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Function of the Endocannabinoid System in Neurodegenerative Diseases and Cancers

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American Journal of Plant Sciences 2019年第10期10卷 1839-1854页

作者： mario soliman Shobha Potlakayala Dhimant Desai Hannah Weeden Rabab Husain Nicole Lookfong Thomas Trite John Spagnola Shantu Amin Sairam Rudrabhatla Burrell College of Osteopathic Medicine Las Cruces NM USA Penn State Harrisburg Middletown PA USA Departments of Pharmacology Pennsylvania State University College of Medicine Hershey PA USA PA Options for Wellness Inc. Harrisburg PA USA.

Neurodegenerative diseases are characterized by progressive degeneration and/or death of neuronal cells and results in a wide array of cognitive impairments and other serious neurological defects. The signaling pathways and definite cause underlying the development of neurodegenerative nerve diseases have not been well defined. There is evidence of mechanisms within the endocannabinoid system that may suggest important pathways involved the progression of neurodegenerative diseases as well as some cancers. The endocannabinoid system is an endogenous ubiquitous neuromodulatory system that plays a critical in the development of the central nervous system (CNS), synaptic plasticity, as well as other primary neuronal functions. The recent identification of various cannabinoid receptors and their endogenous lipid ligands has generated an interest and significant increase in research of the endocannabinoid system and its role in human health and diseases. The Endocannabinoid system possesses essential endogenous receptors—cannabinoid receptors type 1 (CB1R) and type 2 (CB2R)—which are involved in mechanisms that contribute to the progression of neurodegenerative diseases and some cancers. In this review, we discuss the role of the endocannabinoid system in various neurodegenerative diseases as well as some cancers, and its promise as a targeted pharmacological therapy for patients of neurodegenerative diseases.

关键词： Cannabinoid Endocannabinoid System Neurodegenerative Disorders Cancer

Organ and function preservation in gastrointestinal cancer: Current and future perspectives on endoscopic ablation

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 282-291页

作者： Youssef Yousry soliman Megan soliman Shravani Reddy James Lin Toufic Kachaamy Department of Gastroenterology City of Hope PhoenixGoodyearAZ 85338United States Department of Medicine Medical ConsultingGoodyearAZ 85395United States Department of Gastroenterology University of California IrvineIrvineCA 92697United States Department of Gastroenterology City of Hope National Medical CenterDuarteCA 91010United States

The escalating prevalence of gastrointestinal cancers underscores the urgency for transformative *** treatment costs amount to billions of dollars annually,combined with the risks and comorbidities associated with invasive *** highlights the importance of less invasive alternatives with organ preservation being a central aspect of the treatment *** current standard of care typically involves neoadjuvant systemic therapy followed by surgical *** is a growing interest in organ preservation approaches by way of minimizing extensive surgical *** ablation has proven to be useful in precursor lesions,as well as in palliative cases of unrese-ctable *** recently,there has been an increase in reports on the utility of adjunct endoscopic ablative techniques for downstaging disease as well as contributing to non-surgical complete clinical *** expansive field within endoscopic oncology holds great potential for advancing patient *** addressing challenges,fostering collaboration,and embracing technological advancements,the gastrointestinal cancer treatment paradigm can shift towards a more sustainable and patient-centric future emphasizing organ and function *** editorial examines the evolving landscape of endoscopic ablation strategies,emphasizing their potential to improve patient *** briefly review current applications of endoscopic ablation in the esophagus,stomach,duodenum,pancreas,bile ducts,and colon.

关键词： Gastrointestinal cancer Endoscopic ablation Organ preservation Complete clinical response Neoadjuvant therapy Endoscopic oncology Palliative treatment

A Hybrid Cybersecurity Algorithm for Digital Image Transmission over Advanced Communication Channel Models

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Computers, Materials & Continua 2024年第4期79卷 201-241页

作者： Naglaa F.soliman Fatma E.Fadl-Allah Walid El-Shafai Mahmoud I.Aly Maali Alabdulhafith Fathi E.Abd El-Samie Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Electronics and Communications Faculty of EngineeringZagazig UniversityZagazig44519Egypt Security Engineering Lab Computer Science DepartmentPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Electronics and Electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

The efficient transmission of images,which plays a large role inwireless communication systems,poses a significant challenge in the growth of multimedia ***-quality images require well-tuned communication *** Single Carrier Frequency Division Multiple Access(SC-FDMA)is adopted for broadband wireless communications,because of its low sensitivity to carrier frequency offsets and low Peak-to-Average Power Ratio(PAPR).Data transmission through open-channel networks requires much concentration on security,reliability,and *** data need a space away fromunauthorized access,modification,or *** requirements are to be fulfilled by digital image watermarking and *** paper ismainly concerned with secure image communication over the wireless SC-FDMA systemas an adopted communication *** introduces a robust image communication framework over SC-FDMA that comprises digital image watermarking and encryption to improve image security,while maintaining a high-quality reconstruction of images at the receiver *** proposed framework allows image watermarking based on the Discrete Cosine Transform(DCT)merged with the Singular Value Decomposition(SVD)in the so-called DCT-SVD *** addition,image encryption is implemented based on chaos and DNA *** encrypted watermarked images are then transmitted through the wireless SC-FDMA *** linearMinimumMean Square Error(MMSE)equalizer is investigated in this paper to mitigate the effect of channel fading and noise on the transmitted *** subcarrier mapping schemes,namely localized and interleaved schemes,are compared in this *** study depends on different channelmodels,namely PedestrianAandVehicularA,with a modulation technique namedQuadratureAmplitude Modulation(QAM).Extensive simulation experiments are conducted and introduced in this paper for efficient transmission of encrypted watermarked *** addition,different variants of SC-FDMA bas

关键词： Cybersecurity applications image transmission channel models modulation techniques watermarking and encryption

A review of concrete bridge surface defect detection based on deep learning

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Optoelectronics Letters 2024年

作者： LIAO Yanna HUANG Chaoyang Abdel-Hamid soliman School of Electronic Engineering， Xi'an University of Posts and Telecommunications School of Digital， Technology， Innovation and Business， Staffordshire University

The detection of surface defects in concrete bridges using deep learning is of significant importance for reducing operational risks， saving maintenance costs， and driving the intelligent transformation of bridge defect detection. In contrast to the subjective and inefficient manual visual inspection， deep learning-based algorithms for concrete defect detection exhibit remarkable advantages， emerging as a focal point in recent research. This paper comprehensively analyzes the research progress of deep learning algorithms in the field of surface defect detection in concrete bridges in recent years. It introduces the early detection methods for surface defects in concrete bridges and the development of deep learning. Subsequently， it provides an overview of deep learning-based concrete bridge surface defect detection research from three aspects: image classification， object detection， and semantic segmentation. The paper summarizes the strengths and weaknesses of existing methods and the challenges they face. Additionally， it analyzes and prospects the development trends of surface defect detection in concrete bridges.

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Engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2475-2504页

作者： Ahmed O.Elzoghby Omar Samir Hagar E.Emam Ahmed soliman Riham M.Abdelgalil Yomna M.Elmorshedy Kadria A.Elkhodairy Mahmoud L.Nasr Division of Engineering in Medicine and Division of Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(TME)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have been developed to induce immunogenic cell death(ICD)of cancer cells and thereby elicit immunogenicity and boost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for boosting ICD of cancer ***,synergistic approaches used in combination with ICD inducing nanomedicines for remodeling the TME via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell membrane camouflaged nanomedicines,amplified reactive oxygen species(ROS)generation,metallo-immunotherapy,ion modulators and engineered bacteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity T cells Tumor associated antigens Synergistic immune response

基三众核架构中基于同步哈密顿环的无死锁策略

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计算机研究与发展 2024年

作者：李春峰 Karim soliman 计卫星石峰北京理工大学计算机学院北京师范大学人工智能学院

确保片上网络（network-on-chip，NoC）中的数据传输无死锁，是NoC为多处理器片上系统（multi-processor system-on-chip，MPSoC）提供可靠通信服务的前提，决定了NoC甚至MPSoC的可用性.现有的通用防死锁策略难以发挥出特定拓扑结构自... 详细信息

确保片上网络（network-on-chip，NoC）中的数据传输无死锁，是NoC为多处理器片上系统（multi-processor system-on-chip，MPSoC）提供可靠通信服务的前提，决定了NoC甚至MPSoC的可用性.现有的通用防死锁策略难以发挥出特定拓扑结构自身特点和优势，甚至可能会增加网络延迟、功耗以及硬件复杂性.另外，由于路由级和协议级死锁存在显著差异，现有无死锁方案较难同时解决这2类死锁问题，影响了MPSoC的可靠性.利用基三众核架构（Triplet-based many-core architecture，TriBA）中拓扑结构自身具有的哈密顿特性提出了基于同步哈密顿环的无死锁策略，该策略依据拓扑结构自身的对称轴和哈密顿边对数据传输进行分类，预防了协议级死锁并提高了数据传输速度；同时使用循环链表技术判断同一缓冲区内数据同步传输方向，消除了路由级死锁并降低了数据传输延迟.在优化前瞻路由算法基础上，设计了基于同步哈密顿环的无死锁路由机制（Hamiltonian shortest path routing，HamSPR）.GEM5仿真结果表明，与TriBA现有方法相比，HamSPR在合成流量下的平均数据包延迟和功耗分别降低了18.78% ～ 65.40% 和6.94% ～ 34.15%，吞吐量提高了8.00% ～ 59.17%；在PARSEC测试集下的应用运行时间和平均数据包延迟分别最高实现了16.51%和42.75%的降低.与2D-Mesh架构相比，TriBA在PARSEC测试集下的应用性能实现了1% ～ 10%的提升.

关键词：众核处理器片上网络基三众核架构哈密顿特性路由算法死锁预防

Assessment of plant diversity of endemic species of the Saharo-Arabian region in Egypt

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Journal of Arid Land 2024年第7期16卷 1000-1021,I0002-I0044页

作者： Asmaa S ABO HATAB Yassin M AL-SODANY Kamal H SHALTOUT soliman A HAROUN Mohamed M EL-KHALAFY Botany and Microbiology Department Faculty of ScienceKafrelsheikh UniversityKafrelsheikh 33511Egypt Botany Department Faculty of ScienceTanta UniversityTanta 31527Egypt

Savanna, semi-deserts, and hot deserts characterize the Saharo-Arabian region, which includes Morocco, Mauretania, Algeria, Tunisia, Libya, Egypt, Palestine, Kuwait, Saudi Arabia, Qatar, Bahrain, the United Arab Emirates, Oman, Yemen, southern Jordan, Syria, Iraq, Iran, Afghanistan, Pakistan, and northern India. Its neighboring regions, the Sudano-Zambezian region belonging to the Paleotropical Kingdom and the Mediterranean and Irano-Turanian regions included in the Holarctic Kingdom, share a large portion of their flora with the Saharo-Arabian region. Despite the widespread acknowledgment of the region's global importance for plant diversity, an up to date list of the Saharo-Arabian endemics is still unavailable. The available data are frequently insufficient or out of date at both the whole global and the national scales. Therefore, the present study aims at screening and verifying the Saharo-Arabian endemic plants and determining the phytogeographical distribution of these taxa in the Egyptian flora. Hence, a preliminary list of 429 Saharo-Arabian endemic plants in Egypt was compiled from the available literature. Indeed, by excluding the species that were recorded in any countries or regions outside the Saharo-Arabian region based on different literature, database reviews, and websites, the present study has reduced this number to 126 taxa belonging to 87 genera and 37 families. Regarding the national geographic distribution, South Sinai is the richest region with 83 endemic species compared with other eight phytogeographic regions in Egypt, followed by the Isthmic Desert(the middle of Sinai Peninsula, 53 taxa). Sahara regional subzone(SS1) distributes all the 126 endemic species, Arabian regional subzone(SS2) owns 79 taxa, and Nubo-Sindian subzone(SS3) distributes only 14 endemics. Seven groups were recognized at the fourth level of classification as a result of the application of the two-way indicator species analysis(TWINSPAN) to the Saharo-Arabian endemic sp

关键词： endemism phytogeographical regions Saharo-Arabian floristic region Egyptian flora plant diversity two-way indicator species analysis(TWINSPAN)

Does dutasteride reduce the bleeding in transurethral resection of the prostate in patients on antiplatelet drugs?

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Current Urology 2024年第3期18卷 194-198页

作者： Ahmed M.Rammah Alaa Meshref Ebram soliman Islam Nasser Abd Elaziz Enmar Habib Ahmed Yehia Abdelaziz Ahmed H.Abozamel Department of Urology Kasr Alainy HospitalFaculty of MedicineCairo UniversityCairoEgypt El Sahel Teaching Hospital CairoEgypt

Background The aim of this study was to assess the effect of a 4-week dutasteride treatment on reducing the intraoperative and postoperative bleeding,as well as the amount and duration of irrigation required to clear the urine after transurethral resection of the prostate(TURP)≥50 g in men receiving the antiplatelet drug(APD).Materials and methods This double-blind randomized clinical trial included patients with a prostate size≥50 g who were indicated for TURP and were already receiving *** study was conducted in the Urology Department of Cairo University over a 12-month *** preoperative laboratory investigations were performed in all ***,baseline prostate size,serum prostate-specific antigen level,and International Prostate Symptom Score were *** patients were randomly divided into 2 equal groups(groups A and B).Group A,the dutasteride group,received dutasteride(0.5 mg)once daily for 4 *** B,the placebo group,received a placebo capsule once daily for 4 *** groups underwent bipolar *** patients were excluded from the study;9 patients from group A and 6 patients from group B,either due to drug intolerability or loss *** The mean blood loss was insignificant between the 2 groups immediately after and 24 hours after surgery(Δhemoglobin:1.41±0.63 g/dL vs.1.48±0.54 g/dL,2.12±0.70 g/dL vs.2.31±0.78 g/dL,respectively,p=0.631,p=0.333;Δhematocrit:2.97%±1.51%vs.3.16%±1.36%,4.96%±1.87%vs.5.73%±4.39%,respectively,p=0.610,p=0.380).However,there were significant differences in duration of indwelling urethral catheter(5.10±0.55 days vs.5.80±1.79 days,p=0.048),duration of bladder irrigation(13.60±2.85 hours vs.16.33±6.62 hours,p=0.044),and the amount of saline used for bladder irrigation(11.03±2.30 L vs.13.87±6.13 L,p=0.046)between group A and group *** Treatment with dutasteride for 4 weeks before TURP in men receiving APD did not significantly reduce intraoperative or postoperativ

关键词： Dutasteride Transurethral resection of the prostate Postprostatectomy bleeding Antiplatelet drugs

Life Time Attributable Cancer Risk Estimated Using Scanner Reported Dose Length Product during Chest Computed Tomography Imaging in Young Children

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Open Journal of Radiology 2024年第2期14卷 74-82页

作者： Mousa Bakkari Khaled soliman Abdullah Alrushoud Marwan Fahad Alosaimi Hanaa Alsheikh Abdelwahed Alhejaili Medical Physics Department Prince Sultan Military Medical City Riyadh Saudi Arabia Radiogiadnostic and Medical Imaging Department Prince Sultan Military Medical City Riyadh Saudi Arabia

This study aims to estimate the lifetime attributable cancer risk (LAR) for pediatric chest computed tomography (CT) examinations in five age groups using recently published age and region-specific conversion coefficients multiplying the widely available scanner registered dose length products (DLP) displayed on the CT console and hence calculating the Effective Dose (ED). The ED is then multiplied by the International Commission on Radiological Protection (ICRP) published risk factor for LAR. The obtained LAR values are compared with the international literature. Factors that may affect the LAR value are reported and discussed. The study included one hundred twenty five chest CT examinations for both males and females aged from less than one year to fifteen years. The patients reported data are from one single medical institution and using two CT scanners from June 2022 to December 2023. The results of this study may serve as benchmark for institutional radiation dose reference levels and risk estimation.

关键词： Cancer Risk LAR Chest CT Pediatric Radiology Radiation Dose DLP