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Gastroesophageal reflux disease in pediatric esophageal atresia:Assessment of clinical symptoms and pH-impedance data

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World Journal of Clinical Pediatrics 2020年第2期9卷 29-43页

作者： marina Aksionchyk Kirill Marakhouski Aliaksandr Svirsky Department of Pediatric Gastroenterology Diagnostic DivisionRepublican Scientific and Practical Center for Pediatric SurgeryMinsk 220013Belarus Department of Endoscopy Republican Scientific and Practical Center of Pediatric SurgeryMinsk 220013Belarus Department of Pediatric surgery Republican Scientific and Practical Center of Pediatric SurgeryMinsk 220013Belarus

BACKGROUND Esophageal atresia(EA)is the most common congenital anomaly of the gastrointestinal *** reflux disease(GERD)is a frequent and lifelong problem in these *** can be asymptomatic and the incidence of esophageal gastric and intestinal metaplasia(Barrett’s esophagus)is increased in adults with EA compared with the general *** and accurate diagnosis of GERD is important to reduce long-term problems and this may be achieved by pH-impedance *** To assess symptoms and pH-impedance data in children after EA,in order to identify their specific features of *** This study was conducted from November 2017 to February 2020 and involved 37 children who had undergone EA via open surgical repair(51.35%boys,48.65%girls;age range:1-14 years,median:4.99 years).GERD diagnosis was made based on multichannel intraluminal impedance/pH study and two groups were established:EA without GERD,n=17;EA with GERD,n=20.A control group was established with 66 children with proven GERD(68.18%boys,31.82%girls;median age:7.21 years),composed of a nonerosive reflux disease(referred to as NERD)group(n=41)and a reflux esophagitis group(n=25).Upper gastrointestinal endoscopy with a mucosal esophageal biopsy was performed on all *** The most frequently observed symptom in EA patients with GERD and without GERD was cough(70%and 76.5%respectively).The number of patients with positive symptom association probability in the EA groups was significantly larger in the EA without GERD group(P=0.03).In the control reflux esophagitis group,prevalence of gastrointestinal symptoms was significantly higher than in the NERD group(P=0.017).For both EA groups,there was strong correlation with index of proximal events(IPE)and total proximal events(EA with GERD:0.96,Pvel of IPE was significantly lower than in GERD patients without any surgical treatment(P<0.001).Data on distal mean nocturnal baseline i

关键词： Esophageal atresia Gastroesophageal reflux disease pH-impedance testing Mean nocturnal baseline impedance Proximal reflux Reflux esophagitis Nonerosive reflux disease Pediatric

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Utility of routine blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones

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World Journal of Gastrointestinal Surgery 2017年第6期9卷 149-152页

作者： Offir Ben-Ishay marina Zeltser Yoram Kluger Surgical Oncology Pancreatic and Hepatobiliary Surgery ServiceDepartment of General SurgeryDivision of SurgeryRambam Health Care CampusHaifa 35254Israel

AIM To evaluate the value of blood testing after elective laparoscopic cholecystectomy and its association with procedure related *** Charts of all patients undergoing elective laparoscopic cholecystectomy from January 2013 through December2014 were reviewed retrospectively for demographics,indication for surgery,operative course and *** our institution the decision to perform postoperative blood analysis is left for the discretion of the surgeon,therefore we had the possibility to compare the results of those who had blood analyses results to those who did *** was performed to identify variables associated with the decision to perform postoperative blood *** a univariate and multivariate analyses was performed comparing the two *** subgroup analysis was performed to identify factors associated with procedure related *** Five hundred and thirty-two elective laparoscopic cholecystectomies for symptomatic gallstones were performed during the study ***-four percent of the patients(n=340)had blood tests taken post *** that had laboratory tests taken were older(P=0.006,OR=1.01),had longer surgery(Pvealed longer stay in the hospital(Pversion rates(P=0.01,OR=14.6).Postoperative blood tests withdrawals were not associated with complications(P=0.44).On Multivariate analysis BMI and drain placement were independently associated with *** The current study indicate that routine postoperative blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones does not predict complications and may have an added benefit in diagnosis and management of cases w

关键词： Cholecystectomy Blood tests Laparoscopy Complications Post-operative Gallstones symptomatic

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Bacterial and archaeal communities in saline soils from a Los Negritos geothermal area in Mexico

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Pedosphere 2023年第2期33卷 312-320页

作者： Joseph GUEvARA-LUNA Mario HERNÁNDEZ-GUZMÁN Nina MONTOYA-CIRIACO Luc DENDOOvEN marina Olivia FRANCO-HERNÁNDEZ Paulina ESTRADA-DE LOS SANTOS María Soledad vÁSQUEZ-MURRIETA Escuela Nacional de Ciencias Biológicas Instituto Politécnico NacionalCiudad de México 11340(Mexico) Laboratory of Soil Ecology CinvestavMexico City 07360(Mexico) Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de Tlaxcala.Carretera Federal Tlaxcala-Puebla km.1.5Tlaxcala 90070(Mexico) Unidad Profesional Interdisciplinaria de Biotecnología Instituto Politécnico NacionalCiudad de México 07340(Mexico)

In recent years,there has been a growing need to understand how salinity affects microbial communities in agricultural *** and bacterial community diversities and structures were investigated by high-throughput sequencing analysis of their 16S rRNA in two arable soils with low electrical conductivity(EC)(2.3 and 2.6 dS m^(-1))and a saline soil(EC=17.6 dS m^(-1)).The dominant bacterial phyla in the soils were Proteobacteria(relative abundance(RA)=46.2%),followed by Acidobacteria(RA=13.1%)and Actinobacteria(RA=10.0%),whereas Serratia(RA=6.0%)and Bacillus(RA=4.0%)were the dominant bacterial *** Nitrososphaera(53.5%)was the dominant archaeal phylotype in the arable soils,whereas Nitrosopumilus(RA=0.4%)dominated in the saline *** archaeal and bacterial community structures were different between the soils and significantly correlated with soil sand,arsenic,barium,and antimony contents,but not with soil salinity.

关键词： agricultural soil compositional approach microbial community mud volcano soil salinity soluble anion

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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes marina C.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones Ronaldo v.Briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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Pancreatic involvement in celiac disease

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World Journal of Gastroenterology 2022年第24期28卷 2680-2688页

作者： Daniel vasile Balaban Iulia Enache marina Ciochina Alina Popp Mariana Jinga Department of Internal Medicine and Gastroenterology Carol Davila University of Medicine and PharmacyBucharest 020021Romania Dr.Carol Davila Central Military Emergency University Hospital Bucharest 020021Romania Department of Pediatrics Carol Davila University of Medicine and PharmacyBucharest 020021Romania National Institute for Mother and Child Health Bucharest 020021Romania

Celiac disease(CD)is well recognized as a systemic,chronic autoimmune disease mainly characterized by gluten-sensitive enteropathy in genetically predisposed individuals but with various extraintestinal *** of the affected organs in CD is the pancreas,consisting of both endocrine and exocrine *** the last decades there has been increasing interest in the pancreatic changes in CD,and this has been reflected by a great number of publications looking at this extraintestinal involvement during the course of *** pancreatic endocrine changes in CD,focusing on type 1 diabetes mellitus,are well documented in the literature,the relationship with the exocrine pancreas has been less *** review summarizes currently available evidence with regard to pancreatic exocrine alterations in CD,focusing on risk of pancreatitis in CD patients,association with autoimmune pancreatitis,prevalence and outcomes of pancreatic exocrine insufficiency in newly diagnosed and gluten-free diet treated CD patients,and the link with cystic *** addition,we discuss mechanisms behind the associated pancreatic exocrine impairment in CD and highlight the recommendations for clinical practice.

关键词： Pancreas Celiac disease Autoimmune Pancreatitis Cystic fibrosis Exocrine insufficiency

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Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer:A retrospective analysis

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World Journal of Experimental Medicine 2024年第1期14卷 44-57页

作者： marina A Senchukova Evgeniy A Kalinin Nadezhda N volchenko Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia Department of Thoracic Surgery Orenburg Regional Cancer ClinicOrenburg 460021Russia Department of Pathology P.A.Hertzen Moscow Oncology Research CentreNational Medical Research Centre of RadiologyMoscow 125284Russia

BACKGROUND Lung cancer(LC)is a global medical,social and economic problem and is one of the most common cancers and the leading cause of mortality from malignant *** is characterized by an aggressive course,and in the presence of disease recurrence risk factors,patients,even at an early stage,may be indicated for adjuvant therapy to improve ***,combined treatment does not always guarantee a favorable *** this regard,establishing predictors of LC recurrence is highly important both for determining the optimal treatment plan for the patients and for evaluating its *** To establish predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa lung squamous cell carcinoma(LSCC).METHODS A retrospective case-control cohort study included 69 patients with LSCC who underwent radical surgery at the Orenburg Regional Clinical Oncology Center from 2009 to ***,all patients received adjuvant *** samples of the resected lung were stained with Mayer's hematoxylin and eosin and examined under a light *** and multivariate analyses were used to identify predictors associated with the risk of disease *** operating characteristic curves were constructed to discriminate between patients with a high risk of disease recurrence and those with a low risk of disease *** was analyzed using the Kaplan-Meier *** log-rank test was used to compare survival curves between patient *** were considered to be significant at Pve tissue in the tumor stroma(OR=21.70,95%CI=4.27-1

关键词： Lung cancer Lung squamous cell carcinoma Adjuvant chemotherapy Radical resection Disease recurrence risk factors

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Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up

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World Journal of Gastroenterology 2007年第39期13卷 5238-5244页

作者： Renato Caviglia Mentore Ribolsi marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala Department of Digestive Diseases Campus Bio-Medico University Rome Italy

AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Infliximab therapy Steroidsparing

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Playing Well on the Data FAIRground:Initiatives and Infrastructure in Research Data Management

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Data Intelligence 2019年第4期1卷 350-367页

作者： Danielle Descoteaux Chiara Farinelli marina Soares e Silva Anita de Waard Elsevier Inc50 Hampshire StCambridgeMA 02139USA Elsevier B.V.Radarweg 292043NX AmsterdamThe Netherlands

Over the past five years,Elsevier has focused on implementing FAIR and best practices in data management,from data preservation through *** this paper we describe a series of efforts undertaken in this time to support proper data management *** particular,we discuss our journal data policies and their implementation,the current status and future goals for the research data management platform Mendeley Data,and clear and persistent linkages to individual data sets stored on external data repositories from corresponding published papers through partnership with *** analysis of our data policies implementation confirms significant disparities at the subject level regarding data sharing practices,with most uptake within disciplines of Physical *** directions at Elsevier include implementing better discoverability of linked data within an article and incorporating research data usage metrics.

关键词： Open data Data sharing Data citation Open research

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Cancer stem cell plasticity and tumor hierarchy

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World Journal of Stem Cells 2015年第1期7卷 27-36页

作者： marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt MedImmune LLC Department of Oncology ResearchGaithersburg MD 20878 United States

The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer.

关键词： Cancer stem cells Stem cell Plasticity Tumor hierarchy Microenvironment Immune-mediatedtherapies Epithelial-to-mesenchymal transition

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Novel method for the preparation of Cs-containing FAU（Y） catalysts for aniline methylation

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 70-76页

作者： Olga A. Ponomareva Polina A. Shaposhnik marina vo Belova Boris A. Kolozhvari Irina I. Ivanova Department of Chemistry Lomonosov Moscow State University Moscow 119991 Russia A.v. Topchiev Institute of Petrochemical Synthesis Moscow Russia

Cs-containing FAU（Y）-type zeolite catalysts were prepared by conventional and novel ion exchange procedures followed by incipient wetness impregnation with CsOH. The novel ion exchange procedure involved hydrothermal treatment of NaY zeolite in aqueous solution of CsCl at 140-200 ℃ for 6-24 h. The samples were characterized by low-temperature nitrogen adsorption, X-ray fluorescence analysis, X-ray powder diffraction, scanning electron microscopy, 23Na, 27Al and 133Cs magic angle spinning nuclear magnetic resonance, CO2 and NH3-Temperature programmed desorption. The results show that hydrothermal treatment at 200 ℃ allows to obtain higher degrees of ion-exchange （up to 83%） with respect to conventional method giving maximum 66%- 69%. Catalytic properties of Cs-containing FAU（Y） were studied in aniline methylation. The yield of Nomethylani- line is shown to correlate with catalyst＇s basicity. The best catalyst performance was achieved over the catalyst with the highest ion-exchange degree impregnated with CsOH. The selectivity to N-methylaniline over this catalyst reached 96.4%.

关键词： FAU(Y) zeolite ion exchange with cesium aniline alkylation N-methylaniline

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