＣＥＴＯＮＥＴＯＤＩＡＣＥＴＯＮＥＡＬＣＯＨＯＬＳｕｎＨｏｎｇｗｅｉ，ＨｅＦｅｉ，ＸｕＧｅｎｈｕｉ＊，ＭａＸｉｎｂｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃａｌＥｎｇｉｎｅｒｉｎｇ，Ｔｉａｎ...

关键词：催化反应双丙酮醇离子交换树脂

Definitive palliation for neoplastic colonic obstruction using enteral stents:Personal case-series with literature review

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World Journal of gastroenterology 2004年第5期10卷 758-764页

作者： giuseppe Piccinni Anna Angrisano mario Testini g.Martino Bonomo Section of general Surgery Vascular Surgery and Clinical OncologyDepartment of Applications in Surgery of Innovative TechnologiesUniversity of Bari-School of Medicine-BariItaly

Acute colonic obstruction due to malignancies is an emergency that requires surgical *** patients or inoperable tumors require intestinal decompression that is a simple colostomy in almost all ***“manoeuvre” leads the patient to a percentage of moRality/morbidity and to a bad quality of life due to acceptance of *** introduction of enteral metal stent inserted endoscopically has,in our opinion,provided a new way to obtaining the definitive palliation of inoperable colo-rectal cancer with a simple *** reported our case-series and we analyzed the current literature and costs of treatments.

关键词： Stents Aged Aged, 80 and over Colonic Neoplasms Endoscopy female Humans Intestinal Obstruction Male Palliative Care

Reconstruction after pancreatoduodenectomy:Pancreatojejunostomy vs pancreatogastrostomy

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World Journal of gastrointestinal Oncology 2014年第9期6卷 369-376页

作者： Tatiana gómez Ana Palomares mario Serradilla Luis Tejedor Department of Surgery Hospital Punta de Europa Division of Hepato-Pancreatic-Biliary Surgery Department of SurgeryComplejo Hospitalario de Jaén

Pancreatic surgeons try to find the best technique for reconstruction after pancreatoduodenectomy(PD) in order to decrease postoperative complications,mainly pancreatic fistulas(PF).In this work,we compare the two most frequent techniques of reconstruction after PD,pancreatojejunostomy(PJ) and pancreatogastrostomy(Pg),in order to determine which of the two is better.A systematic review of the literature was performed,including major meta-analysis articles,clinical randomized trials,systematic reviews,and retrospective studies.A total of 64 articles were finally *** and Pg are usually responsible for most of the postoperative morbidity,mainly due to the onset of PF,being considered a major trigger of life-threatening complications such as intra-abdominal abscess and *** included systematic reviews reported a significant difference only in the incidence of intraabdominal collections favouring ***,delayed gastric emptying and mortality were not *** there was heterogeneity between these studies,all were conducted in specialized centers by highly experienced surgeons,and the surgical care was likely to be similar for all the *** disadvantages of Pg include an increased incidence of delayed gastric emptying and of main pancreatic duct obstruction due to overgrowth by the gastric *** function appears to be worse after Pg than after PJ,resulting in severe atrophic changes in the remnant *** on the type of PJ or Pg used,the PF rate and other complications can also be *** best method to deal with the pancreatic stump after PD remains *** choice of method of pancreatic anastomosis could be based on individual experience and on the surgeon's preference and adherence to basic principles such as good exposure and *** conclusion,up to now none of the techniques can be considered superior or be recommended as standard for reconstruction after PD.

关键词： Pancreatoduodenectomy Pancreatojeju-nostomy Pancreatogastrostomy Pancreatic fistula Pancreatic cancer Surgical technique