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Laparoscopic Diaphragmatic Plication in Patients with Unilateral Diaphragm Paralysis with Thoracoscopic Verification

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Open Journal of Thoracic Surgery 2012年第4期2卷 104-107页

作者： Willem N. Welvaart Kieng H. Ong marinus A. paul Anton Vonk-Noordegraaf Coen A. C. Ottenheijm Department of Surgery Pulmonology and Physiology VU Medical Center Amsterdam The Netherlands. Department of Surgery Rivierenland Hospital Tiel The Netherlands

Diaphragm eventration or paralysis causes elevation of the ipsilateral diaphragm. Some patients have symptoms. The most common symptom is dyspnea. In symptomatic patients with unilateral diaphragm paralysis and dyspnea disproportionate to the degree of physical activity, diaphragm plication is the treatment of choice to relieve dyspnea. We report on our experience with laparoscopic plication of a paralysed hemidiaphragm. The laparoscopic approach is an attractive surgical alternative for the treatment of phrenic nerve palsy. This technique combines the advantage of an excellent field of vision during surgery with a fast postoperative recovery and early discharge from hospital. In accordance to recent literature, we have successfully applied the laparoscopic approach to treat our patients who suffered from a unilateral paralysis of the diaphragm. Preoperative symptoms of exertional dyspnea and orthopnea were significantly reduced.

关键词： Diaphragm Paralysis Dyspnea Diaphragm Plication Laparoscopy

Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance

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Journal of Sport and Health Science 2023年第2期12卷 194-201页

作者： Wouter M.A.Franssen Charly Keytsman Nastasia marinus Kenneth Verboven Bert O.Eijnde Lisa van Ryckeghem paul Dendale Renate Zeevaert Guy Massa Dominique Hansen Rehabilitation Research Centre(REVAL) Faculty of Rehabilitation SciencesHasselt UniversityHasselt 3500Belgium Biomedical Research Institute(BIOMED) Faculty of Medicine and Life SciencesHasselt UniversityHasselt 3500Belgium ADLON Sports Medical Center Hasselt 3500Belgium Heart Centre Hasselt Jessa HospitalHasselt 3500Belgium Department of Pediatric Endocrinology and Diabetology Jessa HospitalHasselt 3500Belgium

Background:Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing,which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular *** is unknown whether cardiac chronotropic incompetence(CI)during maximal exercise is already present in obese adolescents and,if so,how that relates to cardiometabolic ***:Sixty-nine obese adolescents(body mass index standard deviation score=2.23±0.32,age=14.1±1.2 years;mean±SD)and 29lean adolescents(body mass index standard deviation score=-0.16±0.84,age=14.0±1.5 years)performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were *** resting heart rate and peak heart rate were used to calculate the maximal chronotropic response ***(lipid profile,glycemic control,inflammation,and leptin)was studied in fasted blood samples and during an oral glucose tolerance test within obese *** analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters,respectively,within obese ***:CI was prevalent in 32 out of 69 obese adolescents(46%)and 3 out of 29 lean adolescents(10%).C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI(p=0.012).Furthermore,peak oxygen uptake and peak cycling power output were significantly reduced(p<0.05)in obese adolescents with CI *** adolescents without *** chronotropic index was independently related to blood total cholesterol(standardized coefficientβ=-0.332;p=0.012)and C-reactive protein concentration(standardized coefficientβ=-0.269;p=0.039).Conclusion:CI is more common in the current cohort of obese adolescents,and is related to systemic inflammation and exercise intolerance.

关键词： Adolescents Cardiometabolic health Exercise tolerance Heart rate Obesity

In the name of the rose:a roadmap for rose research in the genome era

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Horticulture Research 2019年第1期6卷 948-964页

作者： marinus J.M.Smulders paul Arens Peter M.Bourke Thomas Debener Marcus Linde Jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant Jeremy Clotault Fabrice Foucher Plant Breeding Wageningen University and ResearchP.O.Box 3866700 AJ WageningenThe Netherlands Faculty of Natural Sciences Institute for Plant GeneticsMolecular Plant BreedingLeibniz University of HannoverHerrenhäuser Strasse 230419 HannoverGermany ILVO Plant Sciences UnitFlanders Research Institute for AgricultureFisheries and FoodCaritasstraat 399090 MelleBelgium BVpam CNRS FRE 3727UJM-Saint-ÉtienneUniv.LyonSaint-EtienneFrance IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaV42 rue Georges Morel BP 6005749071 BeaucouzéFrance

The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting *** to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in *** cultivars are highly heterogeneous and *** vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical *** can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding *** paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be *** outline possible approaches for a number of these questions.

关键词： breeding cultivar linkage

High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array

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Horticulture Research 2016年第1期3卷 68-75页

作者： Mirjana Vukosavljev paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard marinus J M Smulders Wageningen UR Plant Breeding Wageningen University&ResearchWageningenNL-6700 AJThe Netherlands Roath BV EindhovenThe Netherlands Pheno Geno Roses D.O.O.Bulevar oslobođenja 65a 21000 Novi SadSerbia

Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted *** tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental *** rose breeding,crosses with unintended parents occur *** developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one *** of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal *** densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 *** with the strawberry(Fragaria vesca)genome was *** ICM1 corresponded to *** pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to *** ICM2 corresponded to parts of *** pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6.

关键词： breeding linkage dosage