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Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism

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Journal of Molecular Cell Biology 2023年第9期15卷 53-68页

作者： Quanxin Jiang Ning Wang Sĳia Lu Jie Xiong Yanmei Yuan Junli Liu Suzhen Chen Shanghai Diabetes Institute Department of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

Nonalcoholic steatohepatitis(NASH)is a condition that progresses from nonalcoholic fatty liver disease(NAFLD)and is characterized by hepatic fat accumulation,inflammation,and *** has the potential to develop into cirrhosis and liver cancer,and currently no effective pharmacological treatment is *** this study,we investigate the therapeutic potential of targeting ceruloplasmin(Cp),a copper-containing protein predominantly secreted by hepatocytes,for treating *** result show that hepatic Cp is remarkedly upregulated in individuals with NASH and the mouse NASH ***-specific Cp ablation effectively attenuates the onset of dietary-induced NASH by decreasing lipid accumulation,curbing inflammation,mitigating fibrosis,and ameliorating liver *** employing transcriptomics and metabolomics approaches,we have discovered that hepatic deletion of Cp brings about remarkable restoration of bile acid(BA)metabolism during *** deletion of Cp effectively remodels BA metabolism by upregulating Cyp7a1 and Cyp8b1,which subsequently leads to enhanced BA synthesis and notable alterations in BA *** conclusion,our studies elucidate the crucial involvement of Cp in NASH,highlighting its significance as a promising therapeutic target for the treatment of this disease.

关键词： ceruloplasmin nonalcoholic steatohepatitis bile acid inflammation fibrosis

Ground motion prediction equations based on shallow crustal earthquakes in Georgia and the surrounding Caucasus

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Earthquake Science 2022年第6期35卷 497-509页

作者： Jorjiashvili Nato Shengelia ia Godoladze Tea Gunia Irakli Akubardia Dimitri Institute of Earth Sciences and National Seismic Monitoring Center Ilia State UniversityTbilisi 0177Georgia

Strong ground motions caused by earthquakes with magnitudes ranging from 3.5 to 6.9 and hypocentral distances of up to 300km were recorded by local broadband stations and three-component accelerograms within Georgia’s enhanced digital seismic *** data mixing is particularly effective in areas where strong ground motion data are *** data were used to produce models based on ground-motion prediction equations(GMPEs),one benefit of which is that they take into consideration information from waveforms across a wide range of *** this study,models were developed to predict ground motions for peak ground acceleration and 5%-damped pseudo-absolute-acceleration spectra for periods between 0.01 and 10 ***-period ground motions decayed faster than long-period motions,though decay was still in the order of approximately 1/*** mechanisms and local soil conditions greatly influence *** spectral acceleration(SA)of thrust faults was higher than that for either strike-slip or normal faults but the influence of strike-slip faulting on SA was slightly greater than that for normal *** soils also caused significantly more amplification than rocky sites.

关键词： strong ground motion peak ground acceleration spectral acceleration shallow earthquake

A soil quality index for subtropical sandy soils under different Eucalyptus harvest residue managements

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Journal of Forestry Research 2023年第1期34卷 243-255页

作者： Jackson Freitas Brilhante de Sao José Maurício Roberto Cherubin Luciano Kayser Vargas Bruno Brito Lisboa Josiléia Acordi Zanatta Elias Frank Araújo Cimélio Bayer Department of Agricultural Research and Diagnosis Agriculture SecretariatLivestock and Rural Development of Rio Grande do Sul.570Goncalves Dias St.Porto AlegreRio Grande do SulBrazil Department of Soil Science “Luiz de Queiroz”College of Agriculture/University of Sao PauloPadua Dias Ave 11PiracicabaSao PauloBrazil Embrapa Floretas Estrada da Ribeirakm 111ColomboParanáBrazil CMPC Celulose RiograndenseSao Geraldo St.GuaíbaRio Grande do Sul 1680Brazil Department of Soil Science Federal University of Rio Grande do SulPorto AlegreBrazil

Eucalyptus harvest residues are attractive energy production resources for the forestry ***,their removal can have adverse impacts on soil quality and forest productivity,especially in sandy *** this study,we assessed the effects of Eucalyptus harvest residue managements with variable intensity on forest productivity and on physical,chemical,and biological indicators of the soil *** experiment was conducted in a Quartzipsamment(33 g kg-1clay)planted with Eucalyptus saligna in Barra do Ribeiro in southern *** the Eucalyptus was planted,residues from the previous rotation were subjected to five different management treatments:(1)FRM,in which all forest residues(bark,branches,leaves,and litter)were allowed to remain on the soil and only trunk wood was removed;(2)FRMB,in which was identical to FRM except that bark was also removed;(3)FRMBr,in which only trunk wood and branches were removed;(4)FRR,which involved removing all types of residues(bark,branches,leaves,and litter);and,(5)FRRs,in which all forest residues from the previous rotation were removed,and leaves and branches from the new plantation were prevented from falling onto the soil surface using a shade *** years after planting,soil samples were collected at four different depths(0-2.5,2.5-5,5-10,and 10-20 cm)to determine 17 soil chemical,physical,and biological *** results were combined into a soil quality index(SQI)using the principal component analysis *** SQI reduced by 30%,in the 0-20 cm layer,due to removal of harvest residues from the previous rotation,and collection of litter before it falls on the *** main drivers of SQI reduction were the principal components associated with soil organic matter and biological ***,the SQI was positively linearly related to tree height at Piameter at breast height at P=*** adverse impact on soil quality and forest productivity in our study indicates that removal

关键词： Forest residues Soil health Soil organic carbon Microbial biomass Soil conservation

Evaluation of total protein,peroxidase,and nutrients measured by pXRF for the determination of tissue rejuvenation/reinvigoration of Eucalyptus microcorys

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林业研究:英文版 2023年第5期34卷 1563-1576页

作者： Júlio Cézar Tannure Faria Caius Ribeiro-Kumara William Macedo Delarmelina Filipe Aiura Namorato Dione Richer Momolli Anderson Cleiton José Enéas Ricardo Konzen Dulcinéia de Carvalho Gilvano Ebling Brondani Department of Forestry and Wood Sciences Federal University of Espírito SantoJerônimo MonteiroEspírito SantoBrazil Department of Forest Sciences University of HelsinkiHelsinkiFinland Federal Institute of Education Science and Technology of Espírito SantoIbatibaEspírito SantoBrazil Department of Soil Science Federal University of LavrasLavrasMinas GeraisBrazil Department of Forest Engineering Federal University of Santa MariaSanta MariaRio Grande Do SulBrazil Department of Forestry Sciences Federal University of LavrasLavrasMinas GeraisBrazil Department Interdisciplinary Federal University of Rio Grande Do SulImbéRio Grande Do SulBrazil

Ontogenetic aging of tissues and the gradual decrease of adventitious rooting are known challenges for the clonal propagation of woody species,hampering clonal forestry *** study examined possible signatures of tissue rejuvenation/reinvigoration in different propagated materials of Eucalyptus microcorys by analyzing the total protein profile,peroxidase activity,macro-and micronutrient contents,and adventitious rooting of mini *** analyses were performed on *** shoots which were successfully obtained by seminal and grafting propagation,micropropagation with epicormic shoots,and indirect *** four mature trees used in the propagation,tissues from the one with the best propagation results were investigated for signs of tissue rejuvenation and/or *** individuals from each technique were randomly selected and transferred to a semi-hydroponic"channel"*** four weeks in the seedbed,the total protein,peroxidase activity,nutrient content and rooting of the mini cuttings were ***-PAGE enabled the differentiation of leaf samples obtained by grafting from the other propagation techniques,as revealed by two distinct *** obtained by micropropagation with epicormic shoots showed the highest peroxidase activity,while those obtained by seminal propagation and from the selected mature tree showed the lowest peroxidase activity.A portable X-ray fluorescence spectroscope(pXRF)identified adequate nutrient content in most of the nutrients tested in materials obtained by seminal and grafting propagation,and by indirect *** analysis of adventitious rooting showed that the highest rooting percentage was observed in mini cuttings from seminal propagation(75%)followed by indirect organogenesis(35%).Based on principal component analysis,it was concluded that rooting of mini cuttings from both seminal propagation and indirect organogenesis was associated with phosphorous,sulphur,and potassium

关键词： Adventitious rooting Juvenility Reinvigoration Rejuvenation Ontogenetic age

Fine-scale analysis reveals a potential influence of forest management on the spatial genetic structure of Eremanthus erythropappus

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Journal of Forestry Research 2021年第4期32卷 1567-1578页

作者： Lucas Fernandes Rocha Natália Ribeiro de Paula Dulcinéia De Carvalho Department of Forest Science Federal University of Lavras(UFLA)Av.Doutor Sylvio Menicucci1001 Aquental SolLavrasMinas Gerais State 37200-000Brazil Department of Forest Science College of Agricultural Sciences(FCA/UNESP)São Paulo State UniversityAv.Universitária3780Altos do ParaísoBotucatuSão Paulo State 18610-034Brazil

Forest management may have significant effects on forest connectivity and natural population *** old-growth single trees may also change natural patterns of genetic variation and spatial genetic *** study evaluated the impacts of forest management using a silvicultural system of seed trees on the genetic diversity and spatial genetic structure of Eremanthus erythropappus(DC.)MacLeish.A complete survey of 275 trees on four plots was undertaken out to compare the genetic variation of a managed stand with an unmanaged *** genotyped all adult and juvenile individuals 60 months after the management and compared the genetic diversity and the spatial genetic structure *** diversity was considered high because of an efficient gene flow between *** were no genetic differences between stands and no evidence of *** clustering identified a single population(K=1),indicating no genetic differentiation between managed and unmanaged *** and juvenile individuals of the unmanaged stand were more geographically structured than individuals from the managed *** was a tendency of coancestry among juveniles at the first class of distance of the managed stand,suggesting a drift of genetic structure possibly caused by *** early responses to management on genetic diversity and stand structure is a first step to ensuring the effectiveness of conservation practices of tree *** sustainability of forest management of *** on genetic diversity,and more accurately,on spatial genetic structure needs evaluation over time to promote effective conservation of the population size and genetic variability.

关键词： Genetic diversity Microsatellite markers Gene flow Silvicultural management Brazilian Cerrado

New variola(mpox)in Brazil:Epidemiological update and perspectives

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Asian Pacific Journal of Tropical Medicine 2022年第12期15卷 525-528页

作者： Ana Caroline Edwiges Evangelista Maria Eduarda Queiroz Santos Bandeira Larissa Martins de Sena Williana de Paula Marli do Carmo Cupertino Andréia Patrícia Gomes Rodrigo Siqueira-Batista School of Medicine Faculdade Dinâmica do Vale do PirangaPonte NovaMinas GeraisBrazil Departament of Medicine and Nursing Universidade Federal de ViçosaViçosaMinas GeraisBrazil

New variola(NV)-mpox(monkeypox)-is a zoonosis caused by the mpox virus,which belongs to the genus Orthopoxvirus in the family *** disease,in the present year(2022),has caused several cases and deaths around the world,including Brazil[1].The group of poxviruses,in which the species that causes NV is included,consists of agents widely distributed in *** to their considerably large size,they were among the first viruses to be microscopically *** Poxviridae family is capable of infecting epithelial and connective tissue ***,such a viral family is classified as a genome lineage composed of doublestranded DNA,completely independent of the host nucleus[1].

关键词： Brazil belongs considerably

Tax Reforms for Better Tax Administration:Georgian Experience

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Belt and Road Initiative Tax Journal 2021年第1期2卷 41-46页

作者： ia Mikhelidze International Relations Department Georgia Revenue Service

This article sets out to share the experience of the major tax reforms in Georgia,which is eventually recognized worldwide by reputable international organizations,including the International Monetary Fund,the World Bank and *** article highlights,in particular,three factors that we believe were and remain key to Georgia’s *** factors are:*** tax policy;*** administration process;and *** communication with taxpayers.

关键词： Single-window concept e-filing e-invoice Automatic VAT refund system TADAT assessment Doing Business

Digital Transformation of Georgia Revenue Service

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Belt and Road Initiative Tax Journal 2020年第2期1卷 18-23页

作者： ia Mikhelidze International Relations Department Georgia Revenue Service

The article reviews the most inspiring steps and actions Georgia Revenue Service(RS)took in the past *** structural,moral and finally digital transformation,RS made great efforts to build up a taxpayer-friendly environment and as a result,was ranked the 14th among 190 countries/regions around the globe by"Ease of Doing Business"for the"Paying Taxes"*** RS is conducting to strengthen level and quality of transparency,find solutions to the challenges driven by digitalization,*** is hoped that examples described in this article will serve as a good example for those who yet have to face transformation process.

关键词： Taxpayer-friendly Digitalization E-services Blockchain

COVID-19 in Brazil:Epidemiological update and perspectives

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Asian Pacific Journal of Tropical Medicine 2020年第5期13卷 193-196页

作者： Marli C Cupertino Graziela A Cupertino Andréia P Gomes Nicholas AJ Mayers R Siqueira-Batista Medical School Faculdade Dinamica do Vale do PirangaPonte NovaMinas GeraisBrazil Laboratory of Epidemiological and Computational Methods in Health Department of Medicine and NursingUniversidade Federal de VicosaVicosaMinas GeraisBrazil Department of Veterinary Medicine Universidade Federal de VicosaVicosaMinas GeraisBrazil

Coronaviruses are RNA viruses (Family: Coronaviridae) constituents of a significant number of viruses that provoke diseases in animals and human beings. There are four genera of these microorganisms: Alphacoronavirus, Betacoronavirus, Deltacoronavirus and Gammacoronavirus. From this group, the alpha- and beta-coronaviruses are designated as human coronavirus (HCoV) for their propensity to infect human beings[1].

关键词： diseases Corona Brazil