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Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： evangelos Ch.Tsirogiannis evangelos Daskalakis Mohamed H.Hassan Abdalla M.Omar Paulo Bartolo EODH SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance Hybrid composites Vehicle protection

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Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

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Stochastic Analysis and Modeling of Velocity Observations in Turbulent Flows

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Journal of Environmental & Earth Sciences 2024年第1期6卷 45-56页

作者： evangelos Rozos Jorge Leandro Demetris Koutsoyiannis Institute for Environmental Research&Sustainable Development National Observatory of AthensAthens15236Greece Research Institute for Water and Environment University of SiegenSiegen57076Germany Department of Water Resources and Environmental Engineering School of Civil Engineering National Technical University of AthensAthens15780Greece

Highly turbulent water flows,often encountered near human constructions like bridge piers,spillways,and weirs,display intricate dynamics characterized by the formation of eddies and *** formations,varying in sizes and lifespans,significantly influence the distribution of fluid velocities within the ***,the rapid velocity fluctuations in highly turbulent flows lead to elevated shear and normal stress *** this reason,to meticulously study these dynamics,more often than not,physical modeling is employed for studying the impact of turbulent flows on the stability and longevity of nearby *** the effectiveness of physical modeling,various monitoring challenges arise,including flow disruption,the necessity for concurrent gauging at multiple locations,and the duration of *** these challenges,image velocimetry emerges as an ideal method in fluid mechanics,particularly for studying turbulent *** account for measurement duration,a probabilistic approach utilizing a probability density function(PDF)is suggested to mitigate uncertainty in estimated average and maximum ***,it becomes evident that deriving the PDF is not straightforward for all turbulence-induced *** response,this study proposes a novel approach by combining image velocimetry with a stochastic model to provide a generic yet accurate description of flow dynamics in such *** integration enables an approach based on the probability of failure,facilitating a more comprehensive analysis of turbulent *** an approach is essential for estimating both short-and long-term stresses on hydraulic constructions under assessment.

关键词： Smart modeling Turbulent flows Data analysis Stochastic analysis Image velocimetry

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Heroin-induced changes of CD34-positive rat thymus cells

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Health 2010年第8期2卷 957-961页

作者： Gentimi Fotini Perrea Despina marinos evangelos Konstandi Ourania Katsorchis Theodoros 不详

Heroin is a well known opioid that causes al-terations to the immune system of a number of investigated animals. Only a few studies have explored the effect of heroin on the lymphocytes maturation. Thymocyte progenitors originate from haematopoietic stem cells in the bone marrow. The immature T-cells express neither CD4 nor CD8, and are therefore classed as double-negative (CD4-CD8-) cells. CD34 glycoprotein is the only defined marker of the immature T-lymphocytes. In this study we have investigated the changes induced in CD34+ rat thymocytes after heroin administration by immunofluores-cence in frozen rat thymus sections using the 4H11 monoclonal anti-CD34 antibody. There is a remarkable decrease in the number of CD34+ immature thymocytes when examined 1hour after last heroin injection and a small recover when examination took place 20 days after last injection. The above results suggest a major effect of heroin administration early in the ma- turation process of T lymphocytes probably by increasing the apoptotic cell death and the ne- gative consequences for the immune system responses.

关键词： Heroin Rat Thymus CD34

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Applications of Soft Computing Methods in Backbreak Assessment in Surface Mines: A Comprehensive Review

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2207-2238页

作者： Mojtaba Yari Manoj Khandelwal Payam Abbasi evangelos I.Koutras Danial Jahed Armaghani Panagiotis G.Asteris Department of Mining Engineering Faculty of EngineeringMalayer UniversityMalayer***Iran Institute of Innovation Science and SustainabilityFederation University AustraliaBallaratVIC 3350Australia Marane Olia Ornamental Stone Mine Sanandaj***Iran Computational Mechanics Laboratory School of Pedagogical and Technological EducationAthens15122Greece School of Civil and Environmental Engineering University of Technology SydneySydneyNSW 2007Australia

Geo-engineering problems are known for their complexity and high uncertainty levels,requiring precise defini-tions,past experiences,logical reasoning,mathematical analysis,and practical insight to address them *** Computing(SC)methods have gained popularity in engineering disciplines such as mining and civil engineering due to computer hardware and machine learning *** traditional hard computing approaches,SC models use soft values and fuzzy sets to navigate uncertain *** study focuses on the application of SC methods to predict backbreak,a common issue in blasting operations within mining and civil ***,which refers to the unintended fracturing of rock beyond the desired blast perimeter,can significantly impact project timelines and *** study aims to explore how SC methods can be effectively employed to anticipate and mitigate the undesirable consequences of blasting operations,specifically focusing on backbreak *** research explores the complexities of backbreak prediction and highlights the potential benefits of utilizing SC methods to address this challenging issue in geo-engineering projects.

关键词： Backbreak blasting soft computing methods prediction theory-guided machine learning

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Line Patterns Segmentation in Blurred Images Using Contrast Enhancement and Local Entropy Thresholding

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Journal of Computer and Communications 2024年第2期12卷 116-141页

作者： Marios Vlachos evangelos Dermatas Institute of Communication and Computer Systems Athens Greece Department of Computer Engineering and Informatics University of Patras Patras Greece

Finger vein extraction and recognition hold significance in various applications due to the unique and reliable nature of finger vein patterns. While recently finger vein recognition has gained popularity, there are still challenges associated with extracting and processing finger vein patterns related to image quality, positioning and alignment, skin conditions, security concerns and processing techniques applied. In this paper, a method for robust segmentation of line patterns in strongly blurred images is presented and evaluated in vessel network extraction from infrared images of human fingers. In a four-step process: local normalization of brightness, image enhancement, segmentation and cleaning were involved. A novel image enhancement method was used to re-establish the line patterns from the brightness sum of the independent close-form solutions of the adopted optimization criterion derived in small windows. In the proposed method, the computational resources were reduced significantly compared to the solution derived when the whole image was processed. In the enhanced image, where the concave structures have been sufficiently emphasized, accurate detection of line patterns was obtained by local entropy thresholding. Typical segmentation errors appearing in the binary image were removed using morphological dilation with a line structuring element and morphological filtering with a majority filter to eliminate isolated blobs. The proposed method performs accurate detection of the vessel network in human finger infrared images, as the experimental results show, applied both in real and artificial images and can readily be applied in many image enhancement and segmentation applications.

关键词： Finger Vein Vessel Enhancement Vessel Network Extraction Non-Uniform Images Binarization Morphological Post-Processing

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Transurethral resection of bladder tumor: A systematic review of simulator-based training courses and curricula

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Asian Journal of Urology 2024年第1期11卷 1-9页

作者： Panagiotis Kallidonis Angelis Peteinaris Gernot Ortner Kostantinos Pagonis Costantinos Adamou Athanasios Vagionis evangelos Liatsikos Bhaskar Somani Theodoros Tokas Department of Urology University Hospital of RionPatrasGreece Department of Urology and Andrology General Hospital Hall I.T.Hall in TirolAustria Medical University of Vienna ViennaAustria Department of Urology University Hospital Southampton NHS Foundation TrustSouthamptonUK

Objective:Transurethral resection of bladder tumor is one of the most common everyday urological *** kind of surgery demands a set of skills that need training and *** this review,we aimed to investigate the current literature to find out if simulators,phantoms,and other training models could be used as a tool for teaching ***:A systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement and the recommendations of the European Association of Urology guidelines for conducting systematic *** out of 932 studies met our inclusion criteria and are presented in the current ***:The UroTrainer(Karl Storz GmbH,Tuttlingen,Germany),a virtual reality training simulator,achieved positive feedback and an excellent face and construct validity by the *** inspection of bladder mucosa,blood loss,tumor resection,and procedural time was improved after the training,especially for inexperienced urologists and medical *** construct validity of UroSim®(VirtaMed,Zurich,Switzerland)was *** simulator(Samed GmbH,Dresden,Germany)was found to be a realistic and useful tool by experts and urologists with intermediate *** test objective competency model based on SIMBLA simulator could be used for evaluating *** porcine model of the Asian Urological Surgery Training and Education Group also received positive feedback by the participants that tried *** Simulation and Technology Enhanced Learning Initiative Project had an extraordinary face and content validity,and 60%of participants would like to use the simulators in the *** 5-day multimodal training curriculum“Boot Camp”in the United Kingdom achieved an increase of the level of confidence of the participants that lasted months after the ***:Simulators and courses or curricula based on a simulator training could be a valuable learning tool fo

关键词： Simulator Train Curriculum Transurethral resection Vaporesection Laser Bladder

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Grafts in Peyronie’s surgery without the use of prostheses:a systematic review and meta-analysis

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Asian Journal of Andrology 2024年第3期26卷 250-259页

作者： Anastasios Natsos Vasileios Tatanis Stavros Kontogiannis Sharon Waisbrod Kristiana Gkeka Mohamed Obaidad Angelis Peteinaris Konstantinos Pagonis Costas Papadopoulos Panagiotis Kallidonis evangelos Liatsikos Petros Drettas Department of Urology University of PatrasPatras 26500Greece Uroclinic Pfaeffikon 8808Switzerland Department of Medical Physics University of PatrasPatras26500Greece Department of Urology Medical University of ViennaVienna 1090Austria

Peyronie’s disease(PD)is characterized by abnormal penile curvature,and various surgical methods have been developed usingdifferent graft ***,there is currently no universal agreement on which type of graft is the *** objective of thisreview was to evaluate the available literature and identify the most effective graft material for penile curvature correction in PD.A literature search was conducted using electronic databases,including PubMed,Scopus,and the Cochrane *** patients,intervention,comparison,and outcome(PICO)approach was used to define the eligibility of *** authors independentlyselected studies,evaluated them,and extracted ***-effect models using the DerSimonian–Laird method were *** were single-arm studies and had a high risk of *** mucosa grafts(BMG)were found to result in the highest penilestraightening rates and were associated with the least de novo erectile *** grafts demonstrated a high successrate in straightening despite a higher mean preoperative curvature,while Tutoplast grafts had a higher incidence of postoperativeerectile *** had the highest percentage of postoperative penile ***,the TachoSil graft showed thebest performance when preoperative curvature is taken into *** on the available literature,BMG appear to be the mosteffective for penile curvature correction in PD,but this is offset by the requirement for low preoperative *** TachoSilgraft shows the best overall performance when preoperative curvature is *** randomized clinical trials arestill needed to determine graft superiority.

关键词： erectile function penile curvature penile grafts Peyronie’s disease

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Percutaneous antegrade management of large proximal ureteral stones using non-papillary puncture

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Asian Journal of Urology 2024年第1期11卷 110-114页

作者： Arman Tsaturyan Angelis Peteinaris Constantinos Adamou Konstantinos Pagonis Lusine Musheghyan Anastasios Natsos Theofanis Vrettos evangelos Liatsikos Panagiotis Kallidonisa Department of Urology University of PatrasPatrasGreece Gerald and Patricia Turpanjian School of Public Health American University of ArmeniaYerevanArmenia Department of Anesthesiology and ICU University of PatrasPatrasGreece Department of Urology Medical University of ViennaViennaAustria

Objective:To evaluate the feasibility and the safety of medial non-papillary percutaneous nephrolithotomy(npPCNL)for the management of large proximal ureteral ***:We evaluated prospectively collected data of 37 patients with large proximal ureteral stones more than 1.5 cm in diameter treated by prone *** on stone size,in-toto stone removal or lithotripsy using the Lithoclast®Trilogy(EMS Medical,Nyon,Switzerland)was *** parameters including operative time(from start of puncture to the skin suturing),stone extraction time(from the first insertion of the nephroscope to the extraction of all stone fragments),and the stone-free rate were ***:Twenty-one males and 16 females underwent npPCNL for the management of large upper ureteral *** median age and stone size of treated patients were 58(interquartile range[IQR]:51-69)years and 19.3(IQR:18.0-22.0)mm,*** median operative time and stone extraction time were 25(IQR:21-29)min and 8(IQR:7-10)min,*** case(2.7%)of postoperative bleeding and two cases(5.4%)of prolonged fever were managed *** stone-free rate at a 1-month follow-up was 94.6%.Conclusion:The npPCNL provides a straight route to the ureteropelvic junction and proximal *** from a dilated portion of the ureter under low irrigation pressure with larger diameter instruments results in effective and safe stone extraction within a few minutes.

关键词： Antegrade percutaneous nephrolithotomy Proximal ureteral stone Non-papillary puncture Large ureteral stone Prone percutaneous nephrolithotomy

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Action of the Disintegrin Contortrostatin on Breast Cancer Cell Primary Cultures

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Advances in Breast Cancer Research 2013年第4期2卷 161-169页

作者： Ifigeneia Marinou Sophia Havaki Nikos Goutas Dimitrios Vlachodimitropoulos Georgios Baltatzis Eumorphia G. Konstantakou Dimitrios J. Stravopodis Dimitrios G. Koudoumas evangelos marinos Mirsini Kouloukoussa 1st Department of Pathology Medical School University of Athens Athens Greece Department of Cell Biology and Biophysics Faculty of Biology University of Athens Athens Greece Laboratory of Experimental Surgery and Surgical Research University of Athens Athens Greece Laboratory of Forensic Medicine and Toxicology Medical School University of Athens Athens Greece Laboratory of Histology and Embryology Medical School University of Athens Athens Greece

Integrins mediate cell adhesion to the extracellular matrix (ECM). In particular, integrin alphavbeta3 recognizes the RGD motif as a ligand-binding site on various extracellular molecules of the extracellular matrix. Integrin aphavbeta3 has been associated with high malignant potential in breast cancer cells, and has signalized the onset of widespread metastasis. In recent years, several antagonists of integrin alphavbeta3, including snake venom disintegrins, have been used as potential anti-cancer agents. In the present work, the effect of contortrostatin, a disintegrin isolated from the venom of the snake Agkistrodon contortrix, was studied on primary cultures of human breast cancer cell. Scanning and transmission electron microscopy were employed in order to examine alterations in cell morphology and fluorescent microscopy and visualize changes in distribution of integrin alphavbeta3 and talin. Fluorescent localization of caspase 8 was made in order to visualize any sign of proapoptotosis and western immunoblotting of integrin, talin and annexin was undertaken in order to identify changes. The results suggest that the snake venom contortrostatin seriously affects cell morphology, adhesion and mobility and induces breast cancer cells to apoptosis.

关键词： Breast Cancer Disintegrins Contortrostatin Integrin Alphavbeta3 Apoptosis Primary Cultures

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