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Correlation between Central and Lateral Neck Dissection in Differentiated Thyroid Carcinoma

International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 109-115页

作者： Olivia Mazzaschi marine lefevre Bruno Angelard Nathalie Chabbert-Buffet Jean Lacau St.Guily Sophie Perie Department of Otolaryngology-Head and Neck Surgery Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Pathology Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Obstetrics Gynaecology and Reproductive Medicine-Endocrinology SectionFaculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance

Objective: To determine the histopathological correlation between central and lateral neck metastasis in differentiated thyroid carcinoma, and its potential therapeutic impact. Although the central neck dissection (CND) is recommended in differentiated thyroid carcinoma, the indication for lateral neck dissection (LND) remains controversial. Design: Retrospective study. Methods and Main Outcome Measures: Pathological analysis of systematic ipsilateral central neck dissection (CND) and LND performed with total thyroidectomy in differentiated thyroid carcinoma was retrospectively reviewed according to “side” and to “patient”. Results: A total of 56 sides (46 patients) were suitable for analysis. Analysis by “side” revealed that CND and LND dissection samples were both negative in 15 cases, both positive in 32, CND was positive and LND was negative for 8 cases and CND was negative and LND was positive in 1 case. The combined presence of positive LND and positive CND was therefore observed in 32/40 “sides” and 26/46 “patients”. Analysis by “side” of the impact of the treatment decision to perform ipsilateral LND only in patients with positive CND and vice versa demonstrated a sensitivity, specificity, and accuracy of 97%, 65%, and 84%, respectively. Conclusions: In most cases, the presence of positive LND was associated with positive ipsilateral CND. The very low prevalence of positive LND in patients with negative CND may justify LND as a second step procedure only in patients with positive CND, except in the case of documented lateral neck metastasis.

关键词： Central Neck Dissection Lateral Neck Dissection Differentiated Thyroid Carcinoma Pathological Analysis Thyroid Carcinoma Neck Metastasis

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Pulsed export of carbon in the north-western Mediterranean Sea

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Journal of Oceanology and Limnology 2023年第1期41卷 189-202页

作者： Michel DENIS Dominique lefevre Melilotus THYSSEN Ian RJENKINSON Gérald GRÉGORI Aix Marseille Université Universitéde ToulonCNRS/INSUIRDInstitut Méditerranéen d'Océanologie(MIO)Marseille cedex09 13288France Key Laboratory of marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Agency for Consultation and Research in Oceanography Lavergne19320 La Roche CanillacFrance

The short term(hourly scale)variability of heterotrophic prokaryote(HP)vertical distribution and respiratory activity,was investigated in the north-western(NW)Mediterranean *** vertical distribution was determined on board by flow cytometry analysis of seawater samples collected by series of CTD *** counts and viability were determined for all *** respiratory rates were determined later in the laboratory from filtered seawater samples(23 dm^(3))from 300-1150-m *** average cell viability was 94.8%±2.2%(n=240).There was no accumulation of dead cells,due to quick decay of damaged *** the epipelagic layer,three HP groups were distinguished,two(HNA1,HNA2)who se cells exhibited a high nucleic acid content and one(LNA)with low nucleic acid content ***2 was most populated at 50 m but not detected at 90 m and below,presumably aerobic anoxygenic photoheterotrophic bacteria(AAPs).The variability in HP abundance was mainly confined in the upper 80 m.A few secondary peaks of HP abundance were observed(80-150 m)in connection with abundance troughs in the surface *** cells were continuously present in a wide layer around 500 m(mean 191×10^(3)cells/cm^(3)).Below this layer,HP abundance randomly exhibited peaks,coupled to respiratory rate *** HP abundance and variability in the water column was suppressed during a strong wind *** observed sporadic variability was tentatively interpreted through a pulsed carbon-export mechanism induced by the microorganism production of dissolved poly saccharide s,followed by flocculation and rapid *** mechanism would thus contribute to(ⅰ)preventing organic matter accumulation in the epipelagic layer,(ⅱ)seeding the water column with live HP cells,and(ⅲ)supplying the aphotic water column with fre sh and labile organic *** important vertical flux mechanism needs further observations and modelling.

关键词： north-western Mediterranean Sea heterotrophic prokaryote(HP) cell viability cell respiration transparent exopolymeric particle(TEP) aggregation flow cytometry

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Characterization of Mediterranean Magnetotactic Bacteria

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Journal of Ocean University of China 2007年第4期6卷 355-359页

作者： lefevre Christopher Bemadac Alain Pradel Nathalie WU Longfei Yu-Zhang Kui XIAO Tian Yonnet Jean-Paul Lebouc Afef SONG Tao Fukumori Yoshihiro Laboratoire de Chimie Bactkrienne UPR 9043 CNRS Marseille France Service de Microscopic Electronique lnstitut de Biologic Structurale et Microbiologie CNRS Marseille France Laboratoire de Microscopies et d＇Etude de Nanostructures （LMEN） Universite de Reims Champagne-Ardenne 51687 Reims cedex 2 France Key Laboratory of marine Ecology and Environmental Sciences Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 P. R. China Laboratoire d＇Electrotechnique de Grenoble Institut National Polytechniques de Grenoble F-38402 Saint Martin d＇eres Cedex France Institute of Electrical Engineering Chinese Academy of Science Beijing 100080 P. R. China Department of Life Science Graduate School of Nataral Science and Technology Kanazawa University Kanazawa Japan

Magnetotactic bacteria are a diverse group of motile prokaryotes that are ubiquitous in aquatic habitats and cosmopolitan in distribution. In this study, we collected magnetotactic bacteria from the Mediterranean Sea. A remarkable diversity of morphotypes was observed, including multicellular types that seemed to differ from those previously found in North and South America. Another interesting organism was one with magnetosomes arranged in a six-stranded bundle which occupied one third of the cell width. The magnetosome bundle was evident even under optic microscopy. These cells were connected together and swam as a linear entire unit. Magnetosomes did not always align up to form a straight linear chain. A chain composed of rectangle magnetosomes bent at a posi- tion with an oval crystal. High resolution transmission electron microscopy analysis of the crystal at the pivotal position suggested uncompleted formation of the crystal. This is the first report of Mediterranean magnetotactic bacteria, which should be useful for studies of biogeochemical cycling and geohistory of the Mediterranean Sea.

关键词： Magnetotactic bacteria Mediterranean Sea geomagnetism biogeochemical cycling ecology magnetosome crystals

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