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Tunable nano-engineered anisotropic surface for enhanced mechanotransduction and soft-tissue integration

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Nano Research 2023年第5期16卷 7293-7303页

作者： Pingping Han Tianqi Guo Anjana Jayasree Guillermo a.gomez Karan Gulati Sašo Ivanovski The University of Queensland School of DentistryEpigenetics nanodiagnostic and therapeutic groupCenter for Oral-facial RegenerationRehabilitation and Reconstruction(COR3)BrisbaneQueensland 4006Australia The University of Queensland School of DentistryBrisbaneQueensland 4006Australia The University of Queensland School of DentistryGroup for Anodized Therapies for OsseointegrationRegeneration and StimulationCenter for Oral-facial RegenerationRehabilitation and Reconstruction(COR3)BrisbaneQueensland 4006Australia Centre for Cancer Biology South Australia Pathology and the University of South AustraliaAdelaideSouth Australia 5001Australia

Electrochemically engineered titania(TiO_(2))nanopores enable tailored cellular function;however,the cellular mechanosensing mechanisms dictating the cell response and soft tissue integration are yet to be ***,we report the fabrication of anisotropic TiO_(2)nanopores with diameters of 46 and 66 nm on microrough titanium(Ti)via electrochemical anodization,towards short-and long-term guidance of human primary gingival fibroblasts(hGFs).Cells on tissue culture plates and bare Ti substrates were used as ***,we show that nanopores with a diameter of 66 nm induced more mature focal adhesions of vinculin and paxillin at the membrane,encouraged the development of actin fibers at focal adhesion sites,led to elongated cell and nuclear *** topographical-driven changes were attributed to the Ras-related C3 botulinum toxin substrate 1(Rac 1)GTPase pathway and nuclear localisation of LAMIN A/C and yes-associated protein(YAP)and associated with increased ligament differentiation with elevated expression of the ligament marker Mohawk homeobox(MKX).Study findings reveal that minor tuning of nanopore diameter is a powerful tool to explore intracellular and nuclear mechanotransduction and gain insight into the relationships between nanomaterials and mechanoresponsive cellular elements.

关键词： titanium nanopores nanotopography fibroblast mechanosensing mechanotransduction ligament differentiation

Litter buffet:On the use of trash bins by birds in six boreal urban settlements

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Avian Research 2023年第2期14卷 182-190页

作者： Michelle García-Arroyo Miguel a.gomez-Martínez Ian MacGregor-Fors Ecosystems and Environment Research Programme Faculty of Biological and Environmental SciencesUniversity of HelsinkiNiemenkatu 73Lahti15140Finland Instituto de Biotecnología y Ecología Aplicada(INBIOTECA) Universidad VeracruzanaXalapa91090Mexico

Unintentional food resources in urban areas(street litter,food leftovers,overflowing trash bins)are dietary components of some urban-exploiter bird *** this study,we report on 13 bird species in six southern Finnish cities using urban trash bins and describe differences in their activity when provided with food resources(i.e.,bait)in different bin *** used generalized linear models(GLM)and classification and regression trees(CART)to test for associations between environmental variables and bird activity at the *** activity at the binscapes significantly differed among all cities and among types of bins and was significantly higher after placing bait in all *** with the largest opening had more activity as opposed to those with smaller openings or *** and gulls had the highest activity,with corvids usually being present before the bait was placed and gulls increasing their activity *** differences show that trash bin foraging is highly malleable and thus susceptible to management preventing its *** waste management measures could aid in reducing the number of species close to bins and their surroundings,benefiting both bird and human health.

关键词： Avian Behavior Binscape Food resources Urban ecology

High-throughput screening of hypothetical metal-organic frameworks for thermal conductivity

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npj Computational Materials 2023年第1期9卷 2231-2242页

作者： Meiirbek Islamov Hasan Babaei Ryther Anderson Kutay B.Sezginel Jeffrey R.Long Alan J.H.McGaughey Diego a.gomez-Gualdron Christopher E.Wilmer Department of Chemical&Petroleum Engineering University of PittsburghPittsburghPA 15261USA Department of Chemistry University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Chemical and Biological Engineering Colorado School of MinesGoldenCO 80401USA Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyBerkeleyCA 94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Mechanical Engineering Carnegie Mellon UniversityPittsburghPA 15213USA Department of Electrical&Computer Engineering University of PittsburghPittsburghPA 15261USA

Thermal energy management in metal-organic frameworks(MOFs)is an important,yet often neglected,challenge for many adsorption-based applications such as gas storage and *** its importance,there is insufficient understanding of the structure-property relationships governing thermal transport in *** provide a data-driven perspective into these relationships,here we perform large-scale computational screening of thermal conductivity k in MOFs,leveraging classical molecular dynamics simulations and 10,194 hypothetical MOFs created using the ToBaCCo 3.0 *** found that high thermal conductivity in MOFs is favored by high densities(>1.0 g cm^(−3)),small pores(10 W m^(−1) K^(−1)),the structures of which we describe in additional detail.

关键词： conductivity thermal pores

Adsorption removal of roxarsone, arsenite(Ⅲ),and arsenate(Ⅴ) using iron-modified sorghum straw biochar and its kinetics

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Acta Geochimica 2021年第3期40卷 409-418页

作者： Shuyan Zang Yingying Zuo Juan Wang Xiuming Liu mario Alberto gomez Lan Wei Liaoning Engineering Research Center for Treatment and Recycling of Industrially Discharged Heavy Metals Shenyang University of Chemical TechnologyShenyang 110142China Shenyang University of Chemical Technology Shenyang 110142China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Arsenic(As)contamination in groundwater is a major problem in many countries,which causes serious health *** this paper,a novel method has been developed for the simultaneous removal of ROX and As(Ⅲ/Ⅴ)using the modified sorghum straw biochar(MSSB).The MSSB was characterized by X-ray diffraction,scanning electron microscopy,Fourier Transform Infrared,and Brunauer–Emmet–Teller(BET)surface *** removal performance of MSSB for ROX,arsenite[As(Ⅲ)],and arsenate(As(Ⅴ))was investigated using batch *** pH of 5,the arsenic concentration of 1.0 mg/L,adsorbent dose of 1.0 g/L,the maximum adsorptioncapacities of ROX,As(Ⅲ),and As(Ⅴ)were 12.4,5.3,and 23.0 mg/g,*** adsorption behaviors were fit well with the Langmuir and the pseudo-second-order rate *** results showed that MSSB acted as a highly effective adsorbent to simultaneously remove the composite pollution system consisted of ROX and As(Ⅲ/Ⅴ)in aqueous solutions,providing a promising method in environmental restoration applications.

关键词： Roxarsone Arsenic Arsenate Sorghum straw biochar Adsorption

Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 20-23页

作者： Ana Vargas-Calla Luis a.gomez-Puerta Juan Calcina Omar Gonzales-Viera Cesar Gavidia Maria T.Lopez-Urbina Hector H.Garcia Armando E.Gonzalez School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Cysticercosis Elimination Program and Center for Global Heath Tumbes Universidad Peruana Cayetano Heredia Department of Microbiology School of SciencesUniversidad Peruana Cayetano Heredia

Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine ***:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals *** first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management *** pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between ***:All pigs treated with oxfendazole had only degenerated cysts in their *** contrast,TCBZ had very little effect against the parasitic *** from pigs in the TCBZ group looked apparently normal after ***,histological evaluation showed a mild to moderate degree of ***:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

关键词： Taenia solium Cysticercosis Triclabendazole Oxfendazole Treatment

The effect of rippling on the mechanical properties of graphene

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Nano Materials Science 2022年第1期4卷 18-26页

作者： Guillermo Lopez-Polin Cristina.gomez-Navarro Julio gomez-Herrero Instituto de Ciencia de Materiales de Madrid CSICMadrid E 28049Spain Departamento de Física de La Materia Condensada Universidad Autónoma de MadridMadridE-28049Spain IFIMAC Condensed Matter Physics Center(IFIMAC).Universidad Autónoma de Madrid MadridE-28049Spain

Graphene is the stiffest material known so far but, due to its one-atom thickness, it is also very ***, free-standing graphene exhibit ripples that has major effects on its elastic properties. Here we will summarize three experiments where the influence of rippling is essential to address the results. Firstly, we observed that atomic vacancies lessen the negative thermal expansion coefficient(TEC) of free-standing *** also observed an increase of the Young's modulus with global applied strain and with the introduction of small density defects that we attributed to the decrease of rippling. Here, we will focus on a surprising feature observed in the data: the experiments consistently indicate that only the rippling with wavelengths between 5 and 10 nm influences the mechanics of graphene. The rippling responsible of the negative TEC and anomalous elasticity is thought to be dynamic, i.e. flexural phonons. However, flexural phonons with these wavelengths should have minor effects on the mechanics of graphene, therefore other mechanisms must be considered to address our observations. We propose static ripples as one of the key elements to correctly understand the thermomechanics of graphene and suggest that rippling arises naturally due to a competition of symmetry breaking and anharmonic fluctuations.

关键词： Graphene Mechanical properties Atomic force microscopy Defects Ripples Stmain

On the material dependence of experimental shear fracture orientation

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Science China Earth Sciences 2015年第12期58卷 2357-2362页

作者： Enrique gomez-RIVAS Albert GRIERA Department of Geology and Petroleum Geology School of Geosciences King’s College University of Aberdeen Departament de Geologia Universitat Autònoma de Barcelona

It is not uncommon to observe shear fractures in ductile rocks oriented at more than 45° with respect to the maximum compression direction. Since these orientations cannot be explained with the classic Mohr-Coulumb or Tresca yield criteria, Zheng et al.(Journal of Structural Geology, 35: 1394–1405, 2011) proposed the maximum effective moment(MEM) failure criterion. This rule suggests that shear fractures in ductile rocks form at ?55° with the maximum compression axis and that this orientation is material-independent and, therefore, universal. Zheng et al.(Science China: Earth Sciences, 57(11): 2819–2824, 2014) used data from our own experiments as supporting evidence of their failure criterion. In this contribution we discuss why shear fracture formation in ductile rocks indeed strongly depends on the mechanical properties of the deforming medium, and why experimental data should not be taken to prove the validity of the MEM criterion. The formation mechanisms and orientations of shear fractures in our experiments significantly vary depending on the material strength and degree and type of anisotropy(composite and intrinsic). We therefore demonstrate using experimental data that a universal failure angle in ductile and anisotropic rocks does not apply. Additionally, we highlight some inconsistencies of the MEM criterion.

关键词： shear fracture anisotropy fracture orientation material properties failure criteria ductile deformation

Excitatory synapse impairment and mitochondrial dysfunction in Huntington’s disease: heat shock factor 1 (HSF1) converging mechanisms

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Neural Regeneration Research 2020年第1期15卷 69-70页

作者： Nicole Zarate Rocio gomez-Pastor Department of Neuroscience School of Medicine University of Minnesota

Heat shock factor 1(HSF1)is abnormally degraded in Huntington’s disease(HD):HD is a neurodegenerative disorder characterized by severe cognitive and motor *** is caused by a CAG repeat expansion within exon 1 of the huntingtin(HTT)gene(The Huntington’s Disease Collaborative Research Group,1993).These expansions lead to the production of an aberrant mutant huntingtin protein(mHTT)that is prone to misfolding and *** and aggregation of mHTT is present in virtually all cell types in the body but preferentially affects medium spiny neurons of the striatum,a brain region that controls movement and some forms of *** of mHTT leads to,but not only,transcriptional dysregulation,DNA damage,mitochondrial dysfunction and excitatory synaptic failure ultimately causing neuronal ***,the molecular mechanisms by which mHTT exerts these defects are still unclear.

关键词： Huntington impairment shock

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纸芯片显色法用于L-半胱氨酸的快速测定

分析测试学报 2019年第4期38卷 477-481页

作者：张剑谢婷婷杨玉莹刘春叶 Frank a.gomez Wilson LEE 肖倩西安医学院药学院陕西西安710021 加州州立大学化学与生物化学系美国洛杉矶90001

该文以5,5'-二硫硝基苯甲酸(DTNB)为含巯基化合物的衍生化试剂,建立了其纸芯片快速检测新方法。显色剂DTNB和样品在显色区相遇并显色,用手机拍照记录,采用Photoshop软件分析显色强度,进行比色检测,并以L-半胱氨酸(L-Cys)为例,优化得到... 详细信息

该文以5,5'-二硫硝基苯甲酸(DTNB)为含巯基化合物的衍生化试剂,建立了其纸芯片快速检测新方法。显色剂DTNB和样品在显色区相遇并显色,用手机拍照记录,采用Photoshop软件分析显色强度,进行比色检测,并以L-半胱氨酸(L-Cys)为例,优化得到纸芯片检测L-Cys的最佳显色条件。结果显示,L-Cys浓度在0.01～0.1 mmol/L范围内与显色强度呈良好的线性关系(r=0.999 8),检出限达0.001 mmol/L。多种氨基酸和干扰离子对L-Cys在纸芯片上的测定干扰不超过±5%。采用该方法测得牛血清样品中L-Cys含量为0.013 mmol/L,加标回收率为99.1%～103%,该方法检测L-Cys具有操作简单、耗样量少、检测快速、重现性好等优点。

关键词：纸芯片巯基化合物 5,5-二硫硝基苯甲酸(DTNB) 比色法