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Minimal Free Resolutions of Zero-dimensional Schemes in P1 ×P1

Algebra Colloquium 2015年第1期22卷 97-108页

作者： Paola Bonacini lucia marino Universita degli Studi di Catania ViMe A. Doria 6 95125 Catania Italy

Let X be a zero-dimensional scheme in p1 × p1. Then X has a minimal free resolution of length 2 if and only if X is ACM. In this paper we determine a class of reduced schemes whose resolutions, similarly to the ACM case, can be obtained by their Hilbert functions and depend only on their distributions of points in a grid of lines. Moreover, a minimal set of generators of the ideal of these schemes is given by curves split into the union of lines.

关键词： resolution Hilbert function separators

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Human Embryo Neuronal Culture <i>in Vitro</i>: A Model to Study Cellular Physiology, Receptors, Power and Toxicity of Cytostatic Drugs for Human Use

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Neuroscience & Medicine 2012年第3期3卷 321-326页

作者： Stabile Mariano Monaco Roberto Iuorio Tina Buoninfante Luca marino lucia Altieri Vincenzo Della Ragione Carlo Masillo Francesco Anatomy Pathology Department Hospital “A. Cardarelli” Naples Italy Department of Gynecology and Obstetrics Hospital “Maria SS Addolorata” Eboli Italy Genetic Department Hospital “Ele-nad’ Aosta” Naples Italy ZigoteGenetic and Prenatal Diagnosis Centre Salerno Italy

Neural cells cultures from human embryo brain of 9° - 11°W gestational age have been used to study ERα (Estrogens Receptor α) and to perform toxicity test for Mitomycin C and Methotrexate. Histochemical confirmation of cellular neuronal phenotype was based on histochemical evidence of NSE (Neuron Specific Enolase).The detection of ERα in neuronal cells was performed with a rabbit Monoclonal Antibody. ERα was absent both on neurons grown in vitro and on tissue brain specimens. This finding is apparently in contrast with the positive immunoreactivity of ERα and ERβ reported by other Authors on foetal and adult CNS (Central Nervous System). The absence of nuclear ERα on neurons in culture and in brain tissue specimens in our experiment is not in contrast with the relevant physiologic role of estrogens on nervous central system, but it could be correlated to the embryonic period of life and could represent a protection of male brain from an undue estrogens imprinting. The mitomycin C, alkylation agent, has shown in our experiment a major neurotoxic and cytostatic power in comparison with methotrexate. Our conclusion is that human embryo neuronal culture in vitro is a powerful instrument for physiology and human therapy for cancer and neurodegenerative diseases.

关键词： Human Embryo Neuronal Culture ERα on Embryonic Brain Mitomycin C Toxicity Test in Vitro Methotrexate Toxicity Test in Vitro

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A totally mini-invasive approach for colorectal laparoscopic surgery

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World Journal of Gastroenterology 2012年第29期18卷 3869-3874页

作者： Gabriele Anania Mirco Santini lucia Scagliarini Alice Marzetti Laura Vedana Serafino marino Claudio Gregorio Giuseppe Resta Giorgio Cavallesco Department of Surgery Arcispedale S.AnnaMedical University of Ferrara44121 FerraraItaly

AIM:To study the short-term outcome of patients treated with laparoscopic right colectomy and how intracorporeal anastomosis has improved the ***:We retrospectively examined all patients affected by colorectal cancer who underwent a laparoscopic right colectomy between January 2006 and December 2010 in our *** evaluation criteria were:diagnosis of colorectal carcinoma at presurgical biopsy,elective surgery,and the same *** excluded:emergency surgery,conversions from laparotomic colectomy,and other *** endpoints we examined were:surgical time,number of lymph nodes removed,length of stay(removal of nasogastric tube,bowel movements,gas evacuation,solid and liquid feeding,hospitalization),and major ***-two patients were divided into two groups:intracorporeal anastomosis(39 patients)and extracorporeal anastomosis(33 patients).RESULTS:Significant differences were observed between intracorporeal vs extracorporeal anastomosis,respectively,for surgical times(186.8 min vs 184.1 min,P < 0.001),time to resumption of gas evacuation(3 d vs 3.5 d,P < 0.001),days until resumption of bowel movements(3.8 d vs 4.9 d,P < 0.001),days until resumption of liquid diet(3.5 d vs 4.5 d,P < 0.001),days until resuming a solid diet(4.6 d vs 5.7 d,P < 0.001),and total hospitalization duration(7.4 d vs 8.5 d,P < 0.001).In the intracorporeal group,on average,19 positive lymph nodes were removed;in the extracorporeal group,on average,14 were removed P < 0.001).Thus,intracorporeal anastomosis for right laparoscopic colectomy improved patient outcome by providing faster recovery of nutrition,faster recovery of intestinal function,and shorter hospitalization than extracorporeal ***:Short-term outcomes favor intracorporeal anastomosis,confirming that a less traumatic surgical approach improves patient outcome.

关键词： Anastomosis Cancer Colorectal disease Surgery Laparoscopy

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Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

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World Journal of Clinical Oncology 2012年第7期3卷 111-115页

作者： Giovannella Palmieri Carlo Buonerba Piera Federico Luigi Formisano lucia Nappi Giuseppe Di Lorenzo Mirella marino Vincenzo Damiano Dipartimento di Endocrinologia ed Oncologia Clinica e Molecolare Università Federico Ⅱ 80131 Napoli Italy Centro Regionale Tumori Rari (Regional Center for Rare Tumors) University Federico Ⅱ 80128 Naples Italy Department of Pathology Regina Elena National Cancer Institute 00144 Rome Italy

Although thymic epithelial tumors(TETs) are rare in the general population, they represent the most frequently diagnosed primary malignant tumor of the anterior mediastinum. Unlike localized disease, metastatic disease is invariably fatal. While several chemotherapy agents have proven to be effective in TETs, somatostatin analogs are the only targeted agents with an established role in this disease. Everolimus is an m TOR inhibitor with multiple application in oncology. In this report, we show for the first time that everolimus was effective in two heavily pretreated patients with advanced TETs, with a progression-free survival longer than 1 year and minimal toxicity.

关键词： Thymoma Everolimus mTOR Mediastinum Target

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