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The ecological performance of metallophyte plants thriving in geochemical islands is explained by the Inclusive Niche Hypothesis

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Journal of Plant Ecology 2015年第1期8卷 41-50页

作者： Helena C.Serrano Cristina antunes Manuel J.Pinto Cristina Máguas Maria Amélia Martins-Loução Cristina Branquinho Centro de Biologia Ambiental Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisboaPortugal Jardim Botânico do Museu Nacional de História Natural e da Ciência Universidade de LisboaR.Escola Politécnica 581250-102 LisboaPortugal

Aims The Inclusive Niche Hypothesis has not been validated for plants using ecophysiological *** few experiments have measured growth and competition but not the physiological response of plants.A metallophyte plant that hyperaccumulates aluminium(Al),Plantago almogravensis,showed a defined spa-tial distribution by occurring mostly on vegetation gaps associ-ated with metalliferous areas(geochemical islands).This case was used to determine,in situ,whether the Inclusive Niche Hypothesis was suitable to explain the extent of the species real-ized *** The vegetation associated with *** geochemical islands in the SW coast of Portugal was *** biotic(neighbouring plants)and abiotic(edaphic)components of the niche were cor-related with parameters of the plant’s ecological and physiological performances(plant density and cover;leaf C and N concentration and isotopic composition;growth).The results were obtained using image analysis,abundance and morphological measures,isotopic signatures and chemical *** Findings The species showed better physiological performance where its ecological performance was lower due to trade-offs with environ-mental *** species’realized niche was mostly limited by shrub competition and soil *** limits contribute to explain the rarity status of the species:the species has a poor capacity to compete but,due to an enhanced Al-tolerance and Al-hyperaccumulator trait,has the ability to find refuge in geochem-ical islands that are too harsh for most other *** work,based on ecophysiological field studies,provides support for the Inclusive Niche Hypothesis relating to plant species.

关键词： competition ecophysiology edaphic endemism hyperaccumulation stable isotopes trade-off

Biliary tract schwannoma:A rare cause of obstructive jaundice in a young patient

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World Journal of Gastroenterology 2012年第37期18卷 5305-5308页

作者： Gilton Marques Fonseca André Luis Montagnini Manoel de Souza Rocha Rosely antunes Patzina Mário Vinícius Angelete Alvarez Bernardes Ivan Cecconello José Jukemura Digestive Surgery Division Department of GastroenterologySchool of MedicineUniversity of So Paulo

Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastro-intestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumordid not recur in any of the resected cases.

关键词：神经黄疸阻性患者原因雪旺氏细胞 CT检查手术切除

Soil and Rhizosphere Associated Fungi in Gray Mangroves(Avicennia marina) from the Red Sea—A Metagenomic Approach

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Genomics, Proteomics & Bioinformatics 2015年第5期13卷 310-320页

作者： Marta Filipa Simoes Andr antunes Cristiane A.Ottoni Mohammad Shoaib Amini Intikhab Alam Hanin Alzubaidy Noor-Azlin Mokhtar John A.C.Archer Vladimir B.Bajic Computational Bioscience Research Center (CBRC) ComputerElectrical and Mathematical Sciences and Engineering Division (CEMSE)King Abdullah University of Science and Technology (KAUST) Laboratório de Biotecnologia Industrial (LBI) Instituto de Pesquisas Tecnológicas do Estado de Sao Paulo (IPT)

Covering a quarter of the world＇s tropical coastlines and being one of the most threat- ened ecosystems, mangroves are among the major sources of terrestrial organic matter to oceans and harbor a wide microbial diversity. In order to protect, restore, and better understand these ecosystems, researchers have extensively studied their microbiology, yet few surveys have focused on their fungal communities, Our lack of knowledge is even more pronounced for specific fungal populations, such as the ones associated with the rhizosphere. Likewise, the Red Sea gray man- groves （Avicennia marina） remain poorly characterized, and understanding of their fungal commu- nities still relies on cultivation-dependent methods. In this study, we analyzed metagenomic datasets from gray mangrove rhizosphere and bulk soil samples collected in the Red Sea coast, to obtain a snapshot of their fungal communities. Our data indicated that Ascomycota was the dominant phylum （76%-85%）, while Basidiomycota was less abundant （14%-24~）, yet present in higher numbers than usually reported for such environments. Fungal communities were more stable within the rhizosphere than within the bulk soil, both at class and genus level. This finding is consistent with the intrinsic patchiness in soil sediments and with the selection of specific microbial commu- nities by plant roots. Our study indicates the presence of several species on this mycobiome that were not previously reported as mangrove-associated. In particular, we detected representatives of several commercially-used fungi, e.g., producers of secreted cellulases and anaerobic producers of cellulosomes. These results represent additional insights into the fungal community of the gray mangroves of the Red Sea, and show that they are significantly richer than previously reported.

关键词： Fungal diversity Ascomycota Basidiomycota Red Sea Metagenomics Bioinformatics

Swallowing patterns after adenotonsillectomy in children

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Pediatric Investigation 2019年第3期3卷 153-158页

作者： Anete antunes de Oliveira Branco Camila de Castro Corrêa Daniela de Souza Neves Tais Huehara Silke Anna Theresa Weber Ophthalmology OtorhinolaryngologyHead and Neck Surgery DepartmentBotucatu Medical SchoolState University Sao PauloUNESPBrazil

Importance: Hypertrophy of the pharyngeal and palatine tonsils can interfere with breathing, physical and cognitive development, and quality of life, including sleep quality. There are important relationships between the muscles of the airways, the anatomy, and the pattern of breathing and swallowing. Objective: The aims of the present study were to evaluate the swallowing process in children after adenotonsillectomy undertaken to treat obstructive breathing disorders. Methods: Subjects were 85 children or adolescents who underwent adenotonsillectomy in a reference hospital between 2003 and 2007. For the clinical evaluation of swallowing, the protocol of orofacial myofunctional evaluation with scores (OMES) was used, videofluoroscopy of deglutition was performed, and the Dysphagia Outcome and Severity Scale (DOSS) and Classification for Severity of Dysphagia to Videofluoroscopy Scale were applied for analysis. Results: Out of the 85 evaluated children, 43 were male (50.59%), the average age at evaluation was 12.11 years, the average age at the time of surgery was 6.73 years, and post-surgery time was 3.00–8.00 years. In the clinical evaluation of swallowing, half the sample (50.59%) recorded the poorest score for lip and tongue behavior. A score of 1 was observed in 67.06% of subjects for other behaviors, and in 15.30% of subjects for efficiency of swallowing. Videofluoroscopic analysis demonstrated that the most frequent swallowing alterations were labial sealing (50.59%), residue in vallecula (51.76%), and use of compensatory maneuvers (61.18%). Analysis of DOSS showed that normal swallowing was attributed to 48.31% of subjects at level 7, 44.95% at level 6, and 6.74% at level 5. For the Classification for Severity of Dysphagia to Videofluoroscopy, 75.28%were classified as having mild dysphagia. Interpretation: Alterations in the dynamics of swallowing are common in children who have undergone surgery of the tonsils, even at late follow-up.

关键词： Deglutition Deglutition disorders Adenoids Palatine tonsil Child

Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation

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Asian Journal of Andrology 2017年第5期19卷 526-532页

作者： Rheure Alves-Lopes Karla B Neves Marcondes AB Silva Vania C Olivon Silvia G Ruginsk Jose antunes-Rodrigues Leandra NZ Ramalho Rita C Tostes Fernando Silva Carneiro Department of Pharmacology Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil Department of Physics and Chemistry Faculty of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil Department of Physiological Sciences Biomedical Sciences InstituteFederal University of Alfenas Alfenas MG Brazil Department of Physiology Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil Department of Pathology and Legal Medicine Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil

Androgen deficiency is strongly associated with erectile dysfunction （ED）. Inadequate penile arterial blood flow is one of the major causes of ED. The blood flow to the corpus cavernosum is mainly derived from the internal pudendal arteries （IPAs）; however, no study has evaluated the effects of androgen deprivation on IPA＇s function. We hypothesized that castration impairs IPAs reactivity and structure, contributing to ED. In our study, Wistar male rats, 8-week-old, were castrated and studied 30 days after orchiectomy. Functional and structural properties of rat IPAs were determined using wire and pressure myograph systems, respectively. Protein expression was determined by Western blot and immunohistochemistry. Plasma testosterone levels were determined using the IMMULITE 1000 Immunoassay System. Castrated rats exhibited impaired erectile function, represented by decreased intracavernosal pressure/mean arterial pressure ratio. IPAs from castrated rats exhibited decreased phenylephrine- and electrical field stimulation （EFS）-induced contraction and decreased acetylcholine- and EFS-induced vasodilatation. IPAs from castrated rats exhibited decreased internal diameter, external diameter, thickness of the arterial wall, and cross-sectional area. Castration decreased nNOS and α-actin expression and increased collagen expression, p38 （Thr180/ryr182） phosphorylation, as well as caspase 3 cleavage. In conclusion, androgen deficiency is associated with impairment of IPA reactivity and structure and increased apoptosis signaling markers. Our findings suggest that androgen deficiency-induced vascular dysfunction is an event involving hypotrophic vascular remodeling of IPAs.

关键词： androgen castration internal pudendal artery

Improvement in varistor properties of CaCu_(3)Ti_(1)O_(12) ceramics by chromium addition

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Journal of Materials Science & Technology 2020年第6期41卷 12-20页

作者： Edson Cezar Grzebielucka Joao Frederico Haas Leandro Monteiro Eder Carlos Ferreira de Souza Christiane Philippini Ferreira Borges AndréVitor Chaves de Andrade Eloísa Cordoncillo Héctor Beltrán-Mir Sandra Regina Masetto antunes Programa Pós-Graduacao em Química Aplicada Universidade Estadual de Ponta GrossaAv.Gen.Carlos Cavalcanti 474884.030-000Ponta GrossaParanáBrazil Programa de Pós-Graduacao em Ciências/Física Universidade Estadual de Ponta GrossaAv.Gen.Carlos Cavalcanti 474884.030-000Ponta GrossaParanáBrazil Dpto.de Química Inorgánica y Orgánica Universitat Jaume IAv.de Vicent Sos Baynats/n12071Castellón de la PlanaSpain

The effect of chromium addition on the structure and electrical properties of CaCu3Ti4O12 is *** based on the formula CaCu3Ti4-xCrxO12-σ(x = 0, 0.025, 0.050 and 0.075 mol%) are prepared by solid-state reaction. Pellets sintered at 1070℃ for 12 h are characterised by X-ray diffraction, scanning electron microscopy/energy dispersive spectroscopy and impedance spectroscopy. Current densityelectric field, dielectric loss and permittivity measurements are also carried out. Rietveld refinement showed the substitution of Cr(Ⅲ) on the Ti(Ⅳ) site, with the maximum substitution for x = 0.025 mol%.The generation of electrical defects in the grain boundary region by chromium doping is responsible for increasing the electric breakdown field strength and nonlinearity coefficient at room temperature from 1723 V/cm and 5.29 for x = 0 mol% to 3431 V/cm and 8.16 for x = 0.025 mol%. This composition shows the greatest improvement in ceramic varistor parameters.

关键词： CCTO Structural analysis Impedance Varistor Rietveld

肾上腺素对促肾上腺皮质激素分泌的影响及其作用机制的初步探讨

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中国医学科学院学报 1987年第3期9卷 193-197页

作者：许荣(火昆),antunes-Rodrigues J,McCann SM 中国医学科学院基础医学研究所生理研究室巴西Sao Paulo大学美国Texas大学卫生科学中心北京

对颈外静脉预先置入硅橡胶导管的大鼠注射肾上腺素,应用放射免疫测定法,直接测定血浆促肾上腺皮质激素(ACTH)浓度的改变,以了解肾上腺素影响肾上腺皮质活动的机理。实验在脑内正中隆起损伤和假损伤两组动物中进行,结果外周给肾上腺素兴... 详细信息

对颈外静脉预先置入硅橡胶导管的大鼠注射肾上腺素,应用放射免疫测定法,直接测定血浆促肾上腺皮质激素(ACTH)浓度的改变,以了解肾上腺素影响肾上腺皮质活动的机理。实验在脑内正中隆起损伤和假损伤两组动物中进行,结果外周给肾上腺素兴奋垂体前叶释放ACTH,从而兴奋肾上腺皮质的活动;作用点在下丘脑,兴奋促肾上腺皮质激素释放激素(CRF)的分泌,而非直接作用于腺垂体.

关键词：肾上腺素促肾上腺皮质激素促肾上腺皮质激素释放激素正中隆起

Analysis of Technological Developments in the Treatment of Alzheimer’s Disease through Patent Documents

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Intelligent Information Management 2015年第5期7卷 268-281页

作者： Karinne Marieta Carvalho Eduardo Winter Adelaide Maria de Souza antunes School of Chemical Technology Center Federal University of Rio de Janeiro Rio de Janeiro Brazil INPI—Brazilian National Institute of Industrial Property Intellectual Property Academy Rio de Janeiro Brazil

Population aging and the consequent change in the profile of the age pyramid are already a reality the world over. One undeniable effect of this aging process is the significant increase in the number of people with Alzheimer’s disease (AD), which is the most common form of dementia, accounting for around 50% - 60% of all cases. AD tends to affect people in their 60 s, becoming progressively more commonplace in older age groups. It is an incurable disease, and patients can live for many years taking medication on a daily basis. This study shows that research into AD is on the rise around the world because the pharmaceutical industry and research institutions are seeking new types of drugs to treat and even cure Alzheimer’s patients. By analyzing patent documents, we map out the potential future treatments for this disease, indicating the leading countries and drugs companies that have invested most in a bid to accelerate progress towards new discoveries about the disease and the development of new drugs.

关键词： Patents Alzheimer’s Disease Drugs Population Aging Pharmaceutical Industry

School,Museum and University:A New Synergy in Science Education

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地学前缘 2009年第S1期16卷 118-119页

作者： Bruno Filipe C.B.Silva Ribeiro A.Neves J.Cascalho R.Barata T.antunes F.Serralheiro Department of Mineralogy and Geology National Natural History Museum Department of Botany National Natural History Museum Department of Zoology and Anthropology National Natural History Museum

In the last couple of years the Museum developed a project financed by the National Agency for Culture and Technology in partnership with four schools from *** guidelines of this project were the climate change and its influence on human lives in our society and on other living beings."Changing climate, changing lives",our project,evolved 8 months work of about 150 high school grade students,in which

关键词： climate change school university museum science education